References of "Eppe, Gauthier"
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See detailFuran formation upon degradation of carbohydrates in combination with proteins and lipids
Owczarek, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

Conference (2012, September 20)

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See detailFuran formation in starch-based model systems containing carbohydrates in combination with proteins, ascorbic acid and lipids
Owczarek-Fendor, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

in Food Chemistry (2012), 133(3), 816-821

Formation of the ‘‘possibly carcinogenic’’ furan during thermal treatment of a starch-based model food system containing selected sugars alone and in the presence of proteins, ascorbic acid and lipids ... [more ▼]

Formation of the ‘‘possibly carcinogenic’’ furan during thermal treatment of a starch-based model food system containing selected sugars alone and in the presence of proteins, ascorbic acid and lipids, respectively, was investigated. The results showed that in starch gels containing various sugars significantly more furan was formed at pH 6 than at pH 4. Moreover, addition of whey proteins enhanced the generation of furan considerably at both pH values tested. In acidic conditions, no significant difference was observed between the amounts of furan found in a starch–carbohydrate–ascorbic acid model system and those formed in a starch-based samples containing only ascorbic acid. Addition of fresh lipids did not affect furan formation. However, when oxidised soybean oil was applied, the generated amounts of furan were higher than expected from the sum of furan found in the separate starch–carbohydrate and starch–lipid samples. Interestingly, the most efficient carbohydrate in furan generation, among the sugars tested, at pH 6, was lactose, especially when heated in the presence of proteins. This is the first report on the generation of furan from lactose. [less ▲]

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See detailRisk assessment for furan contamination through the food chain in Belgian children
Scholl, Georges ULg; Huybrechts, Inge; Humblet, Marie-France ULg et al

in Food Additives & Contaminants (2012), 29(8), 1219-1229

Young, old, pregnant and immuno-compromised persons are of great concern for risk assessors as they represent the sub-populations most at risk. The present paper focuses on risk assessment linked to furan ... [more ▼]

Young, old, pregnant and immuno-compromised persons are of great concern for risk assessors as they represent the sub-populations most at risk. The present paper focuses on risk assessment linked to furan exposure in children. Only the Belgian population was considered because individual contamination and consumption data that are required for accurate risk assessment were available for Belgian children only. Two risk assessment approaches, so called deterministic and probabilistic, were applied and their results were compared for the estimation of the daily intake. A significant difference between the average Estimated Daily Intake (EDI) was underlined between the deterministic (419 ng * (kgb.w. * day)-1) and the probabilistic (583 ng * (kgb.w. * day)-1) approaches, which results from the mathematical treatment of the null consumption and contamination data. The risk was characterized by two ways: (1) the classical approach by comparison of the EDI to a reference dose (RfDchronic-oral) and (2) the most recent approach, namely the Margin of Exposure (MoE) approach. Both reached similar conclusions: the risk level is not of a major concern, but is neither negligible. In the first approach, only 2.7% or 6.6% (respectively in the deterministic and in the probabilistic way) of the studied population presented an EDI above the RfDchronic-oral. In the second approach, the percentage of children displaying a MoE above 10,000 and below 100 is 3% - 0% and 20% - 0.01% in the deterministic and probabilistic modes respectively. In addition, children were compared to adults and significant differences between the contamination patterns were highlighted. Whilst major contamination was linked to coffee consumption in adults (55%), no item predominantly contributed to the contamination in children. The most important were soups (19%), dairy products (17%), pasta and rice (11%), fruit and potatoes (9% each). [less ▲]

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See detailAnalytical criteria for use of MS/MS for determination of dioxins and dioxin-like PCBs in feed and food
Kotz, A; Malisch, R; Focant, Jean-François ULg et al

in Organohalogen Compounds (2012, August), 74

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See detailIdentification and quantification of concentration-dependent biomarkers in MCF-7/BOS cells exposed to 17β-estradiol by 2-D DIGE and label-free proteomics
Collodoro, Mike ULg; Lemaire, Pascale ULg; Eppe, Gauthier ULg et al

in Journal of Proteomics (2012), in press

This paper reports the identification of biomarkers resulting from the exposure of MCF-7/BOS cells to 17β-estradiol (E2). The biomarkers were identified using 2 independent and complementary techniques, 2 ... [more ▼]

