References of "Frederich, Michel"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailInsect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae
Paul, Aman ULg; Frederich, Michel ULg; Caparros Megido, Rudy ULg et al

in Journal of Asia-Pacific Entomology (2017), 20(2), 337-340

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and ... [more ▼]

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and compared with those of Tenebrio molitor larvae. A. domesticus, Co. discolor, Ch. parallelus and T. molitor larvae were found to contain approximately 15%, 13%, 10% and 32% lipids on dry weight, respectively. The lipids from three Orthopterans contain much higher amounts of essential fatty acids than those of T. molitor larvae. The two Orthopterans of the suborder Ensifera i.e., A. domesticus and Co. discolor contain linoleic acid in major quantities, while Ch. parallelus of the suborder Caelifera, contain α-linolenic acid in major quantities. The consumption of linoleic and α-linolenic fatty acid is linked with numerous health promoting effects. The factors that contribute to differences in fatty acid profiles of these insects are being discussed. At last the nutritional parameters including polyunsaturated to saturated and omega 6 to omega 3 fatty acid ratios of these insect lipids are also being discussed to understand the potential role of these lipids in human nutrition. [less ▲]

Detailed reference viewed: 48 (7 ULg)
Full Text
Peer Reviewed
See detailCyclotheonellazoles A–C, Potent Protease Inhibitors from the Marine Sponge Theonella aff. swinhoei
Issac, Michal; Aknin, Maurice; Gauvin-Bialecki, Anne et al

in Journal of Natural Products (2017)

he extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known ... [more ▼]

he extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known metabolite swinholide A. Further investigation of the extract afforded three unusual cyclic peptides, cyclotheonellazoles A–C (1–3), which contain six nonproteinogenic amino acids out of the eight acid units that compose these natural products. Among these acids the most novel were 4-propenoyl-2-tyrosylthiazole and 3-amino-4-methyl-2-oxohexanoic acid. The structure of the compounds was elucidated by interpretation of the 1D and 2D NMR data, HRESIMS, and advanced Merfay’s techniques. The new compounds were found to be nanomolar inhibitors of chymotrypsin and sub-nanomolar inhibitors of elastase, but did not present antiplasmodial activity. [less ▲]

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailAntiplasmodial activity of Heinsia crinita (Rubiaceae) and identification of new iridoids.
Tshisekedi Tshibangu, P.; Mutwale Kapepula, P.; Kabongo Kapinga, M. J. et al

in Journal of Ethnopharmacology (2017), 196

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in the Democratic Republic of the Congo (DRC) as a remedy against malaria. Investigations were conducted on crude extracts of leaves, fruits and stem barks in view to validate their use and to determine which plant part possesses the best antiplasmodial properties. MATERIALS AND METHODS: Different plant parts were extracted with methanol, ethanol and dichloromethane. Based on the preliminary assays, the dichloromethane extract of the stem bark was subjected to fractionation using preparative HPLC system and column chromatography. This step led to the isolation of two new iridoids which had their structures elucidated by NMR, UV, MS and FT-IR spectroscopic techniques. Extracts and pure compounds were tested in vitro against the 3D7 strain of Plasmodium falciparum. The inhibition of the parasite growth was evaluated in vitro by colorimetric method (p-LDH assay) and their cytotoxicity evaluated in vitro against the human non-cancer fibroblast cell line (WI38) through WST1 assay. The in vivo antiplasmodial activity was assessed by the inhibition of Plasmodium berghei growth in infected mice treated with the ethanol extract of H. crinita stem bark at the concentrations of 200 and 300mg/Kg/day per os, using a protocol based on the 4-d suppressive test of Peters and compared to a non-treated negative control group of mice (growth =100%). Finally the antioxidant activity of the same extract was evaluated using ABTS, DPPH and cell-based assays. RESULTS: A moderate in vitro antiplasmodial activity was observed for the dichloromethane extract of the stem bark of H. crinita (IC50 =29.2+/-1.39microg/mL) and for the two new iridoids, lamalbide 6, 7, 8- triacetate (IC50 =16.39+/-0.43microg/mL) as well as for its aglycone lamiridosin 6, 7, 8-triacetate (IC50 =0.44.56+/-1.12microg/mL). The ethanolic stem bark extract (200 and 300mg/kg/day, oral route) showed a moderate in vivo antimalarial activity in Plasmodium berghei-infected mice with 27.84+/-2.75% and 48.54+/-3.76% of inhibition of the parasite growth, respectively (p<0.01).). This extract displayed high cellular antioxidant activity using dichlorofluorescein-diacetate (DCFDA) on HL-60 monocytes. These crude extracts and pure compounds tested at the higher concentration of 100microg/mL did not show any cytotoxicity against WI38 cells. CONCLUSIONS: The results showed that H. crinita extracts possess antimalarial activity and contain some unusual iridoids with moderate antiplasmodial activity, therefore justifying to some extent its traditional use by the local population in DRC for this purpose. This is the first report of the isolation and antiplasmodial activity of these two new iridoids. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULg et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS
Ebralidze, L.; Mskhiladze, Lasha; Ledoux, Allison ULg et al

