References of "Defraigne, Jean-Olivier"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailResponse to Comment on “High Levels of 18F-FG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress”
Sakalihasan, Natzi ULg; Defraigne, Jean-Olivier ULg; Xu, Yun

in European Journal of Vascular and Endovascular Surgery (2010), 39

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailNon complicated large complex tear in an aneurysmal Marfan ascending aorta.
Brüls, Samuel ULg; Radermacher, Vincent ULg; de Leval, Laurence ULg et al

in Annals of Thoracic Surgery (2010), 89(5), 1674

Detailed reference viewed: 66 (27 ULg)
Full Text
Peer Reviewed
See detailEffects of large pore hemofiltration in a swine model of fulminant hepatic failure
Detry, Olivier ULg; Janssen, Nathalie ULg; Cheramy-Bien, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2010, April), 110

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailConsequences of laparoscopy on liver ischemia during portal triad clamping in a swine model
Nsadi, Berthier; Pire, E.; Gilson, Nathalie ULg et al

in Acta Chirurgica Belgica (2010, April), 110

Detailed reference viewed: 36 (7 ULg)
Full Text
Peer Reviewed
See detailComparison between platelet-rich plasma (PRP) and vascular endothelial growth factor-111 (VEGF-111) as a therapeutic tool in tendon healing process
Kaux, Jean-François ULg; Drion, Pierre ULg; Libertiaux, Vincent ULg et al

Poster (2010, March 20)

Introduction In spite of the availability of various treatments for tendinopathy, this pathology often becomes chronic. For this reason, it is of interest to develop new treatments. Among them, the ... [more ▼]

Introduction In spite of the availability of various treatments for tendinopathy, this pathology often becomes chronic. For this reason, it is of interest to develop new treatments. Among them, the injection of platelet-rich plasma (PRP) seems to be a promising one. Indeed, several animal models have demonstrated that injection of blood platelets can initiate and stimulate tendon and ligament repair by releasing growth factors (GF) locally. Among all the GF released by activated platelets, the vascular endothelial growth factor-A (VEGF-A) is known to induce positive effects on vascular function and angiogenesis, and could be implicated in the healing process of tendons. Recently, a novel VEGF-A isoform was identified, the VEGF-111, a biologically active and proteolysis-resistant VEGF-A isoform, also known to present beneficial effects on ischemic diseases. This prompted us to evaluate whether VEFF-111 would have a therapeutic interest within the framework of the tendon pathology. Aim of the study: We hypothesized that the healing of ruptured Achilles tendons, which is the last stage of the Blazina’s classification, could be improved by injection of VEGF-111 that was compared to the potential effect of PRP injections using a rat model. Methods: A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats were divided into 3 groups: A: control (no injection), B: PRP treatment and C: VEGF-111 treatment. Rats received a local injection of PRP (50µL) or VEGF-111 (100ng) in situ after the surgery and were placed in their cage without immobilization. After 5, 15 and 30 days, the rats were euthanized in each group. The traumatized Achilles tendon of each rat was removed and dissected during the healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Results: Our results show that developed force necessary to induce tendon rupture during biomechanical tensile test was more important for tendons which had received an injection of PRP or VEGF-111. Moreover, the tensile force necessary to break tendons is higher with PRP than with VEGF-111. These results were already noticed from day 5 onwards. Conclusion: This experimentation has shown that both PRP and VEGF-111 injections stimulated tendon healing process as suggested by the increased force needed to break tendons during its healing process. Furthermore, this acceleration of the cicatrisation process was more significant with PRP than with VEGF-111. This could be explained by the release from platelets of a “cocktail” of growth factors acting in synergy on the healing process. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

Detailed reference viewed: 109 (33 ULg)
Full Text
Peer Reviewed
See detailPlatelet-rich plasma (PRP) increases healing process of rats' Achilles tendons
Kaux, Jean-François ULg; Drion, Pierre ULg; Pascon, Frédéric ULg et al

Conference (2010, March 20)

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy ... [more ▼]

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy, physiotherapy, corticosteroid infiltrations, extracorporeal shock waves… Recently, several studies, essentially in vitro, demonstrated the positive effects of platelets on the healing process of different tissues: bones, muscles and tendons. Objectives The aim of our experiment was to ascertain whether the use of platelet-rich plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion. Methods A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats were divided into 2 groups: A: control (no injection) and B: PRP injection. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cage without immobilization. After 5, 15 and 30 days, rats were euthanized. The traumatized Achilles tendon of each rat was removed and dissected during this healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Results We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile test study was more important for tendons which had been submitted to an injection of PRP. These results were noticed from day 5 onwards. Discussion – Conclusion This experimentation has shown that PRP injections could accelerate tendons healing process and increase the force needed to break tendons in their healing process. This “accelerating” process can be observed as early as day 5. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

