References of "Dubois, Bernard"
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See detailThe role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
De Jager, P. L.; Franchimont, D.; Waliszewska, A. et al

in Genes and Immunity (2007), 8(5), 387-397

The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors ... [more ▼]

The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15 - 1.48; P = 0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16 - 1.54; P = 0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04 - 1.30; P = 0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway - in this case, TLR4 and its signaling molecule TIRAP - plays a role in susceptibility to IBD. [less ▲]

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See detailL'épuration extrarénale appliquée au patient hospitalisé aux soins intensifs
Delanaye, Pierre ULg; Dubois, Bernard ULg; Lambermont, Bernard ULg et al

in Néphrologie & Thérapeutique (2007), 3(4), 126-32

Mortality remains high in intensive care patients with renal failure requiring extra corporeal blood purification. This article reviews the recent data that have led to the improvement of the care for ... [more ▼]

Mortality remains high in intensive care patients with renal failure requiring extra corporeal blood purification. This article reviews the recent data that have led to the improvement of the care for such patients. We will discuss the criteria to determine the choice of the technique (intermittent or continuous), of the membrane, of the prescribing dose, and the type of anticoagulation and when to initiate such a treatment. [less ▲]

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See detailCascade high volume hemofiltration : Preliminary data in septic shock patients
WIESEN, Patricia ULg; MONCHI, Mehran; DUBOIS, Bernard ULg et al

in Blood Purification (2007), 25

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See detailNouveautés dans la prise en charge des anomalies du bilan phosphocalcique chez le patient dialysé
Delanaye, Pierre ULg; Van Overmeire, Lionel ULg; Dubois, Bernard ULg et al

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 360-5

Disorders of the phosphocalcic metabolism are frequent in dialysis patients. Such disorders are difficult to treat and have negative impact on bone health, but also on cardiovascular mortality ... [more ▼]

Disorders of the phosphocalcic metabolism are frequent in dialysis patients. Such disorders are difficult to treat and have negative impact on bone health, but also on cardiovascular mortality. Hyperphosphoremia is a strong predictor of cardiovascular mortality. New phosphate binders are now available in Belgium. A new molecule acting on the calcium receptor of the parathyroid glands is able to control secondary and tertiary hyperparathyroidism in dialysis patients. These new therapies, specific for dialysis patients, will be reviewed in this article. [less ▲]

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See detailAnémie et risque cardio-vasculaire chez l'insuffisant rénal chronique. Nouvelles données sur la cible en hémoglobine à atteindre
Krzesinski, Jean-Marie ULg; Dubois, Bernard ULg

in Revue Médicale de Liège (2007), 62(5-6), 366-370

Anemia is frequent when chronic kidney disease develops. Its correction by the use of erythropoietin improves the quality of life, and exercise tolerance, and decreases the cardiovascular risk. However ... [more ▼]

Anemia is frequent when chronic kidney disease develops. Its correction by the use of erythropoietin improves the quality of life, and exercise tolerance, and decreases the cardiovascular risk. However, this later risk is not further decreased or even is increased when the hemoglobin target is set above 13 g/dl as compared to the recommended hemoglobin level between 11 and 12 g/dl.This last target therefore gives the best cost-beneficial effect ratio in the chronic kidney disease population. This target must be the new one. [less ▲]

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See detailConfirmation of high cytokine clearance by hemofiltration with a cellulose triacetate membrane with large pores: an in vivo study
Delanaye, Pierre ULg; Lambermont, Bernard ULg; Dogné, Jean-Michel ULg et al

in International Journal of Artificial Organs (2006), 29(10), 944-948

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 ... [more ▼]

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 mg/kg of lipopolysaccharide from Escherichia Coli over a period of 30 mins). Six pigs were hemofiltrated for 3 hours with a large pore membrane (78 angstrom pore, 80 kDa cut off) (Sureflux FH 70, Nipro, Osaka, Japan). The ultrafiltration rate was 45 ml/kg/min. Samples were taken from arterial, venous line and in the ultrafiltrate at T120 and T240. We measured concentrations of interleukin 6, interleukin 10 and albumin. Results: At T120 and T240, the IL-6 clearances were 22 +/- 7 and 15 +/- 3 ml/min, respectively. The IL-6 sieving coefficients were 0.97 and 0.7 at T120 and T240, respectively. At T120 and T240, the IL-10 clearances were 14 +/- 4 and 10 +/- 7 ml/min, respectively. The sieving coefficients were 0.63 and 0.45 at T120 and T240, respectively. The concentrations of IL-6 and IL-10 were the same at T0 and T240. At T60 and T240, the plasmatic albumin concentrations were 24 +/- 4 g/L and 23 +/- 4 g/L, respectively ( p = 0.13). Conclusions: In this animal model of endotoxinic shock, we confirm the high cytokine clearance observed when hemofiltration is applied to a large pore membrane. The loss of albumin seems negligible. The impact of such clearances on hemodynamic stability and survival remains to be proved. [less ▲]

