References of "Evrard, Brigitte"
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See detailNew developments in quantitative analysis and trace analysis in pharmaceutical matrices by FTIR
Otte, Xavier; Duvivier, France; Evrard, Brigitte ULg et al

in Proceedings de la journée de rencontre des jeunes chimistes mars 1998 (1998)

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See detailThe size of nanoparticles after their incorporation in gastroresistant spheroids
Duvivier, F; Grandfils, Christian ULg; Léonard, F et al

in Journal de Pharmacie de Belgique (1997), 52(3), 123

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See detailEtude de la taille des nanoparticules après incorporation dans des sphéroïdes gastrorésistants
Duvivier, F; Grandfils, Christian ULg; Léonard, F et al

in Journal de Pharmacie de Belgique (1997), 52(3), 123

Nanoparticles can be used as an attractive carrier for the controlled delivery of drugs by the oral route. This nanoparticular delivery system can protect an active ingredient from enzymatic degradations ... [more ▼]

Nanoparticles can be used as an attractive carrier for the controlled delivery of drugs by the oral route. This nanoparticular delivery system can protect an active ingredient from enzymatic degradations and enhance its absorption from the intestinal mucosa. We studied the development of a gastroresistant dosage form for the oral administration of nanoparticles. Fast disintegrating pellets were used for the administration of nanoparticles and for their transit to the site of absorption. A gastroresistant film was applied onto the pellets to protect the nanoparticles and/ or the active substance from the acid gastric environment. The integrity of the nanoparticle size was assessed after two critical manufacturing steps: the extrusion/spheronisation process and the coating process. The determination of the nanoparticles size distribution was performed by photon correlation spectroscopy (PCS). The comparison of the PCS results between the original nanoparticles and the nanoparticles incorporated in the pellets shows a very low aggregation. Moreover the coating process was not a critical step since it was not responsible for an additional agglomeration of the nanoparticles. In conclusion, our manufacturing process allows the redispersion of the nanoparticles with a little change of the size distribution. In a next study we well try to quantify the release of the nanoparticles from the pellets. [less ▲]

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See detailInfluence of the amount of enteric polymer on the disintegration rate of pellets designed for protein delivery : in vitro and in vivo tests
Duvivier, France; Lubbering, B.; Léonard, Françoise ULg et al

in Proceedings of Symposium on Particulate Systems, From Formulation to Prduction (1997)

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See detailComplexes à multicomposants de miconazole avec différents acides et cyclodextrines
Piel, Géraldine ULg; Evrard, Brigitte ULg; Delattre, Luc ULg

in Journal de Pharmacie de Belgique (1997), 52(3), 124

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See detailIn vitro evaluation of lipid matrices for the development of a sustained-release sulfamethazine bolus for lambs
Evrard, Brigitte ULg; Delattre, Luc ULg

in Drug Development & Industrial Pharmacy (1996), 22(2), 111-118

The aim of this study is the development of a high-density bolus to be given to lambs in order to release sulfamethazine during 4 days after a single oral administration. The suitability of 12 lipid ... [more ▼]

The aim of this study is the development of a high-density bolus to be given to lambs in order to release sulfamethazine during 4 days after a single oral administration. The suitability of 12 lipid matrix formulations was assessed in order to maintain the integrity of the tablet even after complete dissolution of the active substance. The influence of both nature and concentration of the lipid excipient on the in vitro release of sulfamethazine was investigated. The influences of the granulation method and of the compression force were assessed on a formulation containing Cutina® HR as a binding and sustained-release agent. Finally, stability tests showed that the in vitro release characteristics remain unchanged during storage. [less ▲]

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See detailFormes pharmaceutiques à libération prolongée en médecine vétérinaire : systèmes à rétention dans le réticulo-rumen = Sustained-released veterinary dosage forms : retention devices in the reticulorumen
Evrard, Brigitte ULg; Delattre, Luc ULg

in STP Pharma Pratiques (1996), 6(6), 479-486

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à ... [more ▼]

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à libération contrôlée ou du moins fortement prolongée. L'anatomie particulière du tube digestive des ruminants offre en outre des possibilités inédites pour le développement de tels systèmes thérapeutiques, notamment grâce à la rétention dans le réticulo-rumen. De telles formes ont essentiellement été développées pour l'administration de médicaments antiparasitaires et antibactériens, de suppléments nutritionnels et de promoteurs croissance. Cette revue décrit les applications potentielles de la technologie des formes à libération contrôlée et prolongée en médecine vétérinaire et les différents dispositifs à rétention dans le réticulo-rumen décrits dans la littérature, brevetés ou commercialisés. More intensive methods ofanimal husbandry have revealed the necessity of avoiding repeated administration ofmedication to animals which are difficult to handle and of developing controlled and sustained release dosage forms. The physiological characteristics of the digestive tract of ruminants provide unique opportunity for controlled release technology, especially due to the animal's reticulo-rumen retention ability. The majorareas of application of these controlled and sustained release dosage forms include the delivery of antibiotic and antiparasitic agents, trace nutrients and growth promoting agents. This review describes the potential applications of controlled and sustained release technology in veterinary medicine and the various reticulo-rumen retention devices which are patented, marketed or described in the literature. [less ▲]

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