References of "Detilleux, Johann"
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See detailRelationships Between Changes in Bone Mineral Density or Bone Turnover Markers and Vertebral Fracture Incidence in Patients Treated with Bazedoxifene
Bruyère, Olivier ULg; Detilleux, Johann ULg; Chines, Arkadi et al

in Calcified Tissue International (2012), 91(4), 244-9

We analyzed the relationships between bone mineral density (BMD) or bone turnover marker (BTM) changes and vertebral fracture incidence in women treated with bazedoxifene using a post hoc analysis from a ... [more ▼]

We analyzed the relationships between bone mineral density (BMD) or bone turnover marker (BTM) changes and vertebral fracture incidence in women treated with bazedoxifene using a post hoc analysis from a 3-year randomized, placebo-controlled study evaluating the effect of bazedoxifene (20 or 40 mg) on fracture risk reduction. BMD was assessed at baseline and every 6 months for 3 years. Osteocalcin and C-telopeptide of type I collagen were assessed at baseline and at 3, 12, and 36 months. Vertebral fractures were assessed with a semiquantitative visual assessment. Data were available for 5,244 women, of whom 3,476 were treated with bazedoxifene. Using a logistic regression analysis and the classical Li approach, the proportion of fracture incidence explained by BMD change after 3 years of bazedoxifene treatment was 29 % for the total hip and 44 % for the femoral neck. The proportion of treatment explained by lumbar BMD change could not be quantified accurately because of the significant interaction between treatment and change in BMD. With the same model, the 12-month BTM changes explained up to 29 % of the fracture risk reduction observed with the two forms of bazedoxifene. In women treated with bazedoxifene, changes in femoral neck BMD, hip BMD, or BTMs explained a moderate proportion of the fracture risk reduction observed during the 3 years of follow-up. However, BMD or BTM changes cannot be recommended for individual monitoring of women treated with bazedoxifene. [less ▲]

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See detailUtilisation par les praticiens des données et des outils issus du projet LAECEA
Theron, Léonard ULg; Reding, Edouard; Bertozzi, Carlo et al

Conference given outside the academic context (2012)

La santé mammaire et la production laitière sont des enjeux capitaux pour le secteur de l'élevage en région wallonne, et donc pour la fonction du médecin vétérinaire rural. Les enjeux modernes de la ... [more ▼]

La santé mammaire et la production laitière sont des enjeux capitaux pour le secteur de l'élevage en région wallonne, et donc pour la fonction du médecin vétérinaire rural. Les enjeux modernes de la production laitière tels que la course à la productivité, la réduction des coûts de production et la maîtrise de la qualité des denrées alimentaire d'origine animale, amènent le vétérinaire du 21ème siècle à être confronté simultanément à ses rôles curatifs, préventifs et de partenaire économique. En outre, la mammite devient la première cause du recours aux antibiotiques en médecine bovine laitière, et l'avenir nous demande d'avantage de réflexion sur l'utilisation de ces thérapeutiques en élevage. Le lancement du projet LAECEA en 2010 a été une opportunité fédératrice, plusieurs praticiens ont été impliqués dans la récolte de données et dans la mise en ouvre, le testage et l'évaluation de nouveaux outils au travers du dossier de santé mammaire (DSM). Les résultats issus du projet LAECEA sont en outre des témoins du quotidien de la santé mammaire dans les élevages participants. L'étude de ces résultats peut orienter le diagnostic présomptif du clinicien en éditant l'épidémiologie loco-régionale de la mammite en Wallonie. Cette approche pourra permettre de cibler plus précisément le diagnostic mammaire, d'en tirer les conclusions en terme de fréquence, de moment d'apparition, d'étiologie. Ainsi, seront abordés les tendances épidémiologiques moyennes, l'impact économique de la variation des indicateurs générés, ainsi que les leviers préventifs associés à ces tendances. Le corollaire évident est une gestion plus précise des substances antimicrobienne, de part un diagnostic plus pré Le moment est venu, lors de ce forum d'été du RTVOL, de partager l'expérience de ces praticiens et de faire état des données rassemblées et de l'utilisation qui peut en être faite. Par la suite, tous les praticiens pourront utiliser ces outils dans leur pratique quotidienne. [less ▲]

