References of "Desaive, Thomas"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA mathematical model of respiration under protective ventilation and extracorporeal CO2 removal therapy
Habran, Simon ULg; Desaive, Thomas ULg; MORIMONT, Philippe ULg et al

Conference (2017, September 27)

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must ... [more ▼]

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must be simple enough to provide rapid solutions and to estimate specific parameters from available clinical data. But it also must be complex enough to be able to simulate the respiratory system when protective ventilation is used and when this system is assisted by an ECCO2RD. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailEffect of citrate anticoagulation on CO2 extraction during low flow extracorporeal veno-venous CO2 removal therapy
MORIMONT, Philippe ULg; Habran, Simon ULg; Hubert, Romain et al

in Intensive Care Medicine Experimental (2016), 4

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailA Comparison between four Techniques to Measure Cardiac Output
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in Proceedings of the 38th International Conference of the IEEE Engineering in Medicine and Biology Society (2016, August 17)

Cardiac output is an important variable when monitoring hemodynamic status. In particular, changes in cardiac output represent the goal of several circulatory management therapies. Unfortunately, cardiac ... [more ▼]

Cardiac output is an important variable when monitoring hemodynamic status. In particular, changes in cardiac output represent the goal of several circulatory management therapies. Unfortunately, cardiac output is very difficult to estimate, either in experimental or clinical settings. The goal of this work is to compare four techniques to measure cardiac output: pressure-volume catheter, aortic flow probe, thermodilution, and the PiCCO monitor. These four techniques were simultaneously used during experiments of fluid and endotoxin administration on 7 pigs. Findings show that, first, each individual technique is precise, with a relative coefficient of repeatability lower than 7 %. Second, 1 cardiac output estimate provided by any technique relates poorly to the estimates from the other 3, even if there is only small bias between the techniques. Third, changes in cardiac output detected by one technique are only detected by the others in 62 to 100 % of cases. This study confirms the difficulty of obtaining a reliable clinical cardiac output measurement. Therefore, several measurements using different techniques should be performed, if possible, and all such should be treated with caution. [less ▲]

Detailed reference viewed: 28 (1 ULg)
See detailA Comparison between four Techniques to Measure Cardiac Output
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

Poster (2016, August 17)

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailModel-Based Decision Support Algorithm to Guide Fluid Resuscitation
Pironet, Antoine ULg; Dauby, Pierre ULg; MORIMONT, Philippe ULg et al

in IFAC-PapersOnLine (2016, July 26), 49(5), 224-229

Detailed reference viewed: 22 (5 ULg)
Full Text
See detailModel-Based Decision Support Algorithm to Guide Fluid Resuscitation
Pironet, Antoine ULg; Dauby, Pierre ULg; MORIMONT, Philippe ULg et al

Conference (2016, June 02)

Fluid resuscitation is the first choice therapy for sepctic shock. However, fluid infusion only increases cardiac output in approximately 50 % of cases, while an excess of fluid can have harmful effects ... [more ▼]

Fluid resuscitation is the first choice therapy for sepctic shock. However, fluid infusion only increases cardiac output in approximately 50 % of cases, while an excess of fluid can have harmful effects. Therefore, clinicians are looking for indices to predict the effect of fluid infusion on cardiac output, before giving fluid. In this work, a minimal mathematical model of the cardiovascular system is used, representing the heart, an artery and a vein. The nine model parameters, including total stressed blood volume, are identified from experimental data. The experimental data was recorded during three 500 ml fluid infusions on two pigs infected with endotoxin, to simulate septic shock. The total stressed blood volume parameter is negatively associated with the change in cardiac output after fluid infusion, as observed in previous studies. Subsequently, an algorithm is proposed to guide fluid resuscitation, based on the value of this parameter. The use of the algorithm results in 60 % less fluid being given with virtually no effect on cardiac output. The decision algorithm has the potential to be used in human clinical trials since the data required for parameter identification can be obtained in an intensive care unit. [less ▲]

Detailed reference viewed: 47 (17 ULg)
See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2016, March 04)

