References of "Desmecht, Daniel"
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See detailAssessment of equine diaphragm strength and activation using transvenous phrenic nerve stimulation
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 18

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailExperimental production of hypocalcemia by EDTA infusion in calves : a critical appraisal assessed from the profile of blood chemicals and enzymes
Desmecht, Daniel ULg; Linden, Annick ULg; Godeau, J. M. et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (1995), 110A(2), 115-130

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See detailComparison of Cardiac Function in Double-Muscled Calves and in Calves with Conventional Muscular Conformation
Amory, Hélène ULg; Desmecht, Daniel ULg; Linden, Annick ULg et al

in American Journal of Veterinary Research (1994), 55(4), 561-6

During growth, central venous, right ventricular, pulmonary arterial, pulmonary capillary wedge, and systemic arterial pressures, heart rate, and cardiac output were repeatedly measured in 41 Friesian ... [more ▼]

During growth, central venous, right ventricular, pulmonary arterial, pulmonary capillary wedge, and systemic arterial pressures, heart rate, and cardiac output were repeatedly measured in 41 Friesian calves, considered as having conventional muscular conformation, and in 19 Belgian White and Blue double-muscled calves. A total of 123 and 70 recordings were collected in conventional and double-muscled calves, respectively. These circulatory indices were calculated: stroke volume, cardiac and stroke indices, pulmonary and systemic pulse pressures, pulmonary and systemic vascular resistance indices, and right and left ventricular work indices. Results indicated that systemic arterial and pulse pressures, as well as cardiac output, stroke volume, cardiac and stroke indices, and right and left ventricular work indices were significantly (P < or = 0.05 to 0.001) lower but, in contrast, pulmonary and systemic vascular resistance indices were significantly (P < or = 0.001) higher in double-muscled than in conventional calves. Right-sided vascular pressures and heart rate were similar in the 2 groups. These results indicated that global cardiac performance may be considerably poorer in double-muscled calves. Diminished cardiac performance of double-muscled calves appears to be related neither to relative bradycardia nor to reduced ventricular preload. The potential role of increased ventricular afterload or of reduced myocardial contractility in double-muscled cattle should be determined by direct measurements. [less ▲]

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See detailEffect of type 2 antiserotonergic agent on altered cardiovascular function of hyperdynamic sepsis in newborn calves
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Proceedings of the 13th Comparative Respiratory Society Meeting (1994)

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See detailControl of breathing in unanesthetized healthy and Pasteurella-exposed calves after 5-HT2 receptor antagonism by metrenperone
Rollin, Frédéric ULg; Close, A; Linden, Annick ULg et al

in Proceedings of the XVIIIth World Buiatrics Congress (1994)

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See detailReduced cardiac functional capacity as a consequence of the double-muscled conformation selection in the Belgian White and Blue breed
Amory, Hélène ULg; Desmecht, Daniel ULg; Linden, Annick ULg et al

in Proceedings of the XVIIIth World Buiatrics Congress, Bologna, Italy (1994)

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See detailBilateral diaphragmatic paralysis in a pony
Amory, Hélène ULg; Lomba, F; Lekeux, Pierre ULg et al

in Proceedings of the 4th Congress of the European Society of Veterinary Internal Medicine, Brussels, Belgium (1994)

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See detail5-HT challenge in healthy vigile calves after MDL72222 pretreatment
Linden, Annick ULg; Desmecht, Daniel ULg; Rollin, Frédéric ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailEffects of blood sampling conditions on ionised calcium in calves
Godisioabois, Y.; Desmecht, Daniel ULg; Lekeux, Pierre ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailControl of breathing in healthy and Pasteurella exposed calves after 5-HT2 receptor blockade
Rollin, Frédéric ULg; Close, Patricia ULg; Linden, Annick ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailAirway occlusion pressure and diaphragm global electromyograph analysis for evaluation of inspiratory muscle drive and neuromechanical coupling in cattle
Desmecht, Daniel ULg; Linden, Annick ULg; Rollin, Frédéric ULg et al

in American Journal of Veterinary Research (1994), 55

Although healthy and diseased bovine respiratory tracts have been intensively studied during the last years, to the authors' knowledge, there have been no attempts to objectively examine the inspiratory ... [more ▼]