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See detailInvestigation of body condition score and insulin sensitivity (RQUICKY) in downer cow syndrome
Bonvoisin, Marie ULg; Rollin, Frédéric ULg; Lebreton, Pascal et al

in Revista Portuguesa de Buiatria (2012, June), (Special Edition),

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See detailTrends in hip fracture incidence and in the prescription of anti-osteoporosis medications during same time period in Belgium (2000-2007)
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Roberfroid, Dominique et al

in Arthritis Care & Research (2012), 64(5), 744-750

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See detailRéalisation de la césarienne dans l’espèce bovine en Europe : l'intervention et ses conséquences.
Hanzen, Christian ULg; Theron, Léonard ULg; Detilleux, Johann ULg

in Bulletin des Groupements Techniques Vétérinaires (2011), 62

Une enquête en ligne de 72 questions relatives aux modalités pratiques habituelles de réalisation d’une césarienne a été conduite auprès de 708 vétérinaires de France, Wallonie, Pays-Bas et Suisse. Ce ... [more ▼]

Une enquête en ligne de 72 questions relatives aux modalités pratiques habituelles de réalisation d’une césarienne a été conduite auprès de 708 vétérinaires de France, Wallonie, Pays-Bas et Suisse. Ce second article, qui fait suite au premier volet publié dans le Bulletin des GTV d’avril 2011 (n° 59), concerne plus spécifiquement les étapes de la césarienne depuis l’incision de la paroi abdominale jusqu’à sa suture, ainsi que les traitements pharmacologiques mis en place et les conséquences le plus souvent observées. Les résultats de cette enquête ont permis de constater la diversité des pratiques, mais également le fait qu’un certain nombre d’entre elles s’écartent des recommandations académiques ou bibliographiques habituelles. Ils concernent les avis exprimés par les vétérinaires et ne sont donc pas rapportés au nombre de césariennes réalisées. [less ▲]

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See detailLAECEA : un outil fédérateur d’aide à la décision pour le suivi de la santé mammaire dans les élevages bovins laitiers wallons
Reding, Edouard; Theron, Léonard ULg; Detilleux, Johann ULg et al

in 18èmes rencontres autour de la recherche sur les ruminants (2011, December)

La santé mammaire représente un des principaux problèmes pour l’élevage laitier. Dans le cadre de la plateforme fédératrice OSaM (Observatoire de la Santé Mammaire), le projet LAECEA (AWE–ULg) vise à la ... [more ▼]

La santé mammaire représente un des principaux problèmes pour l’élevage laitier. Dans le cadre de la plateforme fédératrice OSaM (Observatoire de la Santé Mammaire), le projet LAECEA (AWE–ULg) vise à la construction d’une base de données de la santé mammaire centralisant les informations collectées par les associations de la filière laitière wallonne ainsi que les données cliniques encodées par les éleveurs. De plus, ce projet souhaite mettre à disposition un Dossier de Santé Mammaire (DSM) mensuel permettant à l’éleveur d’évaluer l’impact économique des mammites et de cibler, avec son vétérinaire, la stratégie à mettre en place afin de le diminuer grâce à différents indicateurs ciblés. Dans le but de bénéficier des données du tank (Comité du Lait), des résultats d’analyse bactériologiques (ARSIA, Association Régionale de Santé et d’Identification Animale), et des données zootechniques (AWE), une base de données fédératrice a été mise en place. Afin d’enrichir celle-ci en données cliniques, un nouvel outil de saisie des pathologies en ligne a été créé et mis à la disposition des éleveurs dans leur espace Internet personnalisé my@wenet (www.awenet.be). Ils peuvent y saisir les informations relatives aux évènements de la santé mammaire (date, type d’évènement, quartier, sévérité…) et au(x) traitement(s) qui y est/sont associé(s). Sur les six premiers mois, près de 750 mammites ont été collectées. Les données récupérées dans les historiques en fermes portent ce chiffre à 2300. Les valorisations tirées de ces données sont rassemblées dans le DSM. Celui-ci est composé d’une page récapitulative dont certains aspects sont détaillés à travers différentes rubriques : évaluation économique (déjà disponible), microbisme et traitements, et management (en cours d’élaboration). Ce DSM permet notamment de quantifier la perte économique due à la santé mammaire, de quantifier le nombre de vaches à problèmes tant cliniques que subcliniques, de décrire la dynamique des infections mammaires au niveau du troupeau, d’identifier les groupes d’animaux les plus sensibles, d’identifier les principaux pathogènes impliqués, d’évaluer la qualité de la détection des mammites, de cibler les périodes de l’année et de la lactation les plus à risques. Une analyse statistique préliminaire sur les indicateurs générés dans les 201 premiers DSM confirment l’intérêt de la réussite du traitement au tarissement sur la santé mammaire de l’exploitation. De plus, cette investigation appuie la pertinence de l’approche économique partielle comme indicateur de santé mammaire global. [less ▲]

