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See detailCorrelation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
Bruyère, Olivier ULg; Honore, Aline; Ethgen, Olivier ULg et al

in Osteoarthritis and Cartilage (2003), 11(1), 1-5

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year ... [more ▼]

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year randomized, placebo-controlled, prospective study, of 212 patients with knee OA, recruited in an osteoarthritic outpatient clinic and having been part of a study evaluating the effect of glucosamine sulfate on symptom and structure modification in knee OA. MATERIAL AND METHODS: Measurements of mean joint space width (JSW), assessed by a computer-assisted method, were performed at baseline and after 3 years, on weightbearing anteroposterior knee radiographs. RESULTS: In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003). In the lowest quartile of baseline mean JSW (<4.5mm), the JSW increased after 3 years by (mean (S.D.)) 3.8% (23.8) in the placebo group and 6.2% (17.5) in the glucosamine sulfate group. The difference between the two groups in these patients with the most severe OA at baseline was not statistically significant (P=0.70). In the highest quartile of baseline mean JSW (>6.2mm), a joint space narrowing of 14.9% (17.9) occurred in the placebo group after 3 years while patients from the glucosamine sulfate group only experienced a narrowing of 6.0% (15.1). Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint. In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing. CONCLUSION: These results suggest that patients with the less severe radiographic knee OA will experience, over 3 years, the most dramatic disease progression in terms of joint space narrowing. Such patients may be particularly responsive to structure-modifying drugs. [less ▲]

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See detailPrevention de la vulnerabilite de la personne agee: un defi demographique.
Ethgen, Olivier ULg; Richy, F.; Gosset, Christiane ULg et al

in Revue Médicale de Liège (2003), 58(4), 175-82

World population is ageing. This phenomenon is unprecedented, universal, long-lasting and has important implications. Unprecedented, because never before in human history, so many individuals have reached ... [more ▼]

World population is ageing. This phenomenon is unprecedented, universal, long-lasting and has important implications. Unprecedented, because never before in human history, so many individuals have reached an advanced age. Universal, because all countries are now concerned. Long-lasting, because ageing started in the second half of the XXth century and will become even more pronounced over the XXIst century. With important implications, because it has and will have substantial consequences on human life and social composition. This article reviews quantitative data on ageing to appraise its extent and implication, the goal being to extend and stimulate the debate on ageing. International data are first presented, then analysis moves to Belgium estimates. [less ▲]

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See detailL'evaluation de la qualite de vie dans les essais therapeutiques: un pas vers une approche holistique de la sante
Ethgen, Olivier ULg; Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2002), 57(11), 695-700

The concept of quality of life has been widely developed over the last two decades. As they provide subjective assessment of health, quality of life measures may be broadly and relevantly applied in many ... [more ▼]

The concept of quality of life has been widely developed over the last two decades. As they provide subjective assessment of health, quality of life measures may be broadly and relevantly applied in many areas. Numerous measures are available today to perform discriminative, evaluative or analytical studies in the epidemiological, the therapeutic or the health economic fields. Such measures are increasingly used and may be added to clinical, biological or radiographical criteria to assess medical benefits and health outcomes in order to strengthen decisional choice in health. [less ▲]

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See detailClinical severity of knee osteoarthritis poorly predicts long-term radiographic outcomes
Bruyère, Olivier ULg; Ethgen, Olivier ULg; Lejeune, Eric ULg et al

in Osteoporosis International (2002, November), 13(Suppl.3), 51

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See detailInhaled corticosteroids effects on bone in asthmatic and COPD patients: what is the evidence?
Richy, Florent; Bousquet, Jean; Devogelaer, Jean-Pierre et al

in Osteoporosis International (2002, November), 13(Suppl.3), 22

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See detailStructural and symptomatic efficacy of glucosamine and chondroitine sulfate in osteoarthrits: a comprehensive meta-analysis
Richy, Florent; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Osteoporosis International (2002, November), 13(Suppl.3), 55-56

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See detailMusculoskeletal disorders in a time demographic changes: a real challenge for the future in Europe and Northern America
Ethgen, Olivier ULg; Richy, Florent; De Ceulaer, F. et al

in Osteoporosis International (2002, November), 13(Suppl.3), 48-49

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See detailA comparative analysis between the time trade-off and the willingness to pay approaches in hip and knee osteoarthritis
Ethgen, Olivier ULg; Tancredi, Annalisa ULg; Lejeune, Eric ULg et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 47

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See detailDo willingness to pay and time trade-off approaches suitably reflect health outcomes in hip and knee osteoarthritis?
Ethgen, Olivier ULg; Tancredi, Annalisa; Lejeune, Eric ULg et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 73

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See detailMeta-analysis of the effects of inhaled corticosteroids on bone in asthmatic and COPD patients
Richy, Florent; Bousquet, Jean; Devogelaer, Jean-Pierre et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 464

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See detailClinical severity of knee osteoarthritis poorly predicts long-term radiographic outcomes
Bruyère, Olivier ULg; Ethgen, Olivier ULg; Lejeune, Eric ULg et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 153

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See detailBaseline measurement of urine pyridinoline and deoxypyridinoline is correlated with 3-year hip osteoarthritis progression
Bruyère, Olivier ULg; COLLETTE, Julien ULg; Lejeune, Eric ULg et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 149

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