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See detailRelationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions
Verwilghen, Denis ULg; Busoni, Valeria ULg; Gangl, Monika et al

in Research in Veterinary Science (2009), 87(2), 319-28

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this ... [more ▼]

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this procedure which is time consuming and sometimes technically difficult. The aim of this study was to investigate the relationship between the radiological status of the horses and the levels of biochemical markers of cartilage degradation and synovial inflammation. A specific radiological scoring and classification system was therefore developed and applied on 63 stallions presented for studbook admission. Additionally, groups of horses were established according to the occurrence of osteochondrosis, degenerative joint disease and distal interphalangeal joint effusion. Insulin growth factor-I, myeloperoxidases, Coll2-1 and Coll2-1NO(2) were used as blood markers. The combination of the blood parameters did not seem to correlate with the used scoring system. Coll2-1NO(2) levels however tended to increase with poorer radiological class and this could therefore potentially be a useful predictor of the osteoarticular status in the horse. Coll2-1 levels were significantly higher in the degenerative joint disease group. A high percentage of horses with distal interphalangeal joint effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels. [less ▲]

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See detailReproductive Performance of the Ardennaise Chicken Breed under Traditional and Modern Breeding Management Systems
Larivière, Jean-Marc ULg; Michaux, Charles ULg; Farnir, Frédéric ULg et al

in International Journal of Poultry Sciences (2009), 8(5), 446-451

Enhancing the use of traditional chicken breeds is necessary to insure long-term conservation of global genetic diversity in poultry. A logical start in this process is to evaluate performance. The ... [more ▼]

Enhancing the use of traditional chicken breeds is necessary to insure long-term conservation of global genetic diversity in poultry. A logical start in this process is to evaluate performance. The objective of this study was to estimate reproductive traits in the Ardennaise chicken breed under traditional and modern management systems. Reproductive performance indicated lighting programs [Natural (NAT) or Artificial (ART) day length] were highly significant for egg weight, hatchability (p<0.001), early and mid-term embryonic mortality (p<0.01). Feeding treatments [ad libitum (AL) or mild Feed-restriction (FR)] varied greatly with egg weight, hatchability, fertility (p<0.001) and late embryonic mortality (p<0.05). Most precocious age at first egg (23 weeks), longest duration of laying period (>27 weeks), utmost maximum production peak (56.67%), largest egg number (70.13 eggs/hen) and number of chicks hatched (24.10 chicks/hen) were performed under ART-AL. Heaviest egg weight (53.21g), highest fertility (70.20%), greatest hatchability (55.58%), highest liveability during rearing (95.74%) and lay (100%), lowest early (3.51%) and mid-term embryonic mortality (1.17%) were achieved under NAT-AL. To summarize, most of traits studied in the Ardennaise chicken were moderate when compared to those expected by broiler breeders. [less ▲]

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See detailLoss of hip bone mineral density over time is associated with spine and hip fracture incidence in osteoporotic postmenopausal women.
Bruyère, Olivier ULg; Varela, A. R.; Adami, S. et al

in European journal of epidemiology (2009), 24

The objective of the study assess the relationship between bone mineral density (BMD) loss over time and fracture incidence in postmenopausal women. This is a posthoc analysis that includes women from the ... [more ▼]

The objective of the study assess the relationship between bone mineral density (BMD) loss over time and fracture incidence in postmenopausal women. This is a posthoc analysis that includes women from the placebo group of two large randomized controlled trials having assessed the efficacy of a new anti-osteoporotic drug. BMD was assessed every 6 months during 3 years at the lumbar spine, the femoral neck and the total proximal femur. Vertebral fractures were assessed using a semiquantitative method. Hip fractures were based on written documentation. All patients received calcium and vitamin D. In the present study that included 1,775 patients (with complete data at baseline and after 3 years), the logistic regression analysis, adjusted for covariates, showed that 3-year change in lumbar BMD was not statistically associated with the new vertebral fractures after 3 years. However, femoral neck and total proximal femur BMD changes was statistically correlated with the incidence of new vertebral fractures (P < 0.001). When considering change in BMD after the first year of follow-up, a decrease in total proximal femur BMD was statistically associated with an increase in the incidence of new vertebral fractures during the last 2 years of follow-up (P = 0.048). The 3-year change in femoral neck and total proximal BMD was statistically correlated with the incidence of hip and fragility fracture after 3 years (all P < 0.001). In this elderly osteoporotic population receiving calcium and vitamin D, a decrease in hip BMD after 1 or 3 year of follow-up, is associated with an increased risk of fracture incidence. However, spine BMD changes do not influence vertebral fracture incidence. [less ▲]

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See detailCardiac Power Output during Dobutamine Stress
Sandersen, Charlotte ULg; Mc Entee, Kathleen ULg; Deleuze, Stefan ULg et al

in Journal of Equine Veterinary Science (2009)

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See detailGenetic factors affecting susceptibility to udder pathogens
Detilleux, Johann ULg

in Veterinary Microbiology (2009), 134(1-2), 157-164

Many studies have identified genetic factors underlying resistance or susceptibility to mastitis in dairy cows and heifers. Some authors focused on polygenic variation while others searched for genes and ... [more ▼]

Many studies have identified genetic factors underlying resistance or susceptibility to mastitis in dairy cows and heifers. Some authors focused on polygenic variation while others searched for genes and/or quantitative trait loci with major effects on mastitis. Classical traits related to mastitis include somatic cell counts, electrical conductivity and clinical cases of the disease. With the development of automatic milking devices and '-omics' technologies, new traits are considered, such as acute phase proteins, immunological assays, and milk flow patterns, and new biological pathways are discovered, for example the role of mammary epithelium and the nervous system. The usefulness of these traits for the identification of resistant cows is discussed in relation to the biological mechanisms underlying the development of the disease. In addition, the utility of these traits for genetic improvement is reviewed. Finally, the problem of durability in resistance is addressed, including co-evolution and the cost of resistance. [less ▲]