This paper reports the identification of biomarkers resulting from the exposure of MCF-7/BOS cells to 17β-estradiol (E2). The biomarkers were identified using 2 independent and complementary techniques, 2-D DIGE / MALDI-TOF peptide mass fingerprint, and 2-D UPLC-ESI MS/MS. These markers form a preliminary molecular signature that can be used when testing the estrogenic activity of xenobiotics, either pure or in mixtures. [less ▲]

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See detailThe usefulness of Ion Mobility-Mass Spectrometry for Small Molecules Analysis
Far, Johann ULg; Goscinny, Séverine ULg; Joly, Laure et al

Conference (2012, March)

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See detailRisk assessment of Belgian adults for furan contamination through the food chain
Scholl, Georges ULg; Humblet, Marie-France ULg; Scippo, Marie-Louise ULg et al

in Food Additives & Contaminants (2012), 29(3), 345-353

Risk assessment is an interdisciplinary process used to quantify the risk linked to a hazard. In the present paper it is applied to quantify the risk linked to furan ingestion through the food chain for ... [more ▼]

Risk assessment is an interdisciplinary process used to quantify the risk linked to a hazard. In the present paper it is applied to quantify the risk linked to furan ingestion through the food chain for the Belgian adult population. Two approaches, deterministic and probabilistic, were carried out in parallel. The deterministic method relied on a case study, whereas the probabilistic approach involved statistical distributions of contamination and consumption data to calculate a statistical distribution of the daily intake. First, the deterministic method revealed a low estimated daily intake (EDI) for the average population (380 ng*(kgbw*day)–1) and a huge contribution of coffee consumption to the EDI (55%). Increasing or decreasing the daily coffee consumption by one cup can affect the EDI by about 22%. Afterwards, the probabilistic approach showed that the average population has a low EDI (494 ng*(kgbw*day) 1), and that high contamination levels were only registered in a small proportion of the population. Finally, a comparison of the RfDchronic oral showed that less than 10% of the Belgian population had an EDI above the reference dose proposed by the USEPA; the majority of the population had an EDI 20% below the reference dose. The margin of exposure (MoE) approach indicated that the level of risk related to furan intake through ingestion is low, with a MoE>10,000 for more than 10% of the population and no result < 100. [less ▲]

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See detailLes PCB non apparentés aux dioxines (non dioxin-like PCB) dans les denrées alimentaires et les aliments pour animaux: mise en place d'une législation européenne
Eppe, Gauthier ULg

Article for general public (2012)

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de ... [more ▼]

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de chlore sur la molécule biphényle. Cette famille de composés peut être divisée en deux catégories selon leurs propriétés toxicologiques, et plus particulièrement les effets tératogènes des PCB. Le premier groupe, composé de 12 congénères, se caractérise par des propriétés toxicologiques similaires aux dioxines, et il est par conséquent désigné par le terme ‘PCB de type dioxine’ (dioxin-like PCB, DL-PCB). L’autre groupe de PCB non apparenté aux dioxines (non dioxin-like PCB, NDL-PCB), présente d’autres mécanismes de toxicité pris en compte dans la gestion du risque PCB. Parmi ces 197 NDL-PCB, une sous-catégorie de six congénères relativement abondants dans l’environnement et dans les chaînes alimentaires (PCB 28, 52, 101, 138, 153 et 180), représente ce que nous appelons communément les PCB indicateurs. De par leurs propriétés de persistance, de bioaccumulation et de biomagnification, l’ensemble des PCB (DL-PCB et NDL-PCB) se retrouve fréquemment dans l’alimentation humaine et dans les aliments pour animaux. La fixation de teneurs maximales en NDL-PCB dans divers aliments fait l’objet d’une nouvelle réglementation européenne qui entrera en vigueur dès 2012. Cet article fait le point sur l’impact de ces nouvelles propositions par rapport au niveau de bruit de fond des principales classes d’aliments mais également sur l’évolution des méthodes d’analyse nécessaires pour atteindre les performances requises. [less ▲]

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See detailEstimation of furan contamination across the Belgian food chain.
Scholl, Georges ULg; Scippo, Marie-Louise ULg; De Pauw, Edwin ULg et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2012), 29(2), 172-9

