References of "Desmecht, Daniel"
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See detailLa pleuropneumonie contagieuse bovine
Linden, Annick ULg; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

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See detailCardiovascular Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade, by Metrenperone, in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Veterinary Journal (1999), 157(1), 31-37

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and ... [more ▼]

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and pulmonary hypertension were the major changes elicited by 5-HT. The purpose of the present study was to determine whether the cardiovascular response to 5-HT in calves was attributable to 5-HT2 receptors. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated Friesian calves 30 min before the animals were given a 5-min intravenous 5-HT infusion. Mean systemic arterial (SAP), mean pulmonary arterial (PAP), pulmonary capillary wedge (PW) pressures were obtained by means of fluid-filled catheters, and cardiac output (CO) was measured by the thermodilution technique. Heart rate, stroke volume, systemic (SVR) and pulmonary (PVR) vascular resistances were calculated. Administration of 5-HT after metrenperone induced a short-lasting period of severe bradycardia followed by tachycardia and increased CO. The systemic blood pressure response was exclusively hypotensive and associated with a decrease in SVR. Conversely, PAP, PW, and PVR were not modified by 5-HT administration. The results establish that 5-HT induced systemic as well as pulmonary hypertension is mediated through the activation of type-2 serotonergic or alpha-adrenergic receptors, or both. In contrast, neither apnoea, bradycardia and hypotension, nor the positive chronotropic effect induced by 5-HT in cattle are mediated through such receptors. [less ▲]

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See detailNonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Gilbert, S. et al

in Journal of the American Animal Hospital Association (1999), 35(3, May-Jun), 220222224-8

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular ... [more ▼]

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies. [less ▲]

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See detailDetection of Tryptase in Bovine Mast Cells: Comparison of Enzyme- and Immuno-Histochemistry
Jolly, Sandra ULg; Coignoul, Freddy ULg; Gabriel, Annick ULg et al

in Journal of Comparative Pathology (1999), 120(3), 269-79

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either ... [more ▼]

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either trypsin-like or chymotrypsin-like) are granule constituents which provide an important means of distinguishing subtypes of MCs in man and rodents. The purpose of this study was to compare the distribution of MC trypsin-like protease (tryptase) in a variety of bovine tissues with the aim of examining MC heterogeneity. Tryptase was found in MCs regardless of their location within tissues. With respect to tryptase content, bovine MC distribution resembled more that of human and canine tissues than that of mice and rats. Comparison of the results yielded by enzyme- and immuno-histochemical staining suggested that a tryptase-negative, dual-specific chymase-positive MC subset occurred, at least in duodenal lamina propria, around bronchioles and within alveolar septa. The study also suggested that monoclonal antibodies raised against human tryptase can be used for quantitation of bovine tryptase in biological fluids; this offers a promising tool for evaluating the role of MC activation in disease. [less ▲]

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See detailMaximal Ventilation Assessment in Healthy Calves
Bureau, Fabrice ULg; Coghe, J.; Uystepruyst, C. H. et al

in Veterinary Journal (1999), 157(3), 309-314

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic ... [more ▼]

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic. The effects of these tests on the main ventilatory parameters (tidal volume, VT; respiratory frequency, fR and minute volume,.VE) recorded during the 15 s of maximal response were studied and compared. The sharp rise in.VE(4.8 times higher than the resting value) observed during the rebreathing trial was mainly due to an increase in VT. This rise in ventilation was the highest ever reported in calves. Lobeline dose-dependently enhanced ventilation up to a threshold dose of 0.25 mg/kg, which always produced a maximal response. This maximal response (3.7 times higher than the resting value), reflecting both an increase in fR and VT, was reproducible at an interval of 12 h and was highly correlated with that observed during the rebreathing trial (R = 0.98, P< 0.001). These results suggest that: (1) rebreathing trial is a reliable method to induce and measure maximal ventilation in calves; and (2) lobeline administration (0.25 mg/kg) is a reliable means of accurately estimating this variable. Lobeline administration, unlike the rebreathing trial, is safe and easy to standardize, and the test therefore seems to be the preferred way of studying maximal ventilation in calves. [less ▲]

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See detailMolecular and Clinicopathological Diagnosis of Non-Wildebeest Associated Malignant Catarrhal Fever in Belgium
Desmecht, Daniel ULg; Cassart, Dominique ULg; Rollin, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 144(14), 388

