References of "Desaive, Thomas"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailClinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults.
Finfer, Simon; Wernerman, Jan; Preiser, Jean-Charles et al

in Critical Care (2013), 17(3), 229

The management reporting and assessment of glycemic control lacks standardization. The use of different methods to measure the blood glucose concentration and to report the performance of insulin ... [more ▼]

The management reporting and assessment of glycemic control lacks standardization. The use of different methods to measure the blood glucose concentration and to report the performance of insulin treatment yields major disparities and complicates the interpretation and comparison of clinical trials. We convened a meeting of 16 experts plus invited observers from industry to discuss and where possible reach consensus on the most appropriate methods to measure and monitor blood glucose in critically ill patients and on how glycemic control should be assessed and reported. Where consensus could not be reached, recommendations on further research and data needed to reach consensus in the future were suggested. Recognizing their clear conflict of interest, industry observers played no role in developing the consensus or recommendations from the meeting. Consensus recommendations were agreed for the measurement and reporting of glycemic control in clinical trials and for the measurement of blood glucose in clinical practice. Recommendations covered the following areas: How should we measure and report glucose control when intermittent blood glucose measurements are used? What are the appropriate performance standards for intermittent blood glucose monitors in the ICU? Continuous or automated intermittent glucose monitoring - methods and technology: can we use the same measures for assessment of glucose control with continuous and intermittent monitoring? What is acceptable performance for continuous glucose monitoring systems? If implemented, these recommendations have the potential to minimize the discrepancies in the conduct and reporting of clinical trials and to improve glucose control in clinical practice. Furthermore, to be fit for use, glucose meters and continuous monitoring systems must match their performance to fit the needs of patients and clinicians in the intensive care setting. [less ▲]

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailA multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship.
Pironet, Antoine ULg; Desaive, Thomas ULg; Kosta, Sarah ULg et al

in BioMedical Engineering OnLine (2013), 12(1), 8

ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular ... [more ▼]

ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular contractility. However, many criticisms have been expressed against this index and the underlying time-varying elastance theory: first, it does not consider the phenomena underlying contraction and second, the end-systolic pressure volume relationship has been experimentally shown to be load-dependent. METHODS: In place of the time-varying elastance theory, a microscopic model of sarcomere contraction is used to infer the pressure generated by the contraction of the left ventricle, considered as a spherical assembling of sarcomere units. The left ventricle model is inserted into a closed-loop model of the cardiovascular system. Finally, parameters of the modified cardiovascular system model are identified to reproduce the hemodynamics of a normal dog. RESULTS: Experiments that have proven the limitations of the time-varying elastance theory are reproduced with our model: (1) preload reductions, (2) afterload increases, (3) the same experiments with increased ventricular contractility, (4) isovolumic contractions and (5) flow-clamps. All experiments simulated with the model generate different end-systolic pressure-volume relationships, showing that this relationship is actually load-dependent. Furthermore, we show that the results of our simulations are in good agreement with experiments. CONCLUSIONS: We implemented a multi-scale model of the cardiovascular system, in which ventricular contraction is described by a detailed sarcomere model. Using this model, we successfully reproduced a number of experiments that have shown the failing points of the time-varying elastance theory. In particular, the developed multi-scale model of the cardiovascular system can capture the load-dependence of the end-systolic pressure-volume relationship. [less ▲]

Detailed reference viewed: 55 (39 ULg)
Full Text
Peer Reviewed
See detailAnalysis of different model-based approaches for estimating dFRC for real-time application
van Drunen, EJ; Chase, JG; Chiew, YS et al

in BioMedical Engineering OnLine (2013), 12:9

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailnon invasive estimation of left atrial pressure and mitral valve area waveforms during an entire cardiac cycle
Paeme, Sabine ULg; Pironet, Antoine ULg; LANCELLOTTI, Patrizio ULg et al

in proceeding of 11th national day of the National Committee on Biomedical Engineering (2012, December 07)

