References of "Deneufbourg, Jean-Marie"
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See detailEvaluation des troubles salivaires et gustatifs après radiothérapie de cancers de la tête et du cou
Deneufbourg, Jean-Marie ULg; Lupo, Aurelia

in Revue Médicale de Liège (1986), XLI(17), 649-653

Salivary and taste impairments are the most frequent side-effects of radiotherapy among head and neck cancer patients.They were evaluated by interview, clinical examination, biological dosages and taste ... [more ▼]

Salivary and taste impairments are the most frequent side-effects of radiotherapy among head and neck cancer patients.They were evaluated by interview, clinical examination, biological dosages and taste assessment for sugar, salt, bitter and acid. Results confirm marked differences by comparison to a reference population with significant alterations from the point of view of quality of life. [less ▲]

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See detailPositive correlation between HLA B27 and Larynx Cancer
Deneufbourg, Jean-Marie ULg; Bouillenne, Claire

in Chretien, Paul B (Ed.) Program of continuing Education of Maryland School of Medicine International Conference on head and Neck Cancer Baltimore July 22-27 1984 (1984, July 26)

HLA determinations among 192 larynx cancers were compared to 1613 healthy blood donors. An increased frequency (15 % versus 6 % with P corrected < 0,05) of B27 is present in glottic carcinomas underlying ... [more ▼]

HLA determinations among 192 larynx cancers were compared to 1613 healthy blood donors. An increased frequency (15 % versus 6 % with P corrected < 0,05) of B27 is present in glottic carcinomas underlying a three fold risk. Followed prospectively after treatment, the glottic carcinoma group showed a 18 % incidence of B27 at 3 years and 23 % at 5 years indicating a potential favorable influence of this histocompatibility antigen of second locus [less ▲]

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See detailSplit-Course Irradiation in the Treatment of Larynx Carcinoma
Deneufbourg, Jean-Marie ULg

in Chretien, Paul B. (Ed.) Program of Continuing Education University of Maryland School of Medicine : International Conference on Head and Neck Cancer, Baltimore July 22-27 1984 (1984, July 26)

A hypofractionated split course radiotherapy has been routinely used to treat 201 larynx cancer patients. Two irradiation periods of 6x4 Gy over 2 weeks are separated by a 15 days rest interval. The dose ... [more ▼]

A hypofractionated split course radiotherapy has been routinely used to treat 201 larynx cancer patients. Two irradiation periods of 6x4 Gy over 2 weeks are separated by a 15 days rest interval. The dose equivalent of 12 fractions of 4 Gy over 6 weeks is estimated to 63 Gy/30 fractions/6 weeks.By comparison with our historical controls, cure rates at 5 years proved effective (e.g. 87% for T1 glottic; 43% for T3+T4 supraglottic). The acute and delayed radiation side-effects have been less important with better functional results. [less ▲]

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See detailInfluence of treatment mode on host immunity after cure from transplantable tumours : advantage radiotherapy over surgery and chemotherapy
Deneufbourg, Jean-Marie ULg

in Broerse, jj; Barendsen, gw; Kal, hb (Eds.) et al Tumours Biology and Therapy Proceedings of the 7th ICRR (1983, July)

In 2 murine transplantable systems, specific immunity of animals cured of a primary tumour depends on the therapeutic mode. High single doses of radiations confer a significant advantage over surgery as ... [more ▼]

In 2 murine transplantable systems, specific immunity of animals cured of a primary tumour depends on the therapeutic mode. High single doses of radiations confer a significant advantage over surgery as well as over chemotherapy. Pre-operative irradiation boosts anti-tumour immunity to a level similar of  exclusive radiotherapy group. Late recurrences and metastasis might be influenced by taking advantage of the immunological effects of radiotherapy. [less ▲]

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See detailEnhancement of concomitant immunity after radiation therapy and immunotherapy in a syngeneic murine tumour system
Deneufbourg, Jean-Marie ULg

in Acta Radiologica. Oncology (1982), 21(5), 345-348

Concomitant immunity was evaluated in vivo towards a chemically induced epidermoid carcinoma transplanted in a syngeneic situation. Radiation therapy reversed the declining phase of concomitant immunity ... [more ▼]

