References of "Desaive, Thomas"
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See detailPhysiological relevance and performance of a minimal lung model -- an experimental study in healthy and acute respiratory distress syndrome model piglets
Chiew, Y. S.; Chase, J. G.; LAMBERMONT, Bernard ULg et al

in BMC Pulmonary Medicine (2012), 12:59

Background: Mechanical ventilation (MV) is the primary form of support for acute respiratory distress syndrome (ARDS) patients. However, intra- and inter- patient-variability reduce the efficacy of ... [more ▼]

Background: Mechanical ventilation (MV) is the primary form of support for acute respiratory distress syndrome (ARDS) patients. However, intra- and inter- patient-variability reduce the efficacy of general protocols. Model-based approaches to guide MV can be patient-specific. A physiological relevant minimal model and its patient-specific performance are tested to see if it meets this objective above. Methods: Healthy anesthetized piglets weighing 24.0 kg [IQR: 21.0-29.6] underwent a step-wise PEEP increase manoeuvre from 5cmH2O to 20cmH2O. They were ventilated under volume control using Engstrom Care Station (Datex, General Electric, Finland), with pressure, flow and volume profiles recorded. ARDS was then induced using oleic acid. The data were analyzed with a Minimal Model that identifies patient-specific mean threshold opening and closing pressure (TOP and TCP), and standard deviation (SD) of these TOP and TCP distributions. The trial and use of data were approved by the Ethics Committee of the Medical Faculty of the University of Liege, Belgium.Results and discussions3 of the 9 healthy piglets developed ARDS, and these data sets were included in this study. Model fitting error during inflation and deflation, in healthy or ARDS state is less than 5.0% across all subjects, indicating that the model captures the fundamental lung mechanics during PEEP increase. Mean TOP was 42.4cmH2O [IQR: 38.2-44.6] at PEEP = 5cmH2O and decreased with PEEP to 25.0cmH2O [IQR: 21.5-27.1] at PEEP = 20cmH2O. In contrast, TCP sees a reverse trend, increasing from 10.2cmH2O [IQR: 9.0-10.4] to 19.5cmH2O [IQR: 19.0-19.7]. Mean TOP increased from average 21.2-37.4cmH2O to 30.4-55.2cmH2O between healthy and ARDS subjects, reflecting the higher pressure required to recruit collapsed alveoli. Mean TCP was effectively unchanged. Conclusion: The minimal model is capable of capturing physiologically relevant TOP, TCP and SD of both healthy and ARDS lungs. The model is able to track disease progression and the response to treatment. [less ▲]

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See detailEvolution de l’insulino-résistance au cours de l’hypothermie thérapeutique
Moermans, A; Taccone, F; Penning, Sophie ULg et al

in Proceedings des journees francophone de nutrition 2012 (2012)

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See detailPhysiological Relevance of a Minimal Model in Healthy Pigs Lungs
Chiew, YS; Desaive, Thomas ULg; LAMBERMONT, Bernard ULg et al

in Proceedings of BMS 2012 (2012)

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See detailPerformance of lung recruitment model in healthy anesthetised pigs
Chiew, YS; LAMBERMONT, Bernard ULg; JANSSEN, Nathalie ULg et al

in Proceedings of the World Congress on Medical Physics and Biomedical Engineering 2012 (2012)

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See detailRange90 as indicator for ventilator output versus patients demand: NAVA and pressure support for non-invasively ventilated patients
Chiew, YS; Piquilloud, L.; LAMBERMONT, Bernard ULg et al

in Proceedings of the World Congress on Medical Physics and Biomedical Engineering 2012 (2012)

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See detailGlucose control: How tight? - How modeling could help?
Desaive, Thomas ULg; Chase, JG

Conference (2012)

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See detailEstimating afterload, systemic vascular resistance and pulmonary vascular resistance in an intensive care setting
Stevenson, D; Revie, J.; Chase, JG et al

in Proceedings of BMS2012 (2012)

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See detailCardiovascular modelling and the Intensive Care Unit clinician
Desaive, Thomas ULg; LAMBERMONT, Bernard ULg; Kolh, Philippe ULg et al

in Proceedings of BMS 2012 (2012)

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See detailModel-based Monitoring of Septic Shock Treated with Large-Pore Hemofiltration Therapy
Revie; Stevenson, D; Chase, JG et al

in Proceedings of BMS 2012 (2012)

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See detailAnalysis of Aortic Energetics from Pulse Wave Examination in a Porcine Study of Septic Shock
Revie, JA; Stevenson, D; Chase, JG et al

in Prceedings of BMS 2012 (2012)

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See detailObservation of incretin effects during enteral feed transitions of critically ill patients
Jamaludin, U. K.; Docherty, P. D.; Geoffrey Chase, J. et al

in e-SPEN Journal (2012), 7(4), 154-159

Background & aims: Critically ill patients are regularly feed via constant enteral (EN) nutrition infusions. However, the incretin effect or its impact on endogenous insulin concentration remains unclear ... [more ▼]

