References of "Detilleux, Johann"
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See detailGenetic management of infectious diseases: An heterogeneous epidemio-genetic model illustrated with S. aureus mastitis
Detilleux, Johann ULg

in Genetics, Selection, Evolution [=GSE] (2005), 37(4), 437-453

Given that individuals are genetically heterogeneous in their degree of resistance to infection, a model is proposed to formulate appropriate choices that will limit the spread of an infectious disease ... [more ▼]

Given that individuals are genetically heterogeneous in their degree of resistance to infection, a model is proposed to formulate appropriate choices that will limit the spread of an infectious disease. The model is illustrated with data on S. aureus mastitis and is based on parameters characterizing the spread of the disease (contact rate, probability of infection after contact, and rate of recovery after infection), the demography (replacement and culling rates) and the genetic composition (degree of relationship and heritability of the disease trait) of the animal population. To decrease infection pressure, it is possible to apply non-genetic procedures that increase the culling (e.g., culling of chronically infected cows) and recovery (e.g., antibiotic therapy) rates of infected cows. But the contribution of the paper is to show that genetic management of infectious disease is also theoretically possible as a control measure complementary to non-genetic actions. Indeed, the probability for an uninfected individual to become infected after contact with an infected one is partially related to their degree of kinship: the more closely they are related, the more likely they are to share identical genes like those associated to the non-resistance to infection. Different prospective genetic management procedures are proposed to decrease the contact rate between infected and uninfected relatives and keep the number of secondary cases generated by one infected animal below 1. [less ▲]

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See detailEffects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs.
Jeusette, Isabelle C; Detilleux, Johann ULg; Shibata, Haruki et al

in Research in Veterinary Science (2005), 79(2), 169-75

The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs ... [more ▼]

The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs of both genders and aged between 1 and 9 years, were used for the experiments. Mean body weight was 12.7+/-0.7 kg for the lean group and 21.9+/-0.8 kg for the obese group. The trial was divided into three phases. During phase 1, all 24 Beagle dogs were fed a maintenance diet. During phase 2, the obese dogs were submitted to a weight loss protocol with a high protein-low energy diet. The weight loss protocol ended once dogs reached optimal body weight. During phase 3, the dogs that were submitted to the weight loss protocol were maintained at their optimal body weight for 6 months. Plasma total ghrelin, leptin, insulin and glucose concentrations were measured to evaluate the effects of obesity and weight loss on these parameters in dogs. Body weight, body condition score, thoracic and pelvic perimeters, and ingested food amounts were also recorded during the study. Obese dogs demonstrated a significant decrease in plasma ghrelin and a significant increase in plasma leptin and insulin concentrations when compared with control dogs. During weight loss, significant increases in plasma total ghrelin and glucose and significant decreases in plasma leptin and insulin were observed. The increase in plasma ghrelin concentrations seemed to be transient. Body weight and the morphometric parameters correlated positively with leptin concentrations and negatively with total ghrelin concentrations. These results suggest that ghrelin and leptin could play a role in dogs in the adaptation to a positive or negative energy balance, as observed in humans. [less ▲]

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See detailAn epidemiological study of canine obesity
Lhoest, E.; Detilleux, Johann ULg; Vandenheede, Marc ULg et al

Conference (2005)

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See detailHow vets and veterinary students feed their own dogs
Lhoest, E.; Detilleux, Johann ULg; Vandenheede, M. et al

in Proceedings of the 9th Congress ESVCN (2005)

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See detailAnalysis of canine and feline uroliths in the Benelux. A retrospective study 1994-2005
de Lovinfosse, T.; Detilleux, Johann ULg; Picavet, P. et al

in Proceedings of the 9th Congress ESVCN (2005)

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See detailThyroid hormones in obese dogs submitted to a weight loss protocol
Jeusette, Isabelle; Daminet, Sylvie; Detilleux, Johann ULg et al

in Obesity Reviews : An Official Journal of the International Association for the Study of Obesity (2005), 6

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See detailProduction des ovins Djallonké en station dans la zone guinéenne au Bénin : 1. Performances de reproduction et influence des facteurs non génétiques
Gbangboche, A. B.; Hounzangbe-Adote, S. M.; Doko, S. Y. et al

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2004), 2

Production of Djallonke sheep at an experimental station in the guinean zone of Benin. Reproduction performance and influence of non-genetic factors From 1994 to 2002, data from Djallonke sheep were ... [more ▼]