in World Journal of Pharmaceutical Research (2017), 6(3), 170-175

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailQualité des médicaments antipaludéens et caractéristiques des pharmacies des territoires périurbains de Kinshasa
Mavungu Landu, Don Jethro ULg; Liégeois, Sophie; Manzambi Kuwekita, Joseph ULg et al

Poster (2016, December 14)

Contexte: Le paludisme causé par le Plasmodium falciparum demeure un problème majeur de santé publique. Le traitement avec des antipaludiques de bonne qualité est une composante importante dans le ... [more ▼]

Contexte: Le paludisme causé par le Plasmodium falciparum demeure un problème majeur de santé publique. Le traitement avec des antipaludiques de bonne qualité est une composante importante dans le contrôle de cette maladie. Cependant en Afrique centrale, plus de 25% des médicaments serait contrefaits ou de qualité inférieure, situation qui serait encore plus dramatique dans les territoires périurbains. Méthode: Dans le contexte ci-mentionné, une étude préliminaire et prospective a été menée dans la zone de santé de Mont Ngafula 1 située dans les territoires périurbains de la Ville de Kinshasa durant la période allant du 22 février au 17 mars 2016. Treize échantillons de poudre pour suspension d’artéméther et de luméfantrine ont été collectés. L’analyse de la qualité de ces médicaments a été réalisée au moyen de méthodes séparatives génériques utilisant la technique de chromatographie liquide à haute performance couplé à un détecteur à barrettes de diodes. Une caractérisation a été également effectuée dans 127 établissements pharmaceutiques sur base des normes édictées par le Ministère de la Santé Publique congolais. Résultats: Les résultats des analyses des échantillons d’antimalariques (ou antipaludéens) montre que presque la moitié des poudres pour suspension d’artéméther et de luméfantrine ne contenait pas la concentration prévue en artéméther et/ou en luméfantrine. Par ailleurs, le résultat des observations évoque qu’aucun établissement pharmaceutique ne respecte l’ensemble des normes du Ministère de la Santé Publique. [less ▲]

Detailed reference viewed: 248 (8 ULg)
Full Text
Peer Reviewed
See detailNutritional Composition and Rearing Potential of the Meadow Grasshopper (Chorthippus parallelus Zetterstedt)
Paul, Aman ULg; Frederich, Michel ULg; Uyttenbroeck, Roel ULg et al

in Journal of Asia-Pacific Entomology (2016), 19(4), 1111-1116

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are ... [more ▼]

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are abundantly found throughout Europe. However, these insects were not consumed by Europeans till now, but could possibly be used as human food, which is why we investigated their chemical composition. We found that they contain high level of proteins (69%), with an excellent amino acid profile and protein digestibility (97%). Furthermore, specimens of C. parallelus have an interesting fatty acids profile and minerals composition. Preliminary toxicity assessment indicates that these insects do not exhibit toxicity towards neutrophil cells (white blood cells). These data suggest that C. parallelus could be considered for human consumption. Rearing trials done during the study show that commercial rearing could be developed to produce sufficient biomass for sustaining human consumption. [less ▲]