This paper provides an estimate of the furan content of Belgian foods. The objective of the study was to achieve the best food chain coverage with a restricted number of samples (n = 496). The geographic ... [more ▼]

This paper provides an estimate of the furan content of Belgian foods. The objective of the study was to achieve the best food chain coverage with a restricted number of samples (n = 496). The geographic distribution, different market chains and labels, and consumption frequencies were taken into account in the construction of the sampling plan. Weighting factors such as contamination levels, consumption frequency and the diversity of food items were applied to set up the model. The very low detection capabilities (CC(beta)) of the analytical methods used (sub-ppb) allowed reporting of 78.2% of the overall dataset above CC(beta) and, in particular, 96.7% for the baby food category. The highest furan levels were found in powdered roasted bean coffee (1912 microg kg(-1)) with a mean of 756 microg kg(-1) for this category. Prepared meat, pasta and rice, breakfast cereals, soups, and baby food also showed high mean furan contents ranging from 16 to 43 microg kg(-1). Comparisons with contamination surveys carried out in other countries pointed out differences for the same food group and therefore contamination levels are related to the geographical origin of food items. [less ▲]

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See detailAtmospheric concentrations of PCDD/Fs, dl-PCBs and some pesticides in northern Algeria using passive air sampling.
Moussaoui, Y.; Tuduri, L.; Kerchich, Y. et al

in Chemosphere (2012), 88

Two monitoring campaigns were conducted in northern Algeria to assess the contamination level of pesticides and persistent organic pollutants (POPs) in ambient air. Six pesticides (alpha- and gamma ... [more ▼]

Two monitoring campaigns were conducted in northern Algeria to assess the contamination level of pesticides and persistent organic pollutants (POPs) in ambient air. Six pesticides (alpha- and gamma-hexachlorocyclohexane, fenitrothion, malathion, chlorpyrifos and lambda-cyhalothrin) were monitored at two different sampling locations during the first campaign. The passive sampling was performed at a semi urban/industrial site but also in a rural area between July to September 2008. The pesticides levels, analyzed by GC/MS/MS, ranged from 16pgm(-3) to 11ngm(-3). The second campaign was carried out from May to November 2009. The polychlorodibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) concentrations were evaluated at an urban/industrial and at an industrial site. The PCDD/Fs and dl-PCBs, analyzed by HRGC/HRMS, ranged from 249 to 923fg TEQ m(-3). In addition to passive sampling, active sampling using an isokinetic sampler was also performed at an industrial waste incinerator. The PCDD/Fs and dl-PCBs found was 268pg TEQ m(-3). This paper presents the first measurements of PCDD/Fs, dl-PCBs and pesticides in rural, urban and industrial areas of northern Algeria. [less ▲]

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See detailRecent advances in analytical chemistry and mass spectrometry for organic selenium and tellurium compounds
Far, Johann ULg; De Pauw, Edwin ULg; Eppe, Gauthier ULg

in Rappoport, Zvi (Ed.) The Chemistry of Organic Selenium and Tellurium compounds Volume 3 Part 1 and 2 (2012)

The objective of this chapter is to present the recent developments in mass spectrometry for selenium (Se) and tellurium (Te) analysis. The state-of-the-art of mass spectrometry based techniques available ... [more ▼]

The objective of this chapter is to present the recent developments in mass spectrometry for selenium (Se) and tellurium (Te) analysis. The state-of-the-art of mass spectrometry based techniques available is critically evaluated with particular emphasis in ion sources and mass analyzers. The complexity of identification and characterization of Se, Te species including their speciation in the environment or in biological materials requires methodologies not only limited to mass spectrometry. Particular attention is given to sample preparation and hyphenated techniques with mass spectrometry for a comprehensive characterization of these trace elements. All these aspects are illustrated with up-to-date applications from the literature. Finally, future trends in mass spectrometry give the readers new insights in Se and Te species detection. [less ▲]

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See detailIon Mobility - Mass Spectrometry as a new approach for the screening of pesticide residues in food
Joly, Laure; Goscinny, Séverine ULg; Touilloux, Romain et al

Conference (2011, September)

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See detailInvestigation of Ion Mobility coupled with mass spectrometry (IMMS) for the screening of pesticide residues in food
Goscinny, Séverine ULg; Touilloux, Romain; Joly, Laure et al

Conference (2011, June)

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