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDirect parameter identification in a model of the cardiovascular system
Pironet, Antoine ULg; Dauby, Pierre ULg; Desaive, Thomas ULg

in 11th Belgian Day on Biomedical Engineering (2012, December 07)

Detailed reference viewed: 22 (6 ULg)
Full Text
Peer Reviewed
See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

Poster (2012, December)

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

Detailed reference viewed: 29 (13 ULg)
Full Text
Peer Reviewed
See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

Poster (2012, December)

Detailed reference viewed: 27 (13 ULg)
See detailMathematical models in intensive care units
Desaive, Thomas ULg

Scientific conference (2012, October 22)

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailCumulative time in band (cTIB): glycemic level, variability and patient outcome all in one
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Conference (2012, October 15)

Detailed reference viewed: 28 (2 ULg)
Full Text
Peer Reviewed
See detailCumulative time in band: glycemic level, variability and patient outcome vs. mortality
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Poster (2012, October)

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailCumulative Time in Band (cTIB): Glycemic Level, Variability and Patient Outcome All in 1
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

in Intensive Care Medicine (2012, October), 38 (Suppl 1)

Detailed reference viewed: 26 (4 ULg)
Full Text
Peer Reviewed
See detailSecond pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients
Penning, Sophie ULg; Le Compte, Aaron J.; MASSION, Paul ULg et al

in BioMedical Engineering OnLine (2012)

Detailed reference viewed: 26 (7 ULg)
Full Text
Peer Reviewed
See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

Conference (2012, August 31)

Detailed reference viewed: 52 (6 ULg)
Full Text
Peer Reviewed
See detailStructural model of the mitral valve included in a cardiovascular closed loop model. Static and dynamic validation
Paeme, Sabine ULg; Pironet, Antoine ULg; Chase, J. Geoffrey et al

in proceedings of 8th IFAC Symposium on Biological and Medical Systems, Budapest 29-31 août 2012 (2012, August 31)

Detailed reference viewed: 23 (4 ULg)
Full Text
Peer Reviewed
See detailAutonomous electrical activity induced by cardiac tissue deformation in a thermo-electro-mechanical background
Collet, Arnaud ULg; Desaive, Thomas ULg; Dauby, Pierre ULg

in 8th IFAC Symposium on Biological and Medical Systems (2012, August)

In a healthy heart, the mechano-electric feedback (MEF) process acts as an intrinsic regulatory mechanism of the myocardium which allows the normal cardiac contraction by damping mechanical perturbations ... [more ▼]

In a healthy heart, the mechano-electric feedback (MEF) process acts as an intrinsic regulatory mechanism of the myocardium which allows the normal cardiac contraction by damping mechanical perturbations in order to generate a new healthy electromechanical situation. However, under certain conditions, the MEF can be a generator of dramatic arrhythmias by inducing local electrical depolarizations as a result of abnormal cardiac tissue deformations, via stretch-activated channels (SACs). Then, these perturbations can propagate in the whole heart and lead to global cardiac dysfunctions. In the present study, we examine the spatio-temporal behavior of the autonomous electrical activity induced by the MEF when the heart is subject to temperature variations. For instance, such a situation can occur during a therapeutic hypothermia. This technique is usually used to prevent neuronal injuries after a cardiac resuscitation. From this perspective, we introduce a one-dimensional time-dependent model containing all the key ingredients that allow accounting for excitation-contraction coupling, MEF and thermoelectric coupling. Our simulations show that an autonomous electrical activity can be induced by cardiac deformations, but only inside a certain temperature interval. In addition, in some cases, the autonomous electrical activity takes place in a periodic way like a pacemaker. We also highlight that some properties of the action potentials that are generated by the MEF, are significantly influenced by temperature. Moreover, in the situation where a pacemaker activity occurs, we also show that the period is heavily temperature-dependent. [less ▲]

Detailed reference viewed: 40 (6 ULg)