References of "Delattre, Luc"
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See detailDevelopment of a hydrogel containing GM-CSF to improve the dendritic cells colonisation of HPV+ epithelium
Evrard, Brigitte ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Proceedings of Eur conference on drug delivery and pharmaceutical technology (2004)

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See detailCharacterisation of a novel topical nanoemulsion vehicle with spreading properties
Roland, Isabelle ULg; Gillard, Patricia ULg; Delattre, Luc ULg et al

in Proceedings of Eur conference on drug delivery and pharmaceutical technology (2004)

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See detailSkin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay.
Piel, Géraldine ULg; Moutard, S.; Uhoda, Emmanuelle ULg et al

in European Journal of Pharmaceutics & Biopharmaceutics (2004), 57(3), 479-82

Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on ... [more ▼]

Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on human stratum corneum to compare the skin compatibility of CD currently used in pharmaceutical preparations (betaCD, gammaCD, Rameb, Dimeb, Trimeb, HP-betaCD and HP-gammaCD) and that of new amphiphilic CD derivatives, namely, the phospholipidyl-CD (DMPE-Dimeb and DMPE-Trimeb). All the tested CD were well tolerated by the stratum corneum at a concentration of 5%. However, inter-individual reactivity was larger for DMPE-Dimeb, suggesting a more aggressive trend for this compound. Cutaneous Index of Mildness values obtained confirm that Dimeb is able to extract some skin components and shows that DMPE-Dimeb performs similarly. [less ▲]

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See detailComparison of two methods currently used to determine the interaction between cyclodextrins and drugs: phase solubility diagrams and NMR spectroscopy
Piel, Géraldine ULg; Moutard, Stephane; Perly, Bruno et al

in Journal of Drug Delivery Science and Technology (2004), 14(1, JAN-FEB), 87-91

Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used ... [more ▼]

Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used to determine limitations of both techniques: betamethasone and miconazole, with three cyclodextrins: beta-cyclodextrine (betaCD), dimethylated-betaCD (Dimeb) and trimethylated-betaCD (Trimeb). This study shows that both techniques can give the same Kc value if they are used in exactly the same conditions with well defined cyclodextrins. As a matter of fact, if the degree of substitution of cyclodextrin is not well defined (as it is often the case with Dimeb), results are biased. This study also shows that when interactions between both molecules are weak (< 1000 M-1), stability constants can not be determined by NMR due to low chemical shift variations. The limitations of the phase solubility diagram method are an oversimplification of the solubility data which can lead to large errors in the calculation of the stability constant values. Moreover, this method is time and material consuming. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-410

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailInfluence de la methyl-b-cyclodextrine sur la cinetique de libération de l'inuline encapsulée dans des liposomes bioadhésifs
Piel, Géraldine ULg; Boulmedarat, Laila; Bochot, Amélie et al

Poster (2003, November 12)

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See detailThe skin compatibility of new cyclodextrin derivatives: the phospholipidyl-cyclodextrins
Piel, Géraldine ULg; Moutard, Stéphane; Uhoda, Emmanuelle ULg et al

Poster (2003, October)

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See detailSystematic characterization of oil-in-water emulsions for formulation design
Roland, Isabelle ULg; Piel, Géraldine ULg; Delattre, Luc ULg et al

in International Journal of Pharmaceutics (2003), 263(1-2), 85-94

Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out ... [more ▼]

Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out which tests should systematically be carried Out to assess efficiently the stability and the properties of ail emulsified preparation. Thus, formulation design requires at least the measurement of the droplet size, the determination of the zeta potential, a TurbiScan(R) analysis, the investigation of the stability under centrifugation and freeze/thaw cycles. If the emulsion contains an active substance, stability under storage at 4 degreesC and microscopic analysis are relevant. Quality Control Should be improved by measurements of viscosity and pH. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailSynthèse de b-cyclodextrines modifiées
Bertolla, Carine; Piette, Marie ULg; Evrard, Brigitte ULg et al

Poster (2003, May)

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See detailInfluence of cyclodextrins on the solubility and the stability of cyproterone acetate
Henry de Hassonville, Sandrine; Dive, Georges ULg; Prosperi, Christelle ULg et al

Conference (2003, May)

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See detailEtude de l'hyperactivité bronchique induite par l'administration pulmonaire de cyclodextrines chez la souris
Bertholet, Pascal; Guéders, Maud ULg; Barillaro, Valery et al

Conference (2003, January)

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See detailCyclodextrins as topical permeation enhancers : in vitro and in vivo testing
Henry de Hassonville, S.; Christiaens, B.; Piel, Géraldine ULg et al

Poster (2003)

Detailed reference viewed: 9 (2 ULg)