References of "Farnir, Frédéric"
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See detailẢnh hưởng của allen halothane đến khả năng sinh trưởng của lợn và sự xuất hiện tần số kiểu gen ở đời sau
Do Duc, Luc ULg; Thanh, Nguyen Chi; Dinh, Bui Van et al

in Journal of Science and Development (2011), 9(2), 225-232

A total of 395 tail samples of stress negative Piétrain new born piglets from the pig farm of Dong Hiep Haiphong were used to determine halothane genotypes (CC, CT and TT) in order to study the effect of ... [more ▼]

A total of 395 tail samples of stress negative Piétrain new born piglets from the pig farm of Dong Hiep Haiphong were used to determine halothane genotypes (CC, CT and TT) in order to study the effect of mating type (♂CC×♀CC, ♂CC×♀CT, ♂CT×♀CC, and ♂CT×♀CT) on halothane genotype frequencies. Effects of genotype on live weight (174 pigs of 2 month old, 96 pigs of 5.5 month old), back fat thickness, loin muscle thickness and lean percentage (117 pigs), average daily gain (89 pigs) were also studied. Results showed that the mating type affected halothane genotype frequencies in the progeny. For the mating type ♂CC×♀CT and ♂CT×♀CT, the genotype containing allele T was reduced in the next generation; in the rest two genotypes (♂CC×♀CC and ♂CT×♀CC) the halothane allele frequency in the offspring was consistent with the theoretical frequency. The halothane genotypes CC and CT did not affect live weights at 2.0 and 5.5 months of age, average daily gain, backfat thickness, loin muscle thickness and lean percentage. [less ▲]

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See detailCytochrome P450 1A1 expression in cetacean skin biopsies from the Indian Ocean
Jauniaux, Thierry ULg; Farnir, Frédéric ULg; Fontaine, Michael et al

in Marine Pollution Bulletin (2011)

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See detailPigeon circovirus: baculovirus expression of the capsid protein gene, specific antibody and viral load measured by real time polymerase chain reaction
Duchatel, Jean-Pierre ULg; Todd, D.; Smyth, J. et al

in Israel Journal of Veterinary Medicine (2011), 66(1), 26-31

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See detailChỉ tiêu huyết học của lợn Piétrain kháng stress nuôi tại Xí nghiệp Chăn nuôi Đồng Hiệp Hải Phòng
Thach, Pham Ngoc; Do Duc, Luc ULg; Farnir, Frédéric ULg et al

in Journal of Science and Development (2010), 8(6), 969-974

This study was carried out on 50 stress negative Piétrain pigs (Pietrain ReHal): 15 pigs at 2 months of age, 20 pig at 5.5 months of age, 5 boars and 10 sows raised in the livestock farm of Dong Hiep, Hai ... [more ▼]

This study was carried out on 50 stress negative Piétrain pigs (Pietrain ReHal): 15 pigs at 2 months of age, 20 pig at 5.5 months of age, 5 boars and 10 sows raised in the livestock farm of Dong Hiep, Hai Phong in order to establish the hematological reference values and their variability according to 4 groups of pigs (2 months, 5.5 months old, boar and sow). Significant group differences were found in hematological parameters except red cells, hemoglobin, eosinophil, basophil, total protein and sugar. These values were within the normal ranges generally accepted as reference values for healthy pigs. Piétrain stress negatif pigs could gradually adapt to the animal production condition in Hai Phong, Vietnam. [less ▲]

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See detailAltered systolic left ventricular function in horses completing a long distance endurance race
Amory, Hélène ULg; Votion, Dominique ULg; Fraipont, A. et al

in Equine Veterinary Journal. Supplement (2010), 42(38), 216-219

Reasons for performing the study: It is unknown whether exercise-induced cardiac fatigue (EICF), as demonstrated in athletes performing long duration exercise, occurs in endurance horses. Objective: To ... [more ▼]

