References of "Focant, Jean-François"
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See detailMeasurement of emerging dechloranes in human serum using modulated gas chromatography coupled to electron capture negative ionization time-of-flight mass spectrometry
Brasseur, C; Pirard, C; L'Homme, B et al

in Rapid Communications in Mass Spectrometry (2016), 30

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See detailGC×GC-TOFMS, the Swiss Knife for VOC Mixtures Analysis in Soil Forensic Investigations
Stefanuto, Pierre-Hugues ULg; Focant, Jean-François ULg

in Soil in Criminal and Environmental Forensics (2016)

The study of the ‘smell of death’ is an important part of the thanatochemistry, the chemistry of death. Since 2004 (Vass et al. 2004), an increasing number of studies have been conducted to understand the ... [more ▼]

The study of the ‘smell of death’ is an important part of the thanatochemistry, the chemistry of death. Since 2004 (Vass et al. 2004), an increasing number of studies have been conducted to understand the body decomposition process by measuring the Volatile Organic Compounds (VOCs) released by decaying bodies. However, the chemical profi le of the decomposition odor is still far for from being resolved. Indeed, the complexity of the VOC mixture makes it diffi cult to be carried out by classical GC-MS. A better understanding of the decomposition process could thus possibly be achieved using a multidimensional technique such as Comprehensive Two Dimensional Gas Chromatography coupled to time of fl ight mass spectrometry (GC×GC-TOFMS). The high peak capacity of this multidimensional technique combined with the visualization power of multivariate statistical methods allows a deeper understanding of complex VOC matrices. [less ▲]

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See detailCryogenic zone compression GC-HRTOFMS for the measurement of PCB-153 and DDE in 20 mL serum samples
L'homme, Benjamin; Focant, Jean-François ULg

in Analytical Methods (2016), 8

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See detailChasing the Dioxin Detection Dragon
Focant, Jean-François ULg

in The Analytical Scientist (2016), 0316-701

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See detailgrteg
Focant, Jean-François ULg

Conference (2016)

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See detailFatty Matrices Cleaned-up with a Di erent Approach
Calaprice, Chiara ULg; Focant, Jean-François ULg

Scientific conference (2015, October)

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See detailHigh Resolution Gas Chromatography coupled to Mass Spectrometry for the analysis of volatile organic compounds
Savareear, Benjamin ULg; Brokl, M; Wright, C et al

Scientific conference (2015, September)

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See detailCadaveric VOC profiling from human internal cavity
Stefanuto, Pierre-Hugues ULg; Varlet, Vincent; Grabherr, Silke et al

Conference (2015, September)

The processes tacking place during body decomposition is not yet totally understood. Soon after death, the different parts of a body start to decompose. This phenomenon conduct to the production of gases ... [more ▼]

The processes tacking place during body decomposition is not yet totally understood. Soon after death, the different parts of a body start to decompose. This phenomenon conduct to the production of gases inside or around the different organs. These gases reservoirs can be located using imaging tools as post-mortem computed tomography (PMCT) and subsequently sample (1). The analysis of very volatile compounds inside these internal cavities already provides useful information for legal medicine investigations (2). It gives valuable information about the potential cause of death avoiding the invasiveness of the autopsy procedure. This project wanted to perform an untargeted screening of this internal cavity in order to monitor the decomposition process taking place inside a cadaver. The analytical method was base on previously used techniques for complete decomposition analysis (3-4). This study wanted to investigate the volatile organic compounds (VOC) mixture present in these cavities. To achieve this task, we applied solid phase micro-extraction (SPME) combined with two-dimensional gas chromatography coupled to high-resolution time of flight mass spectrometer (GC×GC-HRTOFMS). The first point was to demonstrate the ability of GC×GC-HRTOFMS to detect these VOC. The combination of different statistical approaches conducted to establishment of potential biomarkers list. Base on these biomarkers identification, different decomposition stages were observed for different organs in the same body. The cardiac area seems to decompose faster than the other tissues studied in this project. References 1. Levy A.D. et al., Am. J. Forensic Med. Pathol. (2010) 31, 12-17. 2. Varlet V. et al., Anal. Chim. Acta (2013) 784, 42-46. 3. Stadler S. et al., Anal Chem (2013) 85, 998–1005. 4. Stefanuto et al. CPC (2014) 79, 786-789. [less ▲]

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