Showing results 41 to 53 of 53
  Paradoxical Stimulation of Matrix Metalloproteinase-9 Expression in Ht1080 Cells by a Broad-Spectrum Hydroxamate-Based Matrix Metalloproteinase InhibitorMaquoi, Erik  ; Munaut, Carine ; Colige, Alain et alin Annals of the New York Academy of Sciences (1999), 878 Detailed reference viewed: 16 (3 ULg) Regulation of cancer invasion and vascularization by plasminogen activator inhibitor-1Noël, Agnès ; Bajou, Khalid ; Masson, Véronique et alin Fibrinolysis and Proteolysis (1999), 13(6), 220-225 Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of ... [more ▼] Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of urokinase-type plasminogen activator (urokinase, uPA) or tissue-type plasminogen activator (tPA). Plasminogen activator inhibitor-1 or PAI-1 is the main inhibitor of uPA and tPA. High levels of components of this proteolytic system, including uPA and its cell surface receptor (uPAR), have been correlated with a poor prognosis for different cancers. It was therefore anticipated that PAI-1 expression would be associated with favorable outcome. Paradoxically, high rather than low PAI-1 levels predict poor survival of patients suffering from a variety of cancers. Recent observations indicate a much more complex role of PAI-1 in tumor progression and angiogenesis than initially expected. The exact mechanisms of this multifunctional molecule remain puzzling. [less ▲] Detailed reference viewed: 16 (7 ULg)Inhibition of Matrix Metalloproteinase 2 Maturation and Ht1080 Invasiveness by a Synthetic Furin InhibitorMaquoi, Erik ; Noël, Agnès ; et alin FEBS Letters (1998), 424(3), 262-6 The close correlation observed between matrix metalloproteinase 2 (MMP-2) activation and metastatic progression in various tumors suggests that MMP-2 is a 'master switch' triggering tumor spread. Recently ... [more ▼] The close correlation observed between matrix metalloproteinase 2 (MMP-2) activation and metastatic progression in various tumors suggests that MMP-2 is a 'master switch' triggering tumor spread. Recently, membrane type 1 MMP (MT1-MMP) was identified as a potential physiological activator of MMP-2. Like all other MMPs, MT1-MMP possesses a pro-domain which must be removed for the enzyme to acquire its catalytic potential. The presence of a typical recognition motif (RXKR) for the furin-like convertases at the end of its pro-domain suggests a potential role for these proteinases in MT1-MMP processing. In order to evaluate the implication of furin in pro-MT1-MMP processing, we treated HT1080 cells with a synthetic furin inhibitor and monitored their ability to activate pro-MMP-2 as well as their invasive potential. Our results demonstrated that the furin inhibitor decreased pro-MT1-MMP processing as well as pro-MMP-2 activation and cell invasiveness. Therefore, our data bring further evidence that furin is a key factor in the maturation of MMPs associated with the invasive and metastatic potential of tumor cells. [less ▲] Detailed reference viewed: 19 (3 ULg)Demonstration of the pituitary expression of the human GH-V gene as assessed by a competitive hybridization technique.Scippo, Marie-Louise ; ; Igout, Ahmed et alin Proceedings of the 72nd Annual Meeting of the Endocrine Society (1990) Detailed reference viewed: 4 (0 ULg)The physiology of pituitary and placental GH function during pregnancy in acromegalic as compared on normal women.Beckers, Albert ; ; Stevenaert, A. et alConference (1990) Detailed reference viewed: 4 (3 ULg)The physiology of pituitary and placental GH function during pregnancy in acromegalic as compared on normal womenBeckers, Albert ; ; Stevenaert, Achille et alin Endocrinology under 35, sienna italy - Abstract book (1990) Detailed reference viewed: 7 (7 ULg)Human placental growth hormone: proof of identity with the GH-V gene product by N-terminal microsequence analysis.Scippo, Marie-Louise ; ; et alin Archives Internationales de Physiologie et de Biochimie (1989), 97 Detailed reference viewed: 3 (1 ULg)The physiology of pituitary and placental GH secretion during pregnancy in acromegalic as compared to normal women.Beckers, Albert ; ; Stevenaert, Achille et alin Journal of Endocrinological Investigation (1989) Detailed reference viewed: 2 (2 ULg)Acromegaly with low plasma GH level. A clinical biological, histological and GH mRNA study; Martial, Joseph ; et alin Advanced in Biosciences (1988), 69 Detailed reference viewed: 6 (0 ULg)Isolation and nucleotide sequence of hGH-V cDNAIgout, Ahmed ; Scippo, Marie-Louise ; et alin Archives Internationales de Physiologie et de Biochimie (1988), 96 Detailed reference viewed: 6 (1 ULg)Monoclonal antibody to growth hormone the discovery of a new variant, human placental growth hormoneHennen, Georges ; ; et alin Monoclonal antibodies : Basic principles, experimental and clinical applications in endocrinology (1985) Detailed reference viewed: 10 (1 ULg)Progress in Endocrinology : the discovery of a new human growth hormone variant as a result of a nex technologies integration.Beckers, Albert ; ; et alConference (1985) Detailed reference viewed: 6 (0 ULg)Régulation de l'hormone de croissance humaine et ractivité à la TRH sous l'effet des oestroprogestatifs et pendant la grossesse.Beckers, Albert ; ; et alConference (1985) Detailed reference viewed: 4 (0 ULg) |
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