Model-based sensor of hemodynamics in critical care

in ICST 2007 (2007)

Confirmation of high cytokine clearance by hemofiltration with a cellulose triacetate membrane with large pores: an in vivo study

in International Journal of Artificial Organs (2006), 29(10), 944-948

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 ... [more ▼]

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 mg/kg of lipopolysaccharide from Escherichia Coli over a period of 30 mins). Six pigs were hemofiltrated for 3 hours with a large pore membrane (78 angstrom pore, 80 kDa cut off) (Sureflux FH 70, Nipro, Osaka, Japan). The ultrafiltration rate was 45 ml/kg/min. Samples were taken from arterial, venous line and in the ultrafiltrate at T120 and T240. We measured concentrations of interleukin 6, interleukin 10 and albumin. Results: At T120 and T240, the IL-6 clearances were 22 +/- 7 and 15 +/- 3 ml/min, respectively. The IL-6 sieving coefficients were 0.97 and 0.7 at T120 and T240, respectively. At T120 and T240, the IL-10 clearances were 14 +/- 4 and 10 +/- 7 ml/min, respectively. The sieving coefficients were 0.63 and 0.45 at T120 and T240, respectively. The concentrations of IL-6 and IL-10 were the same at T0 and T240. At T60 and T240, the plasmatic albumin concentrations were 24 +/- 4 g/L and 23 +/- 4 g/L, respectively ( p = 0.13). Conclusions: In this animal model of endotoxinic shock, we confirm the high cytokine clearance observed when hemofiltration is applied to a large pore membrane. The loss of albumin seems negligible. The impact of such clearances on hemodynamic stability and survival remains to be proved. [less ▲]

Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs

in Artificial Organs (2006), 30(7), 560-564

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with ... [more ▼]

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling. [less ▲]

Dynamics of spontaneous ventricular fibrillation in acutely ischemic pigs

in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2006), 8 (supplement 1)

Comparative effects on LV performance, arterial hemodynamics, and left ventriculo-arterial coupling of two models of coronary artery occlusion in pigs

in CSDS 2006 (2006)

Right ventricular operational mode and changes in mechanical efficiency in acute pulmonary embolism

in 4th European Congress On Emergency Medicine (2006)

Haemodynamic Management Using a Minimal Cardiac Model,” Young Researchers Meeting on Haemodynamic Management

in Pulsion Medical Systems AG (2006)

Rayleigh-Marangoni-Benard instability of a ferrofluid layer in a vertical magnetic field

in Journal of Magnetism and Magnetic Materials (2005), 289

This paper compares the relevance of various scaling for the stability study of the Rayleigh-Benard-Marangoni extended problem when a ferrofluid layer is submitted to a weak magnetic field normal to it ... [more ▼]

This paper compares the relevance of various scaling for the stability study of the Rayleigh-Benard-Marangoni extended problem when a ferrofluid layer is submitted to a weak magnetic field normal to it. Some preliminary results are reported. (c) 2004 Elsevier B.V. All rights reserved. [less ▲]

Closed-loop model of the cardiovascular system including ventricular interaction and valve dynamics: application to pulmonary embolism

in 12th International Conference on Biomedical Engineering (2005)

Thermo-diffusion revisited: A comparative approach between two recent thermodynamic formalisms

in Journal of Non-Equilibrium thermodynamics (2004), 29(4), 405-415

Extended irreversible thermodynamics and the general equation for the non-equilibrium reversible-irreversible coupling are two thermodynamic theories that have recently received much attention, not only ... [more ▼]

Extended irreversible thermodynamics and the general equation for the non-equilibrium reversible-irreversible coupling are two thermodynamic theories that have recently received much attention, not only from the fundamental but also from the practical point of view. The objective of the present work is to compare the respective merits of these two approaches by emphasising their similarities and differences. To avoid formal and tedious developments, we have applied both formalisms to a concrete problem, namely thermo-diffusion in a binary fluid mixture of nonviscous fluids. [less ▲]