References of "Delarge, J."
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See detailNew quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers
Somers, F.; Ouedraogo, R.; De Tullio, Pascal ULg et al

Conference (1998, February 14)

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See detailSéparation énantiomérique du pirlindole à l’échelle préparative
De Tullio, Pascal ULg; Ceccato, A.; Felekidis, Apostolos ULg et al

Poster (1998, January 16)

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See detailComparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques.
Bruhwyler, J.; Liégeois, Jean-François ULg; Gerardy, J. et al

in Behavioural Pharmacology (1998), 9(8), 731-7

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic ... [more ▼]

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic pirlindole (a selective and reversible MAO-A inhibitor) and its two enantiomers using biochemical techniques (in vitro and ex vivo determination of rat brain MAO-A and MAO-B activity) and behavioural models (forced swimming test and reserpine-induced hypothermia and palpebral ptosis test). In vitro, the MAO-A IC50 of (+/-)-pirlindole, R-(-)-pirlindole and S-(+)-pirlindole were 0.24, 0.43 and 0.18 microM, respectively. Ex vivo, their ID50 were 24.4, 37.8 and 18.7 mg/kg i.p. The differences between the three compounds were not significant, with a ratio between the two enantiomers [R-(-)/S-(+)] of 2.2 in vitro and 2.0 ex vivo. MAO-B was only slightly inhibited. In the forced swimming test and the reserpine-induced hypothermia and ptosis model, the three compounds had an antidepressant profile. In the forced swimming test, the minimal effective dose ratio between the R-(-) and the S-(+) was again around 2.0. The behavioural observations were thus clearly in accordance with the biochemical data. [less ▲]

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See detailDopamine D4 receptors, a new opportunity for research on schizophrenia
Liégeois, Jean-François ULg; Eyrolles, L.; Bruhwyler, J. et al

in Current Medicinal Chemistry (1998), 5

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindol
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailRésolution préparative du pirlindol, journées franco-belges de pharmacochimie
De Tullio, Pascal ULg; Felikidis, A.; Liégeois, Jean-François ULg et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes
Somers, F.; Rogister, F.; Ouedraogo, R. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas
Masereel, B.; Ouedraogo, R.; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detail3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

in European Journal of Pharmaceutical Sciences (1998), suppl.1

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See detailPreparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in European Journal of Pharmaceutical Sciences (1998), suppl.1

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See detailConception et synthèses d’activateurs potentiels de canaux potassiques sensibles à l’ATP et bioisostères du BMS 180448
Khelili, S.; Pirotte, Bernard ULg; Dupont, L. et al

in Journal de Pharmacie de Belgique (1998), 53

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