Estimation of the Stability of Parathyroid Hormone when Stored at -80°C for a Long Period
Cavalier, Etienne ; Delanaye, Pierre ; Hubert, Philippe et al
in Clinical Journal of the American Society of Nephrology (2009), 4(12), 1988-92Detailed reference viewed: 48 (22 ULg)
Prevalence of Chronic Kidney Disease in an Elderly Population: Impact of the Choice of the Equation Used for Estimating GFR
; Cavalier, Etienne ; et al
Poster (2009, October)Detailed reference viewed: 17 (6 ULg)
Establishment of a reference range for the Bone Alkaline Phosphatase (BAP) with Diasorin Liaison in a biologically well-designed population.
Cavalier, Etienne ; Delanaye, Pierre ; Bekaert, Anne-Catherine et al
in Clinical Chemistry (2009, June), 55(S6), 178Detailed reference viewed: 40 (4 ULg)
ANALYTICAL PERFORMANCE OF THE C-TERMINAL FGF-23 (IMMUTOPICS)
Cavalier, Etienne ; Rozet, Eric ; Carlisi, Ignazia et al
in Clinical Chemistry & Laboratory Medicine (2009, June), 47(M-A032),Detailed reference viewed: 57 (9 ULg)
Détection et estimation du niveau de la maladie rénale chronique
Delanaye, Pierre ; Cavalier, Etienne ; et al
in Revue Médicale de Liège (2009), 64(2), 73-78
L’insuffisance rénale voit son incidence augmenter. Un diagnostic précoce et précis est requis. Le diagnostic de l’insuffisance rénale repose sur la mesure du débit de filtration glomérulaire. Les ... [more ▼]
L’insuffisance rénale voit son incidence augmenter. Un diagnostic précoce et précis est requis. Le diagnostic de l’insuffisance rénale repose sur la mesure du débit de filtration glomérulaire. Les formules basées sur la créatinine pour déterminer ce débit ont, par rapport à la créatinine sérique seule, apporté un plus mais, dans certaines situations, elles fournissent des résultats erronés. Le recours à la mesure de la clairance de créatinine sur une récolte d’urines de 24 heures peut être, dans ces situations où les caractéristiques anthropométriques sont hors normes, utile, mais avec toujours la difficulté d’une récolte minutée correcte. Si une mesure précise du débit de filtration glomérulaire est absolument nécessaire, une méthode de référence doit être choisie telle celle au chrome EDTA ou à l’iohexol. Enfin, tout bilan néphrologique doit, outre le dosage de créatinine, comprendre au moins une analyse d’urine à la tigette. Toute positivité pour la protéinurie lors de ce test mérite de réaliser un dosage quantitatif de la protéinurie soit sur 24 heures, soit plus aisément sur un échantillon [less ▲]Detailed reference viewed: 124 (19 ULg)
Pertes de nutriments lors de procédures d’épuration extrarénale
WIESEN, Patricia ; VAN OVERMEIRE, Lionel ; DELANAYE, Pierre et al
in Réanimation (2009), 18Detailed reference viewed: 6 (0 ULg)
Influence de la largeur des pores des membranes utilisées au cours de l’hémofiltration et du débit d’ultrafiltration sur la clairance plasmatique de l’interleukine 6 dans un modèle porcin de choc septique.
Delanaye, Pierre ; Janssen, Nathalie ; Dogné, Jean-Michel et al
in Réanimation (2009), 18(1), 037Detailed reference viewed: 53 (19 ULg)
Estimation de filtration glomérulaire chez le patient obese: performances des équations basées sur la créatinine et la cystatine C.
DELANAYE, Pierre ; Cavalier, Etienne ; RORIVE, Marcelle et al
in Néphrologie & Thérapeutique (2009), 5(5), 351-352Detailed reference viewed: 16 (3 ULg)
On the demanding necessity of properly evaluating renal graft function in clinical trials.
