References of "Desaive, Thomas"
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See detailTight Glycemic Control Models for Critically Ill Patients in Intensive Care Units
Penning, Sophie ULg; Le Compte, Aaron; Desaive, Thomas ULg et al

Poster (2010, November 26)

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See detailTight Glycemic Control Models for Critically Ill Patients in Intensive Care Units
Penning, Sophie ULg; Le Compte, Aaron; Moorhead, Katherine ULg et al

in 9th Belgian Day on Biomedical Engineering, "Bridging the gap between medicine and engineering', Friday November 26th 2010 in the Academy Palace, Hertogstraat 1, 1000 Brussels (2010, November 26)

Critically ill patients often present stress-induced hyperglycemia and low insulin sensitivity. Recent studies have shown that high blood glucose (BG) levels are linked to worsened patient outcomes and ... [more ▼]

Critically ill patients often present stress-induced hyperglycemia and low insulin sensitivity. Recent studies have shown that high blood glucose (BG) levels are linked to worsened patient outcomes and increased mortality. Tight glycemic control (TGC) aims at reducing BG levels taking into account inter-patient variability, evolving physiological patient conditions and minimizing hypoglycemic risks. Clinical protocols are used to specify insulin and nutrition rates and BG measurement time interval during control. This research compares different protocols to determine the best one to use at the CHU of Liege. [less ▲]

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See detailInfluence of thermoelectric coupling on ectopic beats generated by mechano-electric feedback (MEF) in a one-dimensional cardiac fiber model
Collet, Arnaud ULg; Desaive, Thomas ULg; Pierard, Luc ULg et al

Poster (2010, November 26)

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential ... [more ▼]

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases. In this research, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on ectopic beats generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional electromechanical model of a cardiac fiber, which considers excitation-contraction coupling (ECC), as well as MEF. [less ▲]

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See detailminimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; chase, J. Geoffrey et al

in 9th Belgian National Day on Biomedical Engineering, Bruxelles, 26th november (2010, November 26)

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the ... [more ▼]

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the “open on pressure, close on flow” law. However, this model does not describe the progressive valve opening and therefore, it is not suitable for studying valve dysfunctions. [less ▲]

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See detailMinimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; Chase, J. Geoffrey et al

Poster (2010, November 26)

This research describes a new closed-loop cardiovascular system (CVS) model including a model of the left atrium and a model describing the progressive aperture of the mitral valve

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See detailModeling the instantaneous pressure-volume relationship in the left ventricle
Lucas, Alexandra ULg; Dauby, Pierre ULg; Kolh, Philippe ULg et al

Poster (2010, November 26)

Pressure-volume loops are a common modeling tool of the cardiovascular system. They are very useful because they characterize the global function of the cardiac pump and can also be analyzed ... [more ▼]

Pressure-volume loops are a common modeling tool of the cardiovascular system. They are very useful because they characterize the global function of the cardiac pump and can also be analyzed by considering the various phases of the cardiac cycle and marking each point of a cycle with the corresponding time. When several loops are considered, the points corresponding to the same time t in each loop can be joined to define a curve named isochrone. In this work, we are interested in models of the instantaneous pressure-volume relationship, i.e. isochrone models. More precisely, we concentrate on the 6 models considered by Lankhaar et al. [1] and we propose a critical analysis of the work of these authors and suggest some improvement of their procedure. [1] Lankhaar J.W. et al. Annals of Biomedical Engineering, Volume 37, Number 9, 1710-1726, 2009. [less ▲]

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See detailPilot Trials of the STAR TGC Protocol in a Cardiac Surgery ICU
LeCompte, Aaron J.; Penning, Sophie ULg; Moorhead, Katherine ULg et al

in Proceedings of the 10th Annual Diabetes Technology Meeting (2010, November)

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See detailA Simplified Rotational Spring Model for Mitral Valve Dynamics
Moorhead, K. T.; Hann, C. E.; Chase, J. Geoffrey et al

in Proceedings of control 2010 (2010, September 07)

A simple non-linear rotational spring model has been implemented to model the motion of mitral valve, located between the left atrium and ventricle. A measured pressure difference curve was used as the ... [more ▼]

A simple non-linear rotational spring model has been implemented to model the motion of mitral valve, located between the left atrium and ventricle. A measured pressure difference curve was used as the input into the model, which represents an applied torque to the valve chords. Various damping and hysteresis states were investigated to find a model that best matches reported animal data of chord movement during a heartbeat. The study is limited by the use of one dataset from the literature, however results clearly highlight some physiological issues such as the damping and chord stiffness changing within one cardiac cycle. Very good correlation was achieved between modeled and experimental valve angle, indicating good promise for future simulation of cardiac dysfunction, such as mitral regurgitation or stenosis. [less ▲]

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See detailMathematical model of the mitral valve and the cardiovascular system, application for studying, monitoring and in the diagnosis of valvular pathologies
Paeme, Sabine ULg; Moorhead, Katherine ULg; Chase, J. Geoffrey et al

in UKACC international Conference on Control 2010 : Coventry, 7-10 september 2010 (2010, September 07)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological accurate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture dynamics and thus doesn’t fully capture valve dysfunction particularly where the dysfunction involves partial closure. This research describes a new closed-loop CVS model including a model describing the progressive aperture of the mitral valve and valid over the full cardiac cycle. This new model is solved for a healthy and diseased mitral valve. [less ▲]

