References of "Delanaye, Pierre"
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See detailIndexing Glomerular Filtration Rate for Body Surface Area: Myth and Reality
DELANAYE, Pierre ULg; Mariat, Christophe; CAVALIER, Etienne ULg et al

in Krüger, E.; Hahn, K. (Eds.) Nephrology Dialysis Transplantation (2009)

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See detailEstimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Radermecker, Régis ULg et al

in Clinical Nephrology (2009), 71(5), 482-91

Background: Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the ... [more ▼]

Background: Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the accuracy and precision of cystatin C-based equations. Method: 27 AN patients were included. GFR was measured with the chromium-51-ethylenediaminetetraacetate (51Cr-EDTA) method. We have compared the accuracy and precision of creatinine-based equations (MDRD and Cockcroft) with those of different new cystatin C-based equations. Results: The creatinine-based equations overestimate measured GFR, especially the MDRD study equation. All the cystatin C-based equations also overestimate measured GFR. The Cockcroft and Gault formula and the cystatin C-based equation published by Rule have the best accuracy and precision, but these last performances remain unsatisfactory. Conclusion: Both creatinine and cystatin C-based equations strongly overestimate measured in patients with AN. [less ▲]

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See detailAn unusual interference in parathormone assay caused by anti-goat IgG: a case report.
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Carlisi, Ignazia ULg et al

in Clinical Chemistry & Laboratory Medicine (2009), 47(1), 118

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See detailPrevalence of chronic kidney disease in Kinshasa: results of a pilot study from the Democratic Republic of Congo
Sumaili, Ernest K.; Krzesinski, Jean-Marie ULg; Zinga, Chantal V. et al

in Nephrology Dialysis Transplantation (2009), 24(1), 117-122

Abstract Background. The burden of chronic kidney disease (CKD) in sub-Saharan Africa is unknown. The aim of this study was to investigate the prevalence and the risk factors associated with CKD in ... [more ▼]

Abstract Background. The burden of chronic kidney disease (CKD) in sub-Saharan Africa is unknown. The aim of this study was to investigate the prevalence and the risk factors associated with CKD in Kinshasa, the capital of the Democratic Republic of Congo (DRC). Methods. In a cross-sectional study, 503 adult residents in 10 of the 35 health zones of Kinshasa were studied in a randomly selected sample. Glomerular filtration rate was estimated using the simplified Modification of Diet in Renal Disease Study equation (eGFR) and compared with the Cockcroft–Gault equation for creatinine clearance. The associations between health characteristics, indicators of kidney damage (proteinuria) and kidney function (<60 ml/min/1.73 m2) were examined. Results. The prevalence of all stages of CKD according to K/DOQI guidelines was 12.4% [95% confidence interval (CI), 11.0–15.1%]. By stage, 2% had stage 1 (proteinuria with normal eGFR), 2.4% had stage 2 (proteinuria with an eGFR of 60–89 ml/min/1.73 m2), 7.8% had stage 3 (eGFR, 30–59 ml/min/1.73 m2) and 0.2% had stage 5 (eGFR < 15 ml/min/1.73 m2). Hypertension and age were independently associated with CKD stage 3. The prevalences of major non-communicable diseases considered in this study were 27.6% (95% CI, 25.7–31.3%) for hypertension, 11.7% (95% CI, 10.3–14.4%) for diabetes mellitus and 14.9% (95% CI, 13.3–17.9%) for obesity. Hypertension was also independently associated with proteinuria. Conclusion. More than 10% of the Kinshasa population exhibits signs of CKD, which is affecting adults in their productive years. Risk factors for CKD, including hypertension, diabetes and obesity, are increasing. These alarming data must guide current and future healthcare policies to meet the challenge raised by CKD in this city and hopefully in the whole country. [less ▲]

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See detailDiscrepancies between creatinine-based and cystatin C-based equations in estimating prevalence of stage 3 chronic kidney disease in an elderly population.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Saint-Remy, Annie ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (2009), 69(3), 344-9

Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration ... [more ▼]

Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration rate (GFR). Cystatin C-based equations are also being used to estimate GFR. Using creatinine-based and cystatin C-based equations, the aim of our study was to measure the difference in prevalence of stage 3 CKD in a population. Methods . CKD screening is organized in the Province of Liege, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited for screening. GFR is estimated using the MDRD study equation and by the three recent cystatin C-based equations proposed by Levey's group. The Levey 1 equation is based on cystatin C only and the Levey 2 equation on cystatin C corrected for age and sex. The Levey 3 equation combines cystatin C, creatinine, age and sex. Results . The population screened comprised 754 people. Cystatin C is highly correlated with creatinine (r = 0.6196, p<0.0001). Prevalence of stage 3 CKD when GFR is estimated by the MDRD equation study is 17.2 %, which is significantly and much higher than the prevalence obtained when cystatin C-based equations are used. Indeed, prevalence is 2 %, 3.3 % and 5.8 % with the Levey 1, 2 and 3 equations, respectively. Conclusions . The prevalence of stage 3 CKD varies strongly following the method used for estimating GFR, creatinine-based or cystatin C-based equations. Such discrepancies must be confirmed and explained in additional studies using GFR measured with a reference method. [less ▲]