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See detailLaryngeal Rhabdomyoma in a Golden Retriever
Clercx, Cécile ULg; Desmecht, Daniel ULg; Michiels, L. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(7), 196-8

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the ... [more ▼]

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the larynx. Histological examination revealed cross-striations in some elongated cells, consistent with a diagnosis of rhabdomyoma, a diagnosis which was confirmed by positive immunohistochemical staining for myoglobin and desmin. The mass could not be removed without total laryngectomy and a permanent tracheostomy and the dog was euthanased. [less ▲]

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See detailEffect of platelet-activating factor on bovine pulmonary function
Van de Weerdt, ML; Desmecht, Daniel ULg; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1997), 141(7), 168-172

The objectives of this study were to determine whether the infusion of platelet-activating factor would modify bovine pulmonary function, heart rate and platelet count and whether any such modifications ... [more ▼]

The objectives of this study were to determine whether the infusion of platelet-activating factor would modify bovine pulmonary function, heart rate and platelet count and whether any such modifications could be antagonised by the prior intravenous injection of a specific antagonist (WEB 2086). In saline-pretreated calves, the respiratory rate, total lung resistance (RL) and maximal changes in transpulmonary pressure (delta Ptp) were significantly increased whereas lung dynamic compliance (CLdyn), tidal volume (VT), platelet count and heart rate were significantly decreased. The changes in RL, CLdyn, VT and delta Ptp were abolished by pretreatment with WEB 2086, whereas respiratory rate remained significantly increased to 125 per cent of the baseline value, but less than in the saline-pretreated calves in which it was 250 per cent of the baseline value. [less ▲]

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See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

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See detailVentilatory Effects of the Single-Breath Co2 Test, Compared with Eructation, in Cattle
Rollin, Frédéric ULg; Desmecht, Daniel ULg; Genicot, B. et al

in American Journal of Veterinary Research (1997), 58(3), 310-6

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated ... [more ▼]

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated Holstein-Friesian and 8 Belgian White and Blue hypermuscled calves. PROCEDURE: An SB of +/- 50% CO2 in equal parts of O2 and N2 was inhaled. Ventilatory response was determined from the increase in ventilation (delta Ve) during the first 20 seconds after the test breath or eructation and from the difference in end-tidal PCO2 between the stimulus and preceding control breaths. RESULTS: Because no difference was found between the 2 breeds of calves, all data were pooled. The increase in Ve peaked during the fifth breath after the SB CO2 test on average, corresponding to a delay of 12.4 seconds. The SB CO2 responses ranged from 0.037 to 0.151 L/min.mm of Hg.m2, with a mean +/- SD of 0.082 +/- 0.032 L/min.mm of Hg.m2 for all calves. The SB CO2 tests, similar to eructations, modified the breathing pattern significantly and in the same direction, by principally shortening expiratory time and increasing mean inspiratory flow. After eructations, Ve peak increase was more important for lower difference in end-tidal PCO2 between the stimulus and preceding control breaths and took place more rapidly than after SB CO2 tests. Accordingly, eructation responses were more marked than SB CO2 responses and averaged 0.925 +/- 0.276 L/min.mm of Hg.m2. CONCLUSIONS AND CLINICAL RELEVANCE: In cattle, the pattern of breathing and ventilation under basal conditions is characterized by a cyclic variability coupled to eructation. [less ▲]

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See detailA new acute respiratory distress syndrome in newborn calves : clinical, laboratory and post-mortem findings
Dardenne, A; Danlois, F; Rollin, Frédéric ULg et al

in In Proceedings of the 15th Comparative Respiratory Society Meeting (1997)

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See detailPemphigus foliacé dans l'espèce équine : synthèse et description de 2 cas.
Amory, Hélène ULg; Beco, Luc; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailMéthodes de stereologie et de morphometrie appliquées a l'etude des poumons
Jolly, S.; Gabriel, Annick ULg; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailPossible renal dysplasia in four dogs of different breeds.
Peeters, Dominique ULg; Clercx, Cécile ULg; Desmecht, Daniel ULg et al

in Proceedings of the 7th Annual Congress of the ESVIM (1997)

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See detailThe Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Research Communications (1997), 21(7), 521-531

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet ... [more ▼]

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. [less ▲]

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See detailEffects of Growth and Breed on Direct Static Measurements of Chest Wall Compliance in Cattle
Desmecht, Daniel ULg; Rollin, Frédéric ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1997), 62(1, Jan-Feb), 1-5

