References of "Delanaye, Pierre"
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See detailInterpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg; VRANKEN, Laura ULg et al

in Nephrology Dialysis Transplantation (2012), 27

Background. The recommended target range for serum parathyroid hormone (PTH) in dialysis patients has changed from 150 to 300 pg/mL in the KDOQI guidelines to two to nine times the upper normal limit in ... [more ▼]

Background. The recommended target range for serum parathyroid hormone (PTH) in dialysis patients has changed from 150 to 300 pg/mL in the KDOQI guidelines to two to nine times the upper normal limit in the KDIGO ones. Although inclusion/exclusion criteria for the reference population are highly important, they are usually not mentioned in the commercial kits. In this study, we used the same reference population of vitamin D-replete normal subjects to establish reference values for 10 commercial PTH kits. We evaluated whether this may improve the classification of dialysis patients according to the KDIGO compared to the use of reference values proposed by the manufacturers. Methods. We measured serum PTH with 10 different kits in 149 haemodialysis patients, and 240 25-OH-vitamin D-replete (>75 nmol/L) individuals with an estimated glomerular filtration rate >60 mL/min/1.73 m2. Results. For the 10 kits, our upper normal limit was lower than those of the manufacturers. The difference was, however, variable from one kit to another. The two kits that yielded the lowest and the highest absolute concentrations classified differently 84/149 patients (56.4%) according to the KDOQI and 53/149 (36.2%) according to the KDIGO using the manufacturers’ normal value.Using our normal values significantly decreased the discrepancies with 24/149 patients (16.1%) being still classified differently. Taking the measurement uncertainty into consideration, 8% of the patients only remained differently classified by these two kits. Conclusions. Using the same vitamin-D-replete population to establish the reference range for 10 commercial PTH kits significantly improved the classification of haemodialysis patients according to the KDIGO target range. [less ▲]

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See detailVascular calcifications in chronic kidney disease: can the Biologist be of some help?
Bargnoux, Anne-Sophie; Morena, Marion; Dupuy, Anne-Marie et al

in DELANAYE, Pierre (Ed.) Clinical Chemistry and Nephrology: the essential link (2012)

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See detailLe débit de filtration glomérulaire est-il un déterminant de la concentration plasmatique du NGAL aux soins intensifs ?
DELANAYE, Pierre ULg; Claisse, Guillaume; Mehdi, Manoli et al

Poster (2012)

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See detailHow Measuring Glomerular Filtration Rate? Comparison of reference methods
DELANAYE, Pierre ULg

in Sahay, Manisha (Ed.) Basic Nephrology and Acute Kidney injury (2012)

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See detailAssessment of kidney function: estimating GFR in children.
DELANAYE, Pierre ULg; Ebert, Natalie

in Nature Reviews Nephrology (2012), 8(9), 503-504

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See detailMaintenir la PTH entre 2 et 9 fois la valeur de référence supérieure du Laboratoire: d'accord, mais quelle valeur???
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg; Souberbielle, Jean-Claude

in Néphrologie & Thérapeutique (2011, October), 7(5), 411-44727

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See detailTumor-induced osteomalacia: The tumor may stay hidden!
van der Rest, Catherine; CAVALIER, Etienne ULg; KAUX, Jean-François ULg et al

in Clinical Biochemistry (2011), 44(14-15), 1264-6

We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth ... [more ▼]

We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not be excised. [less ▲]

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See detailEstimating glomerular filtration rate in Asian subjects: where do we stand?
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Mariat, Christophe et al

in Kidney International (2011), 80(5), 439-440

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See detailEstimation du débit de filtration glomérulaire en transplantation rénale: étude multicentrique d'évaluation de la performance de la cystatine C
Masson, I.; Maillard, N.; Jaafar, A. et al

in Néphrologie & Thérapeutique (2011, September), 7(5), 290-91

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See detailDétection de la maladie rénale chronique dans la population générale: créatinine ou cystatine C?
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; KRZESINSKI, Jean-Marie ULg

in Néphrologie & Thérapeutique (2011, September), 7(5), 298

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See detailVitamin D and type 2 diabetes mellitus: Where do we stand?
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg; SOUBERBIELLE, J.-C. et al

in Diabètes & Métabolism (2011), 37(4), 265-72

AIMS: In-vitro and observational studies have established a link between vitamin D deficiency and different type 2 diabetes outcomes (insulin resistance, insulin secretion, glucose intolerance). Although ... [more ▼]

AIMS: In-vitro and observational studies have established a link between vitamin D deficiency and different type 2 diabetes outcomes (insulin resistance, insulin secretion, glucose intolerance). Although the number of randomized controlled trials vs placebo is small, vitamin D (VTD) has been shown to prevent increases in glucose concentration and insulin resistance, enhance insulin sensitivity and reduce systolic blood pressure in type 2 diabetic patients. METHODS: In this review, we have focused on the potential mechanisms that might explain the association between VTD and type 2 diabetes mellitus (T2DM). We have also evaluated the different epidemiological and observational studies on the topic, as well as the various interventional studies. RESULTS: Although the in vitro studies appear to be promising in explaining the link between VTD metabolism and T2DM, the results of in vivo studies are conflicting. This could be related to differences in their methodological approaches. CONCLUSION: Although more studies are needed to confirm the role of VTD in the treatment of T2DM, there is nevertheless enough evidence at this time to suggest a need to maintain 25-OH vitamin D levels in T2DM patients around 30ng/mL over the course of a year. [less ▲]

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See detailTrimethoprim, creatinine and creatinine-based equations
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Mariat, Christophe et al

in Kidney International (2011), 80(5), 439-40

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis ... [more ▼]

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate (GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation. [less ▲]

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