References of "Eppe, Gauthier"
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See detailAPPLICATION OF THE XDS-CALUX BIOASSAY IN ROUTINE: SEMI-QUANTITATIVE SCREENING USING AL-BEQ CUT-OFF VALUES
Vanderperren, H.; Haedrich, J.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010)

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See detailDISCREPANCIES BETWEEN BIO-ANALYTICAL AND CHEMO-ANALYTICAL RESULTS HAVE A NON-NEGLIGIBLE MESSAGE
Goeyens, L.; Hoogenboom, R.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010)

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See detailFuran formation in baby food model systems from vitamin C and unsaturated fatty acids
Owczarek-Fendor, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

Conference (2010)

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See detailDietary intake of PCDD/Fs and dioxin-like PCBs of the Belgian Population
Windal, Isabelle; Vandevijvere, S.; Maleki, M. et al

in Chemosphere (2010), 79

The World Health Organization recommends assessing human exposure to contaminants on a regular basis. In order to assess the current dietary exposure of the Belgian adult population to PCDD/Fs and dioxin ... [more ▼]

The World Health Organization recommends assessing human exposure to contaminants on a regular basis. In order to assess the current dietary exposure of the Belgian adult population to PCDD/Fs and dioxin-like PCBs and to update exposure estimates of 2000–2001, a total diet study was designed. The mean dietary intake of PCDD/Fs and dioxin-like PCBs in the Belgian adult population in 2008 was estimated to be 0.72 pg TEQ kgbw-1 d-1 (middle bound concentrations, TEF of 1998) based on occurrence data of 2008 and national food consumption data of 2004. This value is clearly below the Tolerable Weekly Intake (TWI) of 14 pg TEQ kgbw-1 week-1 set by the Scientific Committee on Food of the European Commission and below the provisional tolerable monthly intake of 70 pg TEQ kgbw-1 month-1 set by the Joint FAO/WHO Expert Committee on Food Additives. Considering the cumulative distribution, the intake was less than 1 pg TEQ kgbw-1 d-1 for more than 80% of the population, and less than 2 pg TEQ kgbw-1 d-1 for the entire population. When using the 2005 TEF instead of the 1998 TEF, the mean dietary intake in the Belgian adult population was estimated to be 0.61 pg TEQ kgbw-1 d-1. [less ▲]

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See detailImportance of fat oxidation in starch-based emulsions in the generation of the process contaminant furan.
Owczarek-Fendor, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

in Journal of Agricultural and Food Chemistry (2010), 58(17), 9579-86

The formation of the possibly carcinogenic process contaminant furan was studied in starch-based emulsions during heat treatments as applied for sterilization. Fresh and oxidized soybean, sunflower, high ... [more ▼]

The formation of the possibly carcinogenic process contaminant furan was studied in starch-based emulsions during heat treatments as applied for sterilization. Fresh and oxidized soybean, sunflower, high-oleic sunflower, olive, linseed, and rapeseed oils were compared. Results indicated that both the oil type, in particular, the fatty acid composition, and the oxidation degree of the oil determined the susceptibility of the oils to generate furan upon heating. Thus, oils containing the nutritionally relevant omega-3 unsaturated alpha-linolenic acid proved to be able to generate significant amounts of furan if the oils were oxidized. No clear relationship between p-anisidine values of various oils and the amount of generated furan could be observed. However, in the case of soybean oil, significantly more furan was produced upon an increase in oxidation degree. Surprisingly, furan formation in food-relevant systems containing fresh lipids proved to be a minor route (up to 1.5 ppb furan) compared to a previously studied vitamin C containing model system (up to 13 ppb furan). [less ▲]

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See detailHuman Serum biomonitoring: Methodology and Intercalibration
Focant, Jean-François ULg; Eppe, Gauthier ULg

Scientific conference (2009, March)

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See detailIdentification and quantification of selected Metabolites in a Human Plasma by Two Dimensional Gas Chromatography Time of Flight Mass Spectrometry’
Eppe, Gauthier ULg; Mc Gaw, Elizabeth; Dodder, Nathan et al

in 5th International Conference of the Metabolimic Society (2009)

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See detailIdentification and Quantification of Metabolites in a Human Plasma Standard Reference Material by Multiple Mass Spectrometry Methods
Dodder, Nathan; Barak, Ruth; Eppe, Gauthier ULg et al

in 57th ASMS Conference on Mass Spectrometry and Allied topics (2009)