Reasons for performing the study: It is unknown whether exercise-induced cardiac fatigue (EICF), as demonstrated in athletes performing long duration exercise, occurs in endurance horses. Objective: To examine the effects of a long distance endurance race on left ventricular systolic function in horses. Methods: Echocardiography was performed before and after a 2 or 3 star international endurance race (106 to 132 km) in 11 horses. Systolic (s) and diastolic (d) interventricular and left ventricular free wall thickness (IVS and LVFW, respectively), left ventricular, left atrial and aortic internal diameter (LVID, LA and Ao, respectively), fractional shortening (FS) and ejection fraction (EF) were measured by echocardiography. Heart rate (HR), peak flow velocity (Vmax), flow velocity integral (FVI), ejection time (ET), pre-ejection period (PEP), velocity of circumferential fiber shortening (Vcf), stroke volume (SV) and cardiac output (CO) were measured from aortic Doppler wave recordings. Results: After the race, LVIDd, Ao, LA, EF, FS, FVI, SV, ET and ET indexed for HR were significantly lower and IVSd, LVFWd, HR, PEP, PEP/ET, and Vcf were significantly higher as compared with pre-race values. Pre- to post-exercise changes in those parameters were not significantly correlated with changes in HR or in LVIDd. Conclusions: Results suggest that EICF, with a decrease in left ventricular systolic function, could occur post-exercise in horses performing long duration endurance races. However, a confounding effect of altered preload and heart rate on the studied variables cannot be discounted. [less ▲]

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See detailGenetic analysis of a glomerulonephropathy segregating in a pedigree of French Mastiff.
Battaille, Géraldine ULg; Lavoué, Rachel ULg; Peeters, Dominique ULg et al

in Proceedings of 32nd Annual Conference of the International Society of Animal Genetics (2010)

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See detailComparison of the Repeatability of Echocardiographic Measurements from Different Modes and Views in Horses of Various Breeds and Sizes
Al Haidar, Ali; Farnir, Frédéric ULg; Deleuze, Stefan ULg et al

in Journal of Equine Veterinary Science (2010), 30(6), 287-297

The objective of this study was to compare the repeatability of echocardiographic measurements obtained from different echocardiographic modes and views in healthy adult equids of various sizes, breeds ... [more ▼]

The objective of this study was to compare the repeatability of echocardiographic measurements obtained from different echocardiographic modes and views in healthy adult equids of various sizes, breeds and thorax shapes. Ten, free of cardiac disease, equids (body weight: 120 to 662 kg; age: 1 to 26 years) from various breeds were used in this study. Each animal was submitted to a standardized echocardiographic and Doppler protocol 3 times at 1 day interval. This protocol included the measurements of left and right ventricular, aortic, pulmonary, and left atrial parameters obtained from different views using the bidimensional (2D) or the motion (M) modes, and the measurement of several parameters of blood flow obtained from the pulsed wave Doppler mode. Repeatability of each measurement was estimated on the basis of the residual variance using a linear model and the coefficient of variation of repeated measurements. A two by two comparison of the repeatability of measurements performed in different views was performed using the residual variances in a variance ratio F test. Results showed that repeatability of echocardiographic or Doppler measurements in equids of various sizes, breeds and thorax shapes are comparable to previously reported results in thoroughbred and standardbred horses. Left ventricular morphologic parameters showed a good repeatability in the classic M-mode right parasternal short axis (Sax) view at the level of the chordae tendinae, but the 2D-mode right parasternal long axis (LAx) four- chambers view appeared to offer an interesting alternative to measure them. This latter view also allowed obtaining the mostre repeatable measurement of right ventricular internal diameter. The left atrial diameter was maximal and most repeatable in the 2D-mode left parasternal long axisLAx four- chambers angled view, and the repeatability of the aortic diameter was best in the 2D-mode right parasternal long axisLAx five-chambers view. Finally, aortic systolic time intervals were more repeatable when measured from the Doppler mode as compared to the M-mode. ThusIn conclusion, best repeatability of echocardiographic measurements in horses could be optimized following an echocardiographicthe following protocol in equids: 1-M-mode right parasternal short axis view at the level of chordae tendinae, to measure left ventricular morphologic parameters, and 2D-mode right parasternal long axis four-chamber as an alternative view. 2-2D-mode right parasternal long axis five-chambersre, to measure the aortic diameter. 3-2D-mode left parasternal long axis four-chambersre angled view, to measure the left atrial diameter. [less ▲]

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See detailComparative study of egg quality traits in two Belgian local breeds and two commercial lines of chickens
Moula, Nassim ULg; Antoine-Moussiaux, Nicolas ULg; Decuypere, Eddy et al

in Archiv Für Geglügelkunde = European Poultry Science = Revue de Science Avicole Européenne (2010), 74(3), 164-171