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See detailReduced organ failure with effective glycemic control
Preiser, Jean-Charles; Chase, J. G.; Pretty, C. G. et al

in Intensive Care Medicine (2010), 36(2), 173-173

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See detailNAVA enhances ventilatory variability and diaphragmaticactivity/tidal volume coupling
Moorhead, K.; Piquilloud, L.; Desaive, Thomas ULg et al

in Intensive Care Medicine (2010), 36(2), 326-326

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See detailPatient-specific modelling of the cardiovascular system – application to septic shock with a minimal data set
Desaive, Thomas ULg; Chase, J. G.; Starfinger, C. et al

in World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (2010)

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See detailOrgan failure and tight glycemic control in the SPRINT study.
Chase, J Geoffrey; Pretty, Christopher G; Pfeifer, Leesa et al

in Critical Care (2010), 14(4), 154

INTRODUCTION: Intensive care unit mortality is strongly associated with organ failure rate and severity. The sequential organ failure assessment (SOFA) score is used to evaluate the impact of a successful ... [more ▼]

INTRODUCTION: Intensive care unit mortality is strongly associated with organ failure rate and severity. The sequential organ failure assessment (SOFA) score is used to evaluate the impact of a successful tight glycemic control (TGC) intervention (SPRINT) on organ failure, morbidity, and thus mortality. METHODS: A retrospective analysis of 371 patients (3,356 days) on SPRINT (August 2005 - April 2007) and 413 retrospective patients (3,211 days) from two years prior, matched by Acute Physiology and Chronic Health Evaluation (APACHE) III. SOFA is calculated daily for each patient. The effect of the SPRINT TGC intervention is assessed by comparing the percentage of patients with SOFA </=5 each day and its trends over time and cohort/group. Organ-failure free days (all SOFA components </=2) and number of organ failures (SOFA components >2) are also compared. Cumulative time in 4.0 to 7.0 mmol/L band (cTIB) was evaluated daily to link tightness and consistency of TGC (cTIB >/=0.5) to SOFA </=5 using conditional and joint probabilities. RESULTS: Admission and maximum SOFA scores were similar (P = 0.20; P = 0.76), with similar time to maximum (median: one day; IQR: 13 days; P = 0.99). Median length of stay was similar (4.1 days SPRINT and 3.8 days Pre-SPRINT; P = 0.94). The percentage of patients with SOFA </=5 is different over the first 14 days (P = 0.016), rising to approximately 75% for Pre-SPRINT and approximately 85% for SPRINT, with clear separation after two days. Organ-failure-free days were different (SPRINT = 41.6%; Pre-SPRINT = 36.5%; P < 0.0001) as were the percent of total possible organ failures (SPRINT = 16.0%; Pre-SPRINT = 19.0%; P < 0.0001). By Day 3 over 90% of SPRINT patients had cTIB >/=0.5 (37% Pre-SPRINT) reaching 100% by Day 7 (50% Pre-SPRINT). Conditional and joint probabilities indicate tighter, more consistent TGC under SPRINT (cTIB >/=0.5) increased the likelihood SOFA </=5. CONCLUSIONS: SPRINT TGC resolved organ failure faster, and for more patients, from similar admission and maximum SOFA scores, than conventional control. These reductions mirror the reduced mortality with SPRINT. The cTIB >/=0.5 metric provides a first benchmark linking TGC quality to organ failure. These results support other physiological and clinical results indicating the role tight, consistent TGC can play in reducing organ failure, morbidity and mortality, and should be validated on data from randomised trials. [less ▲]

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See detailPatient specific modelling of cardiac muscle activation
Stevenson, D; Hann, CE; Revie, JA et al

in Proceedings of the Health Research Society of Canterbury (HRSC) Clinical Meeting 2010 (2010)

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See detailModel-based cardiac disease diagnosis in critical care
Revie, JA; Hann, CE; Stevenson, D et al

in Proceedings of the Health Research Society of Canterbury (HRSC) Clinical Meeting 2010 (2010)

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See detailVentriculo-Arterial Coupling: an ideal problem for collaboration between clinicians and engineers
MORIMONT, Philippe ULg; Desaive, Thomas ULg; Chase et al

in Proceedings of CONTROL 2010 (2010)

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See detailEstimating the driver function of a cardiovascular system model
Stevenson, D; Hann, CE; Chase, JG et al

in Proceedings of CONTROL 2010 (2010)

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See detailA Model-based Approach to Cardiovascular Monitoring of Pulmonary Embolism
Revie, JA; Hann, CE; Stevenson, D et al

in Proceedings of CONTROL 2010 (2010)

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See detailAssessment of ventricular-arterial coupling with a model-based sensor
Desaive, Thomas ULg; LAMBERMONT, Bernard ULg; GHUYSEN, Alexandre ULg et al

in Proceedings of CONTROL 2010 (2010)

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