Detailed reference viewed: 73 (37 ULg)
See detailPotential Antimalarials from Tropical Plants and Natural Products
Frederich, Michel ULg; Ledoux, Allison ULg

Scientific conference (2016, November 16)

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The ... [more ▼]

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The resistance of parasites to available and affordable medicines has become a widespread problem in exposed countries, making the search of new antimalarial compounds still necessary. As the immeasurable therapeutic potential of plants is well established2, natural products could be an interesting source of new antimalarial drugs. Indeed, according Newmann and Cragg, more than 60% of the antiparasitic drugs discovered between 1981 and 2014 were unaltered naturals products (12.5%), natural products derivatives (31.3%) and synthetic drugs with a natural product pharmacophore (18.8%).3 Then, the pharmacological and phytochemical study of plants, especially from traditional pharmacopoeias can be of first interest to discovered new antimalarial compound and also to valorize the traditional knowledge. The first part of the talk will concern some examples of results obtained in the lab : the in vivo activity of strychnogucine B, which was isolated from strychnos icaja and semi-synthetized, the optimization of ellagic acid as a lead in the treatment of malaria and the validation of MIT from Mezoneuron benthamianum. In the second part of the talk, the work about Poupartia borbonica, an endemic plant from Reunion Island studied in the framework of a collaboration with the University of Reunion Island will be presented. [less ▲]

Detailed reference viewed: 100 (8 ULg)
Full Text
See detailValorization of Seeds from Some Field Border Flowering Seeds
Paul, Aman ULg; Danthine, Sabine ULg; Mutwale Kapepula, Paulin ULg et al

Poster (2016, September 20)

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It ... [more ▼]

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It could be really interesting to valorize some commonly grown plant in these strips to render food or health promoting compounds. With this objective in mind the seeds of Achillea millefolium, Anthriscus sylvestris and Prunella vulgaris were investigated for lipids, proteins and phenolic content. Further the lipids were analyzed for fatty acid profile using gas chromatography and the phenolic compounds in the methanolic extract of defatted seeds were identified using HPLC-DAD. The antiradical activity of the methanolic extracts obtained from defatted seeds was investigated using DPPH and ABTS assays. The anti-inflammatory potential of these seed extracts was evaluated on the reactive oxygen species (ROS) production by stimulated neutrophils and on the specific activity of myeloperoxidase (MPO), a pro-oxidant enzyme marker of inflammation. Seeds from all three plants were analyzed with interesting levels of lipids, proteins and phenolic content. Linoleic acid, oleic acid and alpha-linolenic acid were the major fatty acids analyzed in A. millefolium, A. sylvestris and P. vulgaris respectively. On the other hand different phenolic acid formed the major phenolic constituents. Seed extracts displayed high ABTS and DPPH radical-scavenging activities in a dose dependent manner. Also a strong dose dependent anti-inflammatory activity of all three extracts was observed against ROS production by neutrophils and MPO activity. Results indicate that these seed show a great potential to render lipids which could be utilized as human food, further the defatted seeds could be directly included in human diet due to interesting levels of proteins and anti-inflammation ability. [less ▲]

Detailed reference viewed: 29 (9 ULg)
Full Text
Peer Reviewed
See detailNew antimalarial compounds isolated from Poupartia borbonica, a Mascarene Islands endemic plant
Ledoux, Allison ULg; Jansen, Olivia ULg; St-Gelais, Alexis et al

in Planta Medica (2016, July), 82(S01), 1-381

Detailed reference viewed: 37 (9 ULg)
Full Text
Peer Reviewed
See detailStudy of Mezoneuron benthamianum, a plant traditionally used against malaria in Guinea
Tchinda Tiabou, Alembert ULg; Loua, Jean; Esters, Virginie ULg et al

Poster (2016, July)

Despite some improvements in malaria control, this parasitic disease remains a major public health problem in many African countries, causing about 400 000 deaths/year through the continent, mainly by ... [more ▼]

