Le pseudoxanthome élatique au-delà de la peau, de l'oeil et des vaisseaux.

in Revue Médicale de Liège (2009), 64

The main clinical manifestations of pseudoxanthoma elasticum (PXE) alter small arteries, the eyes and the skin. At the microanatomical level, the feature in common is an alteration of the elastic fibres ... [more ▼]

The main clinical manifestations of pseudoxanthoma elasticum (PXE) alter small arteries, the eyes and the skin. At the microanatomical level, the feature in common is an alteration of the elastic fibres that appear dystrophic and in part calcified. The disease is genetically transmitted as an autosomal recessive trait. The gene coding for the MRP6 protein is often mutated. Thus PXE appears as a metabolic disease conveyed by serum. [less ▲]

Les métastases orphelines d'un cancer d'origine indéterminée.

in Skin (2009), 12

Mini-mélanome papulo-achromique de croissance rapide.

in Dermatologie Actualité (2009), 114

Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women.

in Expert Opinion on Pharmacotherapy (2009), 10(14), 2221-9

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects ... [more ▼]

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects of a 2.5% chitin-glucan formulation with its placebo, and commercially available glycerol formulations. METHODS: This two-step controlled double-blind, randomized, intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet. The formulations were applied once daily for 3 weeks. Electrometric assessments were performed on three sites of the feet at entry in the study, at weekly intervals during the treatment phase, and in a 2-week follow-up out of treatment. Positive controls consisted in two commercially available formulations enriched in glycerol. RESULTS: Data revealed an unequivocal benefit provided by the 2.5% chitin-glucan formulation compared with placebo. The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases. The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization. A steep increase was followed by a plateau level and a rapid decline after stopping the treatments. CONCLUSION: The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles. [less ▲]

Comment j'explore...une escarre de decubitus.

in Revue Médicale de Liège (2009), 64(10), 535-7

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ... [more ▼]

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ulcer is progressively increasing. This condition occurs at home, in old people's homes and in hospitals as well. The severity, duration and orientation of forces applied to the skin represent the most important factors responsible for pressure ulcers. Prevention measures are essential to reduce the prevalence of the disease. [less ▲]

Fondements de la cosmétovigilance sur le mode européen.

in Skin (2009), 12

Comment je traite... une hidradénite suppurée

in Revue Médicale de Liège (2009), 64

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and ... [more ▼]

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and more rarely involves the breasts, perineum and buttocks. There are many myths around hidradenitis suppurativa including its origin and pathomechanisms. Some antibiotics as well as corticosteroids and other immune downregulators are porly effective in this stubborn condition. By contrast, TNF-α antagonists appear promising. Radical surgery is another effective option. [less ▲]

Cornéocytes, Malassezia et pellicules: une trilogie à dompter.

in Réalités Thérapeutiques en Dermato-Vénéréologie (2009), 183

Les pellicules et la dermite séborrhéique font vraisemblablement partie d’un continuum d’états desquamatifs associés à une colonisation de la couche cornée par des levures du genre Malassezia spp. Cette ... [more ▼]

Les pellicules et la dermite séborrhéique font vraisemblablement partie d’un continuum d’états desquamatifs associés à une colonisation de la couche cornée par des levures du genre Malassezia spp. Cette dernière s’avère hétérogène, allant de la rareté à l’abondance selon les cornéocytes. La vitesse d’action des shampooings antipelliculaires met en doute un effet antifongique direct, mais suggère plutôt l’intervention des défenses immunitaires innées. [less ▲]

Avancées physiopathologiques dans la dermatite séborrhéique de l'adulte.

in Keratin (2007), 12

Le mélanome cutané dans une perspective liégeoise. Actualisation de son épidémiologie et avancées diagnostiques.

in Revue Médicale de Liège (2007), 62(Supplément), 52-55

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented ... [more ▼]

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented Neoplasms have scrutenised the epidemiological evolution of this cancer. We have disclosed a sharp increase in the global incidence of melanoma, more particularly in women in the age of procreation. We have also contributed and innovated in terms of clinical diagnosis by introducing dermoscopy and initiating both the ULEV method and the cyanoacrylate skin surface stripping. In the field of dermatopathology we have developed an immunohistological panel allowing to fine tune the diagnosis and to define some histoprognostic criteria. For the checkup of the disease extension, the PET scan method has been particularly refined. [less ▲]