Detailed reference viewed: 134 (36 ULg)
Full Text
Peer Reviewed
See detailMR Imaging of Iron Phagocytosis in Intraluminal Thrombi of Abdominal Aortic Aneurysms in Humans.
NCHIMI LONGANG, Alain ULg; Defawe, Olivier; Brisbois, Denis ULg et al

in Radiology (2010), 254(3), 973-81

Detailed reference viewed: 62 (39 ULg)
Full Text
Peer Reviewed
See detailHigh Levels of 18F-FDG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress
Xu, Yun; Borghi, Alexandre; NCHIMI LONGANG, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery (2010), 39

Detailed reference viewed: 94 (14 ULg)
Full Text
Peer Reviewed
See detailEvaluation of spectrophotometric methods for antioxidant compound measurement in relation to total antioxidant capacity in beverages.
Tabart, Jessica ULg; Kevers, Claire ULg; Pincemail, Joël ULg et al

in Food Chemistry (2010), 120

The validity of different colorimetric methods used to quantify various families of antioxidant compounds was evaluated with standard compounds. The colorimetric tests for global evaluation of flavonoids ... [more ▼]

The validity of different colorimetric methods used to quantify various families of antioxidant compounds was evaluated with standard compounds. The colorimetric tests for global evaluation of flavonoids, anthocyans, and flavanols were found generally unreliable, as reactions could be different for individual compounds within a family (anthocyanins or flavonols or flavan-3-ols) and not specific to one family. In the flavonoid test, for example, flavonols reacted very well, anthocyanins did not react, and flavanons reacted only slightly. The same methods were applied also to beverages known for their antioxidant content (apple, orange, grape, and vegetable juices, ice tea, and red wine) and the data were compared with the results of HPLC analysis of specific compounds. The values obtained in a colorimetric test were generally higher than the sum of the values obtained for the corresponding individual compounds by HPLC analysis, mainly because other compounds can interfere with the colorimetric tests. For example, in wine, anthocyanin concentrations obtained by colorimetric test were 9068  1407 µ mol /100ml (mean  SEM), higher than the sum of the six main anthocyanidins detected by HPLC, only 41 µmol/100 ml. The relative antioxidant capacity values determined for beverages on the basis of colorimetric tests could exceed by far the values previously measured in radical-scavenging tests (for instance, the antioxidant capacity attributable to anthocyans in wine on the basis of the colorimetric test was 50 times higher than the total antioxidant capacity measured by the ORAC assay). In conclusion, colorimetric tests for flavonoids, anthocyans, and flavanols appeared generally unreliable for estimating their content and thus the antioxidant capacity reliable to these compounds. [less ▲]

Detailed reference viewed: 265 (87 ULg)
Full Text
Peer Reviewed
See detailGenome-wide association study identifies sequence variants within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Gretarsdottir, Solveig; Baas, Annette F.; Thorleifsson, G. et al

in Nature Genetics (2010)

Detailed reference viewed: 19 (7 ULg)
Full Text
Peer Reviewed
See detailEffects of large pore hemofiltration in a swine model of fulminant hepatic failure
Detry, Olivier ULg; Janssen, Nathalie ULg; Cavalier, Etienne ULg et al

in Acta Gastro-Enterologica Belgica (2010), 73(1), 35

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailConsequences of laparoscopy on liver ischemia during portal triad clamping in a swine model
Gilson, Nathalie ULg; Nsadi, Berthier; Pire, E. et al

in Acta Gastro-Enterologica Belgica (2010), 73(1), 13

Detailed reference viewed: 46 (13 ULg)
Full Text
Peer Reviewed
See detailL’ECMO (ExtraCorporeal Membrane Oxygenation) aux soins intensifs : intérêt chez le patient en choc cardiogénique réfractaire, en hypoxémie réfractaire ou en arrêt cardiaque.
Massion, Paul ULg; Ledoux, Didier ULg; Piret, S. et al

in Revue Médicale de Liège (2010), 65

ExtraCorporeal Membrane Oxygenation (ECMO) is a cardiopulmonary assistance device able to support patients in cardiac arrest, refractory cardiogenic shock or refractory hypoxemia otherwise sentenced to ... [more ▼]

ExtraCorporeal Membrane Oxygenation (ECMO) is a cardiopulmonary assistance device able to support patients in cardiac arrest, refractory cardiogenic shock or refractory hypoxemia otherwise sentenced to death. Recent technical progresses, early indication decision, bedside multidisciplinary implant, specific complications screening and echocardiographic weaning testing are crucial points to allow success of this exceptional technique. [less ▲]

Detailed reference viewed: 191 (28 ULg)
Full Text
Peer Reviewed
See detailHyperacute graft rejection during heart transplantation for giant cell myocarditis: A case report.
Mutijima, E.; Delbecque, Katty ULg; Defraigne, Jean-Olivier ULg et al

in Pathology - Research & Practice (2010), 15(206), 411-4

We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had ... [more ▼]

