A novel mathematical model to simulate and predict tissue regeneration

in Middleton, J.; Jones, M. L.; Shrive, N. (Eds.) Proceedings of the 7th international symposium on Computer Methods in Biomechanics and Biomedical Engineering (2006)

Numerical simulation and experimental validation of murine fracture healing

in Proceedings of the fifth national day on biomedical engineering (2005)

Efficient and robust simulation of tissue differentiation in fracture healing

in Proceedings of the European Conference on Mathematical and Theoretical Biology (2005)

Different mechanoregulatory models predict different patterns of tissue differentiation

in Middleton, J.; Jones, M. L.; Shrive, N. (Eds.) Proceedings of the 6th international symposium on Computer Methods in Biomechanics and Biomedical Engineering (2005)

Mechanobiology of bone regeneration and bone adaptation to achieve stable long-term fixation of endosseous implants

in Zeman, M. E.; Cerrolaza, M. (Eds.) Computational Modeling of Tissue Surgery (2005)

Experimental and numerical study of fracture healing in a murine fracture model

Poster (2005)

The effect of micromotion on tissues surrounding immediately loaded implants

in Computer Methods in Biomechanics & Biomedical Engineering (2005), 8(S1), 93-94

Reliable and efficient numerical simulation of a model of tissue differentiation in a bone chambe

Report (2004)

Numerical simulation of tissue differentiation around loaded implants in a bone chamber

in In Proceedings of the Mini-Symposium Biomécanique de l'appareil locomoteur (2004)

Numerical simulation of tissue differentiation around loaded titanium implants in a bone chamber.

in Journal of Biomechanics (2004), 37(5), 763-9

The application of a bone chamber provides a controlled environment for the study of tissue differentiation and bone adaptation. The influence of different mechanical and biological factors on the ... [more ▼]

The application of a bone chamber provides a controlled environment for the study of tissue differentiation and bone adaptation. The influence of different mechanical and biological factors on the processes can be measured experimentally. The goal of the present work is to numerically model the process of peri-implant tissue differentiation inside a bone chamber, placed in a rabbit tibia. 2D and 3D models were created of the tissue inside the chamber. A number of loading conditions, corresponding to those applied in the rabbit experiments, were simulated. Fluid velocity and maximal distortional strain were considered as the stimuli that guide the differentiation process of mesenchymal cells into fibroblasts, chondrocytes and osteoblasts. Mesenchymal cells migrate through the chamber from the perforations in the chamber wall. This process is modelled by the diffusion equation. The predicted tissue phenotypes as well as the process of tissue ingrowth into the chamber show a qualitative agreement with the results of the rabbit experiments. Due to the limited number of animal experiments (four) and the observed inter-animal differences, no quantitative comparison could be made. These results however are a strong indication of the feasibility of the implemented theory to predict the mechano-regulation of the differentiation process inside the bone chamber. [less ▲]