Neural network involved in self-judgment in young and elderly adultsFeyers, Dorothée ![]() Master of advanced studies dissertation (2008) Detailed reference viewed: 9 (1 ULg) A Comparison of Unawareness in Frontotemporal Dementia and Alzheimer's DiseaseSalmon, Eric ; ; Collette, Fabienne et alin Journal of Neurology, Neurosurgery & Psychiatry (2008), 79(2), 176-9 BACKGROUND: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer's disease (AD). AIM: To compare unawareness (anosognosia) for ... [more ▼] BACKGROUND: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer's disease (AD). AIM: To compare unawareness (anosognosia) for different symptoms, measured with a discrepancy score between patient's and caregiver's assessment, in AD and FTD. METHOD: In a prospective, multi-centre study, 123 patients with probable AD, selected according to the NINCDS-ADRDA procedure, were matched for age, sex, education, disease duration and dementia severity to patients with FTD (n = 41), selected according to international consensus criteria. A research complaint questionnaire was used to obtained patient's and caregiver's assessment concerning neuropsychological and behavioural symptoms. Data were compared in each group and between groups. Unawareness (measured by discrepancy scores) was compared between patients with AD and FTD. RESULTS: The caregivers generally assessed symptoms more severely than did patients, but both patient groups reported changes in affect (depressive mood or irritability) as their caregivers did. Unawareness was greater in patients with FTD than in patients with AD for language and executive difficulties, and for changes in behaviour and daily activities. CONCLUSION: The main finding is that unawareness was observed in both patients with FTD and patients with AD for most clinical domains. However, qualitative and quantitative differences showed that lack of awareness was greater in patients with FTD. [less ▲] Detailed reference viewed: 65 (14 ULg) Self-reflection across time: cortical midline structures differentiate between present and past selvesD'Argembeau, Arnaud ; Feyers, Dorothée ; Majerus, Steve et alin Social Cognitive and Affective Neuroscience (2008), 3(3), 244-252 The processing of personal changes across time and the ability to differentiate between representations of present and past selves are crucial for developing a mature sense of identity. In this study, we ... [more ▼] The processing of personal changes across time and the ability to differentiate between representations of present and past selves are crucial for developing a mature sense of identity. In this study, we explored the neural correlates of self-reflection across time using functional magnetic resonance imaging (fMRI). College undergraduates were asked to reflect on their own psychological characteristics and those of an intimate other, for both the present time period (i.e. at college) and a past time period (i.e. high school years) that involved significant personal changes. Cortical midline structures (CMS) were commonly recruited by the four reflective tasks (reflecting on the present self, past self, present other and past other), relative to a control condition (making valence judgments). More importantly, however, the degree of activity in CMS also varied significantly according to the target of reflection, with the ventral and dorsal medial prefrontal cortex and the posterior cingulate cortex being more recruited when reflecting on the present self than when reflecting on the past self or when reflecting on the other person. These findings suggest that CMS may contribute to differentiate between representations of present and past selves. [less ▲] Detailed reference viewed: 66 (6 ULg) La maladie d'AlzheimerCollette, Fabienne ; Feyers, Dorothée ; Bastin, Christine ![]() in Dujardin, Kathy; Lemaire, Patrick (Eds.) Neuropsychologie du vieillissement normal et pathologique (2008) Detailed reference viewed: 44 (16 ULg) Controlled memory processes : functional interaction of the ventromedial prefrontal cortex involved in self evaluation in humanFeyers, Dorothée ; Collette, Fabienne ; D'Argembeau, Arnaud et alConference (2007, December 14) Detailed reference viewed: 7 (2 ULg) Exploration of the neuronal substrates of Directed Forgetting with fMRI.Feyers, Dorothée ; ; Salmon, Eric et alConference (2007, June 26) Detailed reference viewed: 3 (2 ULg)![]() Exploration of the neuronal substrates of Directed Forgetting with fMRIFeyers, Dorothée ; ; Salmon, Eric et alConference (2007, June 01) Detailed reference viewed: 5 (4 ULg)![]() Cerebral metabolic correlates of controlled memory processes in questionable Alzheimer’s diseaseBastin, Christine ; LEKEU, Françoise ; Collette, Fabienne et alConference (2007) Detailed reference viewed: 13 (5 ULg) Exploration des processus d'inhibition dans le paradigme d'oubli dirigé.Feyers, Dorothée ![]() Master's dissertation (2006) Detailed reference viewed: 8 (4 ULg)![]() The role of selective rehearsal and attentional inhibition in directed forgettingFeyers, Dorothée ; ; Collette, Fabienne ![]() Poster (2006, May 19) The directed forgetting paradigm has been extensively used to assess how subjects intentionally limit the future expression of specific memory content. In the item method, subjects are given a list of ... [more ▼] The directed forgetting paradigm has been extensively used to assess how subjects intentionally limit the future expression of specific memory content. In the item method, subjects are given a list of words with the instruction to remember every item followed by a “remember” cue (to-be-remembered items or TBR) and to forget items followed by a “forget” cue (to-be-forgotten items or TBF). Typically, TBR items are better recalled or recognized than TBF items when subjects are subsequently tested on all presented words, regardless of study instructions. However, it is currently not clear if this directed forgetting effect is due to a selective rehearsal of TBR items or to an attentional inhibition of TBF items. In the present study, the performance of two groups of subjects that performed a directed forgetting task with or without articulatory suppression was compared. Indeed, if selective rehearsal is responsible of the directed forgetting effect, the effect should disappear when subjects are not allowed to rehearse TBR items because of the articulatory suppression instruction. Results showed an equivalent directed forgetting effect between the two groups on a recognition task. These results suggest that selective rehearsal is not the major determinant of the directed forgetting effect. [less ▲] Detailed reference viewed: 2 (1 ULg) Self-face does not capture attention: an inattentional blindness studyDevue, Christel ; Laloyaux, Cédric ; Feyers, Dorothée et alPoster (2006) It has been shown previously that some categories of stimuli are more likely to capture attention under condition of inattention compared to others. This is the case of faces and auto-referential material ... [more ▼] It has been shown previously that some categories of stimuli are more likely to capture attention under condition of inattention compared to others. This is the case of faces and auto-referential material (e.g., the subject’s own name) in the inattentional blindness paradigm (Mack & Rock, 1998). However, stimuli combining these two properties have never been assessed. Yet it could be that the own face, because it is both a face and a self-referential stimulus, is more prone to attract attention compared to other faces. On the contrary, it could be that the identity and the familiarity of faces are not relevant factors because any face attracts attention by itself and all faces are equally distractive. Moreover, most of previous studies have used schematic unrealistic stimuli. Here, we tested these two opposite hypotheses in a first experiment using photographic stimuli and results showed that the own face does not attract attention compared to another highly familiar face or to an unknown face. Nevertheless, it appears that the own face was still better recognized compared to the others. A second experiment was aimed at verifying whether faces attract attention more than other objects with the same realistic photographic stimuli than used in experiment 1. Results confirmed previous findings that faces are more resistant to inattentional blindness than other objects. Our study suggests that a face by itself attracts attention compared to other objects whatever its familiarity or its identity. These results challenge the view that auto-referential material benefits from specific attentional processes. [less ▲] Detailed reference viewed: 26 (7 ULg) |
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