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See detailCaesarean section (CS) in cattle. Results of an international survey on procedures.
Hanzen, Christian ULg; Theron, Léonard ULg; Detilleux, Johann ULg

in Reproduction in Domestic Animals (2011, September 17), 46(3), 1-161

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See detailAccuracy of inflammation field tests in cattle practice
Guyot, Hugues ULg; Lamain, Guillaume ULg; Detilleux, Johann ULg et al

in Société Belge Francophone de Buiatrie & Vlaamse vereniging voor Buiatrie (Ed.) Proceedings of the 6th European Congress of Bovine Health Management (2011, September)

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See detailEpidemiology of mastitis in 30 walloon dairy farms using a compilation of clinical and subclinical data in a new tool for Udder health assessment
Theron, Léonard ULg; Reding, Edouard; Detilleux, Johann ULg et al

in Proceedings of the 6th European congress of Bovine health management (2011, September)

Bovine mastitis has been assessed through somatic cells or clinical cases by farmers and vets but most of the time the perfect combination of both data remains unavailable. We tried to implement a new ... [more ▼]

Bovine mastitis has been assessed through somatic cells or clinical cases by farmers and vets but most of the time the perfect combination of both data remains unavailable. We tried to implement a new strategy of identification of mastitis-related costs, epidemiological impact and key periods of management. We built an online system for clinical data capture, including facilities for administrative management of veterinary drugs. Herd prevalence rate (HPR) is assessed through clinical and subclinical data. Lactation incidence rate (NIR) and cure rate (CR) were calculated for the period (depending on type of DHI control) using subclinical thresholds (primiparous > 150.000 cells/ml and multiparous >250.000 cells/ml) and clinical cases in susceptible animals (healthy or diseased). Dry-off period is studied through the Dry-off cure rate (DOCR) and new infection rate at first control (NIFC). The average number of cow-day-at-risk was 73.6 (StD=34.80). Mean HPR was 33 % (StD =11%); the average NIR was 16% and CR 35%. Mean DOCR was 62% with an NIFC of 23%. Regarding a mean loss for mastitis of 71€ per cow-year, the average difference was +40.7€ (StD=66.7€). It is explained partly by DOCR (R²=0.20; β=-131; p<0.0001). NIR is mainly influenced by HPR, but mainly by primiparous infection rate (R²=0.36; β= 0.33; p<0.0001). Those figures are coherent with subclinical data indicating that multiparous cows are becoming more and more infected, limiting efficacy of dry-off therapy. Communication has to be done around dry-off and preventive measures in primiparous cows. As CR had few significant impact on global udder health, cure at the herd level should more be regarded as cow ability to cure in its environment than by considerations on medication once infected. [less ▲]

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See detailTime trends of blood leucocytes, neutrophils and plasmatic myeloperoxidase in the perioperative period of horses undergoing colic surgery.
Salciccia, Alexandra ULg; Grulke, Sigrid ULg; Detilleux, Johann ULg et al

Poster (2011, July)

Background: Despite the recent advances in this area, colic remains a major cause of morbidity and death in horses. Neutrophilic activation and degranulation may play a key role in the postoperative ... [more ▼]