Although healthy and diseased bovine respiratory tracts have been intensively studied during the last years, to the authors' knowledge, there have been no attempts to objectively examine the inspiratory drive from the brain to the nerves and muscles and its transformation in pressure. Such technique would be useful in assessing the possibility of altered ventilatory drive or inspiratory muscle fatigue in the context of an animal with ventilatory failure. The relation among ventilation, airway opening occlusion pressure generated 100 milliseconds after onset of inspiration (Pawo100ms) and 6 indexes describing diaphragmatic electromyographic activity (EMGdi) recorded via implanted fishhooks was evaluated during free and impeded CO2 rebreathing in 6 young bulls. The best significant linear correlations (r > 0.8) with inspiratory center afferent stimulation, as judged by end-tidal CO2 concentration in expired air, were found for Pawo100ms, peak moving time average or variance EMGdi, and mean integrated EMGdi, whatever had been the respiratory impedance. However, with an inspiratory load, Pawo100ms responses systematically had greater increase for a given change in the driving EMGdi, implying dependence of the former not only on neural input, but also on configurational factors that determine inspiratory muscle excitation-pressure generation couplings. The reproducibility of EMGdi absolute values and changes was satisfactory up to 10 hours, but could not be repeated from one day to the other. It was concluded that, provided the constancy of the electrical coupling of the recording system to the tissue being studied is ensured, specific EMGdi and Pawo100ms values correlate reliably with amount of CO2 during free and loaded breathing.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailHereditary muscular hypertrophy in cattle is associated with a reduced myocardial contractility
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailThe functional proof of the diaphragm's specific type of motor innervation in Ongulae
Desmecht, Daniel ULg; Linden, Annick ULg; Leroy, Pascal ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailSpectrum analysis of diaphragmatic global electromyograms in cattle, with special regard to appropriate strategy for detection of fatigue.
Desmecht, Daniel ULg; Linden, Annick ULg; Close, R. P. et al

in American Journal of Veterinary Research (1994), 55

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been ... [more ▼]

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been reported. Such technique would be useful in assessing the possibility of inspiratory muscle fatigue in the context of ventilatory failure. Fatigue in skeletal muscle is associated with characteristic changes in the electromyographic power spectrum. Power spectral analysis was therefore applied to cattle diaphragmatic electromyograms (EMGdi) to precisely determine the exact influence of motion and ECG artifacts, describe its basic frequency content, and extract a spectral index capable of providing an accurate warning of fatigue. The EMGdi was recorded via intramuscularly placed fishhook electrodes in 5 healthy young bulls during resting and stimulated respiration. The EMGdi and EGC signals were analyzed by use of power spectral density analysis after band-pass filtering (20 to 1,800 Hz). The EMGdi spectrum was concentrated in the band width 20 to 530 Hz. Electrode motion artifacts were absent, and it was always possible to find an electrode pair giving ECG-free EMGdi. Of the 12 power and frequency values used to quantitate the spectrum, the most stable was the centroid frequency. It was reproducible within and between calves and was only minimally altered by changing inspiratory load.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailBilateral diaphragmatic paralysis in a pony
Amory, Hélène ULg; Lomba, Fernand; Lekeux, Pierre ULg et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1994), 205(4), 587-591

An adult pony had a 1-month history of severe respiratory distress that was resistant to treatment and environmental changes. Results of blood gas analysis were indicative of alveolar hypoventilation ... [more ▼]

An adult pony had a 1-month history of severe respiratory distress that was resistant to treatment and environmental changes. Results of blood gas analysis were indicative of alveolar hypoventilation. Simultaneous recordings of thoracic and abdominal wall motion by inductance plethysmography, together with complete pulmonary mechanics evaluation that included transdiaphragmatic pressure monitoring, revealed complete passive behavior of the diaphragm during breathing. Because radiography, necropsy, and histologic examination did not reveal any major lesion to explain the clinical and functional observations, bilateral diaphragmatic paralysis was diagnosed [less ▲]

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See detailOxygen Transport Chain in Double-Muscled Blue Belgian Cattle
Lekeux, Pierre ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in British Veterinary Journal (The) (1994), 150(5, Sep-Oct), 463-471

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that ... [more ▼]

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that the increased susceptibility of these cattle to stress, resulting mainly in respiratory diseases, is due to an insufficient functional reserve capacity mainly involving the pulmonary and cardiovascular systems. The resulting lack of 'functional hardiness' of the oxygen transport chain is seen in those double-muscled cattle which do not react in an appropriate or predictable way when submitted to a hostile environment. [less ▲]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1994), 37

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair ... [more ▼]

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair haemodynamics in calves. Central venous, pulmonary arterial and capillary wedge and systemic arterial pressures were measured by fluid-filled catheters in 11 calves. Cardiac output was measured by the thermodilution technique, heart rate (HR) was derived from the ECG and stroke volume (SV), pulmonary and systemic vascular resistance were calculated. The haemodynamic values were measured hourly from the first to the tenth hour alter intratracheal inoculation of P. haemolytica. Cardiovascular response was marked and typically consisted of two hypotensive hypodynamic phases. The first, which occurred by the second hour after inoculation, consisted of a transient bradycardia and a systemic vasodilation leading to profound hypotension and reduced venous return. Cardiac performance then recovered, but systemic hypotension persisted and hypoxaemia developed. The second phase occurred by the seventh hour alter inoculation and was associated with a decline in SV, an increase in HR, and pulmonary hypertension. Three different degrees of cardiovascular dysfunctions were found, differing basically in the intensity of the first phase bradycardia and second phase reduction in SV and systemic arterial pressure, suggesting that experimental pneumonia produced by intratracheal instillation of P. haemolytica in calves results in distinct cardiovascular dysfunctions depending on the animal. Ignorance of the underlying haemodynamic status therefore precludes reliable interpretation of physiological as well as pharmacological results using this model of respiratory disease [less ▲]

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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