References of "Defraigne, Jean-Olivier"
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See detailMisdiagnosed malignancy in transplanted organs
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, Milbor et al

in Touraine, J. L.; Traeger, J.; Bétuel, H. (Eds.) et al Cancer in Transplantation: Prevention and Treatment (1996)

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See detailRevisiting the evaluation of the performance of fluid-filled catheters
GERARD, P; POCHET, T; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailSelection and identification of lumped models of the arterial vasculature using multiple regression and backward elimination in the time domain
POCHET, T; GERARD, P; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailRole of pulmonary input impedance in right ventricular failure during experimental septic shock
D'Orio, Vincenzo ULg; LAMBERMONT, Bernard ULg; DETRY, Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1996), 2

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See detailEffects of PEEP on venous return
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; Defraigne, Jean-Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1996), 2

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See detailEffects of PEEP on abdominal aortic input impedance
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Intensive Care Medicine (1996), 22

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See detailEffets de la PEEP sur les propriétés hémodynamiques du réseau artériel systémique
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; fossion, A et al

in Réanimation (1996), 4

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See detailUne cause parfois meconnue de lesions vasculaires: la maladie de Behcet.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1996), 51(10), 639-46

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See detailThe Impact of Renal Revascularisation on Renal Dysfunction
Van Damme, Hendrik ULg; Jeusette, F.; Pans, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (1995), 10(3), 330-7

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990 ... [more ▼]

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990. PATIENTS AND METHODS: The study population included 23 patients with ischaemic nephropathy whose preoperative baseline creatinine level exceeded 20 mg/l (range 21-65 mg/l). This represents 20% of all patients operated on for renal artery disease during the same time interval. Preoperative risk profile, operative mortality, impact on hypertension and on renal function, and late survival were analysed. Renal function response to kidney revascularisation was defined as favourable (20% or more reduction of serum creatinine), moderate (stabilised serum creatinine values) or bad (further deterioration of renal function). All patients had atherosclerotic renal artery disease, involving a solitary kidney in five, both kidneys in 15 and one of the two kidneys in three patients. Hypertension was present in 74%. Revascularisation was unilateral in 10, bilateral in nine and associated with controlateral nephrectomy in four patients. RESULTS: Four patients died postoperatively (three myocardial infarctions, one stroke). Four patients needed postoperative short-term dialysis. After operation, renal function improved in 13, stabilised in six and deteriorated in four patients (of whom two died). Follow-up among the survivors averaged 46 months. The mean serum creatinine value at last follow-up visit was 26.2 mg/l, a decrease of 7.7 mg/l compared to preoperative values (p < 0.05). Overall, 69% of azotemic patients submitted to renal revascularisation manifested a favourable response (45% improved and 24% stabilised). Three patients required long-term dialysis. The 5-year survival rate was 48%. CONCLUSION: These data suggest that kidney revascularisation in patients with ischaemic nephropathy can restore or stabilise renal function, preventing evolution and end-stage renal disease and dialysis dependency. [less ▲]

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See detailAntioxidant Defense and Free Radical Production in a Rabbit Model of Kidney Ischemia-Reperfusion
Franssen, Colette ULg; Defraigne, Jean-Olivier ULg; Detry, Olivier ULg et al

in Transplantation Proceedings (1995), 27(5), 2880-3

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See detailDiaspirin Crosslinked Hemoglobin (Dclhb): Absence of Increased Free Radical Generation Following Administration in a Rabbit Model of Renal Ischemia and Reperfusion
Pincemail, Joël ULg; Detry, Olivier ULg; Philippart, C. et al

in Free Radical Biology & Medicine (1995), 19(1), 1-9

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free ... [more ▼]