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in 14th Belgian Day on Biomedical Engineering (2016, March 04)

Detailed reference viewed: 18 (1 ULg)
Peer Reviewed
See detailParameter Correlation Analysis in Four Mathematical Models of Left Ventricular Relaxation
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Dauby, Pierre ULg et al

in 14th Belgian Day on Biomedical Engineering (2016, March 04)

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailStructural identifiability analysis of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in Medical engineering & physics (2016)

The six-chamber cardiovascular system model of Burkhoff and Tyberg has been used in several theoretical and experimental studies. However, this cardiovascular system model (and others derived from it) are ... [more ▼]

The six-chamber cardiovascular system model of Burkhoff and Tyberg has been used in several theoretical and experimental studies. However, this cardiovascular system model (and others derived from it) are not identifiable from any output set. In this work, two such cases of structural non-identifiability are first presented. These cases occur when the model output set only contains a single type of information (pressure or volume). A specific output set is thus chosen, mixing pressure and volume information and containing only a limited number of clinically available measurements. Then, by manipulating the model equations involving these outputs, it is demonstrated that the six-chamber cardiovascular system model is structurally globally identifiable. A further simplification is made, assuming known cardiac valve resistances. Because of the poor practical identifiability of these four parameters, this assumption is usual. Under this hypothesis, the six-chamber cardiovascular system model is structurally identifiable from an even smaller dataset. As a consequence, parameter values computed from limited but well-chosen datasets are theoretically unique. This means that the parameter identification procedure can safely be performed on the model from such a well-chosen dataset. Thus, the model may be considered suitable for use in diagnosis. [less ▲]

Detailed reference viewed: 36 (8 ULg)
Full Text
Peer Reviewed
See detailAre Survivors Easier to Control? Why the Association of Glycemia and Mortality in Critical Care is Real
Uyttendaele, Vincent ULg; Dickson, Jennifer; Stewart, Kent et al

Poster (2016)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailBlood Glucose Levels of Subelite Athletes During 6 Days of Free Living.
Thomas, Felicity Louise ULg; Pretty, Chris G.; Desaive, Thomas ULg et al

in Journal of Diabetes Science and Technology (2016)

BACKGROUND: Continuous glucose monitoring (CGM) devices, with their 1-5 min measurement interval, allow blood glucose (BG) concentration dynamics to be captured more frequently and less invasively than ... [more ▼]

BACKGROUND: Continuous glucose monitoring (CGM) devices, with their 1-5 min measurement interval, allow blood glucose (BG) concentration dynamics to be captured more frequently and less invasively than traditional BG measures. One cohort CGM could provide insight is athletes. This study investigates what impact their heightened energy expenditure and dietary intake may have on their ability to achieve optimal BG. METHODS: Ten subelite athletes (resting HR<60 bpm, training>6 hrs per week) were recruited. Two Ipro2 CGM devices (Medtronic Minimed, Northridge, CA) were inserted into the abdomen and remained in place for ~6 days. Time in band was calculated as the percentage of CGM BG measurements with in the 4.0-6.0 mmol/L. Fasting glucose was calculated using CGM calibration BG measurements and postprandial glucose response was also calculated using the CGM values. RESULTS: 4/10 athletes studied spent more than 70% of the total monitoring time above 6.0 mmol/L even with the 2-hour period after meals is excluded. Fasting BG was also in the ADA defined prediabetes range for 3/10 athletes. Only 1 participant spent substantial time below 4.0 mmol/L which was largely due to significantly lower energy intake compared to recommendations. CONCLUSIONS: Contrary to expectations high BG appears to be more of a concern for athletes then low BG even in those with the highest energy expenditure and consuming below the recommended carbohydrate intake. This study warrants further investigation on the recommended diets and the BG of athletes to better determine the causes and impact of this hyperglycemia on overall athlete health. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailAssessing respiratory mechanics using pressure reconstruction method in mechanically ventilated spontaneous breathing patient.
Damanhuri, Nor Salwa; Chiew, Yeong Shiong; Othman, Nor Azlan et al

in Computer Methods & Programs in Biomedicine (2016), 130

BACKGROUND: Respiratory system modelling can aid clinical decision making during mechanical ventilation (MV) in intensive care. However, spontaneous breathing (SB) efforts can produce entrained "M-wave ... [more ▼]

