References of "Desmecht, Daniel"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEffect of somatic growth, strain and sex on double-chamber plethysmographic respiratory function values in healthy mice
Flandre, Thierry; Leroy, Pascal ULg; Desmecht, Daniel ULg

in Journal of Applied Physiology (2003), 94

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically ... [more ▼]

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically, however, this technique combines the advantages of single-chamber plethysmography with a quantitative assessment of flow and/or volume and a calculated resistance, the interpretation of which in terms of bronchoconstriction is not disputed. Here we show that, when appropriately preconditioned, mice are able to gradually grow accustomed to the apparatus and display extremely stable nasal and thoracoabdominal flow tracings. Overall, strain, sex, and somatic growth had a significant effect on pulmonary function values. The changes in specific airway resistance (sRaw) and enhanced pause (Penh) values were never in the same direction, indicating that they measure different things. The respiratory frequency was far higher in C57BL/6 compared with BALB/c mice. Peak flows, minute volume, specific tidal and minute volumes, and sRaw were also higher, but Penh was smaller. Males breathed at a higher frequency than females, leading to a higher minute volume. Nevertheless, the specific volumes were considerably higher among females. Penh was lower in males, whereas sRaw was identical in both sexes. Changes associated with somatic growth were rapid and important between 5 and 9 wk, then slowed down between 9 and 12-13 wk and became almost imperceptible after. [less ▲]

Detailed reference viewed: 27 (3 ULg)
Full Text
Peer Reviewed
See detailFunctional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi
Jolly, Sandra ULg; Desmecht, Daniel ULg

in Comparative Biochemistry & Physiology Part C : Toxicology & Pharmacology (2003), 134(1), 91-100

Theoretically, the overall effect of histamine on respiratory smooth muscle is the result of a subtle balance of contraction and relaxation. The aim of the study was to identify histamine type 2 (H2) and ... [more ▼]

Theoretically, the overall effect of histamine on respiratory smooth muscle is the result of a subtle balance of contraction and relaxation. The aim of the study was to identify histamine type 2 (H2) and 3 (H3) receptor-dependent relaxing mechanisms in the contractile elements of the bovine tracheobronchial tree. In bronchial preparations, histamine induced very weak contractions, which were not exacerbated with the H2-antagonist cimetidine. Moreover, precontracted bronchial rings never relaxed in response to cumulative doses of histamine or amthamine (H2-agonist). In intact tracheal preparations, histamine induced strong contractions that were exacerbated by cimetidine (E-max : + 17.2 +/- 6.6%) but not by thioperamide (H3-antagonist). Precontracted tracheal bundles did not relax in response to cumulative doses of the H3-agonist R-alpha-methylhistamine. The tracheal contractile response was higher in denuded compared to intact preparations (11.0+/-1.2 vs. 6.0+/-1.7 g). Cimetidine effect was dramatically potentiated in denuded tracheal strips (+40.0+/-11.7%). It is concluded that the weak response. of bovine bronchi to histamine is due to a relative scarcity of H1 receptors on bronchial smooth muscle rather than to H2- or H3-dependent relaxation. In the bovine trachea, the smooth muscle possesses relaxing H2 but no H3 receptors. The epithelium exercises a relaxation, which is independent from H2 and H3 receptors. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailInfiltrative lipoma in the foreleg of a horse
Olle, Edwin; Saunders, Jimmy; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2002), 71

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding ... [more ▼]

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding. Cytological fea-tures were that of a benign lipoma. Surgical resection was attempted but failed due to the infiltrative natureof the mass. Consequently, the horse was euthanized. Histopathology revealed an infiltrative lipoma. Thistumor is histologically benign but surgical resection is usually impossible due to its infiltrative nature. [less ▲]

Detailed reference viewed: 38 (2 ULg)
Peer Reviewed
See detailLocal administration of nuclear factor-kB decoy oligodeoxinucleotides prevents allergic airway inflammation
Bureau, Fabrice ULg; Gosset, P.; Desmet, Christophe ULg et al

in 12th European Respiratory Society Annual Congress (2002)