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See detailAltered diastolic and systolic left ventricular function in horses completing a long distance endurance race
Amory, Hélène ULg; Votion, Dominique ULg; Fraipont, Audrey ULg et al

in In Proceedings of the 8th International Conference on Equine Exercise Physiology (ICEEP) (2010)

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See detailDemonstrating polymorphic miRNA-mediated gene regulation in vivo: application to the g+6223G->A mutation of Texel sheep.
Takeda, Haruko ULg; Charlier, Carole ULg; Farnir, Frédéric ULg et al

in RNA (New York, N.Y.) (2010), 16(9), 1854-63

We herein describe the development of a biochemical method to evaluate the effect of single nucleotide polymorphisms (SNPs) in target genes on their regulation by microRNAs in vivo. The method is based on ... [more ▼]

We herein describe the development of a biochemical method to evaluate the effect of single nucleotide polymorphisms (SNPs) in target genes on their regulation by microRNAs in vivo. The method is based on the detection of allelic imbalance in RNAs coimmunoprecipitated with AGO proteins from tissues of heterozygous individuals. We characterize the performances of our approach using a model system in a cell culture, and then apply it successfully to prove that the 3'UTR g+6223G-->A mutation operates by promoting RISC-dependent down-regulation of myostatin (MSTN) in skeletal muscle of Texel sheep. [less ▲]

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See detailBone Turnover During Pregnancy in Horses
Greiner, Claudia; Cavalier, Etienne ULg; Remy, Benoit et al

in Journal of Bone and Mineral Research (2010), 25

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See detailBovine herpesvirus 4 ORF73 is dispensable for viral growth in vitro but is essential for viral persistence in vivo.
Thirion, M.; Machiels, Bénédicte ULg; Farnir, Frédéric ULg et al

in Journal of General Virology (The) (2010), 91(10), 2574-84

ORF73 orthologues encoded by different rhadinoviruses have been studied extensively. These studies revealed that the ORF73 expression product (pORF73) is a multifunctional protein essential for latency ... [more ▼]

ORF73 orthologues encoded by different rhadinoviruses have been studied extensively. These studies revealed that the ORF73 expression product (pORF73) is a multifunctional protein essential for latency that enables episome tethering to mitotic chromosomes and modulates cellular pathways implicated in growth and survival of latently infected cells. Comparison of pORF73 orthologues encoded by rhadinoviruses reveals important variations in amino acid sequence length and composition. Bovine herpesvirus 4 (BoHV-4) encodes by far the shortest ORF73 orthologue with a size equivalent to only 22% of the largest orthologues. The present study focused on determining if BoHV 4 ORF73 is a bona fide gene and investigating whether it is essential for latency as established for larger ORF73 orthologues. Our results demonstrate that BoHV-4 ORF73 is transcribed as immediate-early bicistronic mRNA together with ORF71. Using a BoHV-4 bacterial artificial chromosome clone, we produced a strain deleted for ORF73 and a revertant strain. Deletion of BoHV-4 ORF73 did not affect the capacity of the virus to replicate in vitro, but it prevented latent infection in vivo using a rabbit model. Interestingly, the strain deleted for ORF73 induced an anti-BoHV-4 humoral immune response comparable to that elicited by wild-type and revertant recombinants. Together, these results demonstrate that despite its relatively small size, BoHV-4 ORF73 is a functional homologue of larger rhadinovirus ORF73 orthologues, and highlight the potential of ORF73 deletion for the development of BoHV-4 as a vector in vaccinology. [less ▲]

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See detailMalignant catarrhal fever induced by alcelaphine herpesvirus 1 is associated with proliferation of CD8+ T cells supporting a latent infection
Dewals, Benjamin G ULg; Boudry, Christel; Farnir, Frédéric ULg et al

Poster (2009, September 11)

Alcelaphine herpesvirus 1 (AlHV 1), carried by wildebeest asymptomatically, causes malignant catarrhal fever (WD MCF) when cross species transmitted to a variety of susceptible species of the Artiodactyla ... [more ▼]

