Formulation and in vitro evaluation of inhalable dry powders containing solid lipid nanoparticles

Poster (2007)

Contribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007)

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

Encapsulation of betamethasone-HP-gCD complex in deformable liposomes

Poster (2007)

Controlled release of drugs from an original multi-component device

Poster (2007)

Optimisation de la réaction de complexation entre une cyclodextrine et un composé pharmaceutique par utilisation du CO2 supercritque

Conference (2007)

Theoretical and experimental investigations on miconazole/cyclodextrin/acid complexes: Molecular modeling studies

in International Journal of Pharmaceutics (2007), 342(1-2), 152-160

The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present ... [more ▼]

The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present study, AM1 approximate molecular orbital calculations have been performed on several cyclodextrins complexes ( CD, HP CD and HP CD) with miconazole and acidic compounds (maleic, fumaric and L-tartaric acids) as partners. For all the binary complexes, the inclusion of the dichlorobenzene–CH2–O-group leads to the most stable complex. For the ternary complexes, depending on their conformation and/or their structures, the acids can either stabilize or destabilize the complex. All the theoretical results were in good agreement with experimental data of miconazole inclusion yields into cyclodextrins. This work clearly demonstrates that the structure of both cyclodextrin and acid plays a key-role in the formation of inclusion complexes. [less ▲]

Controlled release of drugs from an original multi-component device

Poster (2007)

Development of an original intra-uterine implant allowed specific release kinetics of several drugs

Poster (2007)

Mucoadhesive composition comprising polyacrylate and chemoattractant

Patent (2006)

Linking compaction dynamics to the flow properties of powders

in Applied Physics Letters (2006), 89(9),

The authors have investigated the flow properties of powders by using two classical techniques based on the shear stress measurements and the count of intermittent avalanches, respectively. Results are ... [more ▼]

The authors have investigated the flow properties of powders by using two classical techniques based on the shear stress measurements and the count of intermittent avalanches, respectively. Results are compared with measurements of the compaction dynamics. Strong correlations are evidenced between compaction relaxation parameters and free flow characteristics. Those correlations are given by semiempirical laws based on physical arguments. This work opens perspectives in powder technology and the knowledge on granular matter. (c) 2006 American Institute of Physics. [less ▲]