References of "Gillet, Marie-Claire"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEffects of gold compounds, free or incorporated in liposomes, on human synovial cells in culture
Lhoest-Gauthier, Marie -Paule; Gillet, Marie-Claire ULg; Van Ophem, P. et al

in Archives de Biologie (1984), 95(4), 413-21

Two gold compounds with anti-inflammatory action are separately introduced into fluid negative liposomes : Aurol-sulfide (colloidal gold compound) into the aqueous phase of liposomes, Auranofin (soluble ... [more ▼]

Two gold compounds with anti-inflammatory action are separately introduced into fluid negative liposomes : Aurol-sulfide (colloidal gold compound) into the aqueous phase of liposomes, Auranofin (soluble organic compound) into the lipidic phase. Their effects are analysed in synovial cells in culture. Aurol-sulfide, given alone, rapidly enters into the cells where it is found inside membrane limited inclusions. Under our experimental conditions, this agent is atoxic and has no effect on the cell cycle. When transported inside liposomes, Aurol-sulfide is found free, at least in part, in the cytoplasm and rapidly induces cell degeneration. Auranofin, given alone, is very cytotoxic under some experimental conditions. On the contrary, synovial cells are less sensitive to Auranofin whe encapsulated in liposomes. [less ▲]

Detailed reference viewed: 33 (1 ULg)
Full Text
Peer Reviewed
See detailEtude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Bassleer, Roger ULg; Marnette, J. M.; Wiliquet, P. et al

in Planta Medica (1983), 49(11), 158-161

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A ... [more ▼]

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailAlteration in the nucleosome and chromatin structures upon interaction with platinum coordination complexes
Houssier, Claude ULg; Gillet, Marie-Claire ULg; Hacha, Renée et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (1983), 739(3), 317-25

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and ... [more ▼]

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and thermal denaturation, at low binding ratios (r < 0.1–0.2). The general trend of the changes in these physicochemical properties is similar to that observed for the DNA-platinum complexes, which indicates that the same binding sites are involved in the platinum interaction with DNA and with its nucleoprotein complex. The cis-bidentate ligands, cis-dichlorodiammine, diaminocyclohexane and ethylenediamine platinum(II), showed a distinct behavior, with a more important destabilization of the DNA structure in the nucleoprotein than the trans-bidentate ligand, trans-dichlorodiammine-Pt(II), and monodentate ligand, diethylenetriamine-Pt(II). The drastic decrease of the negative electric dichroism in the 260 nm absorption band of the bases, observed with the five ligands, indicates a profound alteration of the DNA arrangement in chromatin and nucleosomes, attributed to a condensation of its superhelical structure. Some differences with previous observations on DNA complexes with the same platinum compounds indicate the possible formation of protein-DNA crosslinks in chromatin and nucleosomes. These could have some importance for the biological effects. [less ▲]

Detailed reference viewed: 4 (1 ULg)
See detailEffects of colloïdal gold either free or incorporated into liposomes on human synovial cells in culture
Lhoets-Gautier, Marie -Paule; Gillet, Marie-Claire ULg; Van Ophem P et al

in Biology of the Cell (1982, July), 45(1), 3

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailEffets de trois Alcaloides Extraits du Strychnos usambarensis sur des Cellules Cancereuses en Culture
Bassleer, Roger ULg; Gillet, Marie-Claire ULg; Massart, B. et al

in Planta Medica (1982), 45(6), 123-6

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours ... [more ▼]

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours cultivated IN VITRO (B 16 mouse melanoma cells, mouse Ehrlich tumour cells ELT, HW 165 rat hepatoma). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated. [less ▲]

Detailed reference viewed: 46 (4 ULg)
See detailEffects of Cis-Pt loaded liposomes on Ehrlich tumor cells
Gillet, Marie-Claire ULg; Heinen, Ernst ULg; Bassleer R

Conference (1982, April)

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailLa melanogenese, expression de la differenciation de cellules cancereuses en culture
Bassleer, Roger; Gillet, Marie-Claire ULg; Giet, Didier ULg et al

in Bulletin de l'Association des Anatomistes (1982), 66(194), 291-295

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months ... [more ▼]

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months), melanogenesis is expressed according to a cyclic way, even when maintained in a culture medium of constant composition and without adding any chemical agent eventually able to influence this phenomenon. The spontaneous cyclic activity is analyseed and an explanation is given as an hypothesis. [less ▲]

