Comparaison d'une méthode "acide" et enzymatique pour le dosage de l'inuline

in Néphrologie & Thérapeutique (2010, September), 6(5), 316

Mesure de la PTH chez le patient hémodialysé avec une trousse de 2è ou de 3è génération: impact pour le clinicien

in Néphrologie & Thérapeutique (2010, September), 6(5), 397

Dosage de la vitamine D : attention aux erreurs analytiques!

in Annales d'Endocrinologie (2010, September), 71(5), 368

Détection précoce de l'hyperparathyroïdie secondaire : impact de l'établissement des valeurs de références de la parathormone

in 27ème Congrès de la Société Française d'Endocrinologie - Deauville, 29 septembre - 2 octobre 2010 (2010, September)

The Ratio of Parathyroid Hormone as Measured by Third- and Second-Generation Assays as a Marker for Parathyroid Carcinoma.

in Journal of Clinical Endocrinology and Metabolism (2010), 95

Background: Parathyroid carcinoma (PCa) is a rare disease that can be difficult to differentiate initially from severe benign parathyroid adenoma. PCa oversecrete the amino form of PTH, which is ... [more ▼]

Background: Parathyroid carcinoma (PCa) is a rare disease that can be difficult to differentiate initially from severe benign parathyroid adenoma. PCa oversecrete the amino form of PTH, which is recognized by third-generation but not by second-generation PTH immunoassays. In normal individuals, the third-generation to second-generation PTH ratio should be less than 1. Objective: Our objective was to study the utility of the third-generation to second-generation PTH ratio as a means of distinguishing PCa patients (n = 24) from control groups with and without disorders of calcium secretion, including patients on renal hemodialysis (n = 74), postrenal transplantation (n = 60), and primary hyperparathyroidism (PHP; n = 30). Setting and Design: We conducted a retrospective, laboratory-based study at tertiary referral academic centers. Results: The mean third-generation to second-generation ratio was 0.58 ± 0.10 in the dialysis patients, 0.54 ± 0.10 in the renal transplant group, 0.54 ± 0.12 in the elderly healthy patients, and 0.68 ± 0.11 in the PHP group. All 245 of these patients presented a PTH third-generation to second-generation ratio of less than 1. In contrast, we observed an inverted third-generation to second-generation PTH ratio of more than one in 20 PCa patients, whereas only four PCa patients had a normal ratio of less than 1. Conclusions: An inverted third-generation to second-generation PTH ratio occurred in the majority of patients with advanced PCa and was absent in all 245 relevant controls. A third-generation to second-generation PTH ratio higher than 1 had a sensitivity of 83.3% and a specificity of 100% among PHP patients as a marker for PCa. This ratio may be useful to identify patients with PCa earlier and to detect patients either at risk of developing PCa or those in whom recurrence is taking place. [less ▲]

Evaluation of Liaison Calcitonin II Gen, a new kit for Calcitonin determination

in Clinical Chemistry (2010, June), 56(S6), 188

Evaluation of the DiaSorin Liaison 1-84 PTH Assay, a new automated immunoassay for the determination of the 3rd Generation PTH

in Clinical Chemistry (2010, June), 56(S6), 56

Donor-Estimated Glomerular Filtration Rate as a Criterion for Allocation of Expended Criteria Donors Kidney into Single or Dual Transplantation : The Choice of the Estimating Equation Matters

in American Journal of Transplantation (2010, April), 10(sp Iss SI Suppl 4), 443

Analytical validation of the BAP OSTASE on Liaison (DiaSorin).

in Clinical Chemistry & Laboratory Medicine (2010), 48(1), 67-72

Effects of large pore hemofiltration in a swine model of fulminant hepatic failure

in Acta Gastro-Enterologica Belgica (2010), 73(1), 35