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free glutathione (42%), protein-bound GSH (17%), and vitamin E (49%). In contrast, catalase or glutathione peroxidase activities were not affected by these experimental conditions. Free radical production in this model was also measured directly using electron spin resonance (ESR) spectroscopy associated with a PBN (alpha-phenyl N-tert-butyl-nitrone) spin trap agent in the venous blood arising from the ischemic kidney. The signal consisted of a triplet of doublets. In contrast, no signal could be detected in control blood samples taken prior to inducing ischemia. The burst of free radical production occurred in the early phase after restoration of flow in the kidneys rendered ischemic, as evidenced by a signal of weak intensity which generally appeared within the third minute after reperfusion and progressively increased to form a well-defined asymmetric signal following 10 min of reperfusion. The precise nature of free radicals trapped by the PBN agent remains, however, to be elucidated, but analysis of the coupling constants (aN = 14.5-15 G; a beta H = 2.5-3 G) and asymmetry of the central doublets suggests that the ESR signal may arise from a nitorxy-radical adduct resulting from the spin trapping by PBN of both oxygen- or carbon-centered radicals of lipid origin. As evidenced by both direct and indirect measurements, exchange of rabbit blood immediately after inducing renal ischemia with 30 ml/kg of Diaspirin Crosslinked Hemoglobin (7.5 g/dl in lactated electrolyte) or human serum albumin (7.5 g/dl in lactated electrolyte) did not exacerbate free radical production mediated by an ischemia reperfusion phenomenon, a typical situation found in a resuscitation setting. [less ▲]

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See detailAttitude of a Young Surgeon toward Experimental Surgery. Roles and Limits of Experimental Surgery
Defraigne, Jean-Olivier ULg

in Acta Chirurgica Belgica (1995), 95(2, Mar-Apr), 113-7

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is ... [more ▼]

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is through research that surgeons can keep some critical mind, essential in their daily activities. However, too often actually, the surgeons abandon research. Two essential reasons explain the phenomenon: on the one hand, the weight of the clinical tasks and on the other hand the complexity of research founded on more and more specialized basic notions. In fact, the part of a surgical investigator must be to form a link between basic research and clinical activities. As such, work in collaboration with motivated basic investigators is cardinal. Also, the success of research depends upon the will of the departments to maintain a research activity, but it meets often with the difficulty in obtaining sufficient research credits. Finally, research can play an essential part in the education of the trainees and partly fill some gaps in their clinical training. [less ▲]

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See detailValve Replacement for Acute Left Heart Endocarditis
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Cardiovascular Surgery (1995), 3(5), 529-35

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 ... [more ▼]

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 mitral valve infections. Four patients had bivalvular involvement. Fifty-three patients suffered from native valve endocarditis, with underlying valvular lesions documented for 31 patients. Staphylococci and Streptococci spp. were responsible for 68% of infection, and 20% of blood and valve cultures were negative. Refractory congestive heart failure was the leading surgical indication in 86% of patients. The mean follow-up period was 44 months. The perioperative mortality rate was 6%. Actuarial survival rates were 88.5% at 1 year and 83% at 3 years. No early recurrence of infection was noted. Six patients (9%) needed reoperation. Satisfactory results confirm that early surgical management should be considered in patients with complicated infective endocarditis. [less ▲]

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See detailEffects of PEEP on systemic vascular compliance in intact pigs
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailSuccessful abdominal aortic aneurysm resection in long-term survivors of cardiac transplantation.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; DEMOULIN, Julie ULg et al

in Cardiovascular Surgery (1995), 3(3), 321-4

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm ... [more ▼]

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm successfully operated on in cardiac allograft recipients 1 to 4 years after transplantation. Indications for transplantation were valvular, idiopathic and ischaemic cardiomyopathy. Post-transplant hypertension and hyperlipidaemia may have played a role in the rapid growth of the aneurysms. Cardiac function and the incidence of graft atherosclerosis were assessed before surgery by coronary angiography. All three patients were discharged from hospital. Abdominal aortic aneurysm resection may be a safe procedure in cardiac transplant patients. In view of the rapid increase in the size of the aneurysms in transplanted patients, careful screening should be performed during follow-up. [less ▲]

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See detailPacemaker Implantation for Early Sinus Node Dysfunction after Orthotopic Heart Transplantation
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(1), 31-4

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node ... [more ▼]

