References of "Delattre, Luc"
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See detailContribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor
Evrard, Brigitte ULg; Bertholet, Pascal; Guéders, Maud ULg et al

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007), 57(1-4), 303-308

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or <br />nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion <br />complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

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See detailSupercritical fluid technology to produce solid lipid microparticles
Nizet, Dominique; Jaspart, Séverine ULg; Brion, Michael et al

Conference (2007)

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See detailEffect of cyclodextrins on the viability of endothelial cells
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2007), 57(1-4), 105-107

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See detailDEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT
Krier, Fabrice ULg; Nizet, Dominique; Riva, Raphaël ULg et al

Conference (2007)

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See detailControlled release of drugs from an original multi-component device
Nizet, dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

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See detailOptimization of drug-cyclodextrin complexation reaction by a static supercritical carbon dioxide method
Brion, Michael; Nizet, Dominique; Piel, Géraldine ULg et al

Conference (2007)

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See detailTheoretical and experimental investigations on miconazole/cyclodextrin/acid complexes: Molecular modeling studies
Barillaro, Valéry; Dive, Georges ULg; Bertholet, Pascal et al

in International Journal of Pharmaceutics (2007), 342(1-2), 152-160

The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present ... [more ▼]

The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present study, AM1 approximate molecular orbital calculations have been performed on several cyclodextrins complexes ( CD, HP CD and HP CD) with miconazole and acidic compounds (maleic, fumaric and L-tartaric acids) as partners. For all the binary complexes, the inclusion of the dichlorobenzene–CH2–O-group leads to the most stable complex. For the ternary complexes, depending on their conformation and/or their structures, the acids can either stabilize or destabilize the complex. All the theoretical results were in good agreement with experimental data of miconazole inclusion yields into cyclodextrins. This work clearly demonstrates that the structure of both cyclodextrin and acid plays a key-role in the formation of inclusion complexes. [less ▲]

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See detailEffect of cyclodextrin derivatives on bronchial epithelial cell layer permeability
Belhadj-Salem, Leila; Bosquillon, Cynthia; Delattre, Luc ULg et al

Poster (2007)

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See detailControlled release of drugs from an original multi-component device
Nizet, Dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

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See detailControlled release of drug from multicomponent device
Nizet, Dominique; Zalfen, Alina; Jérôme, Christine ULg et al

Poster (2007)

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See detailDevelopment of an original intra-uterine implant allowed specific release kinetics of several drugs
Nizet, Dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

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See detailLinking compaction dynamics to the flow properties of powders
Lumay, Geoffroy ULg; Vandewalle, Nicolas ULg; Delattre, Luc ULg et al

in Applied Physics Letters (2006), 89(9),

The authors have investigated the flow properties of powders by using two classical techniques based on the shear stress measurements and the count of intermittent avalanches, respectively. Results are ... [more ▼]

The authors have investigated the flow properties of powders by using two classical techniques based on the shear stress measurements and the count of intermittent avalanches, respectively. Results are compared with measurements of the compaction dynamics. Strong correlations are evidenced between compaction relaxation parameters and free flow characteristics. Those correlations are given by semiempirical laws based on physical arguments. This work opens perspectives in powder technology and the knowledge on granular matter. (c) 2006 American Institute of Physics. [less ▲]

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See detailComparison of FT-NIR transmission and UV-vis spectrophotometry to follow the mixing kinetics and to assay low-dose tablets containing riboflavin
Bodson, Cédric; Dewé, Walthère ULg; Hubert, Philippe ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2006), 41(3), 783-790

For several years, near-infrared spectroscopy (NIRS) has become an analytical technique of great interest for the pharmaceutical industry, particularly for the non-destructive analysis of dosage forms ... [more ▼]

For several years, near-infrared spectroscopy (NIRS) has become an analytical technique of great interest for the pharmaceutical industry, particularly for the non-destructive analysis of dosage forms. The goal of this study is to show the capacity of this new technique to assay the active ingredient in low-dosage tablets. NIR spectroscopy is a rapid, non-destructive technique and does not need any sample preparation. As an example, a binary mixture of microcrystalline cellulose and riboflavin was used to prepare tablets of different weights by direct compression. A prediction model was built by using a partial least square regression fit method. The NIR assay was performed by transmission. The results obtained by NIR spectroscopy were compared with a conventional UV-vis spectrophotometry method. The study showed that tablets can be individually analysed by NIR with high accuracy. It was shown that the variability of this new technique is less important than that of the conventional method which is the UV-vis spectrophotometry. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailPharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions
Piette, Marie ULg; Evrard, Brigitte ULg; Frankenne, Francis et al

in European Journal of Pharmaceutical Sciences (2006), 28(3), 189-195

Ro 28-2653 (5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione) is a new synthetic inhibitor of matrix metalloproteinases (MMPs) with a high selectivity towards MMP2, MMP9 and ... [more ▼]

Ro 28-2653 (5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione) is a new synthetic inhibitor of matrix metalloproteinases (MMPs) with a high selectivity towards MMP2, MMP9 and membrane type 1-MMP. It has been shown that cyclodextrins (CDs) are able to form inclusion complexes with Ro 28-2653 and to increase its aqueous solubility. The aim of this study is to demonstrate that an increase in Ro 28-2653 solubility, via ternary complex formation, can lead to an increase in the oral bioavailability of this drug. This study shows that a synergistic effect exists between hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and L-lysine. The use of this multicomponent system enabled the preparation of oral and intravenous solutions of Ro 28-2653. In vivo evaluation of the oral solution of the inclusion complex of Ro 28-2653 in comparison with a suspension of the same uncomplexed drug showed a significant (p < 0.05) increase in absolute bioavailability. The area under curve (AUC) and the peak serum concentration (C-max) were approximately 10 times higher than those obtained with the suspension, while the time (T-max) to reach C-max was reduced. Moreover, in vivo administration of Ro 28-2653 solutions highlighted some information about the pharmacokinetic behavior of Ro 28-2653: a long biologic half-life (about 15.5 h) and a small overall volume of distribution (81). (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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