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See detailDerivatization of Amino Acids in Human Plasma for Quantitation by Comprehensive Two Dimensional Gas Chromatography Time of Flight Mass Spectrometry
Mc Gaw, Elizabeth; Eppe, Gauthier ULg; Lowenthal, Mark et al

in 57th ASMS Conference on Mass Spectrometry and Allied Topics (2009)

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See detailIdentification of Metabolites in a Human Plasma Standard Reference Material by Comprehensive two Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry
Eppe, Gauthier ULg; Mc Gaw, Elizabeth; Dodder, Nathan et al

in 57th ASMS Conference on Mass Spectrometry and Allied Topics (2009)

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See detailAbsolute quantification of amino acids in plasma using stable isotope dilution LC-MS/MS – application to a reference material for metabolomics
Lowenthal, Mark; Eppe, Gauthier ULg; Mc Gaw, Elizabeth et al

in 57th ASMS Conference on Mass Spectrometry and Allied Topics (2009)

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See detailPCDD/Fs and dioxin-like PCBs in home-produced eggs from Belgium: levels, contamination sources and health risks.
Van Overmeire, I.; Waegeneers, N.; Sioen, I. et al

in Science of the Total Environment (2009), 407(15), 4419-29

This paper discusses the dioxin TEQ levels as determined by the chemically activated luciferase gene expression assay (CALUX) and by HRGC-HRMS in eggs, soils, faeces and kitchen waste samples obtained in ... [more ▼]

This paper discusses the dioxin TEQ levels as determined by the chemically activated luciferase gene expression assay (CALUX) and by HRGC-HRMS in eggs, soils, faeces and kitchen waste samples obtained in the CONTEGG study. The samples were collected in each Belgian province at private homes and in small gardens where chickens are held. The CALUX levels for eggs sampled in autumn were higher than the levels in eggs obtained at the same locations in spring (median values of 5.86 and 4.08 pg CALUX TEQ/g fat, respectively). The total WHO-TEQ levels in eggs, determined by HRGC-HRMS, ranged from 3.29 to 95.35 pg TEQ/g fat in autumn and from 1.50 to 64.79 pg TEQ/g fat in spring. In the soils on which the chickens forage, levels of 2.51-11.35 pg I-TEQ/g in autumn and 2.00-7.86 pg I-TEQ/g in spring were found. The congener pattern of PCDD/Fs in the eggs, soils and faeces was dominated by OCDD, in addition to 1,2,3,4,6,7,8-HeptaCDD, OCDF and 1,2,3,4,6,7,8-HeptaCDF. The predominant dioxin-like PCBs were PCB118, PCB 105 and PCB 156. The dioxin-like PCBs contributed on average 47%, 14% and 20% to the total WHO-TEQ in eggs, soils and faeces, respectively. Kitchen waste samples were very low-contaminated with dioxin-like compounds. The present results showed a good agreement between egg and soil TEQ levels for PCDD/Fs but not for dioxin-like PCBs. This study showed that current soil levels found in some private gardens do not lead to egg levels below the current EU maximal level of 6 pg total TEQ/g fat for dioxins and dioxin-like PCBs. The consumers of the analysed eggs attained 5-79% of the tolerable weekly intake (TWI) of 14 pg TEQ/kg bw for dioxins and dioxin-like PCBs by exposure to their home-produced eggs only. [less ▲]

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See detailAdvances in quality control for dioxins monitoring and evaluation of measurement uncertainty from quality control data.
Eppe, Gauthier ULg; De Pauw, Edwin ULg

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877

This paper describes an application of multivariate and multilevel quality control charts with the aim of improving the internal quality control (IQC) procedures for the monitoring of dioxins and dioxin ... [more ▼]

This paper describes an application of multivariate and multilevel quality control charts with the aim of improving the internal quality control (IQC) procedures for the monitoring of dioxins and dioxin-like PCBs analysis in food. Dioxin analysts have to use the toxic equivalent concept (TEQ) to assess the toxicity potential of a mixture of dioxin-like compounds. The TEQ approach requires quantifying individually 29 dioxin-like compounds. Monitoring the congeners separately on univariate QC charts is misleading owing to the increase of false alarm rate. We propose to subdivide the TEQ value into 3 sub-groups and to control simultaneously the 3 variables in a T(2) chart. When a T(2) exceeds the upper control limit, it acts as a warning to trigger additional investigations on individual congeners. We discuss the minimum number of runs required to reliably estimate the QC chart parameters and we suggest using data from multilevel QC charts to properly characterize the standard deviations and the correlation coefficients. Moreover, the univariate QC chart can be sensitised to detect systematic errors by using exponentially weighted moving average (EWMA) technique. The EWMA chart provides an additional guidance on setting appropriate criteria to control the method bias and to support trend analysis. Finally, we present an estimate of measurement uncertainty by computing the accuracy profile in a retrospective way with the QC data generated and we discuss assessment of compliance with regulatory maximum levels. [less ▲]