Despite some improvements in malaria control, this parasitic disease remains a major public health problem in many African countries, causing about 400 000 deaths/year through the continent, mainly by children under the age of five (WHO, 2015). In Guinea, the leaves of Mezoneuron benthamianum Baill. are traditionally used to treat malaria (Traore et al., 2013) and showed a good antiplasmodial activity in an antiprotozoal in vitro screening (Traore et al., 2014), as well as promising results in a preliminary small-scale ethnomedical study (unpublished data), encouraging us to continue the study of this plant. The aim of this work was to evaluate the activity of M. benthamianum leaves extracts against P. falciparum using an in vitro test model (p-LDH assay) and to undertake a bio-guided fractionation to identify the compounds responsible for the activity. Hydroethanolic extracts (70% v/v) of M. benthamianum leaves showed a moderate in vitro activity against P. falciparum 3D7, with IC50 = 22.5 – 32.6 µg/ml, depending on the batch; while a dark precipitate formed during ethanol evaporation showed higher activity (IC50 = 6,5µg/ml). The bioguided fractionation was performed on this most active fraction and allowed the isolation of three diterpens, two flavonoids, resveratrol, gallic acid and its ethylester, β-sitosterol glucoside and pheophorbide derivatives. The active compounds belong to several phytochemical classes, including flavonoids, pheophorbide and gallic acid derivatives, contributing together to the global antiplasmodial activity of the hydroalcoholic extract against P. falciparum parasite. This study gives some concrete evidence to support the ethnopharmacological use of Mezoneuron benthamianum leaves extract in the management of malaria. The active compounds can be further studied for their antiplasmodial potential, as well as their suitability to be used as quality markers for the standardization of this herbal drug from the Guinean traditional pharmacopeia. [less ▲]

Detailed reference viewed: 35 (7 ULg)
Full Text
Peer Reviewed
See detailIsolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum
Mskhiladze, Lasha; Chincharadze, David; St-Gelais, Alexis et al

in International Journal of Pharmaceutical Sciences and Drug Research (2016), 8(4), 240-243

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers ... [more ▼]

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers of Allium gramineumthat growsin Georgia.The structures of isolated compounds havebeen determined by 1H and 13C nuclear magnetic resonance (NMR) Isolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum. Available from: https://www.researchgate.net/publication/305851744_Isolation_and_Identification_of_Steroid_and_Flavonoid_Glycosides_from_the_Flowers_of_Allium_gramineum [accessed Aug 5, 2016]. [less ▲]

Detailed reference viewed: 81 (8 ULg)
Full Text
Peer Reviewed
See detailFingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines
Tshisekedi Tshibangu, Pascal ULg; Mutwale Kapepula, Paulin ULg; Kabongo Kapinga, Marie Josée et al

in Journal of Pharmaceutical & Biomedical Analysis (2016), 128(2016), 382-390

African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ... [more ▼]

African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ensuring the health of population and in order to advance towards improved traditional medicines (ITMs). In this paper chromatographic methods were developed for qualitative and quantitative analyses of a per os antimalarial ITM containing Garcinia kola. The identified analytical markers were used to establish TLC and HPLC fingerprints. G. kola seeds were analysed by HPLC to confirm the identity of the extract used by the Congolese manufacturer in the ITM. The main compounds (GB1, GB2, GB-1a and Kolaflavanone) were isolated by preparative TLC and identified by UPLC–MS and NMR. For the quantification of the major compound GB1, a simple and rapid experimental design was applied to develop an LC method, and then its validation was demonstrated using the total error strategy with the accuracy profile as a decision tool. The accurate results were observed within 0.14–0.45 mg/mL range of GB1 expressed as naringenin. The extracts used in several batches of the analysed oral solutions contained GB1 (expressed as naringenin) within 2.04–2.43%. Both the fingerprints and the validated LC-DAD were found suitable for the quality control of G. kolabased raw material and finished products, respectively. [less ▲]