; ; et al
in Transplant International (2009), 22(2), 247-8Detailed reference viewed: 46 (8 ULg)
Indexing Glomerular Filtration Rate for Body Surface Area: Myth and Reality
DELANAYE, Pierre ; ; CAVALIER, Etienne et al
in Krüger, E.; Hahn, K. (Eds.) Nephrology Dialysis Transplantation (2009)Detailed reference viewed: 7 (3 ULg)
Estimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa.
Delanaye, Pierre ; Cavalier, Etienne ; Radermecker, Régis et al
in Clinical Nephrology (2009), 71(5), 482-91
Background: Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the ... [more ▼]
Background: Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the accuracy and precision of cystatin C-based equations. Method: 27 AN patients were included. GFR was measured with the chromium-51-ethylenediaminetetraacetate (51Cr-EDTA) method. We have compared the accuracy and precision of creatinine-based equations (MDRD and Cockcroft) with those of different new cystatin C-based equations. Results: The creatinine-based equations overestimate measured GFR, especially the MDRD study equation. All the cystatin C-based equations also overestimate measured GFR. The Cockcroft and Gault formula and the cystatin C-based equation published by Rule have the best accuracy and precision, but these last performances remain unsatisfactory. Conclusion: Both creatinine and cystatin C-based equations strongly overestimate measured in patients with AN. [less ▲]Detailed reference viewed: 71 (17 ULg)
An unusual interference in parathormone assay caused by anti-goat IgG: a case report.
Cavalier, Etienne ; Delanaye, Pierre ; Carlisi, Ignazia et al
in Clinical Chemistry & Laboratory Medicine (2009), 47(1), 118Detailed reference viewed: 34 (8 ULg)
Estimation du debit de filtration glomérulaire chez le patient obese: performances des équations basées sur la créatinine et la cystatine C
Delanaye, Pierre ; Cavalier, Etienne ; Rorive, Marcelle et al
in Néphrologie & Thérapeutique (2009), 5(5), 003Detailed reference viewed: 52 (8 ULg)
Prevalence of chronic kidney disease in Kinshasa: results of a pilot study from the Democratic Republic of Congo
; Krzesinski, Jean-Marie ; et al
in Nephrology Dialysis Transplantation (2009), 24(1), 117-122
Abstract Background. The burden of chronic kidney disease (CKD) in sub-Saharan Africa is unknown. The aim of this study was to investigate the prevalence and the risk factors associated with CKD in ... [more ▼]
Abstract Background. The burden of chronic kidney disease (CKD) in sub-Saharan Africa is unknown. The aim of this study was to investigate the prevalence and the risk factors associated with CKD in Kinshasa, the capital of the Democratic Republic of Congo (DRC). Methods. In a cross-sectional study, 503 adult residents in 10 of the 35 health zones of Kinshasa were studied in a randomly selected sample. Glomerular filtration rate was estimated using the simplified Modification of Diet in Renal Disease Study equation (eGFR) and compared with the Cockcroft–Gault equation for creatinine clearance. The associations between health characteristics, indicators of kidney damage (proteinuria) and kidney function (<60 ml/min/1.73 m2) were examined. Results. The prevalence of all stages of CKD according to K/DOQI guidelines was 12.4% [95% confidence interval (CI), 11.0–15.1%]. By stage, 2% had stage 1 (proteinuria with normal eGFR), 2.4% had stage 2 (proteinuria with an eGFR of 60–89 ml/min/1.73 m2), 7.8% had stage 3 (eGFR, 30–59 ml/min/1.73 m2) and 0.2% had stage 5 (eGFR < 15 ml/min/1.73 m2). Hypertension and age were independently associated with CKD stage 3. The prevalences of major non-communicable diseases considered in this study were 27.6% (95% CI, 25.7–31.3%) for hypertension, 11.7% (95% CI, 10.3–14.4%) for diabetes mellitus and 14.9% (95% CI, 13.3–17.9%) for obesity. Hypertension was also independently associated with proteinuria. Conclusion. More than 10% of the Kinshasa population exhibits signs of CKD, which is affecting adults in their productive years. Risk factors for CKD, including hypertension, diabetes and obesity, are increasing. These alarming data must guide current and future healthcare policies to meet the challenge raised by CKD in this city and hopefully in the whole country. [less ▲]Detailed reference viewed: 106 (5 ULg)
Discrepancies between creatinine-based and cystatin C-based equations in estimating prevalence of stage 3 chronic kidney disease in an elderly population.
