Showing results 61 to 80 of 179
  Gaïa, le stress géoclimatique et la peau.Pierard, Sébastien  ; ; Franchimont, Claudine et alin Dermo'Sphère (2010), 2 Le Soleil est à l’origine de la vie sur Terre. Le grand ensemble d’interactions biogéochimiques entre la vie, le sol, l’atmosphère et l’océan n’est pas sans rappeler la physiologie d’un grand organisme ... [more ▼] Le Soleil est à l’origine de la vie sur Terre. Le grand ensemble d’interactions biogéochimiques entre la vie, le sol, l’atmosphère et l’océan n’est pas sans rappeler la physiologie d’un grand organisme unique. Ce dernier a reçu le nom de Gaïa. Tout le fonctionnement de la biosphère qui en fait partie est largement dépendant de l’apport énergétique solaire. Celui-ci est diversifié car le spectre des rayonnements électromagnétiques est large et variable en intensité et en nature. Le réchauffement global de la Terre et le « trou d’ozone » sont sous les feux de l’actualité. De tels bouleversements sont-ils la préfiguration d’une apocalypse ? L’écologie et la dérive géoclimatique vont-elles influencer la dermatologie de demain ? [less ▲] Detailed reference viewed: 21 (1 ULg) Updating corneofungimetry: a bioassay exploring dermatomycoses and antifungal susceptibility.Pierard, Gérald ; Franchimont, Claudine ; Quatresooz, Pascale in Mycopathologia (2010), 169(1), 27-35 Superficial dermatomycoses are frequent conditions in humans and animals. Specific treatment modalities have been designed using a variety of different antifungal compounds. The need for antifungal ... [more ▼] Superficial dermatomycoses are frequent conditions in humans and animals. Specific treatment modalities have been designed using a variety of different antifungal compounds. The need for antifungal susceptibility testing (AST) has been growing steadily over the last two decades due to the extending number of newer antifungal agents. Objective inter- and intraindividual comparisons of their respective efficacies are nearly impossible to perform in vivo. Currently, a series of standardized AST methods and interpretative guidelines have been designed. However, their clinical relevance for dermatomycoses is not consistent. The corneofungimetry bioassay was designed to test comparatively a series of antifungals on pathogenic fungi growing on sheets of human stratum corneum. Computerized morphometric assessments bring numerical values allowing statistical comparisons. Variants of corneofungimetry address more specific aspects related to fungal cell adhesion, fungitoxicity and lipid-dependent fungi. [less ▲] Detailed reference viewed: 22 (5 ULg)Complications des comblements de rides et de volumateurs faciaux.Paquet, Philippe ; Uhoda, Emmanuelle ; Quatresooz, Pascale et alin Dermatologie Actualité (2010), 119 Detailed reference viewed: 11 (2 ULg)Avoir le rythme dans la peau.Szepetiuk, Grégory ; Franchimont, Claudine ; Pierard, Gérald in Dermatologie Actualité (2010), 118 Detailed reference viewed: 37 (2 ULg)Le pilomatricome unique ou multifocal et son pendant malin.Reginster, Marie-Annick ; Quatresooz, Pascale ; Franchimont, Claudine et alin Dermatologie Actualité (2010), 121 Detailed reference viewed: 40 (1 ULg)Neurofibromatose de type 1Hermanns-Le, Trinh ; Devillers, Céline ; Franchimont, Claudine et alin Revue Médicale de Liège (2009), 64 Detailed reference viewed: 59 (2 ULg)Kératoses actiniques sous la loupe.PIERARD, Gérald ; ; et alBook published by Publ. Artoos (2009) Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have ... [more ▼] Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have an occupational activity outside or who spend a lot of spare time under the sun. The depletion of the ozone layer might also be involved. [less ▲] Detailed reference viewed: 23 (2 ULg)Le diagnostic précoce des cancers de la peau est primordialPIERARD, Gérald ; ; et alBook published by bioderma (2009) Detailed reference viewed: 6 (2 ULg)Cancers cutanés photo induits en 3D, version spécialistePIERARD, Gérald ; ; et alBook (2009) Detailed reference viewed: 10 (4 ULg)La couche cornée, le point de rosée et l'eau-comme-de-la-glace.Uhoda, Emmanuelle ; Franchimont, Claudine ; Quatresooz, Pascale et alin Dermatologie Actualité (2009), 112 Detailed reference viewed: 