References of "Eppe, Gauthier"
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See detailGender dependent accumulation of dioxins in smokers
Fierens, S.; Eppe, Gauthier ULg; De Pauw, Edwin ULg et al

in Occupational and Environmental Medicine (2005), 62(1), 61-62

Aims: To evaluate the contribution of tobacco smoking to dioxin accumulation. Methods: Dioxin (17 PCDD/F) concentrations in fasting blood from 251 subjects ( 161 never smokers, 54 past smokers, and 36 ... [more ▼]

Aims: To evaluate the contribution of tobacco smoking to dioxin accumulation. Methods: Dioxin (17 PCDD/F) concentrations in fasting blood from 251 subjects ( 161 never smokers, 54 past smokers, and 36 current smokers) were quantified. Results: Whereas serum dioxin concentrations of male smokers were on average 40% higher than those of nonsmokers, in women, smoking was associated with significantly lower serum dioxin levels. A synergistic potentiation of dioxin metabolism by tobacco smoke in women is postulated to explain these paradoxical findings. Conclusions: Current smoking is associated with gender dependent effects on dioxin body burden and is a potential source of confounding in human studies using blood dioxins as indicators of exposure. [less ▲]

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See detailComprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs - Comparison with other methods
Focant, Jean-François ULg; Eppe, Gauthier ULg; Scippo, Marie-Louise ULg et al

in Journal of Chromatography. A (2005), 1086(1-2), 45-60

A comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOF-MS) experimental setup was tested for the measurement of seven 2,3,7,8-substituted polychlorinated dibenzo ... [more ▼]

A comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOF-MS) experimental setup was tested for the measurement of seven 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs), ten 2,3,7,8-substituted polychlorinated dibenzofurans (PCDFs), four non-ortho-polychlorinated biphenyls (PCBs), eight mono-ortho-PCBs, and six indicator PCBs (Aroclor 1260) in foodstuff samples. A 40 m RTX-500 (0.18 mm I.D., 0.10 mu m df) was used as the first dimension (D-1) and a 1.5 nn BPX-50 (0.10 mm I.D., 0.10 mu m df) as the second dimension (2 D). The GC x GC chromatographic separation was completed in 45 min. Quantification was performed using C-13-label isotope dilution (11)). Isotope ratios of the selected quantification ions were checked against theoretical values prior to peak assignment and quantification. The dynamic working range spanned three orders of magnitude. The lowest detectable amount of 2,3,7,8-TCDD was 0.2 pg. Fish, pork, and milk samples were considered. On a congener basis, the GC x GC-ID-TOF-MS method was compared to the reference GC-ID high resolution mass spectrometry (HRMS) method and to the alternative GC-ID tandem-in-time quadrupole ion storage mass spectrometry (QIST-MS/MS). PCB levels ranged from low picogram (pg) to low nanogram (ng) per gram of sample and data compared very well between the different methods. For all matrices, PCDD/Fs were at a low pg level (0.05-3 pg) on a fresh weight basis. Although congener profiles were accurately described, RSDs of GC x GC-ID-TOF-MS and GC-QIST-MS/MS were much higher than for GC-ID-HRMS, especially for low level pork and milk. On a toxic equivalent (TEQ) basis, all methods, including the dioxin-responsive chemically activated luciferase gene expression (DR-CALUX) assay, produced similar responses. A cost comparison is also presented. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailEvaluation of the DR-CALUX screening of food and feed, according to regulation levels including DL-PCB
Scippo, Marie-Louise ULg; Rybertt, Soledad; Focant, Jean-François ULg et al

in Organohalogen Compounds (2005), 67

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See detailPerformance of GC-LRMS/MS and GCxGC methods for compliance monitoring of the PCDD/F-TEQ and the total TEQ in food and feed
Van Cleuvenbergen, Rudy; Santos, Javier; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2005), 67

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See detailRemoval of PCDD/Fs and DL-PCBs from fish oil by activated carbon: Compliance with European Legislation
Eppe, Gauthier ULg; Carbonnelle, Sophie; Hellebosch, Laeticia et al

in Organohalogen Compounds (2005), 67

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See detailDecrease of serum concentrations of dioxins and PCBs in Belgium between 2000 and 2003
Fierens, Sébastien; Heilier, Jean-François; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2005), 67

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See detailFactors influencing the PCDD/F levels in plasma of Belgian blood donors
Debacker, Neomi; Van Wouwe, Nathalie; Sasse, André et al

in Organohalogen Compounds (2005)

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See detailRemoval of dioxins and PCBs in fish oils: comparison of CALUX and GC-HRMS results
Carbonnelle, Sophie; Eppe, Gauthier ULg; Hellebosch, Laeticia et al

in Organohalogen Compounds (2005)

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See detailPerformances and limitations of the HRMS method for dioxins, furans and dioxin-like PCBs analysis in animal feedingstuffs Part I: Results of an inter-laboratory study
Eppe, Gauthier ULg; Cofino, W. P.; De Pauw, Edwin ULg

in Analytica Chimica Acta (2004), 519(2), 231-242

The European strategy for dioxin monitoring of the food chain has defined high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) method as the confirmatory method that ... [more ▼]

The European strategy for dioxin monitoring of the food chain has defined high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) method as the confirmatory method that can provide reliable and comparable results at sub-parts per trillion (ppt) level. This paper describes the first inter-laboratory study on dioxins, furans and dioxin-like PCBs by HRGC/HRMS method in animal feedingstuffs. Two different statistical approaches (ISO 5725 and Cofino's statistics) were used for the statistical evaluation. For this particular study, the performances of the HRGC/HRMS method seem to be congener-independent in repeatability and reproducibility conditions over a concentration range covering more than four orders of magnitude. Results clearly show the effect of precision loss below 0.1 ppt level per congener in repeatability conditions and below 0.2 ppt level per congener in reproducibility conditions. LODs reported by the laboratories give median values of 0.02 ng/kg for most of the toxic congeners. Relative standard deviation between the laboratories' mean values using upper-bound approach for TEQ calculation is 6.2%, more than twice the maximum level set at 0.75 ng TEQ/kg of product. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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