Platelet-rich plasma (PRP) increases healing process of rats' Achilles tendons

Conference (2010, March 20)

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy ... [more ▼]

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy, physiotherapy, corticosteroid infiltrations, extracorporeal shock waves… Recently, several studies, essentially in vitro, demonstrated the positive effects of platelets on the healing process of different tissues: bones, muscles and tendons. Objectives The aim of our experiment was to ascertain whether the use of platelet-rich plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion. Methods A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats were divided into 2 groups: A: control (no injection) and B: PRP injection. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cage without immobilization. After 5, 15 and 30 days, rats were euthanized. The traumatized Achilles tendon of each rat was removed and dissected during this healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Results We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile test study was more important for tendons which had been submitted to an injection of PRP. These results were noticed from day 5 onwards. Discussion – Conclusion This experimentation has shown that PRP injections could accelerate tendons healing process and increase the force needed to break tendons in their healing process. This “accelerating” process can be observed as early as day 5. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

High Levels of 18F-FDG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress

in European Journal of Vascular and Endovascular Surgery (2010), 39

Genome-wide association study identifies sequence variants within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

in Nature Genetics (2010)

Consequences of laparoscopy on liver ischemia during portal triad clamping in a swine model

in Acta Gastro-Enterologica Belgica (2010), 73(1), 13

L’ECMO (ExtraCorporeal Membrane Oxygenation) aux soins intensifs : intérêt chez le patient en choc cardiogénique réfractaire, en hypoxémie réfractaire ou en arrêt cardiaque.

in Revue Médicale de Liège (2010), 65

ExtraCorporeal Membrane Oxygenation (ECMO) is a cardiopulmonary assistance device able to support patients in cardiac arrest, refractory cardiogenic shock or refractory hypoxemia otherwise sentenced to ... [more ▼]

ExtraCorporeal Membrane Oxygenation (ECMO) is a cardiopulmonary assistance device able to support patients in cardiac arrest, refractory cardiogenic shock or refractory hypoxemia otherwise sentenced to death. Recent technical progresses, early indication decision, bedside multidisciplinary implant, specific complications screening and echocardiographic weaning testing are crucial points to allow success of this exceptional technique. [less ▲]

L’image du mois : découverte fortuite d’un pseudo-anévrysme post-traumatique de l’isthme aortique après 15 ans de latence.

in Revue Médicale de Liège (2010), 65(11), 603-605

Management of blood volume during extracorporeal circulation in cardiac surgery

in IRBM - Ingénierie et Recherche Biomédicale = BioMedical Engineering and Research (2010), 31

The management of blood volume during major surgical procedures as cardiac surgery during extracorporeal circulation (ECC) is crucial in maintaining the homeostasis of the patient [1]. Currently, the ... [more ▼]

The management of blood volume during major surgical procedures as cardiac surgery during extracorporeal circulation (ECC) is crucial in maintaining the homeostasis of the patient [1]. Currently, the perfusionnist has few medical or perfusion data based on the evidence (EBM and EBP) in this area. It’s only the relationship between the level of hemodilution and the restriction or absence of homologous blood transfusion and mortality or postoperative morbidity that is supported by EBM and EBP [2-7]. The adequate control is not only limited to the miniaturization of the cardio pulmonary circuits ; it implies, on a practical standpoint, a circuit design and a choice of components combining safety, biocompatibility and reduced priming volume and dilution. The clinical and therapeutic constraints are dependent on the patient [8]. These ones require an analysis of the useful blood volume upstream and downstream the E.C.C. sequence [8]. [less ▲]

Evaluation biologique du stress oxydant : application en routine clinique.

in Nutritions & Endocrinologie (2009), HS Stress Oxydant

Reasoning versus knowledge retention and ascertainment throughout a problem-based learning curriculum

in Medical Education (2009), 43

CONTEXT: Since 2000, problem-based learning (PBL) seminars have been introduced into the curriculum of medical studies at the University of Liège. We aimed to carry out a cross-sectional investigation of ... [more ▼]

CONTEXT: Since 2000, problem-based learning (PBL) seminars have been introduced into the curriculum of medical studies at the University of Liège. We aimed to carry out a cross-sectional investigation of the maturational increase in biomedical reasoning capacity in comparison with factual knowledge retention throughout the curriculum. METHODS: We administered a factual knowledge test (i.e. a true ⁄ false test with ascertainment degree) and a biomedical reasoning test (i.e. an adapted script concordance test [SCT]) to 104 students (Years 3–6) and a reference panel. The selected topic was endocrinology. RESULTS: On the SCT, the students obtained higher scores in Years 5 and 6 than in Years 3 and 4. In Year 3, the scores obtained on SCT questions in a new context indicated transfer of reasoning skills. On the true ⁄ false test, the scores of Year 3 students were significantly higher than those of students in the other three year groups. A positive correlation between SCT scores and true ⁄ false test scores was observed only for students in Years 3 and 4. In each group, the ascertainment degree scores were higher for correct than for incorrect responses and the difference was calculated as an index of self-estimation of core knowledge. This index was found to be positively correlated to SCT scores in the four year groups studied. CONCLUSIONS: Biomedical reasoning skills are evidenced early in a curriculum involving PBL and further increase during training. This is accompanied by a decrease in factual knowledge retention. The self-estimation of core knowledge appears to be related to reasoning capacity, which suggests there is a link between the two processes. [less ▲]

Pseudoanevrisme de l'artere gastrique gauche.

in Journal de Chirurgie (2009), 146(4), 413-5

We report the case of a 65-year-old man admitted for an upper-GI hemorrhage. A CT scan performed with vascular reconstructions demonstrated a pseudoaneurysm of the left gastric artery. Proximal vascular ... [more ▼]

We report the case of a 65-year-old man admitted for an upper-GI hemorrhage. A CT scan performed with vascular reconstructions demonstrated a pseudoaneurysm of the left gastric artery. Proximal vascular control of the celiac axis was obtained by balloon occlusion with a Fogarty balloon inserted retrograde via the femoral artery: the pseudoaneurysm was then successfully controlled with direct suture. [less ▲]