27 (5 ULg)Epidermal field carcinogenesis in bald-headed. An attempt at finetuning early noninvasive detection.Quatresooz, Pascale ; Uhoda, Emmanuelle ; Franchimont, Claudine et alin Oncology Reports (2009), 21 Skin weathering and photoaging of the balding scalp have not attracted much investigative attention so far. However, the concept of field cancerization, in particular actinic field carcinogenesis, is ... [more ▼] Skin weathering and photoaging of the balding scalp have not attracted much investigative attention so far. However, the concept of field cancerization, in particular actinic field carcinogenesis, is likely applicable to this body region. The aim of the study was to finetune the epidermal actinic changes present on hairlessness scalp. The ultraviolet light-enhanced visualization (ULEV) method was used to assess a series of 50 healthy men older than 50 years with documented baldness for over 15 years. They were scrutenized looking for altered epidermal structures corresponding to photoaging-associated changes. Attention was focused on the faint mosaic melanoderma (FMM) and atypical scaliness. Observations were made on the scalp and forehead. FMM was recognized in each case. It presented either as a single manifestation of photoaging or it was associated with an unusual pattern of discrete rimmed scaliness. In this latter case histology and morphometry disclosed keratinocyte dysplasia. A similar scaly pattern was not seen on the forehead. Subtle skin surface changes were disclosed on long-standing sun-exposed balding scalps. The scaly aspect was distinct from dandruff, seborrheic dermatitis or any other common inflammatory scalp dermatosis. The presently described changes had not previously been described during early balding. It is suggested that the presently described condition may be associated with or indicative for actinic field carcinogenesis and incipient keratinocyte dysplasia. [less ▲] Detailed reference viewed: 23 (4 ULg)Vulnerability of reactive skin to electric current perception--a pilot study implicating mast cells and the lymphatic microvasculature.Quatresooz, Pascale ; Franchimont, Claudine ; Pierard, Gérald in Journal of Cosmetic Dermatology (2009), 8(3), 186-9 BACKGROUND/OBJECTIVE: Sensitive/reactive skin is regarded as a manifestation of sensory irritation. This susceptibility condition to various exogenous factors suggests the intervention of some ... [more ▼] BACKGROUND/OBJECTIVE: Sensitive/reactive skin is regarded as a manifestation of sensory irritation. This susceptibility condition to various exogenous factors suggests the intervention of some neuropeptides and other neurobiological mediators. Mast cells are among the putative implicated cells. METHOD: The present immunohistochemical and morphometric study was performed on two groups of 36 gender- and age-matched subjects complaining or not from reactive skin as determined by electric current perception. In the mid upper part of the dermis, the numerical density in mast cells and the size of the microvasculature were assessed distinguishing the blood and lymphatic vessels. RESULTS: Globally, the distributions of data were large in reactive skin. This condition was characterized by a prominent increase in both the numerical density in mast cells and the overall size of the lymphatics. By contrast, no difference was found in the size of cutaneous blood vessels. More precisely, it appeared that a subgroup of people with reactive skin exhibited these changes contrasting with some other individuals whose data remained close to the normal range. CONCLUSION: Mast cells and lymphatics are probably involved in the process of sensory irritation affecting a subgroup of the population. [less ▲] Detailed reference viewed: 10 (2 ULg)Molecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review).Quatresooz, Pascale ; Franchimont, Claudine ; Pierard, Gérald in Oncology Reports (2009), 22(6), 1263-7 In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant ... [more ▼] In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant melanomas (MM), i.e. the fast-growing neoplasms, usually escape the classical clinical criteria of MM. As a result, a number of puzzling cases exhibit uncertain