Background: Despite the recent advances in this area, colic remains a major cause of morbidity and death in horses. Neutrophilic activation and degranulation may play a key role in the postoperative complications. Activated neutrophils release enzymes like proteases and myeloperoxidase (MPO). MPO concentrations in plasma and tissue are considered as a marker of neutrophil activation. (McConnico et al. 1999; Hoy et al. 2002). When freed in the tissue, active MPO is able to oxidize, nitrate and chlorate most organic molecules (Klebanoff 2005). Objectives: The aim of this study was 1) to determine the time trends of blood leukocyte and neutrophil counts as well as of plasmatic MPO concentrations in the perioperative period of horses undergoing colic surgery and 2) to relate these time trends to the location of the pathology, the severity of postoperative complications and to the outcome of the patients. Methods: Fifty two horses undergoing colic surgery at the Equine Teaching Hospital of the University of Liege were included in this study. The location of the predominant lesion of the intestine, the severity of the postoperative complications and the outcome were recorded for each horse. Total leukocyte and neutrophil counts were performed in all of the horses while plasmatic myeloperoxidase levels were determined in 16 of them. The blood samplings were realized before and during the surgery (after correction of the intestinal lesion), during the recovery and every 4 hours during the first 4 days (from day 0 until day 4) and then every 12 hours until day 6 (150th hour after the first blood sampling) or until euthanasia. Hematologic analyses were performed at the time of sampling by use of the Medonic CA 530 (Menarini, Zaventem, Belgium). The blood was then centrifuged and the plasma was aliquoted and frozen at -20° C until assayed. MPO was assayed with a specific enzyme-linked immunosorbent assay (Equine MPO-ELISA kit, BiopTis, Liège, Belgium). A mixed model was used to analyze the time trends of leukocytes, neutrophils and MPO. All computations were done with the SAS (Statistical Analysis System) procedure Proc Mixed, with Satterthwaite degrees of freedom. The significance level was set at p=0.05. Results: The main pathology was found in the large intestine in 30 horses (58%) and the small intestine in 22 horses (42%). Forty horses (77%) survived to discharge from the clinic. Twelve horses were euthanized during the postoperative period. Their survival time varied from 0.5 day to 20 days with a mean of 7.8 days. Twenty-two horses (42%) showed none or mild complications, 12 horses (23%) showed moderate complications and 18 horses (35%) suffered from severe complications. Time trends for leukocytes and neutrophils were similar to each other (p= 0.7205) and significantly different (p< 0.0001) from the MPO time trend, which increased during the first hours, while the neutrophil time trend decreased immediately after the admission. The time trend of neutrophils was higher in large intestinal than in small intestinal pathologies and the time trend of MPO was lower in large intestinal than in small intestinal pathologies. The time trends of neutrophils were significantly different between the degrees of complications (no/mild vs moderate vs severe). For the first part of the curve, the more severe the complication, the lower is the time trend. The time trend of MPO was lower in survivors. The time trend of neutrophils in survivors was higher during the first 4 days thereafter it becomes lower than in non survivors. Conclusions: These results confirm that neutrophil counts and MPO levels undergo timely changes and that they are related to the severity of the inflammatory reaction in surgical colic cases. Knowing the kinetics of these parameters is an essential step to further determine cut-off values (with a larger group of horses) for the prognosis of horses after colic surgery. References Hoy, A., Leininger-Muller, B., Kutter, D., Siest, G. and Visvikis, S. (2002) Growing significance of myeloperoxidase in non-infectious diseases. Clin. Chem. Lab. Med. 40, 2-8. Klebanoff, S.J. (2005) Myeloperoxidase: friend and foe. J. Leukoc. Biol. 77, 598-625. McConnico, R.S., Weinstock, D., Poston, M.E. and Roberts, M.C. (1999) Myeloperoxidase activity of the large intestine in an equine model of acute colitis. Am. J. Vet. Res. 60, 807-813. [less ▲]

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See detailModalités de réalisation de la césarienne dans l’espèce bovine en Europe. Première partie.
Hanzen, Christian ULg; Theron, Léonard ULg; Detilleux, Johann ULg

in Bulletin des Groupements Techniques Vétérinaires (2011), 59

La césarienne constitue l’une des plus importantes interventions chirurgicales pratiquées sur les bovins. Une enquête de 72 questions relatives aux modalités de réalisation de la césarienne a été proposée ... [more ▼]

La césarienne constitue l’une des plus importantes interventions chirurgicales pratiquées sur les bovins. Une enquête de 72 questions relatives aux modalités de réalisation de la césarienne a été proposée en ligne pendant six mois aux praticiens ruraux de Wallonie, France, Pays-Bas et Suisse. Un taux de réponse de 19 % (774 réponses) a été obtenu. Cet article synthétise les conditions de réalisation de la césarienne, ses indications, les prémédications et les conditions d’asepsie adoptées par les praticiens. L’impact de la race, du nombre de césariennes et de la région d’exercice a également été considéré. Un second article présentera les résultats relatifs à l’intervention proprement dite et à ses conséquences. [less ▲]