Delanaye, Pierre ; Cavalier, Etienne ; Saint-Remy, Annie et al
in Scandinavian Journal of Clinical & Laboratory Investigation (2009), 69(3), 344-9
Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration ... [more ▼]
Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration rate (GFR). Cystatin C-based equations are also being used to estimate GFR. Using creatinine-based and cystatin C-based equations, the aim of our study was to measure the difference in prevalence of stage 3 CKD in a population. Methods . CKD screening is organized in the Province of Liege, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited for screening. GFR is estimated using the MDRD study equation and by the three recent cystatin C-based equations proposed by Levey's group. The Levey 1 equation is based on cystatin C only and the Levey 2 equation on cystatin C corrected for age and sex. The Levey 3 equation combines cystatin C, creatinine, age and sex. Results . The population screened comprised 754 people. Cystatin C is highly correlated with creatinine (r = 0.6196, p<0.0001). Prevalence of stage 3 CKD when GFR is estimated by the MDRD equation study is 17.2 %, which is significantly and much higher than the prevalence obtained when cystatin C-based equations are used. Indeed, prevalence is 2 %, 3.3 % and 5.8 % with the Levey 1, 2 and 3 equations, respectively. Conclusions . The prevalence of stage 3 CKD varies strongly following the method used for estimating GFR, creatinine-based or cystatin C-based equations. Such discrepancies must be confirmed and explained in additional studies using GFR measured with a reference method. [less ▲]Detailed reference viewed: 35 (4 ULg)
Human anti-mouse antibodies interferences in Elecsys PTH assay after OKT3 treatment.
Cavalier, Etienne ; Carlisi, Ignazia ; Chapelle, Jean-Paul et al
in Transplantation (2009), 87(3), 451-2Detailed reference viewed: 60 (6 ULg)
Mesure du débit de filtration glomérulaire aux soins intensifs basée sur l’iohexol : clairance plasmatique ou urinaire ?
Delanaye, Pierre ; Cavalier, Etienne ; Lambermont, Bernard et al
in Réanimation (2009), 18(1), 112Detailed reference viewed: 112 (15 ULg)
Errors induced by indexing glomerular filtration rate for body surface area: reductio ad absurdum.
Delanaye, Pierre ; ; Cavalier, Etienne et al
in Nephrology Dialysis Transplantation (2009), 24(12), 3593-6Detailed reference viewed: 17 (10 ULg)
Indexation du debit de filtration glomerulaire par la surface corporelle : mythe et realite
Delanaye, Pierre ; ; Cavalier, Etienne et al
in Néphrologie & Thérapeutique (2009), 5(7), 614-22
Indexing glomerular filtration rate (GFR) for body surface area (BSA) is often realized without arising any questions. However, physiological basis for such an indexation are very poor. Indeed, indexing ... [more ▼]
Indexing glomerular filtration rate (GFR) for body surface area (BSA) is often realized without arising any questions. However, physiological basis for such an indexation are very poor. Indeed, indexing GFR for BSA to avoid variation due to differences in body size necessarily implies that GFR is a linear function of BSA and that the intercept of this linear function is zero. Moreover, when GFR is indexed for BSA, the relation indexed GFR-BSA must completely disappear. These physiological prerequisites are not found for BSA indexation. We will review the history of this indexation and will underline errors and defaults. Different equations to estimate BSA exist and will be discussed. The choice of "1.73m(2)" will be also criticized. Moreover, indexing GFR for BSA has little impact on GFR results in "normal" body size population. Nevertheless, this indexation will have strong consequences in very lean (such as anorexia) and in obese patients. We will discuss possible alternatives proposed to substitute for BSA indexation. [less ▲]Detailed reference viewed: 47 (8 ULg)