Detailed reference viewed: 31 (6 ULg)
Full Text
Peer Reviewed
See detailMetabolic and Structural Abnormalities in Dogs with Early Left Ventricular Dysfunction Induced by Incessant Tachycardia
Mc Entee, Kathleen ULg; Flandre, Thierry; Doizé, Cécile ULg et al

in American Journal of Veterinary Research (2001), 62(6), 889-94

OBJECTIVE: To assess morphologic and metabolic abnormalities in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP). ANIMALS: 7 Beagles. PROCEDURE: Plasma ... [more ▼]

OBJECTIVE: To assess morphologic and metabolic abnormalities in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP). ANIMALS: 7 Beagles. PROCEDURE: Plasma carnitine concentrations were measured before and after development of ELVD induced by RRVP. At the same times, transvenous endomyocardial biopsy was performed, and specimens were submitted for determination of myocardial carnitine concentrations and histologic, morphometric, and ultrastructural examination. RESULTS: In 4 dogs in which baseline plasma total carnitine concentration was normal, RRVP induced a decrease in myocardial total and free carnitine concentrations and an increase in myocardial esterified carnitine concentration. In 3 dogs in which baseline plasma total carnitine concentration was low, plasma and myocardial carnitine concentrations were unchanged after pacing. Structural changes associated with pacing included perinuclear vacuolization in 3 dogs. Morphometric analyses indicated there was a decrease in myofiber cross-sectional diameter and area following pacing. Electron microscopy revealed changes in myofibrils and mitochondria following pacing. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that moderate to severe alterations in myocyte cytoarchitecture are present in dogs with ELVD induced by RRVP and that in dogs with normal plasma carnitine concentrations, myocardial carnitine deficiency may be a biochemical marker of ELVD. Results also indicated that transvenous endomyocardial biopsy can be used to evaluate biochemical and structural myocardial changes in dogs with cardiac disease. [less ▲]

Detailed reference viewed: 36 (9 ULg)
Full Text
Peer Reviewed
See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailHormonal, metabolic and structural investigation in a conscious canine model of early heart failure induced by rapid right ventricular pacing
Mc Entee, Kathleen ULg; Clercx, Cécile ULg; Dessy, C. et al

in 10th ESVIM Meeting - Neuchatel - Suisse - Octobre 2000 (2000, October)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailCorrelation between Nuclear Factor-Kappab Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma
Bureau, Fabrice ULg; Bonizzi, G.; Kirschvink, N. et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(4, Pt 1), 1314-1321

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the ... [more ▼]

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the transcriptional initiation of inflammatory genes, has been poorly investigated in asthma. In the present report, bronchial cells (BCs), recovered by bronchial brushing in healthy and heaves-affected horses (i.e., an animal model of asthma), were assessed for NF-kappaB activity. Small amounts of active NF-kappaB were present in BCs of healthy horses, whereas high levels of NF-kappaB activity was found during crisis (i.e., acute airway obstruction) in all heaves-affected horses. Three weeks after the crisis, the level of NF-kappaB activity found in BCs of heaves-affected horses was highly correlated (p < 0.01) to the degree of residual lung dysfunction. Unexpectedly, active NF- kappaB complexes found in BCs of heaves-affected horses were mainly p65 homodimers, rather than classic p65-p50 heterodimers. At last, intercellular adhesion molecule-1 (ICAM-1) expression paralleled p65 homodimers activity in these cells. These results demonstrate that the kinetics of NF-kappaB activity is strongly related to the course of the disease and confirm the relevance of NF-kappaB as a putative target in asthma therapy. Moreover, uncommon p65 homodimers could transactivate, in BCs, a subset of genes, such as ICAM-1, characteristic of chronic airway inflammation. [less ▲]

Detailed reference viewed: 27 (3 ULg)
Full Text
Peer Reviewed
See detailEnzyme-Histochemical Detection of a Chymase-Like Proteinase within Bovine Mucosal and Connective Tissue Mast Cells
Jolly, Sandra ULg; Detilleux, Johann ULg; Coignoul, Freddy ULg et al

in Journal of Comparative Pathology (2000), 122(Feb-Apr), 155-162

The presence of chymase-like proteinase in bovine mast cells was investigated by an enzyme-histochemical technique (naphthol-AS-D-chloroacetate as substrate) in normal skin, primary bronchus, lung and ... [more ▼]