BACKGROUND: Respiratory system modelling can aid clinical decision making during mechanical ventilation (MV) in intensive care. However, spontaneous breathing (SB) efforts can produce entrained "M-wave" airway pressure waveforms that inhibit identification of accurate values for respiratory system elastance and airway resistance. A pressure wave reconstruction method is proposed to accurately identify respiratory mechanics, assess the level of SB effort, and quantify the incidence of SB effort without uncommon measuring devices or interruption to care. METHODS: Data from 275 breaths aggregated from all mechanically ventilated patients at Christchurch Hospital were used in this study. The breath specific respiratory elastance is calculated using a time-varying elastance model. A pressure reconstruction method is proposed to reconstruct pressure waves identified as being affected by SB effort. The area under the curve of the time-varying respiratory elastance (AUC Edrs) are calculated and compared, where unreconstructed waves yield lower AUC Edrs. The difference between the reconstructed and unreconstructed pressure is denoted as a surrogate measure of SB effort. RESULTS: The pressure reconstruction method yielded a median AUC Edrs of 19.21 [IQR: 16.30-22.47]cmH2Os/l. In contrast, the median AUC Edrs for unreconstructed M-wave data was 20.41 [IQR: 16.68-22.81]cmH2Os/l. The pressure reconstruction method had the least variability in AUC Edrs assessed by the robust coefficient of variation (RCV)=0.04 versus 0.05 for unreconstructed data. Each patient exhibited different levels of SB effort, independent from MV setting, indicating the need for non-invasive, real time assessment of SB effort. CONCLUSION: A simple reconstruction method enables more consistent real-time estimation of the true, underlying respiratory system mechanics of a SB patient and provides the surrogate of SB effort, which may be clinically useful for clinicians in determining optimal ventilator settings to improve patient care. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailGlucose Control in the ICU: A Continuing Story.
Preiser, Jean-Charles; Chase, J. Geoffrey; Hovorka, Roman et al

in Journal of diabetes science and technology (2016)

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing ... [more ▼]

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing authorities and to enable comparisons across studies and devices. Adequately powered, good quality, randomized, controlled studies are needed to assess the impact of different CGM devices on the quality of glucose control, workload, and costs. The additional effects of continuing glucose control on the general floor after the ICU stay also need to be investigated. Current algorithms need to be adapted and validated for CGM, including effects on glucose variability and workload. Improved collaboration within the industry needs to be encouraged because no single company produces all the necessary components for an automated closed-loop system. Combining glucose measurement with measurement of other variables in 1 sensor may help make this approach more financially viable. [less ▲]

Detailed reference viewed: 25 (0 ULg)
Full Text
See detailSize of cannula for extracorporeal CO2 removal therapies
Habran, Simon ULg; Desaive, Thomas ULg; MORIMONT, Philippe ULg et al

Conference (2015, November 26)

Extracorporeal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome. In this ... [more ▼]

Extracorporeal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome. In this work, we propose a model of the respiratory system coupled with such a device to analyze the decrease of CO2 partial pressure in the blood as a function of the blood flow through the device. Thanks to this information, the size of the cannulae can be optimized. [less ▲]

Detailed reference viewed: 13 (1 ULg)
See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2015, November 26)

Detailed reference viewed: 17 (0 ULg)
Peer Reviewed
See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Proceedings of the IEEE-EMBS Benelux chapter 2015 meeting (2015, November 26)

Detailed reference viewed: 15 (3 ULg)
Peer Reviewed
See detailParameter Correlation Analysis in Four Mathematical Models of Left Ventricular Relaxation
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Dauby, Pierre ULg et al

in Proceedings of the IEEE-EMBS Benelux chapter 2015 meeting (2015, November 26)

Detailed reference viewed: 18 (6 ULg)