References of "Denoix, J.M."
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See detailEffect of a CpG-ODN on the innate immune system of the horse: an in-vivo trial
Tosi, Irène ULg; Pirottin, Dimitri ULg; Fievez, Laurence ULg et al

Poster (2015, October 16)

Oligodeoxynucleotides containing cytosine-phosphate-guanosine motifs (CpG-ODN) represent a class of agonists of Toll-like Receptor 9 (TLR9). TLR9 activation induces the secretion of cytokines and the ... [more ▼]

Oligodeoxynucleotides containing cytosine-phosphate-guanosine motifs (CpG-ODN) represent a class of agonists of Toll-like Receptor 9 (TLR9). TLR9 activation induces the secretion of cytokines and the maturation of immune cells, thus initiating both innate and adaptive immune responses. Therefore, CpG-ODN has been investigated in different species as a potential immune-modulator targeting infectious, allergic and neoplastic diseases. It has been administered by nebulisation to RAO-affected horses with promising results. Nonetheless, there is no in-vivo study on the effect of CpG administered systemically to the horse. Therefore, we tested the effect of CpG, given by intramuscular injection, on the equine immune response. Eight horses were used for this study. Five mg/horse were injected to 4 horses at D0 and D7; the other horses received a placebo (PBS). Blood was collected 2 days prior to each injection, then regularly up to D21. A clinical exam was realised daily. Laboratory analyses included haematology, ELISA tests for IFN-alpha, IFN-gamma, TNF-alpha and IL-10 and cytometry analyses for MCHII and CD86 expressions on B-lymphocytes. A cross-over of the 2 groups was realised after 2 months of washout. CpG was well tolerated. Significant transient eosinopenia, monocytosis and leukopenia were observed after CpG injection, while ELISA and cytometry analyses did not reveal any significant modification. This trial represents the first in-vivo study where CpG is administered systemically to healthy horses. Further studies are needed to adjust the dose, the formulation and the sampling schedule and to fully investigate this molecule as potentiel modulator of the equine immune system. [less ▲]

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See detailComment investiguer la contre-performance d’origine médicale : de la clinique au laboratoire
Richard, Eric; Pitel, P. H.; Fortier, G. et al

in 35ème Journée de la Recherche équine (2009)

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen ... [more ▼]

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen system (respiratory, cardiovascular, blood, muscular and metabolic) may also become a limiting factor concerning the athletic capacities of the horse. A systematic medical examination of the horse, combining ail the clinical and laboratory exams, is thus necessary in order to establish a precise and comprehensive diagnosis regarding the different affections. The objectives of this communication are therefore to present the different methods currently available for the practitioner as well as the techniques recently developed for horses. The complementarity of the different clinical and laboratory exams, as well as the ideal moment for performing each test are clarified in order to accurately determine the different causes of poor performance as well as their functional repercussions [less ▲]

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See detailAssociation between inflammatory airway disease, tracheal inflammation and respiratory function evaluated by impulse oscillometry
Richard, Eric ULg; Fortier, G.; Dupuis, Marie-Capucine ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailEvaluation clinique et cytologique de l’inflammation chez des chevaux atteints de maladie inflammatoire des petites voies respiratoires
Richard, E.; Fortier, G.; Dupuis, M. C. et al

in Proceedings: 36èmes Journées AVEF (2008)

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See detailEsame ecografico dell'apparato podotrocleare del cavallo
Busoni, Valeria ULg; Denoix, J. M.

in Proceedings du Congrès Annuel de la SIVE (1999)

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See detailUltrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach
Busoni, Valeria ULg; Denoix, J. M.

in Proceedings of the 5th EAVDI Annual Conference (1998)

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See detailEtude radiographique des affections ostéo-articulaires juvéniles (AOAJ) chez des chevaux de races françaises âgés de 3 ans : présentation globale des résultats sur 761 sujets.
Denoix, JM; Valette, JP; Robert, C et al

in Bulletin de la Société Vétérinaire Pratique de France (1997)

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See detailUltrasonographic examination of the soft tissue of the palmar aspect of the fetlock
Busoni, Valeria ULg; Denoix, J. M.

in Proceedings of the 5th WEVA conference (1997)

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See detailEsame ecografico del legamento sopraspinoso nel cavallo
Busoni, Valeria ULg; Denoix, J. M.

in Proceedings del Congresso annuale della Società Italiana di Ippologia (1996)

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See detailEsame ecografico dello scutum prossimale nel cavallo
Busoni, Valeria ULg; Denoix, J. M.

Poster (1996)

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See detailAnatomia clinica della briglia radiale nel cavallo
Denoix, J. M.; Busoni, Valeria ULg

Poster (1996)

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See detailPathologie osthéoarticulaire juvénile chez le cheval - Etat actuel des recherches en France
Denoix, J. M.; Houliez, D.; Moreau, H. et al

in Proceedings de la 21ème Journée d'études sur la recherche équine en France (1995)

Detailed reference viewed: 20 (2 ULg)