The presence of chymase-like proteinase in bovine mast cells was investigated by an enzyme-histochemical technique (naphthol-AS-D-chloroacetate as substrate) in normal skin, primary bronchus, lung and duodenum. The counts and distribution of chymase-positive and toluidine blue-positive mast cells were compared by means of successive staining. Mast cells with chymase-like activity were detected in all areas, but their proportion was greater in connective than mucosal tissues, with the exception of the skin. These results contrast with those obtained in rodents, in which chymase-like proteinases are detected in all tissues and also in all mast cells. Bovine mast cells are closer to those of human beings, in which chymase-containing mast cells predominate in connective tissues, including skin. The results suggest that more than one chymase subset is present, at least in duodenum. The possible occurrence of dual-specific chymase mast cells, as in other ruminants, is discussed. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Peer Reviewed
See detailJuvenile Nephropathy in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound
Peeters, Dominique ULg; Clercx, Cécile ULg; Michiels, L. et al

in Australian Veterinary Journal (2000), 78(3), 162-5

Juvenile nephropathy was diagnosed in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound dog, each presenting with signs compatible with chronic renal failure. The diagnosis in each case was based on ... [more ▼]

Juvenile nephropathy was diagnosed in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound dog, each presenting with signs compatible with chronic renal failure. The diagnosis in each case was based on the presence of persistence of poorly differentiated tissue (immature glomeruli and/or tubules, persistent mesenchyme) on histopathologic examination. Although juvenile nephropathy has been reported in many breeds of dog, this is the first report of the condition in the Collie and the Irish Wolfhound and only the second description in the Boxer and the Rottweiler. The possibility of an inherited origin of the condition in these four breeds is at present unknown. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Peer Reviewed
See detailLa pleuropneumonie contagieuse bovine
Linden, Annick ULg; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailCardiovascular Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade, by Metrenperone, in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Veterinary Journal (1999), 157(1), 31-37

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and ... [more ▼]

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and pulmonary hypertension were the major changes elicited by 5-HT. The purpose of the present study was to determine whether the cardiovascular response to 5-HT in calves was attributable to 5-HT2 receptors. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated Friesian calves 30 min before the animals were given a 5-min intravenous 5-HT infusion. Mean systemic arterial (SAP), mean pulmonary arterial (PAP), pulmonary capillary wedge (PW) pressures were obtained by means of fluid-filled catheters, and cardiac output (CO) was measured by the thermodilution technique. Heart rate, stroke volume, systemic (SVR) and pulmonary (PVR) vascular resistances were calculated. Administration of 5-HT after metrenperone induced a short-lasting period of severe bradycardia followed by tachycardia and increased CO. The systemic blood pressure response was exclusively hypotensive and associated with a decrease in SVR. Conversely, PAP, PW, and PVR were not modified by 5-HT administration. The results establish that 5-HT induced systemic as well as pulmonary hypertension is mediated through the activation of type-2 serotonergic or alpha-adrenergic receptors, or both. In contrast, neither apnoea, bradycardia and hypotension, nor the positive chronotropic effect induced by 5-HT in cattle are mediated through such receptors. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Peer Reviewed
See detailNonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Gilbert, S. et al

in Journal of the American Animal Hospital Association (1999), 35(3, May-Jun), 220222224-8

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular ... [more ▼]

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailDetection of Tryptase in Bovine Mast Cells: Comparison of Enzyme- and Immuno-Histochemistry
Jolly, Sandra ULg; Coignoul, Freddy ULg; Gabriel, Annick ULg et al

in Journal of Comparative Pathology (1999), 120(3), 269-79

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either ... [more ▼]

