References of "Frankenne, F."
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRegulation of cancer invasion and vascularization by plasminogen activator inhibitor-1
Noël, Agnès ULg; Bajou, Khalid ULg; Masson, Véronique ULg et al

in Fibrinolysis and Proteolysis (1999), 13(6), 220-225

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of ... [more ▼]

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of urokinase-type plasminogen activator (urokinase, uPA) or tissue-type plasminogen activator (tPA). Plasminogen activator inhibitor-1 or PAI-1 is the main inhibitor of uPA and tPA. High levels of components of this proteolytic system, including uPA and its cell surface receptor (uPAR), have been correlated with a poor prognosis for different cancers. It was therefore anticipated that PAI-1 expression would be associated with favorable outcome. Paradoxically, high rather than low PAI-1 levels predict poor survival of patients suffering from a variety of cancers. Recent observations indicate a much more complex role of PAI-1 in tumor progression and angiogenesis than initially expected. The exact mechanisms of this multifunctional molecule remain puzzling. [less ▲]

Detailed reference viewed: 19 (7 ULg)
Full Text
Peer Reviewed
See detailInhibition of Matrix Metalloproteinase 2 Maturation and Ht1080 Invasiveness by a Synthetic Furin Inhibitor
Maquoi, Erik ULg; Noël, Agnès ULg; Frankenne, F. et al

in FEBS Letters (1998), 424(3), 262-6

The close correlation observed between matrix metalloproteinase 2 (MMP-2) activation and metastatic progression in various tumors suggests that MMP-2 is a 'master switch' triggering tumor spread. Recently ... [more ▼]

The close correlation observed between matrix metalloproteinase 2 (MMP-2) activation and metastatic progression in various tumors suggests that MMP-2 is a 'master switch' triggering tumor spread. Recently, membrane type 1 MMP (MT1-MMP) was identified as a potential physiological activator of MMP-2. Like all other MMPs, MT1-MMP possesses a pro-domain which must be removed for the enzyme to acquire its catalytic potential. The presence of a typical recognition motif (RXKR) for the furin-like convertases at the end of its pro-domain suggests a potential role for these proteinases in MT1-MMP processing. In order to evaluate the implication of furin in pro-MT1-MMP processing, we treated HT1080 cells with a synthetic furin inhibitor and monitored their ability to activate pro-MMP-2 as well as their invasive potential. Our results demonstrated that the furin inhibitor decreased pro-MT1-MMP processing as well as pro-MMP-2 activation and cell invasiveness. Therefore, our data bring further evidence that furin is a key factor in the maturation of MMPs associated with the invasive and metastatic potential of tumor cells. [less ▲]

Detailed reference viewed: 21 (3 ULg)
Peer Reviewed
See detailDemonstration of the pituitary expression of the human GH-V gene as assessed by a competitive hybridization technique.
Scippo, Marie-Louise ULg; Frankenne, F.; Igout, Ahmed ULg et al

in Proceedings of the 72nd Annual Meeting of the Endocrine Society (1990)

Detailed reference viewed: 4 (0 ULg)
See detailThe physiology of pituitary and placental GH function during pregnancy in acromegalic as compared on normal women
Beckers, Albert ULg; Frankenne, F.; Stevenaert, Achille ULg et al

in Endocrinology under 35, sienna italy - Abstract book (1990)

Detailed reference viewed: 7 (7 ULg)
Peer Reviewed
See detailHuman placental growth hormone: proof of identity with the GH-V gene product by N-terminal microsequence analysis.
Scippo, Marie-Louise ULg; Frankenne, F.; Van Beumen, J. et al

in Archives Internationales de Physiologie et de Biochimie (1989), 97

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailThe physiology of pituitary and placental GH secretion during pregnancy in acromegalic as compared to normal women.
Beckers, Albert ULg; Frankenne, F.; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1989)

Detailed reference viewed: 4 (2 ULg)
Peer Reviewed
See detailAcromegaly with low plasma GH level. A clinical biological, histological and GH mRNA study
Pagesy, P.; Martial, Joseph ULg; Delalande, O. et al

in Advanced in Biosciences (1988), 69

Detailed reference viewed: 7 (0 ULg)
See detailMonoclonal antibody to growth hormone the discovery of a new variant, human placental growth hormone
Hennen, Georges ULg; Frankenne, F.; Closset, J. et al

in Monoclonal antibodies : Basic principles, experimental and clinical applications in endocrinology (1985)

Detailed reference viewed: 16 (2 ULg)