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See detailEnantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives.
Fillet, Marianne ULg; Hubert, Philippe ULg; Crommen, Jacques ULg

in Electrophoresis (1997), 18(6), 1013-8

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta ... [more ▼]

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta-cyclodextrin) in combination with a neutral cyclodextrin as chiral additives to a pH 3 phosphoric acid-triethanolamine buffer. In the presence of a negatively charged cyclodextrin, the analytes were given an appropriate mobility but relatively low enantioselectivities were generally obtained when such a cyclodextrin was the only selector added to the buffer. The addition of an uncharged cyclodextrin, such as the native beta-cyclodextrin or one of its derivatives (dimethyl-, trimethyl- and hydroxypropyl-beta-cyclodextrin), to this kind of buffer containing an anionic cyclodextrin, was found to give rise to considerable improvement in chiral resolution for all compounds studied. Resolution and analysis time were optimized by varying the nature and concentration of the two cyclodextrins. The best compromise was usually achieved by the simultaneous addition of sulfobutyl ether beta-cyclodextrin and trimethyl-beta-cyclodextrin. Under optimum conditions, the enantiomers of all NSAIDs examined could be completely separated (most often with resolution values higher than 5) in short analysis times (generally lower than 15 min). [less ▲]

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See detailResolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis
Fillet, Marianne ULg; Bechet, I.; Hubert, Philippe ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1996), 14(8-10), 1107-14

Three beta-cyclodextrin derivatives--carboxymethyl-, dimethyl- and hydroxypropyl-beta-cyclodextrin--were tested as chiral selectors for the enantioseparation of seven basic drugs in free solution ... [more ▼]

Three beta-cyclodextrin derivatives--carboxymethyl-, dimethyl- and hydroxypropyl-beta-cyclodextrin--were tested as chiral selectors for the enantioseparation of seven basic drugs in free solution capillary electrophoresis, using buffers made of 100 mM phosphoric acid adjusted to pH 3.0 with triethanolamine in fused silica capillaries thermostatted at 15 degrees C. The best results with respect to chiral resolution were obtained with carboxymethyl-beta-cyclodextrin (CMCD): the enantiomers of all compounds examined were completely resolved with this beta-cyclodextrin derivative. The influence of the CMCD concentration on the migration times, the apparent electrophoretic mobility difference and the resolution of the drug enantiomers was investigated thoroughly. Particularly impressive resolution values, up to 23.7, were obtained for several compounds in these capillary electrophoretic systems, using CMCD in the 5-15 mM concentration range. [less ▲]

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See detailDetermination of water-soluble vitamins by capillary zone electrophoresis
Fotsing, Lucas ULg; Bechet, I.; Fillet, Marianne ULg et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailEnantiomeric separation of acidic and basic drugs by capillary electrophoresis using neutral and anionic cyclodextrins
Fillet, Marianne ULg; Bechet, I.; Schomburg, G. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailQuantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis
Bechet, Isabelle; Hubert, Philippe ULg; Crommen, Jacques ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1995), 13(4-5), 497-503

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of ... [more ▼]

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%. [less ▲]

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See detailCZE separation of basic and acidic drug by use of cyclodextrin additives
Bechet, I.; Fillet, Marianne ULg; Fotsing, Lucas ULg et al

Poster (1995)

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See detailEnantiomeric separation of basic drugs by cyclodextrin modified capillary electrophoresis using poly(vinyl alcohol) coated fused silica capillaries
Fillet, Marianne ULg; Schomburg, G.; Bechet, I. et al

in Journal de Pharmacie de Belgique (1995), 50

Detailed reference viewed: 7 (2 ULg)
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See detailComparison of Ce and LC methods for the determination of B vitamins in pharmaceutical dosage forms
Fotsing, Lucas ULg; Fillet, Marianne ULg; Bechet, I. et al

in Journal de Pharmacie de Belgique (1995), 50

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See detailEnantiomeric separations by capillary electrophoresis applications in pharmaceutical, biomedical and environmental analysis, chapitre #L-7
Crommen, Jacques ULg; Fillet, Marianne ULg; Bechet, Isabelle et al

in Buszewski, B. (Ed.) New analytical methods for environmental control and monitoring (1995)

Detailed reference viewed: 4 (1 ULg)