References of "Gillet, Marie-Claire"
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See detailControl of B16 mealnoma cells differentiation and proliferation by CuSO4 and vitamin C
Gillet, Marie-Claire ULg; Siwek, Brigitte; Pozzi, G. et al

in Anticancer Research (1990), 10(2A), 391-405

The paper demonstrates that the toxicity of CuSO4 in B16 melanoma cells is increased in serum-free medium and in the presence of Vitamin C. Vitamin C toxicity for B16 cells was increased in the presence ... [more ▼]

The paper demonstrates that the toxicity of CuSO4 in B16 melanoma cells is increased in serum-free medium and in the presence of Vitamin C. Vitamin C toxicity for B16 cells was increased in the presence of CUS04. [less ▲]

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See detailToxic and mitogenic activities of culture media conditioned by B16 melanoma cells
Coucke, Paul; Siwek, Brigitte; Gillet, Marie-Claire ULg et al

Conference (1990)

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See detailIdentification of cytotoxic factors in media conditioned by mouse B16 melanoma cells
Siwek, Brigitte; Gillet, Marie-Claire ULg; Sabbioni, Enrico et al

in Anticancer Research (1990), 10(5B), 1390

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See detailAntimitotic and cytotoxic Activities of Guattegaumerine, a Bisbenzylisoquinoline Alkaloid
Quetin-Leclercq, Joëlle; Gillet, Marie-Claire ULg; Bassleer, Roger et al

in Planta Medica (1987), 53

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine ... [more ▼]

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells. [less ▲]

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See detailEffects of copper sulfate given alone or with alpha-MSH and L-tyrosine on B16 melanoma cells cultured in serum-free media.
Gillet, Marie-Claire ULg; wang, François; Simonon, A. et al

in Archives of Biology (1987), 98(3), 327-39

This study shows that copper sulphate (0.1mM) has antiproliferative effects in B16 melanoma cells cutured in various serum-free media.

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See detailLe mélanome B16 de la souris en culture à trois dimensions
Gillet, Marie-Claire ULg; Christiane, Y.; Foidart, Jean-Michel ULg et al

in Bulletin de l'Association des Anatomistes (1986), 70(210), 21-4

Multicellular spheroids composed of mouse B16 melanoma cells have been prepared in non agitated culture on solid agar. Cells present frequent contacts and an extracellular matrix appears during ... [more ▼]

Multicellular spheroids composed of mouse B16 melanoma cells have been prepared in non agitated culture on solid agar. Cells present frequent contacts and an extracellular matrix appears during cultivation (up to 2 months in agitated suspension); it contains laminin, fibronectin and collagen I, III and IV. Cellular differentiation takes place inside these spheroids (melanogenesis progressively increases), but a relatively intense cell proliferation rate is also maintained. [less ▲]

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See detailEtude de la matrice extracellulaire dans des sphéroïdes multi-cellulaires de mélanome B16 en culture
Gillet, Marie-Claire ULg; Vanstichel, Sabine; Bassleer, Roger

Poster (1986, May)

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See detailOur research program in neurobiology and experimental cancerology
Bassleer, Roger; Moonen, Gustave ULg; Gillet, Marie-Claire ULg et al

Conference (1986, April)

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See detailCo-cultures of mouse B16 melanoma cells and 3T3 fibroblasts in three dimensions
Gillet, Marie-Claire ULg; Dequinze, Benoit; Borlon, Anne et al

in European Journal of Cell Biology. Supplement (1986), 42(Suppl 15), 49

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See detailScreening of cytotoxic activities of Strychnos alkaloids ( methods and results)
Leclercq, Joëlle; Gillet, Marie-Claire ULg; Bassleer, Roger et al

in Journal of Ethnopharmacology (1986), 15

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple ... [more ▼]

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple microtest which gives good reproducibility. Most of the active compounds belong to the usambarane skeleton but other structure-activity relationships are being discussed. [less ▲]

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See detailQuantitative cytochemical analysis by microdensitometry of spontaneous or alpha-MSH-stimulated melanogenesis in B16 melanoma cells cultivated in vitro
Gillet, Marie-Claire ULg; Hennet, Jacques; Bassleer, Roger

in European Journal of Cancer & Clinical Oncology (1985), 21(8), 951-956

Spontaneous and alpha-MSH stimulated melanogenesis has been studied in B16 cells by densitometry. De novo synthesis of the enzyme dopa-oxydase takes place following alpha-MSH treatment.