Detailed reference viewed: 22 (5 ULg)
Full Text
Peer Reviewed
See detailEffects of L-thiazolidine-4-carboxylic acid (thiaproline) on cancer cells in culture
Bassleer, Roger; Gillet, Marie-Claire ULg; Massart, B. et al

in Annales Pharmaceutiques Françaises (1982), 40(4), 385-389

Three animal and experimental cancer cell lines are cultivated in vitro and treated with thiaproline. At relatively high concentrations, a significant inhibition of mitotic activity is noted, especially ... [more ▼]

Three animal and experimental cancer cell lines are cultivated in vitro and treated with thiaproline. At relatively high concentrations, a significant inhibition of mitotic activity is noted, especially when cell population density is high (confluence, superposition). The sensitivity of these cell lines to thiaproline is not identical. No necrosis, no morphological alterations and no mitotic anomalies are noted. [less ▲]

Detailed reference viewed: 24 (0 ULg)
See detailModulation of melanogenesis of B16 melanoma cells in culture
Gillet, Marie-Claire ULg; Bassleer, R.

Conference (1981, May)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailPresence of histone H1 and the electric birefringence behavior of nucleosome fractions from sucrose gradient and column chromatography
Houssier, Claude ULg; Hacha, renée; Gillet, Marie-Claire ULg et al

in International Journal of Biological Macromolecules (1981), 3(1), 3159-62

Differences in H1 content and electric birefringence properties are observed in chromatin fractions and can explain tail folding against the nucleosome core.

Detailed reference viewed: 5 (1 ULg)
See detailScanning electron microscopic study on the interaction of liposomes with cells in vitro
Heinen, Ernst ULg; Gillet, Marie-Claire ULg

in European Journal of Cell Biology (1980), 22

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailUse of liposomes to reduce enhancement-absorption effects in PIXE
Robaye, G.; Weber, Georges ULg; Delbrouck-Habaru, J.-M. et al

in Nuclear Instruments & Methods (1980), 172(3), 535-9

It is demonstrated that enhancement-absorption effects which perturb the quantitative feature of PIXE can be lowered by using liposomes (synthetic phospholipid bilayer vesicles) as homogenizers in the ... [more ▼]

It is demonstrated that enhancement-absorption effects which perturb the quantitative feature of PIXE can be lowered by using liposomes (synthetic phospholipid bilayer vesicles) as homogenizers in the preparation of thin targets; [less ▲]

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailBiomedical application of PIXE in University of LIEGE
Weber, Georges ULg; Robaye G; Delbrouck JM et al

in Nuclear Instruments and Methods (1980), 168

Three biomedical applications of charged particle induced X-ray emission spectroscopy (PIXE) are outlined. The different fields investigated include biophysics (protein study), cancer chemotherapy (cis ... [more ▼]

Three biomedical applications of charged particle induced X-ray emission spectroscopy (PIXE) are outlined. The different fields investigated include biophysics (protein study), cancer chemotherapy (cis-dichlorodiamineplatinum (II) associated to liposomes as carriers) and lung pathology (serum and bronchio-alveolar lavages). The samples were irradiated with 3 Me V protons (cyclotron) in a nitrogen atmosphere. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
See detailThe kinetics of a microbial population
Gillet, Marie-Claire ULg; Remacle, Jean

in Loutit, M. W.; Miles, J. A. R. (Eds.) Microbila Ecology (1978)

The study is an attempt to show the relationship between environmental variables such as pH and temperature and the control of some microbial growth characteristics. Two models were used in order to ... [more ▼]

The study is an attempt to show the relationship between environmental variables such as pH and temperature and the control of some microbial growth characteristics. Two models were used in order to calculate the death rate in continuous cultures. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailHow to choose an appropriate carrier for platinum drugs
Gillet, Marie-Claire ULg; Houssier, Claude ULg

in Biochimie (1978), 60

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailEffets du complexe cis-dichlorodiammino-platine(II) - acide désoxyribonucléique sur des cellules normales ou cancéreuses
Heinen, Ernst ULg; Desaive, Claude ULg; Houssier, Claude ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1976), 170(4), 919-921

The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumor cells, in peritoneal macrophages and in chick embryo fibroblasts ... [more ▼]

The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumor cells, in peritoneal macrophages and in chick embryo fibroblasts cultivated in vitro.Cis-Pt has no antimitotic activity anymore when linked tp DNA. This would be due to the fact that free cis-Pt is not released from cis-Pt-DNA complex inside lysosomes. [less ▲]

Detailed reference viewed: 45 (8 ULg)