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See detailIncidence of hip fracture in Belgium between 2000 and 2007 and future projections
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Detilleux, Johann ULg et al

in Osteoporosis International (2011, March), 22(Suppl.1), 145

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See detailRelationship between changes in bone mineral density or bone turnover markers and vertebral fracture incidence in patients treated with Bazedoxifene
Bruyère, Olivier ULg; Detilleux, Johann ULg; Chines, Arkadi et al

in Osteoporosis International (2011, March), 22(Suppl.1), 324

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See detailEffectiveness analysis of resistance and tolerance to infection
Detilleux, Johann ULg

in Genetics, Selection, Evolution (2011)

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See detailComparison of Four Refractometers for the Investigation of the passive transfer in Beef Calves
Vandeputte, Sébastien ULg; Detilleux, Johann ULg; Rollin, Frédéric ULg

in Journal of Veterinary Internal Medicine (2011), 25

Background: Failure of passive transfer (FPT) in beef calves can be detected by refractometry. Nevertheless, different models of refractometers are available, and few studies compare them for the ... [more ▼]

Background: Failure of passive transfer (FPT) in beef calves can be detected by refractometry. Nevertheless, different models of refractometers are available, and few studies compare them for the detection of FPT. Objectives: To compare the accuracy of 4 different refractometers for measuring serum total protein concentrations in comparison with results obtained by the biuret method and, based on the serum IgG threshold of 1,600 mg/mL, to determine, for each refractometer, the optimal serum protein concentration’s lowest threshold for successful passive transfer. Animals: One hundred and eight healthy beef calves, 3–8 days of age. Methods: Observational study. The concentrations of serum total proteins were determined with 4 different models of refractometers and compared with the biuret method by a Bland–Altman statistical method. The optimal serum protein concentration’s lowest threshold for successful passive transfer was determined for each refractometer by receiver operating characteristic (ROC) analysis. In addition, the serum immunoglobulin G (IgG) concentration was compared with the serum gamma-glutamyl transferase (c-GT) activity and with the total immunoglobulin concentration. Results: The refractometric measurements were highly correlated with those obtained by the biuret method. Serum total protein concentration threshold values of 56, 58, 54, and 56 g/L were found respectively for the Atago, Atago ATC, Wolf ATC, and digital ATC refractometers. Immunoglobulins were highly correlated with IgG, whereas Gamma-GT only reflected colostrum uptake by the calf. Conclusions and Clinical Importance: All refractometers could be used for the assessment of passive transfer using their individual serum protein concentration threshold. [less ▲]

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See detailClinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves
Brihoum, Mounir ULg; Rollin, Frédéric ULg; Desmecht, Daniel ULg et al

in Biomedcentral Veterinary Research (2011), 7

Background Cardiac morphologic and functional changes consistent with cardiomyopathy have been reported in field cases of calves with accidental doxycycline overdosing. The purpose of this study was to ... [more ▼]

Background Cardiac morphologic and functional changes consistent with cardiomyopathy have been reported in field cases of calves with accidental doxycycline overdosing. The purpose of this study was to evaluate clinically the cardiac effects of an experimentally-induced doxycycline overdosing in healthy calves. Twelve 2 months-old healthy Belgian Blue calves were studied. Six of them (group 1) received the normal dose (5 mg/kg, BID) and the six others (group 2) received five times the normal dose (25 mg/kg, BID) of oral doxycycline for five consecutive days (D1 to D5). Each calf was clinically examined daily. Measurement of serum AST, CK, Iso-CKs and LDH activities and an echocardiographic examination were performed before (D0) and one day after (D6) the last doxycycline administration. An ECG tracing was recorded at D0, D4, and D6. Results In both groups, no clinical, blood, echocardiographic or electrocardiographic changes suggestive of a cardiomyopathy were observed. Only a decreased appetite was observed in the calves of the group 2 between D3 and D6. Conclusions This trial failed to reproduce cardiac changes reported in accidental doxycycline-poisoning in calves, suggesting that high doses of doxycycline may not be the only etiologic factor of the cardiomyopathy reported in the field cases. [less ▲]

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