Showing results 241 to 252 of 252
 Enantiomeric separations of basic drugs by capillary electrophoresis using derivatized cyclodextrins and dynamically or permanently modified capillariesFillet, Marianne  ; ; et alPoster (1995) Detailed reference viewed: 4 (1 ULg)Enantioseparations of basic compounds by capillary electrophoresis using neutral and anionic cyclodextrinsFillet, Marianne ; ; Ceccato, Attilio et alPoster (1995) Detailed reference viewed: 3 (1 ULg)Enantiomeric purity of propranolol by cyclodextrin modified capillary electrophoresisFillet, Marianne ; ; Chiap, Patrice et alPoster (1995) Detailed reference viewed: 5 (1 ULg) Determination of Benzodiazepines by Micellar Electrokinetic Chromatography; Fillet, Marianne ; Hubert, Philippe et alin Electrophoresis (1994), 15(10), 1316-21 A method for the separation and determination of benzodiazepines by micellar electrokinetic chromatography (MEKC) has been developed. Separation buffers consisted of aqueous solutions of glycine and ... [more ▼] A method for the separation and determination of benzodiazepines by micellar electrokinetic chromatography (MEKC) has been developed. Separation buffers consisted of aqueous solutions of glycine and triethanolamine (pH 9.0), containing sodium dodecyl sulfate (SDS) as surfactant and methanol as organic modifier. The effect of the concentration of SDS, methanol, glycine and triethanolamine on migration times and resolution was studied. Ten benzodiazepines were baseline separated at a 25 mM SDS concentration and 20% v/v methanol in a 75 mM glycine-250 mM triethanolamine buffer. Under these conditions, the within-day reproducibilities were 0.3-0.5% for migration times and 1.7-1.9% for peak areas at a concentration of 10 micrograms/mL. The limits of detection and quantification for oxazepam were 0.2 and 0.7 micrograms/mL, respectively, using an injection time of 5 s. [less ▲] Detailed reference viewed: 14 (4 ULg)Chiral Separation of Basic Drugs by Capillary Zone Electrophoresis with Cyclodextrin Additives; ; Fillet, Marianne et alin Electrophoresis (1994), 15(6), 818-23 The enantiomers of a series of basic drugs were separated in capillary zone electrophoresis (CZE) in phosphate buffers, pH 3, containing beta-cyclodextrin or one of its derivatives as chiral selectors and ... [more ▼] The enantiomers of a series of basic drugs were separated in capillary zone electrophoresis (CZE) in phosphate buffers, pH 3, containing beta-cyclodextrin or one of its derivatives as chiral selectors and uncoated fused silica capillaries thermostated at 15 degrees C. The nature of the cationic component of the background electrolyte was found to have a significant influence on achiral resolution and peak symmetry. The best results were obtained with triethanolamine, which was then used to adjust the buffer pH in all further experiments. The effects on chiral resolution of the nature and concentration of cyclodextrin, of the addition of methanol, and of capillary temperature were studied. Maximum resolution was obtained at a particular cyclodextrin concentration for each analyte, depending on the affinity of the analyte for this cyclodextrin. On the basis of the results, the effects of methanol addition and temperature on enantiomeric resolution could be explained and predicted. Numerous chiral separations are presented and suggestions for the rapid optimization of CZE enantioseparations with cyclodextrin additives are given. [less ▲] Detailed reference viewed: 12 (3 ULg)Enantiomeric purity determination of propranolol enantiomers by capillary electrophoresisFillet, Marianne ; ; Chiap, Patrice et alPoster (1994) Detailed reference viewed: 2 (1 ULg)Chiral separations of basic drugs in capillary electrophoresis using cyclodextrin derivatives as chiral selectorsCrommen, Jacques ; Fillet, Marianne ; et alConference (1994) Detailed reference viewed: 6 (2 ULg)Determination of acidic and basic drugs by capillary zone electrophoresisCrommen, Jacques ; ; Fillet, Marianne et alConference (1994) Detailed reference viewed: 8 (1 ULg)Chiral and achiral separations of basic drugs in capillary electrophoresis using cyclodextrin additivesCrommen, Jacques ; ; Fillet, Marianne et alConference (1994) Detailed reference viewed: 6 (1 ULg)Drug quality control by capillary electrophoresisCrommen, Jacques ; ; Fillet, Marianne et alConference (1994) Detailed reference viewed: 5 (2 ULg)Quantitative analysis of B-adrenergic blocking agents by capillary zone electrophoresis; Fillet, Marianne ; Hubert, Philippe et alin Journal de Pharmacie de Belgique (1994), 49 Detailed reference viewed: 5 (1 ULg)Determination of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis; ; Fillet, Marianne et alPoster (1994) Detailed reference viewed: 2 (1 ULg) |
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