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See detailControl of proliferation and differentiation in B16 melanoma cells in bi- or tridimensional cultures
Bassleer, Roger; Gillet, Marie-Claire ULg; Simonon, Anne et al

Poster (1985, May)

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See detailMechanism of action of free or incorporated into liposomes cis-DDPt : a comparative study in Ehrlich tumour cells
Gillet, Marie-Claire ULg; Houssier, Claude ULg; weber, georges et al

in Hacher, M. P.; Douple, F. B.; Krakoff, I. M. (Eds.) Platinum Coordination Complexes in Cancer Chemotherapy (1984)

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See detailEffects of gold compounds, free or incorporated in liposomes, on human synovial cells in culture
Lhoest-Gauthier, Marie -Paule; Gillet, Marie-Claire ULg; Van Ophem, P. et al

in Archives de Biologie (1984), 95(4), 413-21

Two gold compounds with anti-inflammatory action are separately introduced into fluid negative liposomes : Aurol-sulfide (colloidal gold compound) into the aqueous phase of liposomes, Auranofin (soluble ... [more ▼]

Two gold compounds with anti-inflammatory action are separately introduced into fluid negative liposomes : Aurol-sulfide (colloidal gold compound) into the aqueous phase of liposomes, Auranofin (soluble organic compound) into the lipidic phase. Their effects are analysed in synovial cells in culture. Aurol-sulfide, given alone, rapidly enters into the cells where it is found inside membrane limited inclusions. Under our experimental conditions, this agent is atoxic and has no effect on the cell cycle. When transported inside liposomes, Aurol-sulfide is found free, at least in part, in the cytoplasm and rapidly induces cell degeneration. Auranofin, given alone, is very cytotoxic under some experimental conditions. On the contrary, synovial cells are less sensitive to Auranofin whe encapsulated in liposomes. [less ▲]

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See detailEtude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Bassleer, Roger ULg; Marnette, J. M.; Wiliquet, P. et al

in Planta Medica (1983), 49(11), 158-161

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A ... [more ▼]

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO. [less ▲]

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See detailAlteration in the nucleosome and chromatin structures upon interaction with platinum coordination complexes
Houssier, Claude ULg; Gillet, Marie-Claire ULg; Hacha, Renée et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (1983), 739(3), 317-25

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and ... [more ▼]

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and thermal denaturation, at low binding ratios (r < 0.1–0.2). The general trend of the changes in these physicochemical properties is similar to that observed for the DNA-platinum complexes, which indicates that the same binding sites are involved in the platinum interaction with DNA and with its nucleoprotein complex. The cis-bidentate ligands, cis-dichlorodiammine, diaminocyclohexane and ethylenediamine platinum(II), showed a distinct behavior, with a more important destabilization of the DNA structure in the nucleoprotein than the trans-bidentate ligand, trans-dichlorodiammine-Pt(II), and monodentate ligand, diethylenetriamine-Pt(II). The drastic decrease of the negative electric dichroism in the 260 nm absorption band of the bases, observed with the five ligands, indicates a profound alteration of the DNA arrangement in chromatin and nucleosomes, attributed to a condensation of its superhelical structure. Some differences with previous observations on DNA complexes with the same platinum compounds indicate the possible formation of protein-DNA crosslinks in chromatin and nucleosomes. These could have some importance for the biological effects. [less ▲]

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See detailEffects of colloïdal gold either free or incorporated into liposomes on human synovial cells in culture
Lhoets-Gautier, Marie -Paule; Gillet, Marie-Claire ULg; Van Ophem P et al

in Biology of the Cell (1982, July), 45(1), 3

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See detailEffets de trois Alcaloides Extraits du Strychnos usambarensis sur des Cellules Cancereuses en Culture
Bassleer, Roger ULg; Gillet, Marie-Claire ULg; Massart, B. et al

in Planta Medica (1982), 45(6), 123-6

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours ... [more ▼]

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours cultivated IN VITRO (B 16 mouse melanoma cells, mouse Ehrlich tumour cells ELT, HW 165 rat hepatoma). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated. [less ▲]

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