Concomitant immunity was evaluated in vivo towards a chemically induced epidermoid carcinoma transplanted in a syngeneic situation. Radiation therapy reversed the declining phase of concomitant immunity associated with tumour progression. Radiation induced immune recovery was dose related and proved to be different from surgery effect.Corynebacterium parvum i.p. significantly improved concomitant immunity. Immunostimulation and irradiation act synergistically on host anti-tumour resistance. [less ▲]

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See detailAnti-tumour effect of an aromatic retinoic acid analog in a mouse syngeneic transplantable sarcoma
Deneufbourg, Jean-Marie ULg

in Biomedicine Express (1979), 31

Anti-tumour activity of an aromatic retinoic acid analog was tested on Sarcoma J. Complete regression and survival time are significantly improved. These results are at variance with observations ... [more ▼]

Anti-tumour activity of an aromatic retinoic acid analog was tested on Sarcoma J. Complete regression and survival time are significantly improved. These results are at variance with observations suggesting the lack of activity of this compound on transplanted murine tumours. Arguments in favour of an immunological stimulation are presented. [less ▲]

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See detailRadiothérapie concentrée discontinue des cancers de la peau et de la lèvre inférieure
Deneufbourg, Jean-Marie ULg

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (1979), 62

186 skin and 18 lower lip cancers have been treated by hypofractionated radiotherapy with two courses of 6x4 Gy in 2 weeks separated by a rest interval of 15 days. This protocol cured 98% of skin tumours ... [more ▼]

186 skin and 18 lower lip cancers have been treated by hypofractionated radiotherapy with two courses of 6x4 Gy in 2 weeks separated by a rest interval of 15 days. This protocol cured 98% of skin tumours and 100% of lip localisations with a remarkable cutaneous and mucosal tolerance. Functional and cosmetic results proved significantly better than using conventional doses and fractionation. [less ▲]

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See detailRadiocurability of a transplantable murine sarcoma as influenced by immune competence of the host and adjuvant active specific immunotherapy
Deneufbourg, Jean-Marie ULg

in Strahlentherapie (1975), 149(4), 457-462

The immunization induced in CBA mice by allogenic transplantation of sarcoma J was evaluated through the rejection rate of a subsequent isologous tumour graft. Female animals appear to be significantly ... [more ▼]

The immunization induced in CBA mice by allogenic transplantation of sarcoma J was evaluated through the rejection rate of a subsequent isologous tumour graft. Female animals appear to be significantly much more competent at various stages of sarcoma growth as after their definite cure by radiation or surgery. A difference of response according to the sex is also present with regard to the auto-immune reaction evoked by tumour irradiation. A marked discrepancy in radiotherapy efficiency is linked to the disparity of immune behaviour, emphasizing the fact that an immunological competent host constitutes an important factor of tumour radiocurability. In male recipients, an adjuvant active specific immunotherapy potentiates tumour response to a single dose of radiations. On the contrary, the adjunct treatment may display a detrimental effect in animals which already possess a high degree of anti-tumour immunization. [less ▲]

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See detailRadiothérapie tumorale et status immunitaire de l'hôte dans un système allogénique
Deneufbourg, Jean-Marie ULg

in Bulletin du Cancer (1972), 59(1), 61-76

Immunological effects on CBA mice grafted with Sarcoma J were studied after tumour irradiation by gamma rays. Rejection rate of a second sarcoma graft was used as in vivo measure of anti-tumour immunity ... [more ▼]

Immunological effects on CBA mice grafted with Sarcoma J were studied after tumour irradiation by gamma rays. Rejection rate of a second sarcoma graft was used as in vivo measure of anti-tumour immunity.Radiotherapy boosts the auto-immune reaction of the host against its growing tumour. Cured animals reject the test graft proportionnally to the curative dose. As compared to surgery, high doses of radiations induce a better anti-tumour immunity. An active specific immunotherapy markedly increases the tumour response to radiotherapy. Moreover the therapeutic association confers to the cured animals a maximum degree of specific immunity. [less ▲]

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