References of "FRANCHIMONT, Claudine"
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See detailMolecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review).
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Oncology Reports (2009), 22(6), 1263-7

In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant ... [more ▼]

In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant melanomas (MM), i.e. the fast-growing neoplasms, usually escape the classical clinical criteria of MM. As a result, a number of puzzling cases exhibit uncertain clues for MM. Thus, the risk of microscopic misdiagnosis is likely on the rise if the histological criteria are not fine-tuned. This review summarizes a conceptual classification of atypical melanocytic neoplasms grouped under the heading of melanocytomas. Some immunohistochemical markers are tentatively used as discriminators between fast-growing MM and melanocytomas. However, some differences seem to be more statistically significant than clinically useful due to extensive overlap in immunoreactivity from any case to case. A multipronged immunohistological screening is therefore welcome. [less ▲]

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See detailPseudolymphomes cutanés et pseudoclonalité des infiltrats lymphoïdes.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Devillers, Céline ULg et al

in Revue Médicale de Liège (2009), 64

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The ... [more ▼]

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The histological and immunohistological examinations combined with molecular biology help to elucidate any diagnostic uncertainty. In these diseases, monoclonality and pseudoclonality must be distinguished in the lymphoid infiltrates. Searching for any specific etiology is important because removing the cause is likely to clear the lesions. [less ▲]

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See detailLe cosméceutique, oxymoron de la quête d'une efficacité cosmétique?
Pierard, Gérald ULg; Meunier, J.; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2009), 113

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See detailComment j'explore... des lésions cutanées chez un toxicomane adepte de la cocaïne ou du crack.
Devillers, Céline ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (2009), 64

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the ... [more ▼]

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the predominant issues. In addition, tactile and visual hallucinations may occur suggesting insect crawling underneath the skin. [less ▲]

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See detailSyndrome de Birt-Hogg-Dube sporadique.
Vandenbossche, Géraldine; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2009), 64(7-8), 358-60

Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was ... [more ▼]

Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was covered by hundreds of small molluscoid papules corresponding to trichodiscomas, fibrofolliculomas and skin tags. [less ▲]

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See detailMolecular pathways supporting the proliferation staging of malignant melanoma (review).
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Franchimont, Claudine ULg et al

in International Journal of Molecular Medicine (2009), 24(3), 295-301

The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in ... [more ▼]

The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicative of the neoplastic progression and is related to the clinical growth rate of the neoplasm. It allows to distinguish high risk melanomas showing a high growth rate from those of lower malignancy associated with a restricted growth rate. In melanoma, the recruitment and progression of neoplastic cells in the cell cycle of proliferation have lost some of their controls that are normally processed by a series of key regulatory molecules. In addition, the apoptotic pathway counteracting any hyperproliferative activity is released of the dependency of specific regulated molecular mechanisms. This review summarizes the current knowledge on key molecular components involved in the deregulation of the growth fraction, cell proliferation and apoptosis in melanocytic neoplasms. The implication of cyclins and of the mitogen-activated protein kinase pathways are scrutinized. The involvement of neoplastic stem cells in the metastatic process is also discussed. [less ▲]

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See detailEn chemin vers les cancers photo-induits.
Pierard, Gérald ULg; André, J.; Brochez, L. et al

in Skin (2009), 12

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See detailLa biodiversité, reflet des soubresauts de la biosphère et de l'équilibre géophysiologique.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (2009), 42

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See detailLe pseudoxanthome élatique au-delà de la peau, de l'oeil et des vaisseaux.
Blaise, Géraldine ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64

The main clinical manifestations of pseudoxanthoma elasticum (PXE) alter small arteries, the eyes and the skin. At the microanatomical level, the feature in common is an alteration of the elastic fibres ... [more ▼]

The main clinical manifestations of pseudoxanthoma elasticum (PXE) alter small arteries, the eyes and the skin. At the microanatomical level, the feature in common is an alteration of the elastic fibres that appear dystrophic and in part calcified. The disease is genetically transmitted as an autosomal recessive trait. The gene coding for the MRP6 protein is often mutated. Thus PXE appears as a metabolic disease conveyed by serum. [less ▲]

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See detailSpotlight on adapalene.
Pierard, Gérald ULg; Franchimont, Claudine ULg; Paquet, Philippe ULg et al

in Expert opinion on drug metabolism & toxicology (2009), 5(12), 1565-75

BACKGROUND: In the field of dermatology, topical retinoids represent a mainstay in acne treatment. Adapalene is a naphthoic acid derivative showing some pharmacological activities similar to the regular ... [more ▼]