We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis. [less ▲]

Detailed reference viewed: 30 (7 ULg)
Full Text
Peer Reviewed
See detailManagement of blood volume during extracorporeal circulation in cardiac surgery
Blaffart, Francine ULg; Defraigne, Jean-Olivier ULg

in IRBM - Ingénierie et Recherche Biomédicale = BioMedical Engineering and Research (2010), 31

The management of blood volume during major surgical procedures as cardiac surgery during extracorporeal circulation (ECC) is crucial in maintaining the homeostasis of the patient [1]. Currently, the ... [more ▼]

The management of blood volume during major surgical procedures as cardiac surgery during extracorporeal circulation (ECC) is crucial in maintaining the homeostasis of the patient [1]. Currently, the perfusionnist has few medical or perfusion data based on the evidence (EBM and EBP) in this area. It’s only the relationship between the level of hemodilution and the restriction or absence of homologous blood transfusion and mortality or postoperative morbidity that is supported by EBM and EBP [2-7]. The adequate control is not only limited to the miniaturization of the cardio pulmonary circuits ; it implies, on a practical standpoint, a circuit design and a choice of components combining safety, biocompatibility and reduced priming volume and dilution. The clinical and therapeutic constraints are dependent on the patient [8]. These ones require an analysis of the useful blood volume upstream and downstream the E.C.C. sequence [8]. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailThe use of an adapted model allows contributing to the “Reduction” of mice used in experimental protocols: the case of the apoE–deficient (apo E-/-) mice in a model of atherosclerosis control
Cherdon, Céline ULg; Rolin, Stéphanie; de Leval, Laurence ULg et al

Poster (2009, December 01)

Atherosclerosis is a chronic vascular disease whose development is influenced by several mediators 1. Among them, the prostanoids large family lipids generated from the metabolism of arachidonic acid by ... [more ▼]

Atherosclerosis is a chronic vascular disease whose development is influenced by several mediators 1. Among them, the prostanoids large family lipids generated from the metabolism of arachidonic acid by the action of COX includes various types of PGs and thromboxane. Thromboxane A2 and PGI2 are present in abnormally elevated concentration in atherosclerosis 2-3. To exert its effects TXA2 and its precursor PGH2 act at a specific receptor termed TP receptor 4. As a result, TXA2 synthase inhibitors and TP antagonists have been developed to reduce and to prevent TXA2 production and actions, respectively. The present study was undertaken in order to investigate whether BM-573, an original sulfonylurea derivate synthesized in our lab 5, and aspirin would be effective in preventing the progression of atherosclerosis in an apo E deficient mouse model. [less ▲]

Detailed reference viewed: 55 (13 ULg)
Full Text
Peer Reviewed
See detailLe pneumopéritoine aggrave l'ischémie hépatique lors du clampage hilaire dans un modèle porcin
Nsadi, Berthier; Gilson, Nathalie; Pire, E. et al

in Journal de Chirurgie (2009, December), 146

Detailed reference viewed: 64 (19 ULg)
Full Text
Peer Reviewed
See detailReasoning versus knowledge retention and ascertainment throughout a problem-based learning curriculum
Collard, Anne ULg; Gelaes, Sabine ULg; Vanbelle, Sophie ULg et al

in Medical Education (2009), 43

CONTEXT: Since 2000, problem-based learning (PBL) seminars have been introduced into the curriculum of medical studies at the University of Liège. We aimed to carry out a cross-sectional investigation of ... [more ▼]

CONTEXT: Since 2000, problem-based learning (PBL) seminars have been introduced into the curriculum of medical studies at the University of Liège. We aimed to carry out a cross-sectional investigation of the maturational increase in biomedical reasoning capacity in comparison with factual knowledge retention throughout the curriculum. METHODS: We administered a factual knowledge test (i.e. a true ⁄ false test with ascertainment degree) and a biomedical reasoning test (i.e. an adapted script concordance test [SCT]) to 104 students (Years 3–6) and a reference panel. The selected topic was endocrinology. RESULTS: On the SCT, the students obtained higher scores in Years 5 and 6 than in Years 3 and 4. In Year 3, the scores obtained on SCT questions in a new context indicated transfer of reasoning skills. On the true ⁄ false test, the scores of Year 3 students were significantly higher than those of students in the other three year groups. A positive correlation between SCT scores and true ⁄ false test scores was observed only for students in Years 3 and 4. In each group, the ascertainment degree scores were higher for correct than for incorrect responses and the difference was calculated as an index of self-estimation of core knowledge. This index was found to be positively correlated to SCT scores in the four year groups studied. CONCLUSIONS: Biomedical reasoning skills are evidenced early in a curriculum involving PBL and further increase during training. This is accompanied by a decrease in factual knowledge retention. The self-estimation of core knowledge appears to be related to reasoning capacity, which suggests there is a link between the two processes. [less ▲]

Detailed reference viewed: 29 (14 ULg)