Chest wall compliance (CW) was measured in 59 conscious standing calves, aged six to 162 days, which were breathing air spontaneously through a face mask. The airways were occluded at the end of ... [more ▼]

Chest wall compliance (CW) was measured in 59 conscious standing calves, aged six to 162 days, which were breathing air spontaneously through a face mask. The airways were occluded at the end of inspiration in order to elicit the Hering-Breuer reflex, the effectiveness of which was ensured by the presence of a plateau on the tracings of airway opening and oesophageal pressure (Pes). CW was measured directly from the inspired volume of the occluded breath and changes in Pes generated by the recoil of the relaxed chest wall. This airway-occlusion technique yielded reproducible CW values similar to those measured by classical invasive methods. The ratio of CW to bodyweight in the growing calves (sCW) ranged from 2.2 to 11.5 ml cmH2O-1 kg-1 and was correlated negatively with age: (log sCW = 0.91-0.003 x age, r = 0.68), the rate of decline corresponding well to the multispecies allometric growth relationship. [less ▲]

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See detailMultiple-Breath Washout and Washin Experiments in Steers
Rollin, Frédéric ULg; Desmecht, Daniel ULg; Verbanck, S. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1996), 81(2), 957-63

Multiple-breath N2 washouts (WO) and washins (WI) were performed during regular tidal breathing in 11 unsedated healthy steers approaching pulmonary functional maturity (mean body weight = 271 kg). They ... [more ▼]

Multiple-breath N2 washouts (WO) and washins (WI) were performed during regular tidal breathing in 11 unsedated healthy steers approaching pulmonary functional maturity (mean body weight = 271 kg). They inspired 20% O2 in 80% Ar during the WO and air during the WI. For each steer, we computed two indexes of ventilation inhomogeneity from the N2 WO curves: 1) the curvilinearity of the logarithm of end-tidal N2 concentrations as a function of cumulative expired volume reflected in the ratio of two slopes fitted between 100 and 50% and between 50 and 10%, respectively, of end-tidal N2 concentration of the first breath of the WO; and 2) the N2 phase III slope divided by the mean expired concentration (Sn) of each breath also plotted as a function of cumulative expired volume. Equivalent computation of both parameters was done on WI and WO curves, and similar results were obtained. The mean slope ratio was 0.812 +/- 0.119 (SD) for all the steers, which is consistent with topographic gravity-dependent specific ventilation distribution inhomogeneity. Sn was independent of the breath number both for WO and WI (mean Sn = 0.130 +/- 0.057 liters-1), suggesting that emptying between unequally ventilated units, is synchronous. This behavior resembles that observed in rats postmortem (S. Verbanck, E.R. Weibel, and M. Paiva. J. Appl Physiol. 71: 847-854, 1991) but contrasts with experiments in humans, in whom convection-dependent ventilation inhomogeneities generate a marked increase in Sn throughout the entire WO (A. B. H. Crawford, M. Makowska, M. Paiva, and L. A. Engel. J. Appl. Physiol. 59: 838-846, 1985). This is surprising because one would expect gravity-dependent sequential emptying in animals of this size. [less ▲]

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See detailParasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in health calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(6), 896-901

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See detailCardiovascular response to exogenous serotonin in healthy calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(5), 731-738

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT ... [more ▼]

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT administrations were performed: II slow infusions (duration, 5 minutes) and 30 bolus infusions (duration, 5 seconds). Cardiovascular function values were recorded before, during, and after the infusion. RESULTS: Slow infusion of 5HT first resulted in a brief period of severe bradycardia, then in sustained tachycardia with a concomitant increase in cardiac output. Systemic initial hypotension concomitant with bradycardia, then a pressor phase associated with an increase in systemic vascular resistance, and finally, a long-lasting hypotensive phase associated with decreased systemic vascular resistance. Pulmonary hypertension was associated with increased pulmonary vascular resistance, reflecting intense pulmonary vasoconstriction. Bolus infusion at increasing dosages resulted in dose-dependent bradycardia and systemic hypotension, followed by dose-dependent systemic hypertension. Unlike with slow infusion, neither the second tachycardiac nor the third systemic hypotensive phases were evident. CONCLUSIONS: 5-HT induces dose-dependent cardiovascular responses, including a reflex response followed by pulmonary and systemic vasoconstriction, in healthy calves. CLINICAL RELEVANCE: Determining the type of serotonergic receptors responsible for these responses may help to determine whether 5-HT is involved in the mechanisms underlying brisket disease in cattle. [less ▲]

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