New insights on the stability of the (1-84) PTH as determined with an automated 3rd generation PTH assay

in Clinical Chemistry (2011, October), 57(S10), 190

Maintenir la PTH entre 2 et 9 fois la valeur de référence supérieure du Laboratoire: d'accord, mais quelle valeur???

in Néphrologie & Thérapeutique (2011, October), 7(5), 411-44727

Estimating glomerular filtration rate in Asian subjects: where do we stand?

in Kidney International (2011), 80(5), 439-440

Estimation du débit de filtration glomérulaire en transplantation rénale: étude multicentrique d'évaluation de la performance de la cystatine C

in Néphrologie & Thérapeutique (2011, September), 7(5), 290-91

Suivi à court et à long terme de la concentration de parathormone chez le patient hémodialysé: dosage de seconde et troisième génération

in Néphrologie & Thérapeutique (2011, September), 7(5), 320

Définition d'un débit de filtration "normal" fixe ou adapté à l'âge et au genre: impact sur l'épidémiologie de la maladie rénale chronique

in Néphrologie & Thérapeutique (2011, September), 7(5), 404-405

Trimethoprim, creatinine and creatinine-based equations

in Kidney International (2011), 80(5), 439-40

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis ... [more ▼]

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate (GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation. [less ▲]

New insights on the stability of the (1-84) PTH as determined with an automated 3rd generation PTH assay.

Poster (2011, July 28)

Native vitamin D in dialysis patients : safety and biological effects

Conference (2011, June 25)

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We ... [more ▼]

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We designed a randomized double-blind prospective study comparing the effects of VTD and placebo in dialysis patients on mortality, vascular calcifications and different paremeters: 25-OH vitamine D- 25(OH)D -, parathormone (PTH), calcium and phosphorus. [less ▲]

Are the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations ?

in Clinical Journal of the American Society of Nephrology (2011), 6

Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence of early stages of chronic kidney disease in this specific population. Because serum ... [more ▼]

Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence of early stages of chronic kidney disease in this specific population. Because serum creatinine concentration is dependent on muscular mass, an ethnic factor has to be applied to creatinine-based equations. Such ethnic factors have been proposed in the Modification of Diet in Renal Disease (MDRD) study equation and in the more recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. This review analyzes how these correction factors have been developed and how they have, or have not, been validated in external populations. It will be demonstrated that the African American factor in the MDRD study equation is accurate in African American chronic kidney disease (CKD) patients. However, it will be shown that this factor is probably too high for subjects with a GFR of >60 ml/min per 1.73 m2, leading to an underestimation of the prevalence of CKD in the global African American population. It will also be confirmed that this ethnic factor is not accurate in African (non-American) subjects. Lastly, the lack of true external validation of the new CKD-EPI equations will be discussed. Additional trials seem necessary in American African and African populations to better estimate GFR and apprehend the true prevalence of CKD in this population with a high renal risk. [less ▲]