Background & aims: Critically ill patients are regularly feed via constant enteral (EN) nutrition infusions. However, the incretin effect or its impact on endogenous insulin concentration remains unclear. This study determines whether there is an EN-driven incretin effect in critically ill patients requiring glycaemic control. Methods: Clinically validated, model-based time-variant insulin sensitivity (S I) profiles were identified for 52 non-diabetic patients on Specialized Relative Insulin Nutrition Titration (SPRINT) glycaemic control during transitions off EN (ON/OFF), and back on to EN (OFF/ON). Incretin effects were observable via increased modelled S I after the OFF/ON transition or a decreased S I after the ON/OFF transition. Results: Patients exhibited a median -36% (IQR -82% to 24% p = 0.001) reduction after the ON/OFF feed transition, and a median of +32% (IQR -5% to 53%, p = 0.05) rise in measured S I after the OFF/ON transition. However, 32% of patients exhibited increased S I at the OFF/ON transition, and 37% exhibited reduced S I at the ON/OFF transition. The results are likely due to changes in patient condition over the 5-8 h considered outweighing this effect. Blood glucose was the same during both transitions with median shifts of -2% and -3% after the ON/OFF, and OFF/ON transitions (p > 0.5), respectively. Conclusions: Results imply a significant incretin effect is observed at a cohort level. The impact was stronger for the OFF/ON transition indicating that this effect may be blunted by long-term continuous EN infusions. These results provide the data to design conclusive studies, and to inform glycaemic control protocol development and implementation. © 2012 European Society for Clinical Nutrition and Metabolism. [less ▲]

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See detailSTAR Development and Protocol Comparison
Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M. et al

in IEEE Transactions on Biomedical Engineering (2012)

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See detailModèle unidimensionnel instationnaire de l'activité pacemaker cardiaque induite par le feedback mécano-électrique dans un environnement thermo-électro-mécanique
Collet, Arnaud ULg; Desaive, Thomas ULg; Dauby, Pierre ULg

in Annales de Cardiologie et d'Angeiologie (2012)

Aim of the study: In a healthy heart, the mechano-electric feedback (MEF) process acts as an intrinsic regulatory mechanism of the myocardium which allows the normal cardiac contraction by damping ... [more ▼]

Aim of the study: In a healthy heart, the mechano-electric feedback (MEF) process acts as an intrinsic regulatory mechanism of the myocardium which allows the normal cardiac contraction by damping mechanical perturbations in order to generate a new healthy electromechanical situation. However, under certain conditions, the MEF can be a generator of dramatic arrhythmias by inducing local electrical depolarizations as a result of abnormal cardiac tissue deformations, via stretch-activated channels (SACs). Then, these perturbations can propagate in the whole heart and lead to global cardiac dysfunctions. In the present study, we qualitatively investigate the influence of temperature on autonomous electrical activity generated by the MEF. Method: We introduce a one-dimensional time-dependent model containing all the key ingredients that allow accounting for the excitation-contraction coupling, the MEF and the thermoelectric coupling. Results: Our simulations show that an autonomous electrical activity can be induced by cardiac deformations, but only inside a certain temperature interval. In addition, in some cases, the autonomous electrical activity takes place in a periodic way like a pacemaker. We also highlight that some properties of action potentials, generated by the mechano-electric feedback, are significantly influenced by temperature. Moreover, in the situation where a pacemaker activity occurs, we also show that the period is heavily temperature-dependent. Conclusions: Our qualitative model shows that the temperature is a significant factor with regards to the electromechanical behavior of the heart and more specifically, with regards to the autonomous electrical activity induced by the cardiac tissue deformations. [less ▲]

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See detailInterface Design and Human Factors Consideration for Model-Based Tight Glycemic Control in Critical Care
Ward, Logan; Steel, James; Le Compte, Aaron et al

in Journal of Diabetes Science and Technology (2012)

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See detailStochastic Targeted (STAR) Glycemic Control - Design, Safety and Performance
Evans, Alicia; Le Compte, Aaron; Tan, Chian-Siong et al

in Journal of Diabetes Science and Technology (2012)

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See detailData Entry Errors and Design for Model-Based Tight Glycemic Control in Critical Care
Ward, Logan; Steel, James; Le Compte, Aaron et al

in Journal of Diabetes Science and Technology (2012)

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See detailParameter Identification in a Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

in 10th Belgian Day on Biomedical Engineering (2011, December 02)

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See detailEffects of temperature on pacemaker activity induced by mechano-electric feedback in a one-dimensional model of a ring-shaped cardiac fiber
Collet, Arnaud ULg; Desaive, Thomas ULg; Dauby, Pierre ULg

in NCBME (Ed.) 10th Belgian Day on Biomedical Engineering (2011, December 02)

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