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either trypsin-like or chymotrypsin-like) are granule constituents which provide an important means of distinguishing subtypes of MCs in man and rodents. The purpose of this study was to compare the distribution of MC trypsin-like protease (tryptase) in a variety of bovine tissues with the aim of examining MC heterogeneity. Tryptase was found in MCs regardless of their location within tissues. With respect to tryptase content, bovine MC distribution resembled more that of human and canine tissues than that of mice and rats. Comparison of the results yielded by enzyme- and immuno-histochemical staining suggested that a tryptase-negative, dual-specific chymase-positive MC subset occurred, at least in duodenal lamina propria, around bronchioles and within alveolar septa. The study also suggested that monoclonal antibodies raised against human tryptase can be used for quantitation of bovine tryptase in biological fluids; this offers a promising tool for evaluating the role of MC activation in disease. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Full Text
Peer Reviewed
See detailMaximal Ventilation Assessment in Healthy Calves
Bureau, Fabrice ULg; Coghe, J.; Uystepruyst, C. H. et al

in Veterinary Journal (1999), 157(3), 309-314

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic ... [more ▼]

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic. The effects of these tests on the main ventilatory parameters (tidal volume, VT; respiratory frequency, fR and minute volume,.VE) recorded during the 15 s of maximal response were studied and compared. The sharp rise in.VE(4.8 times higher than the resting value) observed during the rebreathing trial was mainly due to an increase in VT. This rise in ventilation was the highest ever reported in calves. Lobeline dose-dependently enhanced ventilation up to a threshold dose of 0.25 mg/kg, which always produced a maximal response. This maximal response (3.7 times higher than the resting value), reflecting both an increase in fR and VT, was reproducible at an interval of 12 h and was highly correlated with that observed during the rebreathing trial (R = 0.98, P< 0.001). These results suggest that: (1) rebreathing trial is a reliable method to induce and measure maximal ventilation in calves; and (2) lobeline administration (0.25 mg/kg) is a reliable means of accurately estimating this variable. Lobeline administration, unlike the rebreathing trial, is safe and easy to standardize, and the test therefore seems to be the preferred way of studying maximal ventilation in calves. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Peer Reviewed
See detailMolecular and Clinicopathological Diagnosis of Non-Wildebeest Associated Malignant Catarrhal Fever in Belgium
Desmecht, Daniel ULg; Cassart, Dominique ULg; Rollin, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 144(14), 388

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailLaryngeal Rhabdomyoma in a Golden Retriever
Clercx, Cécile ULg; Desmecht, Daniel ULg; Michiels, L. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(7), 196-8

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the ... [more ▼]

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the larynx. Histological examination revealed cross-striations in some elongated cells, consistent with a diagnosis of rhabdomyoma, a diagnosis which was confirmed by positive immunohistochemical staining for myoglobin and desmin. The mass could not be removed without total laryngectomy and a permanent tracheostomy and the dog was euthanased. [less ▲]

Detailed reference viewed: 24 (5 ULg)
Full Text
Peer Reviewed
See detailEffect of platelet-activating factor on bovine pulmonary function
Van de Weerdt, ML; Desmecht, Daniel ULg; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1997), 141(7), 168-172

The objectives of this study were to determine whether the infusion of platelet-activating factor would modify bovine pulmonary function, heart rate and platelet count and whether any such modifications ... [more ▼]

The objectives of this study were to determine whether the infusion of platelet-activating factor would modify bovine pulmonary function, heart rate and platelet count and whether any such modifications could be antagonised by the prior intravenous injection of a specific antagonist (WEB 2086). In saline-pretreated calves, the respiratory rate, total lung resistance (RL) and maximal changes in transpulmonary pressure (delta Ptp) were significantly increased whereas lung dynamic compliance (CLdyn), tidal volume (VT), platelet count and heart rate were significantly decreased. The changes in RL, CLdyn, VT and delta Ptp were abolished by pretreatment with WEB 2086, whereas respiratory rate remained significantly increased to 125 per cent of the baseline value, but less than in the saline-pretreated calves in which it was 250 per cent of the baseline value. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Peer Reviewed
See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

Detailed reference viewed: 43 (4 ULg)