clues for MM. Thus, the risk of microscopic misdiagnosis is likely on the rise if the histological criteria are not fine-tuned. This review summarizes a conceptual classification of atypical melanocytic neoplasms grouped under the heading of melanocytomas. Some immunohistochemical markers are tentatively used as discriminators between fast-growing MM and melanocytomas. However, some differences seem to be more statistically significant than clinically useful due to extensive overlap in immunoreactivity from any case to case. A multipronged immunohistological screening is therefore welcome. [less ▲] Detailed reference viewed: 14 (4 ULg)Pseudolymphomes cutanés et pseudoclonalité des infiltrats lymphoïdes.Quatresooz, Pascale ; Franchimont, Claudine ; Devillers, Céline et alin Revue Médicale de Liège (2009), 64 Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The ... [more ▼] Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The histological and immunohistological examinations combined with molecular biology help to elucidate any diagnostic uncertainty. In these diseases, monoclonality and pseudoclonality must be distinguished in the lymphoid infiltrates. Searching for any specific etiology is important because removing the cause is likely to clear the lesions. [less ▲] Detailed reference viewed: 29 (1 ULg)Le cosméceutique, oxymoron de la quête d'une efficacité cosmétique?Pierard, Gérald ; ; Franchimont, Claudine et alin Dermatologie Actualité (2009), 113 Detailed reference viewed: 83 (13 ULg)Comment j'explore... des lésions cutanées chez un toxicomane adepte de la cocaïne ou du crack.Devillers, Céline ; Franchimont, Claudine ; Pierard, Gérald et alin Revue Médicale de Liège (2009), 64 Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the ... [more ▼] Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the predominant issues. In addition, tactile and visual hallucinations may occur suggesting insect crawling underneath the skin. [less ▲] Detailed reference viewed: 66 (8 ULg)Syndrome de Birt-Hogg-Dube sporadique.; Franchimont, Claudine ; Quatresooz, Pascale et alin Revue Médicale de Liège (2009), 64(7-8), 358-60 Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was ... [more ▼] Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was covered by hundreds of small molluscoid papules corresponding to trichodiscomas, fibrofolliculomas and skin tags. [less ▲] Detailed reference viewed: 36 (4 ULg)Molecular pathways supporting the proliferation staging of malignant melanoma (review).Quatresooz, Pascale ; Pierard, Gérald ; Franchimont, Claudine et alin International Journal of Molecular Medicine (2009), 24(3), 295-301 The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in ... [more ▼] The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicative of the neoplastic progression and is related to the clinical growth rate of the neoplasm. It allows to distinguish high risk melanomas showing a high growth rate from those of lower malignancy associated with a restricted growth rate. In melanoma, the recruitment and progression of neoplastic cells in the cell cycle of proliferation have lost some of their controls that are normally processed by a series of key regulatory molecules. In addition, the apoptotic pathway counteracting any hyperproliferative activity is released of the dependency of specific regulated molecular mechanisms. This review summarizes the current knowledge on key molecular components involved in the deregulation of the growth fraction, cell proliferation and apoptosis in melanocytic neoplasms. The implication of cyclins and of the mitogen-activated protein kinase pathways are scrutinized. The involvement of neoplastic stem cells in the metastatic process is also discussed. [less ▲] Detailed reference viewed: 27 (9 ULg)En chemin vers les cancers photo-induits.Pierard, Gérald ; ; et alin Skin (2009), 12 Detailed reference viewed: 52 (25 ULg)La biodiversité, reflet des soubresauts de la biosphère et de l'équilibre géophysiologique.Pierard, Sébastien ; Franchimont, Claudine ; Pierard, Gérald in Association des Géologues Amateurs de Belgique Minibul (2009), 42 Detailed reference viewed: 8 (3 ULg) |
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