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See detailErrors induced by indexing glomerular filtration rate for body surface area: reductio ad absurdum.
Delanaye, Pierre ULg; Mariat, Christophe; Cavalier, Etienne ULg et al

in Nephrology Dialysis Transplantation (2009), 24(12), 3593-6

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See detailIndexation du debit de filtration glomerulaire par la surface corporelle : mythe et realite
Delanaye, Pierre ULg; Mariat, Christophe; Cavalier, Etienne ULg et al

in Néphrologie & Thérapeutique (2009), 5(7), 614-22

Indexing glomerular filtration rate (GFR) for body surface area (BSA) is often realized without arising any questions. However, physiological basis for such an indexation are very poor. Indeed, indexing ... [more ▼]

Indexing glomerular filtration rate (GFR) for body surface area (BSA) is often realized without arising any questions. However, physiological basis for such an indexation are very poor. Indeed, indexing GFR for BSA to avoid variation due to differences in body size necessarily implies that GFR is a linear function of BSA and that the intercept of this linear function is zero. Moreover, when GFR is indexed for BSA, the relation indexed GFR-BSA must completely disappear. These physiological prerequisites are not found for BSA indexation. We will review the history of this indexation and will underline errors and defaults. Different equations to estimate BSA exist and will be discussed. The choice of "1.73m(2)" will be also criticized. Moreover, indexing GFR for BSA has little impact on GFR results in "normal" body size population. Nevertheless, this indexation will have strong consequences in very lean (such as anorexia) and in obese patients. We will discuss possible alternatives proposed to substitute for BSA indexation. [less ▲]

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See detailVitamin D: current status and perspectives.
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Chapelle, Jean-Paul ULg et al

in Clinical Chemistry & Laboratory Medicine (2009), 47(2), 120-127

Abstract The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25 ... [more ▼]

Abstract The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)(2) vitamin D, has led to a very promising future for this "old" molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels <30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level <30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents. Clin Chem Lab Med 2009;47. [less ▲]

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See detailEtude analytique des trois trousses de cystatine C et impact sur les formules basées sur la cystatine pour l'estimation du DFG.
Cavalier, Etienne ULg; Péroni, Laurence; Abshoff, Christelle et al

in Néphrologie & Thérapeutique (2008, November), 4(6), 399-400

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See detailAnalytical Validation of Diasorin Liaison and Roche Elecsys Methods for the Determination of Osteocalcin
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Carlisi, Ignazia ULg et al

in Journal of Bone and Mineral Research (2008, September), 23

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See detailL'insuffisance rénale et sa prise en charge
Krzesinski, Jean-Marie ULg; DELANAYE, Pierre ULg; Smelten, Nicole ULg et al

in Revue Médicale de Liège (2008, March 13)

Chronic kidney disease is a worldwide growing problem, especially nowadays due to 3 factors very often encountered together (old age, diabetes mellitus and arterial hypertension) A multidisciplinary ... [more ▼]

Chronic kidney disease is a worldwide growing problem, especially nowadays due to 3 factors very often encountered together (old age, diabetes mellitus and arterial hypertension) A multidisciplinary approach is needed to reduce this epidemic with important health implication. This needs of course well trained health partners. On the occasion of the world kidney day on March 2008, five lectures were given on the topic. The lecturers have insisted on the up to date management of chronic kidney insufficiency, a serious problem of public health. [less ▲]

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See detailFalse positive PTH results: An easy strategy to test and detect analytical interferences in routine practice
Cavalier, Etienne ULg; Carlisi, Agnès; Chapelle, Jean-Paul ULg et al

in Clinica Chimica Acta (2008), 387(1-2), 150-152

Background: As other immunoassays, PTH determination is not free from interferences. Indeed, natural antibodies like heterophile antibodies (HAMA) and rheumatoid factor (RF) can induce falsely elevated ... [more ▼]

Background: As other immunoassays, PTH determination is not free from interferences. Indeed, natural antibodies like heterophile antibodies (HAMA) and rheumatoid factor (RF) can induce falsely elevated results, leading to misdiagnosis and expensive unnecessary explorations. However, in routine practice, these interferences are not always obvious to detect. Methods: On 2084 PTH samples, we applied a validation strategy in four steps to screen for HAMA and rheumatoid factor interferences. Results: 36% of our samples presented an elevated PTH. We found a clinically plausible reason for 91% of them. The remaining 63 suspicious samples were treated with HBT and 40% of them were found to be HAMA positive. RF determination was performed on the HAMA-negative samples and RE was positive in 21 of them. They were then treated with RF-Absorbent. Nine of these 21 samples presented RE interference. Conclusion: Applying this strategy in our routine validation, we managed to avoid spuriously elevated PTH results, which could have caused medical errors as well as unnecessary cost-effective extra-investigations. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailCystatine C: point d'etape et perspectives.
Seronie-Vivien, Sophie; Delanaye, Pierre ULg; Pieroni, Laurence et al

in Annales de Biologie Clinique (2008), 66(3), 301-23

Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production ... [more ▼]

Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine. This paper intends to summarize the current knowledge about the physiology of cystatin C and about its use as a renal marker, alone or within formulas developed to estimate the glomerular filtration rate. Moreover, this paper reviews the recent data about potential other applications of cystatin C, especially in cardiology, in oncology and in clinical pharmacology. [less ▲]

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See detailCystatin C: current position and future prospects.
Séronie-Vivien, Sophie; Delanaye, Pierre ULg; Piéroni, Laurence et al

in Clinical Chemistry & Laboratory Medicine (2008), 46(12), 1664-1686

Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by ... [more ▼]

Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86. [less ▲]

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