Production of Djallonke sheep at an experimental station in the guinean zone of Benin. Reproduction performance and influence of non-genetic factors From 1994 to 2002, data from Djallonke sheep were collected for reproduction performance. The data were obtained from the farm of the Faculty of Agronomic Sciences (University of Abomey Calavi). Data analysed by GLM procedure and Student’s t-test, were used to identify and quantify non-genetics factors affecting the age at first lambing, intervals between lambing and prolificacy. Results indicated: age at first lambing, 609.64days±110.26 days; intervals between lambing, 243.01days±68.19days; prolificity, 1.28±0.45; annual reproduction rate, 1.92%; temporary sterility rate, 5.79%. Lambing season, lambing year and the year*season interaction affected significantly (p<0.01) the age at first lambing and the interval between lambing. The same factors were not significant (p>0.05) for prolificacy. [less ▲]

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See detailExtensive mast cell degranulation in bovine respiratory syncytial virus-associated paroxystic respiratory distress syndrome
Jolly, Sandra ULg; Detilleux, Johann ULg; Desmecht, Daniel ULg

in Veterinary Immunology and Immunopathology (2004), 97(3-4), 125-136

Bovine respiratory syncytial virus (BRSV) infection is an important cause of outbreaks of respiratory disease among calves. This virus commonly induces mild to severe respiratory signs but, in a ... [more ▼]

Bovine respiratory syncytial virus (BRSV) infection is an important cause of outbreaks of respiratory disease among calves. This virus commonly induces mild to severe respiratory signs but, in a substantial proportion of cases, is also reported to be associated with paroxystic respiratory distress syndrome (PRDS). The pathogenesis of this 'malignant' clinical form has not been fully elucidated. The present study aimed at determining whether mast cell (MC) degranulation plays a role in the physiopathologic cascade leading to the PRDS. Paired serum samples were taken in herds during outbreaks of severe respiratory diseases (acute sera) and 3 weeks after (convalescent sera). Based on seroconversion to BRSV and clinical picture, 67 pairs of sera were selected from calves with a BRSV-associated PRDS for circulating MC tryptase determination. A MC metachromatic score was measured in post-mortem lungs from animals died from a BRSV-associated PRDS (principals) and compared with reference scores obtained from healthy lungs (controls). Levels of tryptase were significantly higher in acute sera (26.6+/-12.4 mug/l) compared to convalescent sera (8.4+/-7.8 mug/l; P < 0.001). Metachromatic scores yielded significantly different results between controls and principals (P < 0.01), demonstrating a significant disappearance of metachromatic granules from lung MCs in principals. Taken together, these data demonstrate the presence of an extensive MC degranulation in BRSV-associated PRDS. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailSomatic Cell (Neutrophil) Counts in the War Against Staphylococcus aureus: Predator-Prey Models at the Rescue
Detilleux, Johann ULg

in Journal of Dairy Science (2004), 87(11), 3716-3724

To address the question of whether a minimum concentration of blood neutrophils is necessary to decrease Staphylococcus aureus concentration in mastitic milk, literature was searched for studies in which ... [more ▼]

To address the question of whether a minimum concentration of blood neutrophils is necessary to decrease Staphylococcus aureus concentration in mastitic milk, literature was searched for studies in which neutrophils were incubated with Staph. aureus. Different mathematical models that describe the changes in Staph. aureus population as a function of neutrophilic concentrations were applied to the collected data. The best fitted model established (1) that the rate of bacterial killing depended on the ratio of neutrophils to bacteria with neutrophilic attack rate accelerating at first before decelerating as the ratio increases, and (2) that neutro-phil concentration should be within a limited range to trigger a decline in the bacterial population. Outcomes of this model are supported by what is known about neutrophilic functions and laboratory findings in bovine and human neutrophils. These results may be of assistance in setting selection goals for a better resilience to Staph. aureus mastitis in dairy cattle. Indeed, an optimal neutrophilic concentration appears to exist for successful clearance of Staph. aureus infection, which is neither the lowest nor the highest one. [less ▲]

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See detailAd libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites.
Jeusette, Isabelle; Detilleux, Johann ULg; Cuvelier, Christine ULg et al

in Journal of Animal Physiology & Animal Nutrition (2004), 88(3-4), 117-21

The aim of this study was (i) to evaluate the effect of ovariectomy on daily energy requirement in Beagle dogs, and (ii) to evaluate the effects of ad libitum feeding with a high energy diet on energy ... [more ▼]