Detailed reference viewed: 42 (15 ULg)
Full Text
See detailScreening of mahoran plants for cosmetic applications.
Saive, Matthew ULg; Frederich, Michel ULg; Fauconnier, Marie-Laure ULg

Poster (2016, June 01)

This study’s main aim is to identify plant species showing anti-oxidant, anti-inflammatory and skin whitening properties. A selection of 89 samples from previous infield studies on the traditional uses of ... [more ▼]

This study’s main aim is to identify plant species showing anti-oxidant, anti-inflammatory and skin whitening properties. A selection of 89 samples from previous infield studies on the traditional uses of plants in Mayotte were analyzed. The anti-oxidant activity was assessed using the α, α-diphenyl-β-picrylhydrazyl (DPPH) method developed by Blois [1]. The anti-inflammatory activity and the skin whitening activity were both assessed through the study of inhibition kinetics from specific enzymes: respectively, lipoxygenase (EC 1.13.11.12) due to its important role in the leukotriene pathway and tyrosinase (EC. 1.14.18.1) as it takes part in the melanogenesis pathway. The IC 50 value for each sample and for each activity was obtained using UV/Vis spectrophotometric technics. These IC 50 were then compared with the ones obtained from known molecules found in the literature: namely, (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (IC50 = 4,388 µM) for the anti-oxidant activity, nordihydroguaiaretic acid (IC50 = 3,5µM) for the anti-inflammatory activity and kojic acid (IC50 = 722 µM) for the anti-tyrosinase activity. The most effective anti-oxidant activity was observed in fresh leaves from Acalypha wilkesiana Müll.Arg. (IC50 = 0,381 g/L) and Leea guineensis G. Don. (IC50 = 0,225 g/L) as well as in dried roots from Litchi chinensis Sonn. (IC50 = 0,346 g/L). All results are expressed in grams of fresh matter. According to the preliminary tests for the-anti-inflammatory and skin whitening activities, the crude extracts from Kalanchoe pinnata Lam. Pers., Litchi chinensis Sonn., Zingiber zerumbet (L.) Sm., Leea guineensis G. Don. and Paullinia pinnata L. are likely to show promising activities. [less ▲]

Detailed reference viewed: 91 (13 ULg)
Full Text
Peer Reviewed
See detailTerpenoids from Phaulopsis imbricata (Acanthaceae)
Kengne, A.B.O.; Tene, M.; Tchinda Tiabou, Alembert ULg et al

in Journal of Medicinal Plants Research (2016), 10(10), 122-129

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate ... [more ▼]

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate secondary metabolites from this plant species that has not been investigated so far. Two lupane-type triterpenoids, one β-type carotenoid, one eudesmane-type sesquiterpenoid, and one sterol glycoside were isolated from the dried methanol extract using solvent partitioning, column chromatography and re-crystallization. They were identified as lupeol, betulin, (all-E)-lutein, cryptomeridiol, and sitosterol 3- O-β-D-glucopyranoside, respectively. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods including 1D- and 2D- nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometry (MS). This is the first report of these compounds from the genus Phaulopsis. To the best of our knowledge, P. imbricata is also the first species of the genus to be phytochemically studied. [less ▲]

Detailed reference viewed: 46 (10 ULg)
Full Text
Peer Reviewed
See detailFrom Valeriana officinalis to cancer therapy: the success of a bio-sourced compound
Hamaïdia, Malik ULg; Barez, Pierre-Yves ULg; Carpentier, Alexandre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20

Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. In this review, we recapitulate the story ... [more ▼]

Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. In this review, we recapitulate the story of one of these compounds, 2-propylpentanoic acid, derived from the Valeriana officinalis flowering plant and its path to validation as a cancer treatment. [less ▲]

Detailed reference viewed: 186 (53 ULg)
Full Text
Peer Reviewed
See detailSubstituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
Marquise, Nada; Chevallier, Floris; Nassar, Ekhlas et al

in Tetrahedron (2016), 72(6), 825-836

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions ... [more ▼]

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties [less ▲]

Detailed reference viewed: 35 (13 ULg)