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See detailAssessment of the chemical contamination in home-produced eggs in Belgium: General overview of the CONTEGG study
Van Overmeire, Ilse; Pussemier, Luc; Wageneers, Nadia et al

in Science of the Total Environment (2009), 407(15), 4403-4410

This overview paper describes a study conducted for the Belgian Federal Public Service of Health, Food Chain Safety and Environment during 2006–2007. Home-produced eggs from Belgian private owners of hens ... [more ▼]

This overview paper describes a study conducted for the Belgian Federal Public Service of Health, Food Chain Safety and Environment during 2006–2007. Home-produced eggs from Belgian private owners of hens were included in a large study aiming to determine concentration levels of various environmental contaminants. Bymeans of the analyses of soil samples and of kitchen waste samples, obtained from the same locations, an investigation towards the possible sources of contaminants was possible. Eggs, soils, faeces and kitchen waste samples were checked for the presence of dioxins, PCBs (including dioxin-like PCBs), organochlorine pesticides, trace elements, PAHs, brominated flame retardants and mycotoxins. The study design, sampling methodology and primary conclusions of the study are given. It was found that in some cases dioxin-like compounds were present at levels that are of concern for the health of the egg consumers. Therefore, measures to limit their contamination in eggs, produced by hens of private owners, were proposed and deserve further attentio [less ▲]

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See detailEmpirical Relationship between Precision and Ultra-Trace Concentrations of Pcdd/Fs and Dioxin-Like Pcbs in Biological Matrices
Eppe, Gauthier ULg; Van Cleuvenbergen, Rudy; Smastuen Haug, Line et al

in Chemosphere (2008), 71(2), 379-87

Dioxin analysis in food and feed can be characterized as an analytical application where very high accuracy is required at very low levels of contamination. Gas chromatography (GC) in combination with (13 ... [more ▼]

Dioxin analysis in food and feed can be characterized as an analytical application where very high accuracy is required at very low levels of contamination. Gas chromatography (GC) in combination with (13)C-label isotope dilution (ID) high resolution mass spectrometry (HRMS) is the reference congener-specific technique characterized by pronounced selectivity, precision and trueness at parts-per-trillion (ppt) and sub-parts-per-trillion (sub-ppt) levels. The quality of the analytical data produced routinely by a laboratory should be adequate for its intended purpose, i.e., one will seek a compromise between the cost and time needed and the consequences of incorrect decisions due to erroneous results. The requirements for reproducibility are usually dependent on the analyte concentrations and have been expressed in various empirical functions. While Horwitz or modified functions are widely useful for many purposes, it would be difficult to expect these functions to cover every analytical problem. This study reports on precision characteristics achieved by the GC-ID-HRMS reference method for polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in food and feed in two interlaboratory method-performance studies among expert laboratories with long-standing experience in this field. Striking linear functions in log scale between reproducibility standard deviation and congener's level over a concentration range of 10(-8)-10(-14)g per g fresh weight are observed. The data fit very well to a Horwitz-type function of the form s(R)=0.153c(0.904), where s(R) and c are dimensionless mass ratios expressed in pgg(-1) on fresh weight, regardless of the nature of the toxic congeners, food and feed matrices, or sample preparation methods. We demonstrate that the proposed function is suitable for use as a fitness-for-purpose criterion for proficiency assessment in interlaboratory comparisons on dioxins and related compounds in food. [less ▲]

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See detailSerum dioxin and PCB levels among PCB waste processing plant workers
Eppe, Gauthier ULg; Dupas, D.; Chisacof, I. et al

in Organohalogen Compounds (2008)

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in ... [more ▼]

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in France. The aim of this study was to assess the body burden of polychlorinated dibenzo-p- dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like (DL) PCBs and marker PCBs for those workers. We examined 8 representative workers (34-44 years old). The subjects of this study worked from 5 years to 19 years at the plant. All workers reported daily multiple contacts with various metal and wood parts of dismantled transformers during working hours. On a yearly basis, the exposed subjects were examined by the occupational health physician for a check-up. Basic parameters such as liver function and lipid statement were performed. [less ▲]

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See detailSerum dioxin and PCB levels among PCB waste processing plant workers
Eppe, Gauthier ULg; Dupas, D.; Chisacof, I. et al

in Organohalogen Compounds (2008), 70

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