The aim of this study was (i) to evaluate the effect of ovariectomy on daily energy requirement in Beagle dogs, and (ii) to evaluate the effects of ad libitum feeding with a high energy diet on energy consumption, body weight gain and blood metabolites in these spayed dogs. Four young adult female Beagle dogs were used. Ovariectomy induced a significant decrease of daily energy requirement in dogs. Ad libitum feeding, initiated 6 months after spaying, induced a significant increase in consumption in spayed dogs. This overconsumption was greatest during the first month of ad libitum feeding but continued for the entire 4 months of this period. When fed ad libitum, dogs gained excess body weight without significant effect on plasma cholesterol, triglycerides, glucose and insulin, at short term. These data suggest that energy intake should be strictly controlled to avoid excess weight gain in spayed dogs. [less ▲]

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See detailMixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference
Gianola, D.; Odegard, J.; Heringstad, B. et al

in Genetics, Selection, Evolution [=GSE] (2004), 36(1, JAN-FEB), 3-27

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop ... [more ▼]

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an important udder disease. Parameter estimation is by maximum likelihood or by an extension of restricted maximum likelihood. A Monte Carlo expectation- maximization algorithm is used for this purpose. The expectation step is carried out using Gibbs sampling, whereas the maximization step is deterministic. Ranking rules based on the conditional probability of membership in a putative group of uninfected animals, given the somatic cell information, are discussed. Several extensions of the model are suggested. [less ▲]

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See detailStress echocardiography in horses: comparison of cardiac output during incremental dobutamine infusion in atropinised and non-atropinised ponies
Sandersen, Charlotte ULg; Detilleux, Johann ULg; Delguste, Catherine ULg et al

in Proceedings of the 42d Annual Congress of the British Equine Veterinairy Association (2003, September)

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See detailClinicopathological data in equids suffering from ante-hepatic, hepatic and post-hepatic diseases
Amory, Hélène ULg; Perron, MF; Sandersen, Charlotte ULg et al

in Proceedings of the 42th Annual Congress of the British Equine Veterinary Association (BEVA) (2003)

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See detailPrognostic value of clinical signs and blood parameters in equids suffering from acute hepatic insufficiency: a retrospective study on 31 cases
Amory, Hélène ULg; Perron, MF; Sandersen, Charlotte ULg et al

in Proceedings of the 21st ACVIM annual meeting, Charlotte, North Carolina (2003)

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULg; Reichler, I.; Peeters, Dominique ULg et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailUse of atropine to inhibit vagally mediated baroreceptor reflex in horses undergoing dobutamine stress test
Sandersen, Charlotte ULg; Detilleux, Johann ULg; Delguste, Catherine ULg et al

in Pflügers Archiv : European Journal of Physiology (2003), 446(5), 4

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See detailDefense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes
Paape, Max; Mehrzad, Jalil; Zhao, Xin et al

in Journal of Mammary Gland Biology and Neoplasia (2002), 7(2), 109-121

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal ... [more ▼]

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal healthy mammary gland, macrophages predominate and act as sentinels to invading mastitis-causing pathogens. Once invaders are detected, macrophages, and possibly mammary epithelial cells, release chemoattractants that direct migration of PMN into the area. In the mammary gland, protection is only effective if rapid influx of PMN from the circulation and subsequent phagocytosis and killing of bacteria occur. The second line of defense against infection consists of a network of memory cells and immunoglobulins that interact with the first line of defense. To minimize mammary tissue damage caused by bacterial toxins and oxidative products released by PMN, elimination of invading bacteria must proceed quickly. Therefore, the inflammatory response needs to be regulated. Hormones, metabolites, and acute phase proteins act to influence the outcome of mastitis, especially around parturition. The number of circulating PMN in cows during early lactation is highly heritable and closely related to susceptibility to clinical mastitis at this time. Advances in molecular biology are making available the tools, techniques, and products to study and modulate host-pathogen interactions. For example, the cloning and expression of proteins such as recombinant bovine soluble (rbos) CD (cluster of differentiation) 14 antigens, may provide ways of minimizing damaging effects of endotoxin during acute coliform mastitis. Soluble CD14 binds and neutralizes lipopolysacharide (LPS) and causes local recruitment of PMN after binding of CD14-LPS complexes to mammary epithelial cells. Development of transgenic animals that express rbosCD14 in their milk could prevent infection by Gram-negative pathogens. [less ▲]

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