BACKGROUND: In the field of dermatology, topical retinoids represent a mainstay in acne treatment. Adapalene is a naphthoic acid derivative showing some pharmacological activities similar to the regular retinoids. The drug is used singly or in combination for treating acne and a few other miscellaneous skin disorders. OBJECTIVE: To critically review the pharmacokinetic, pharmacologic aspects and clinical benefits and adverse effects associated with topical adapalene. METHOD: A systematic literature review was conducted primarily based on PubMed citations. RESULTS/CONCLUSIONS: Adapalene shares some biological activities in common with retinoic acid. However, it exhibits distinct physicochemical and binding properties for selective retinoic acid receptors. In acne, adapalene is expected to reduce comedogenesis, expel mature comedones and exert some anti-inflammatory effects. The drug is effective as monotherapy in mild comedonal acne and in combination with benzoyl peroxide for mild-to-moderate inflammatory acne. The safety profile of adapalene is good. Indeed, only discrete to moderate adverse events including erytheme, xerosis, itching and stinging may develop during the early treatment phase. Clinical experience has established that adapalene represents a valuable addition to the other current treatments for acne. [less ▲]

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See detailNodules violacés sporotrichoïdes chez une patiente immunodéprimée.
Devillers, Céline ULg; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2009), 115

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See detailMini-mélanome papulo-achromique de croissance rapide.
Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2009), 114

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See detailVoir l'iceberg au ras des flots en scotomisant la métrologie cutanée.
Pierard, Gérald ULg; Quatresooz, Pascale ULg; Neuberg, S. et al

in Dermatologie Actualité (2009), 117

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See detailFungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Szepetiuk, Grégory ULg et al

in Expert Opinion on Pharmacotherapy (2009), 10(14), 2221-9

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects ... [more ▼]

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects of a 2.5% chitin-glucan formulation with its placebo, and commercially available glycerol formulations. METHODS: This two-step controlled double-blind, randomized, intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet. The formulations were applied once daily for 3 weeks. Electrometric assessments were performed on three sites of the feet at entry in the study, at weekly intervals during the treatment phase, and in a 2-week follow-up out of treatment. Positive controls consisted in two commercially available formulations enriched in glycerol. RESULTS: Data revealed an unequivocal benefit provided by the 2.5% chitin-glucan formulation compared with placebo. The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases. The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization. A steep increase was followed by a plateau level and a rapid decline after stopping the treatments. CONCLUSION: The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles. [less ▲]

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See detailComment j'explore...une escarre de decubitus.
Devillers, Céline ULg; Franchimont, Claudine ULg; Giet-Lesuisse, M. et al

in Revue Médicale de Liège (2009), 64(10), 535-7

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ... [more ▼]

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ulcer is progressively increasing. This condition occurs at home, in old people's homes and in hospitals as well. The severity, duration and orientation of forces applied to the skin represent the most important factors responsible for pressure ulcers. Prevention measures are essential to reduce the prevalence of the disease. [less ▲]

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See detailLe carcinome de Merkel: du diagnostic a la prise en charge therapeutique.
Franchimont, Claudine ULg; Devillers, Céline ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(10), 500-5

Merkel cell carcinoma is a skin malignancy showing an increasing trend of incidence in the white population. Its viral origin due to the MC polyomavirus is likely. The diagnosis relies on the histological ... [more ▼]

Merkel cell carcinoma is a skin malignancy showing an increasing trend of incidence in the white population. Its viral origin due to the MC polyomavirus is likely. The diagnosis relies on the histological and targeted immunopathological examinations. Histoprognostic criteria remain to be defined. An assessment using medical imaging is important to establish. Treatments rely on surgery and radiotherapy. Chemotherapy is mandatory at the metastatic stage. Some biotherapies are potentially active. [less ▲]

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See detailFondements de la cosmétovigilance sur le mode européen.
Franchimont, Claudine ULg; Meunier, J.; Quatresooz, Pascale ULg et al

in Skin (2009), 12

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See detailStreamlining of cellulite concepts.
Pierard, Gérald ULg; Devillers, Céline ULg; Franchimont, Claudine ULg

in European Dermatology (2009), 4

Basically, cellulite is a gender-related condition. It is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio. There are glaring discrepancies in the ... [more ▼]

Basically, cellulite is a gender-related condition. It is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio. There are glaring discrepancies in the microanatomical descriptions regarding this condition. A lumpy aspect of the dermo-hypodermal interface is often mentioned, but this aspect rather represents a gender-linked characteristic of the thighs and buttocks of women without being a specific sign of cellulite. Incipient cellulite recognized by a discrete padded look or “orange peel” aspect appears correlated with the presence of a network of focally enlarged fibrosclerotic strands partitioning the hypodermis and serving as a physiologic buttress limiting the outpouching of fat lobules on pinching the skin. Such connective tissue structures have been ascribed to be the result of a hormonal-dependent reactive process to sustained mechanical tensions caused by the adipocyte lobules. Full blown cellulite is recognized by a lumpy-bumpy and dimpled skin surface. It likely represents subjugation of the hypertrophic response of the hypodermal connective tissue strands when their resistance is overcome by progressive fat accumulation. In these cases, histological aspects reminiscent of striae distensae are identified within the hypodermal connective tissue strands. The mechanical properties of skin involved in the cellulite process are altered. They influence the mechanobiology of connective tissue cells, in particular the Factor XIIIa-positive dermal dendrocytes. [less ▲]

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