References of "FRANCHIMONT, Claudine"
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See detailThe weather-beaten dorsal hand. Clinical rating, shadow casting optical profilometry and skin capacitance mapping.
Delvenne, Marie; FRANCHIMONT, Claudine ULg; SEIDEL, Laurence ULg et al

in BioMed Research International (2013), 2013

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See detailAnalytic dermoscopy of superficial basal cell carcinoma.
FRANCHIMONT, Claudine ULg; Hermanns, Jean-Francois; Caucanas, Marie et al

in Journal of Case Reports in Medicine (2013), 3

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See detailIn vivo evaluation of the skin tensile strength by the suction method: pilot study coping with hysteresis and creep extension.
PIERARD, Gérald ULg; Pierard, Sébastien ULg; Delvenne, Philippe ULg et al

in ISRN dermatology (2013), 2013

From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes ... [more ▼]

From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes in the cutaneous viscoelasticity represent an important aspect in a series of skin conditions. The aim of this work was to explore the methodology of biomechanical measurements in order to better appreciate the evolution and severity of some connective tissue diseases. The Cutometer MPA 580 (C+K electronic) was used in the steep and progressive suction procedures. Adapting measurement modalities was explored in order to mitigate any variability in data collection. The repeat steep suction procedure conveniently reveals the creep phenomenon. By contrast, the progressive suction procedure highlights the hysteresis phenomenon. These viscoelastic characteristics are presently described using the 2 and 4 mm probes on normal skin and in scleroderma, acromegaly, corticosteroid-induced dermatoporosis, and Ehlers-Danlos syndrome. The apposition of an additional outer contention on the skin altered differently the manifestations of the creep extension and hysteresis among the tested skin conditions. Any change in the mechanical test procedure affects the data. In clinical and experimental settings, it is mandatory to adhere to a strict and controlled protocol. [less ▲]

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See detailScrutinizing skinfield melanin patterns in young Caucasian women.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Expert Opinion on Medical Diagnostics (2013)

Introduction: When using adequate wavelength illumination and high resolution recordings, Caucasian skin color appears uneven. The patterns of faint mosaic melanoderma (FMM) are diverse and possibly ... [more ▼]

Introduction: When using adequate wavelength illumination and high resolution recordings, Caucasian skin color appears uneven. The patterns of faint mosaic melanoderma (FMM) are diverse and possibly related to the risk of skin cancer development. Areas covered: The current peer-reviewed publications about objective methods quantifying FMM are revisited. The images from the Visioscan(R) and Visioface(R) Quick devices are computerized in order to record the ultraviolet light-enhanced visualization (ULEV) and the color-enhanced visualization (CEV) of the skin. Previously published data regarding the FMM are gathered in 20 odd Caucasian women. Seven FMM patterns are distinguished. They appear expressed differently according to body regions, but the mean gray level appears more uniform. Expert opinion: The combination of larger subclinical melanotic macules and ivory spots during early adulthood is apparently associated with an increased risk for non-melanoma skin cancers. [less ▲]

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See detailThe thousand and one facets of actinic keratosis.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; DELVENNE, Philippe ULg

Book published by Nova Science Publishers (2013)

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See detailCritical assessment of diabetic xerosis.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Scheen, André ULg

in Expert Opinion on Medical Diagnostics (2013), 7(2), 201-7

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing ... [more ▼]

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing diabetes xerosis. Peer-reviewed articles on objective non-invasive methods were scrutinized. The reviewed methods address i) the xerosis severity grading scale, ii) corneodynamics referring to the desquamation rate, iii) electrometric assessment of skin hydration including skin capacitance mapping and iv) implication of the imperceptible perspiration. The subjective clinical assessment often fails to disclose diabetic xerosis with confidence and precision. By contrast, a multipronged biometrological approach identifies a cluster of diabetic patients who experience alterations in the structural and functional maturation of the stratum corneum. Expert opinion: A multipronged biometrological approach helps identifying the changes in the stratum corneum of diabetic xerosis. There is a continuum between the 'dry skin' feeling, xerosis and ichthyosiform presentations, particularly on the shins and feet of diabetic patients. [less ▲]

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See detailCharacterization of spontaneous collagen fibrillogenesis in a cell-free and tension-free environment.
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Delvenne, Philippe ULg et al

in Clinical & Experimental Dermatology (2013)

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored ... [more ▼]

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored an in vitro fibrillogenesis model using the property of heat polymerization. The process was performed on glass slides with mixtures of collagen I and III, and the material was viewed by scanning electron microscopy. In all instances, collagen I and III formed fibrils with regular sizes. The formation of threads was influenced by the relative proportions of collagen I and III; increasing the relative proportion of collagen I resulted in the formation of threads showing increasing variations in thickness. These findings are in line with the differential presentation and compositions of the different parts of the dermis. The possible interventions of stromal cells and of other macromoleules of the extracellular matrix were not considered in this study. [less ▲]

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See detailDermatoses non infectieuses de la grossesse.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg et al

in Thérapeutique Dermatologique (2012)

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See detailFondements physico-biologiques de la fluorescence cutanee - Revue.
SZEPETIUK, Grégory ULg; FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Pathologie Biologie (2012), 60

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be ... [more ▼]

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be used for identifying some specific aspects of skin physiopathology. Recent technological evolution has provided new devices bringing sensitive and specific information from the skin. This review presents a synthesis of the progress made in the field of fluorescence and specular reflexion of incident UV light on the skin. [less ▲]

