References of "Evrard, Brigitte"
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See detailIn vitro safety assessment of inhaled products using respiratory epithelial cells
Forbes, Ben; Cao Minh, Quin An; Evrard, Brigitte ULg et al

Poster (2010)

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See detailDevelopment of an in vitro endotoxin test for monoolein-water liquid crystalline gel for use as an implant
Ouédraogo, Moustapha; Semdé, Rasmané; Somé, Issa T. et al

in Tropical Journal of Pharmaceutical Research [=TJPR] (2009), 8(6), 501-508

Purpose : Drugs that are administered by parenteral route must be apyrogenic. The aim of this study was to develop an in vitro endotoxin test for liquid crytalline gels for use as implants, using a ... [more ▼]

Purpose : Drugs that are administered by parenteral route must be apyrogenic. The aim of this study was to develop an in vitro endotoxin test for liquid crytalline gels for use as implants, using a monoolein-water liquid crystalline gel as a model. Methods : The gel-clot technique was used. The gel was dissolved first in isopropyl myristate, and the endotoxins were extracted with water for bacterial endotoxin test. Tests for the labelled lysate sensitivity and interfering factors were performed to validate the developed method. The limit of detection of endotoxin in the gel was also determined. Results : The labelled lysate sensitivity was confirmed. It was not influenced by the presence of extracts from the gels. Endotoxins in the contaminated test gels were completely extracted. Endotoxin concentration in the tested gels was below the calculated threshold endotoxin level. Conclusion : A method to perform in vitro endotoxins test of liquid crystalline gels was successfully developed and validated. Application of the technique to gels currently being developed in our laboratories indicate that the gels were apyrogenic. [less ▲]

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See detailThe supercritical micronization of solid dispersions by Particles from Gas Saturated Solutions using experimental design
Brion, Michaël ULg; Jaspart, Séverine ULg; Perrone, Leonardo et al

in Journal of Supercritical Fluids (2009), 51(1), 50-56

The Particle from Gas Saturated Solutions process was successfully used to micronize solid dispersions containing hydrophilic carriers and a new chemical entity, YNS3107. By means of experimental design ... [more ▼]

The Particle from Gas Saturated Solutions process was successfully used to micronize solid dispersions containing hydrophilic carriers and a new chemical entity, YNS3107. By means of experimental design, the effects of several experimental parameters on micronization were investigated. Within the chosen experimental conditions, the results showed that the autoclave temperature, autoclave pressure, drug loading, flow rate of carbon dioxide and air pressure were significant parameters. During the optimization step, the most relevant parameters of the screening were optimized using a central composite design meanwhile other factors were kept constant. Optimal conditions were used to produce microparticles with a volume weighted mean diameter of 30.4 µm. The closeness between the measured and predicted response, evaluated at 28.1 µm, demonstrated the validity of the statistical analyses. Finally, an enhancement of the rate of dissolution of YNS3107 in the solid dispersion microparticles was measured using USP II dissolution test apparatus. [less ▲]

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See detailDevelopment of a new topical system: Drug-in-cyclodextrin-in-deformable liposome
Gillet, Aline ULg; Grammenos, Angeliki ULg; Compère, Philippe ULg et al

in International Journal of Pharmaceutics (2009), 380(1-2), 174-180

A new delivery system for cutaneous administration combining the advantages of cyclodextrin inclusion complexes and those of deformable liposomes was developed, leading to a new concept: drug ... [more ▼]

A new delivery system for cutaneous administration combining the advantages of cyclodextrin inclusion complexes and those of deformable liposomes was developed, leading to a new concept: drug-incyclodextrin-in-deformable liposomes. Deformable liposomes made of soybean phosphatidylcholine (PC) or dimyristoylphosphatidylcholine (DMPC) and sodium deoxycholate as edge activator were compared to classical non-deformable liposomes. Liposomes were prepared by the film evaporation method. Betamethasone, chosen as the model drug,was encapsulated in the aqueous cavity of liposomes by the use of cyclodextrins. Cyclodextrins allowan increase in the aqueous solubility of betamethasone and thus, the encapsulation efficiency in liposome vesicles. Liposome size, deformability and encapsulation efficiency were calculated. The best results were obtained with deformable liposomes made of PC in comparison with DMPC. The stability of PC vesicles was evaluated by measuring the leakage of encapsulated calcein on the one hand and the leakage of encapsulated betamethasone on the other hand. In vitro diffusion studies were carried out on Franz type diffusion cells through polycarbonate membranes. In comparison with non-deformable liposomes, these new vesicles showed improved encapsulation efficiency, good stability and higher in vitro diffusion percentages of encapsulated drug. They are therefore promising for future use in ex vivo and in vivo experiments. [less ▲]

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See detailProduction line real time near infrared (NIR) monitoring
Mantanus, Jérôme ULg; Ziemons, Eric ULg; Streel, Bruno et al

Conference (2009, September)

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See detailPreparations and characterisations of semi-solid formulations containing a hydrophilic drug for vaginal administration
Coia, Isabelle ULg; Evrard, Brigitte ULg; Piette, Marie ULg

Poster (2009, April 01)

The purpose of this study is to demonstrate the effect of different types of semi-solid formulations (aqueous gels, liquid jellified emulsions and hydrophilic or lipophilic creams) for vaginal ... [more ▼]

The purpose of this study is to demonstrate the effect of different types of semi-solid formulations (aqueous gels, liquid jellified emulsions and hydrophilic or lipophilic creams) for vaginal administration on the release kinetic of a hydrophilic drug. This drug is an acidic and hydrophilic (log P (octanol/water) = -3.3) molecule with an aqueous solubility upper than 170mg/ml at pH 6-8. The formulations characterisations consisted in the in vitro evaluation of the drug release kinetic and the measure of all formulations viscosity as well as the creams stability and emulsions droplets size. [less ▲]

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See detailDéveloppement d'un implant intra-péritonéal contre l'endométriose
Krier, Fabrice ULg; Evrard, Brigitte ULg; Piel, Géraldine ULg et al

Scientific conference (2009, February 03)

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