References of "Evrard, Brigitte"
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See detailPolyplex Based on Polycarbonate Polymers for an Efficient Delivery of HDAC5 and HDAC7 siRNA
Frère, Antoine ULg; Tempelaar, Sarah; Peulen, Olivier ULg et al

Poster (2015, June 02)

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See detailHow to choose a suitable dissolution test for BCS II drugs?
Thiry, Justine ULg; Pestieau, Aude ULg; Krier, Fabrice ULg et al

Conference (2015, May)

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See detailLIPOSOME CONTAINING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULg; Karim, Reatul ULg; Mawet, Marie et al

Poster (2015, April 14)

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See detailEtude de l’efficacité et de la tolérance d’une tisane à base de Artemisia annua L. (Asteraceae) cultivée au Bénin pour la prise en charge du paludisme simple
Zime-Diawara, Hermine; Sissinto-Savi de Tove, Yolande; Akogbeto, Oscar Eric et al

in International Journal of Biological and Chemical Sciences (2015), 9(2), 692-702

Artemisia annua L. est une plante annuelle, glabre, de la famille des Asteraceae et originaire de la Chine. Cette plante contient plusieurs sesquiterpènes dont l’artémisinine (0,01% à 1,4% du poids des ... [more ▼]

Artemisia annua L. est une plante annuelle, glabre, de la famille des Asteraceae et originaire de la Chine. Cette plante contient plusieurs sesquiterpènes dont l’artémisinine (0,01% à 1,4% du poids des feuilles sèches) et d’autres composés comme les flavonoïdes, les coumarines, les triterpènes, les stéroïdes, les composés phénoliques, les purines, les lipides et les composés aliphatiques. Cette plante a été acclimatée et cultivée au Bénin. Elle a ensuite été testée pour la prise en charge du paludisme simple par un essai clinique. La concentration en artémisinine de cette plante était d’environ 0,30%.Il ressort de notre étude que la tisane de Artemisia annua L. (Asteraceae) obtenue au Bénin a une capacité d’action sur Plasmodium falciparum avec un taux d’efficacité supérieur à 95%, taux retenu par l’OMS pour valider un traitement. [less ▲]

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See detailA Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up
Thiry, Justine ULg; Krier, Fabrice ULg; Evrard, Brigitte ULg

in International Journal of Pharmaceutics (2015), 479(1), 227-240

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However ... [more ▼]

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However, the process parameters of the extruder should be as much investigated as the formulation since they have a major impact on the final product characteristics. Moreover, a design space should be defined in order to obtain the expected product within the defined limits. This gives some freedom to operate as long as the processing parameters stay within the limits of the design space. Those limits can be investigated by varying randomly the process parameters but it is recommended to use design of experiments. An examination of the literature is reported in this review to summarize the impact of the variation of the process parameters on the final product properties. Indeed, the homogeneity of the mixing, the state of the drug (crystalline or amorphous), the dissolution rate, the residence time, can be influenced by variations in the process parameters. In particular, the impact of the following process parameters: temperature, screw design, screw speed and feeding, on the final product, has been reviewed. [less ▲]

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