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See detailFibromes cutanés.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Fondation René Touraine (Ed.) Thérapeutique Dermatologique (2012)

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See detailToxic epidermal necrolysis and antifolate drugs in cancer chemotherapy.
Franchimont, Claudine ULg; Lesuisse, Marianne; Humbert, Philippe et al

in Current Drug Safety (2012), 7(5), 357-60

Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The ... [more ▼]

Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The latter cells lack the capacity to synthesize folates. In some patients, high dosages of antifolate drugs (eg: methotrexate, pemetrexed) used in cancer chemotherapy alter the keratinocytes, endothelial cells and Factor XIIIa+ dermal dendrocytes in a range of various severities. Such conditions clinically designed under the heading antifolate cytotoxic skin reaction (ACSR) occasionally resemble the toxic epidermal necrolysis (TEN) / Stevens-Johnson syndrome (SJS) spectrum. Whether or not the TEN/SJS presentation of ACSR is a regular condition similar to that induced by other drugs or a variant condition supported by a unique pathomechanism is unsettled. [less ▲]

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See detailCold injuries.
PIERARD, Gérald ULg; QUATRESOOZ, Pascale ULg; FRANCHIMONT, Claudine ULg

in Goldsmith, L.; Gilchrest, B; Katz, S (Eds.) et al Fitzpatrick's Dermatology in General Medicine (2012)

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See detailHow to manage hair changes in cancer patients.
FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; RORIVE, Andrée ULg et al

in Vereecken, P.; Awada, A. (Eds.) Handbook of skin care in cancer patients. (2012)

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See detailImpact climatique sur les ulcères veineux de jambe.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; LESUISSE, Marianne et al

in Revue Médicale de Liège (2012), 67

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See detailLa vignette diagnostique de l'étudiant. Le phénomène de Raynaud.
FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg

in Revue Médicale de Liège (2012), 67

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See detailLe melanome cutane: une seule maladie?
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2012), 67(9), 458-60

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations ... [more ▼]

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations, histopathology and molecular genetics point to the fact that malignant melanoma is not a single monolithic pathological condition. Different types of melanomas are distinguished based on distinct origins and contrasted prognoses. The management and information for the patient should be handled individually. [less ▲]

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See detailDeux bacteries et une kyrielle d'infections cutanees communes.
Franchimont, Claudine ULg; Lesuisse, M.; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(10), 513-9

Common bacterial skin infections represent frequent disorders encountered in general practice and in dermatology as well. They encompass a series of infections affecting the epidermis, dermis, hypodermis ... [more ▼]

Common bacterial skin infections represent frequent disorders encountered in general practice and in dermatology as well. They encompass a series of infections affecting the epidermis, dermis, hypodermis and subcutaneous tissues. The two main bacteria involved in these processes are Streptococcus pyogenes and Staphylococcus aureus. The resulting infections show various clinical presentations. Their management must be adapted to their gravity and to the putative or proven nature of the causal microorganism. Searching for any skin ingress possibility and any favouring factor is always of importance in order to stimulate healing and avoid recurrences. Of note, skin possibly allows the ingress way for a secondary septicemic dissemination. Conversely, skin is possibly involved in tissue localisation of septicemia. [less ▲]

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See detailLe melanome metastatique: un vent d'espoir porte par l'ipilimumab et le vemurafenib.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(2), 64-8

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In ... [more ▼]

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In addition, translational research fueled the development of new treatments with at last increased efficacy in the metastatic stage. Such therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the beneficial effects. [less ▲]

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See detailDermal ultrastructure in low Beighton score members of 17 families with hypermobile-type Ehlers-Danlos syndrome.
Hermanns-Lê, Trinh ULg; REGINSTER, Marie-Annick ULg; Franchimont, Claudine ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural ... [more ▼]

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural abnormalities of EDSH and BJHS among different families. Skin of 23 EDSH, 27 BJHS, and 41 asymptomatic subjects from 17 families was examined using transmission electron microscopy. Similar ultrastructural abnormalities were found irrespective of the Beighton score. Flower-like collagen fibrils represented the key change and elastic fibers were altered as well. Beighton score is a clinical parameter rating joint mobility that appeared unrelated to quantitative and qualitative collagen ultrastructural alterations in the skin. Some EDSH family members fit with BJHS diagnosis. BJHS possibly represents a mild variant of EDSH. [less ▲]

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See detailMiconazole , a pharmacological barrier to skin fungal infections.
Pierard, Gérald ULg; Hermanns-Lê, Trinh ULg; Delvenne, Philippe ULg et al

in Expert Opinion on Pharmacotherapy (2012), 13(8), 1187-94

Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14alpha-demethylase ... [more ▼]

Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14alpha-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic methylated sterols occurs and the synthesis of triglycerides and phospholipids is altered. Disturbances in oxidative and peroxidative enzyme activities lead to an intracellular toxic concentration of hydrogen peroxide. As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria. Areas covered: This review aims at revisiting the MCZ antifungal activity in dermatomycoses. Expert opinion: MCZ's wide spectrum of activity appears noteworthy. The full pharmacological profile of MCZ indicates its fungistatic profile through its effect on ergosterol biosynthesis. In addition, it exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation. MCZ is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses. [less ▲]

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