Alcelaphine herpesvirus 1 (AlHV 1), carried by wildebeest asymptomatically, causes malignant catarrhal fever (WD MCF) when cross species transmitted to a variety of susceptible species of the Artiodactyla order. Experimentally, WD-MCF can be induced in rabbits. The lesions observed are very similar to those described in natural host species. Here, we used the rabbit model and in vivo 5-Bromo-2’-Deoxyuridine (BrdU) incorporation to study WD-MCF pathogenesis. The results obtained can be summarized as follows. (i) AlHV-1 infection induces CD8+ T cell proliferation detectable as early as 15 days post-inoculation. (ii) While the viral load in peripheral blood mononuclear cells remains below the detection level during most of the incubation period, it increases drastically few days before death. At that time, at least 10% of CD8+ cells carry the viral genome; while CD11b+, IgM+ and CD4+ cells do not. (iii) RT-PCR analyses of mononuclear cells isolated from the spleen and the popliteal lymph node of infected rabbits revealed no expression of ORF25 and ORF9, low or no expression of ORF50, and high or no expression of ORF73. Based on these data, we propose a new model for the pathogenesis of WD-MCF. This model relies on proliferation of infected CD8+ cells supporting a predominantly latent infection. [less ▲]

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See detailMalignant catarrhal fever induced by alcelaphine herpesvirus 1 is associated with proliferation of CD8+ T cells supporting a latent infection
Dewals, Benjamin G ULg; Boudry, Christel; Farnir, Frédéric ULg et al

Conference (2009, April)

Alcelaphine herpesvirus 1 (AlHV 1), carried by wildebeest asymptomatically, causes malignant catarrhal fever (WD MCF) when cross species transmitted to a variety of susceptible species of the Artiodactyla ... [more ▼]

Alcelaphine herpesvirus 1 (AlHV 1), carried by wildebeest asymptomatically, causes malignant catarrhal fever (WD MCF) when cross species transmitted to a variety of susceptible species of the Artiodactyla order. Experimentally, WD-MCF can be induced in rabbits. The lesions observed are very similar to those described in natural host species. Here, we used the rabbit model and in vivo 5-Bromo-2’-Deoxyuridine (BrdU) incorporation to study WD-MCF pathogenesis. The results obtained can be summarized as follows. (i) AlHV-1 infection induces CD8+ T cell proliferation detectable as early as 15 days post-inoculation. (ii) While the viral load in peripheral blood mononuclear cells remains below the detection level during most of the incubation period, it increases drastically few days before death. At that time, at least 10% of CD8+ cells carry the viral genome; while CD11b+, IgM+ and CD4+ cells do not. (iii) RT-PCR analyses of mononuclear cells isolated from the spleen and the popliteal lymph node of infected rabbits revealed no expression of ORF25 and ORF9, low or no expression of ORF50, and high or no expression of ORF73. Based on these data, we propose a new model for the pathogenesis of WD-MCF. This model relies on proliferation of infected CD8+ cells supporting a predominantly latent infection. [less ▲]

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See detailPerformances zootechniques de la poule Ardennaise, une race ancienne pour le futur ?
Moula, Nassim ULg; Antoine-Moussiaux, Nicolas ULg; Farnir, Frédéric ULg et al

in Annales de Médecine Vétérinaire (2009), 153(1), 66-75

Nowadays, Belgian poultry breeding is characterized by a strong biodiversity that is nevertheless greatly endangered. The present work aims at evaluating the zootechnical potential of an ancient poultry ... [more ▼]

Nowadays, Belgian poultry breeding is characterized by a strong biodiversity that is nevertheless greatly endangered. The present work aims at evaluating the zootechnical potential of an ancient poultry breed originating from the Franco-Belgian Ardennes region, the Ardennaise. This breed shows an important phenotypic variation, with 10 different varieties being recognized. This study evaluates the Ardennaise production performances and is divided into three parts: (1) the analysis of the growth and the consumption indices over a twelve weeks period, (2) the comparison of the growth over seventeen weeks in four varieties, (3) the study of eggs number and eggs weight over 70 weeks laying. The results indicate that the Ardennaise breed constitutes a good dual purpose breed that could be interestingly submitted to selection. Its use in industrial crosses for egg composition amelioration is also proposed. Lastly, this works shows the importance of extending the here developed evaluation protocol to other Belgian endangered poultry breeds to motivate the necessary conservation programs. [less ▲]

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See detailL’Ardennaise: statut de la race et de ses variétés.
Moula, Nassim ULg; Antoine-Moussiaux, Nicolas ULg; Farnir, Frédéric ULg et al

in Annales de Médecine Vétérinaire (2009), 153

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