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See detailLarge-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs
Lambermont, Bernard ULg; Delanaye, Pierre ULg; Dogné, Jean-Michel ULg et al

in Artificial Organs (2006), 30(7), 560-564

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with ... [more ▼]

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling. [less ▲]

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See detailAnkle-brachial blood pressure index and cardiovascular risk in hemodialized patients
Saint-Remy, Annie ULg; Sumaili, Ernest; Xhignesse, Patricia ULg et al

in Journal of Hypertension (2006, June 12), 24(suppl 4), 167

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See detailOne year follow-up of ankle-brachial blood pressure index in hemodialized patients
Saint-Remy, Annie ULg; Sumaili, Ernest; Dubois, Bernard ULg et al

in Kidney & Blood Pressure Research (2006), 29

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See detailAnkle-Brachial blood pressure index in hemodialyzed patients.
Saint-Remy, Annie ULg; Sumaili, Ernest; XHIGNESSE, Patricia ULg et al

Conference (2005, October 22)

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See detailPrévalence des calcifications vasculaires et facteurs associés chez le patient hémodialysé
XHIGNESSE, Patricia ULg; Saint-Remy, Annie ULg; WEEKERS, Laurent ULg et al

Poster (2005, September 27)

Les maladies cardiovasculaires constituent la première cause de décès chez les patients dialysés chroniques. Parmi les facteurs impliqués on trouve les anomalies du métabolisme phosphocalcique. Le but de ... [more ▼]

Les maladies cardiovasculaires constituent la première cause de décès chez les patients dialysés chroniques. Parmi les facteurs impliqués on trouve les anomalies du métabolisme phosphocalcique. Le but de cette étude est de relier l'incidence de nouvelles calcifications et des décès (22%, n=18) avec les paramètres du métabolisme phosphocalcique au travers d'une étude prospective portant sur les années 2003-2004. L'établissement d'un score de calcification vasculaire précoce (dès la prise en charge en dialyse) permettra un suivi étroit et une adaptation prudente du traitement contrôlant le métaboisme phosphocalcique. [less ▲]

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See detailAmputation des membres inférieurs, diabète et survie chez le patient dialysé chronique
sumaili, Ernest; Saint-Remy, Annie ULg; DUBOIS, Bernard ULg et al

Poster (2005, September 27)

Chez les patients HD, la mortalité après amputation est importante (83%). La période critique post opératoire est de 2 mois avec une médiane de survie d'environ 1 an. Le diabète et les troubles ... [more ▼]

Chez les patients HD, la mortalité après amputation est importante (83%). La période critique post opératoire est de 2 mois avec une médiane de survie d'environ 1 an. Le diabète et les troubles phosphocalciques sont en relation avec la nécessité d'amputation et la survie médiocre chez des patients ayant de lourds antécédents cv. Une optimalisation de la prise en charge thérapeutique de ces patients à risque est nécessaire. [less ▲]

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See detailPrévalence des calcifications vasculaires et facteurs associés chez le patient hémodialysé
Xhignesse, Patricia ULg; Saint-Remy, Annie ULg; Weekers, Laurent ULg et al

in Néphrologie & Thérapeutique (2005, September), 1(S2), 107

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See detailAmputation des membres inférieurs, diabète et survie chez le patient dialysé chronique
Sumaili, Ernest; Saint-Remy, Annie ULg; Dubois, Bernard ULg et al

in Néphrologie & Thérapeutique (2005, September), 1(S2), 110

Objectif. – La mortalité cardiovasculaire (cv) est très élevée chez les patients hémodialysés chroniques (HD). Les atteintes vasculaires responsables d'amputations ne font qu'accroître cette mortalité. Le ... [more ▼]

Objectif. – La mortalité cardiovasculaire (cv) est très élevée chez les patients hémodialysés chroniques (HD). Les atteintes vasculaires responsables d'amputations ne font qu'accroître cette mortalité. Le but de cette étude est de décrire les causes de décès et la courbe de survie post-amputation ainsi que d'analyser les facteurs pouvant influencer cette survie. [less ▲]

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