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See detailInfluence de l'apport énergétique et de l'hibernation sur la croissance des tortues terrestres
Diez, Marianne ULg; Justet, Delphine; Detilleux, Johann ULg et al

in 15th FECAVA Eurocongress - Proceedings (2009)

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See detailEffects of different levels of energy allowances and of hibernation on growth in hatchling Testudo hermanni boettgeri (Mojsisovic, 1889)
Diez, Marianne ULg; Vanstrazeele, Boris; Justet, Delphine et al

in Clauss, M.; Fidgett, A.; Hatt, J. M. (Eds.) et al Zoo Animal Nutrition IV (2009)

Cet article présente des données de croissance de Testudo nouveaux nés dont les apports alimentaires et l'hibernation ont été contrôlés.

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See detailThe Influence of Phylogenic Origin on the Occurrence of Brachycephalic Airway Obstruction Syndrome in a Large Retrospective Study
Njikam Nsangou, Ibrahim ULg; Huault, Maxime; Pirson, Vincent et al

in International journal of applied research in veterinary medicine (2009), 7(3), 138-143

Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily ... [more ▼]

Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily affordable information of clinical significance. When this clinical information is enriched with knowledge on the phylogenetic origins, breed histories of the dog and adjusted for known biases, they may lead the way to more in depth genetic research. We illustrated here with a very complex disease, the brachycephalic airway obstruction syndrome (BAOS). No cases were reported in the boxer breed while almost half of the dogs from the other brachycephalic breeds of the same phylogenetic cluster were BAOS, making these breeds good candidates for further genetic studies. Critical issues to improve utility of clinical data for genetic studies are discussed along with methods to handle biases inherent to such type of studies. [less ▲]

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See detailComparative Pharmacokinetics of Two Intravenous Administration Regimens of Tiludronate in Healthy Adult Horses and Effects on the Bone Resorption Marker Ctx-1
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, J. et al

in Journal of Veterinary Pharmacology & Therapeutics (2008), 31(2), 108-16

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days ... [more ▼]

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX-1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX-1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX-1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses. [less ▲]

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See detailEffects of two levels of energy allowances and of hibernation on growth in hatchling Testudo hermanni boettgeri (Mojsisovic, 1889)
Diez, Marianne ULg; Vanstrazeele, Boris; Detilleux, Johann ULg et al

in Fidgett, Andrea; Noble, Jacqueline E (Eds.) Abstract book of the 5th European Zoo Nutrition Conference (2008, January)

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See detailThe analysis of disease biomarker data using a mixed hidden Markov model
Detilleux, Johann ULg

in Genetics, Selection, Evolution (2008), 40(5), 491-509

A mixed hidden Markov model (HMM) was developed for predicting breeding values of a biomarker (here, somatic cell score) and the individual probabilities of health and disease (here, mastitis) based upon ... [more ▼]

A mixed hidden Markov model (HMM) was developed for predicting breeding values of a biomarker (here, somatic cell score) and the individual probabilities of health and disease (here, mastitis) based upon the measurements of the biomarker. At a first level, the unobserved disease process (Markov model) was introduced and at a second level, the measurement process was modeled, making the link between the unobserved disease states and the observed biomarker values. This hierarchical formulation allows joint estimation of the parameters of both processes. The flexibility of this approach is illustrated on the simulated data. Firstly, lactation curves for the biomarker were generated based upon published parameters (mean, variance, and probabilities of infection) for cows with known clinical conditions (health or mastitis due to Escherichia coli or Staphylococcus aureus). Next, estimation of the parameters was performed via Gibbs sampling, assuming the health status was unknown. Results from the simulations and mathematics show that the mixed HMM is appropriate to estimate the quantities of interest although the accuracy of the estimates is moderate when the prevalence of the disease is low. The paper ends with some indications for further developments of the methodology. [less ▲]

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See detailGenetic and non genetic effects on growth traits of West African Dwarf sheep in Benin (West Africa)
Gbangboche, A. B.; Abiola, F. A.; Alimi, S. et al

in Livestock Production Science (2008)

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See detailComparison of bronchoalveolar lavage cytospins and smears in dogs and cats.
Dehard, Sandrine ULg; Bernaerts, Frederique ULg; Peeters, Dominique ULg et al

in Journal of the American Animal Hospital Association (2008), 44(6), 285-94

Differences in the cytological interpretation of bronchoalveolar lavage fluid (BALF) after cytospin preparation (CP) or manual smearing of pelleted cells preparation (MSP) were investigated in client ... [more ▼]

Differences in the cytological interpretation of bronchoalveolar lavage fluid (BALF) after cytospin preparation (CP) or manual smearing of pelleted cells preparation (MSP) were investigated in client-owned dogs and cats with inflammatory or infectious lower respiratory disease. Bronchoalveolar lavage fluid from healthy cats was also examined. With MSP, cell lysis was more frequently observed, and cellular distribution was more heterogeneous throughout the slide. When samples from healthy and diseased animals were considered together, a significantly greater percentage of neutrophils was seen on CP than on MSP slides (P<0.002). Cytospin preparations were considered of better quality in all individual comparisons. Cytospin preparation is advised in the evaluation of BALF with low total cell count. When only MSPs are evaluated, clinicians should be aware that differential neutrophil counts may underestimate the counts found on CP slides. [less ▲]

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