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node dysfunction were identified and were satisfactorily paced on the VVIR mode. All three showed sinus recovery within three months following implantation and had their pacemaker switched from the VVIR mode to a simple ventricular demand pacing. Interestingly, administration of beta-blocking drugs quickly reinstituted pace dependence. The patients' outcome is excellent (18 to 48 months follow-up). No difference with the global cohort of our OHT recipients was noticed, apart from an apparent high incidence of infections (3/3) with (2/3) CMV and severe rejection (3/3) during the first month postoperatively. This data suggests that sinus dysfunction may be the result of a multifactorial (rejection, CMV, ...) injury to the conduction system, and is only clinically relevant beyond a threshold level. Denervation hypersensitivity, together with correction of these factors, may account for the restoration of a sufficient reserve of conduction system, and therefore appropriate sinus node function in basal conditions. [less ▲]

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See detailLa thrombose veineuse profonde des membres supérieurs. Revue de la littérature. A propos d'un cas de syndrome de Paget-Schrotter
Defraigne, Jean-Olivier ULg; Remy, D.; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(8), 336-46

Un cas de thrombose veineuse profonde (TVP) du membre supérieur survenue dans le contexte d'un effort chez un sujet jeune (syndrome de Paget-Schrötter) est présenté. La TVP des membres supérieurs présente ... [more ▼]

Un cas de thrombose veineuse profonde (TVP) du membre supérieur survenue dans le contexte d'un effort chez un sujet jeune (syndrome de Paget-Schrötter) est présenté. La TVP des membres supérieurs présente des caractéristiques étiologiques et physiopathologiques différentes de celles de la TVP des membres inférieurs. On distingue des phlébites primaires et secondaires. La phlébite primaire survient généralement chez des sujets plus jeunes, et une notion d'effort est fréquemment retrouvée. Les phlébites secondaires s'observent dans différentes circonstances: mise en place de cathéters ou de sonde de pacemaker, affections néoplasiques, troubles de l'hémostase... Certaines controverses thérapeutiques existent, et, notamment, sur la nécessité de recourir ou non à la fibrinolyse et, dans les phlébites d'effort qui rentrent dans un contexte de syndrome du défilé costo-claviculaire, sur l'utilité de proposer un traitement chirurgical, en vue de lever la compression extrinsèque et/ou de reperméabiliser la veine. [less ▲]

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See detailIsolated Atherosclerotic Aneurysms of the Iliac Arteries
Desiron, Quentin ULg; Detry, Olivier ULg; Sakalihasan, Natzi ULg et al

in Annals of Vascular Surgery (1995), 9(Suppl), 62-6

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two ... [more ▼]

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two women; mean age 69 years) treated for isolated iliac aneurysms in the Department of Cardiovascular Surgery at the University Hospital of Liege over a period of 18 years. They had a total of 25 aneurysms (20 common iliac and five internal iliac). Six patients were treated electively and nine on an emergency basis for rupture. Five of the emergency patients (33%) died in the early postoperative period (< 30 days); in each case the aneurysm had ruptured and an emergency operation was performed (55.5% mortality in the ruptured iliac aneurysm group). On the other hand, all patients treated electively survived. Our study is comparable to other recent series in the literature, which also reported a high incidence of rupture and death in emergency operations. Prophylactic elective surgery is recommended for iliac aneurysms. [less ▲]

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See detailPreservation of Cortical Microcirculation after Kidney Ischemia-Reperfusion: Value of an Iron Chelator
Defraigne, Jean-Olivier ULg; Pincemail, Joël ULg; Detry, Olivier ULg et al

in Annals of Vascular Surgery (1994), 8(5), 457-67

Treatment of suprarenal aneurysms and renal artery reconstructions are both responsible for normothermic ischemia of the kidney (during clamping) followed by reperfusion (declamping). During reflow ... [more ▼]

Treatment of suprarenal aneurysms and renal artery reconstructions are both responsible for normothermic ischemia of the kidney (during clamping) followed by reperfusion (declamping). During reflow through an organ undergoing ischemia the production of free radicals can be associated with cell injury and a no-reflow phenomenon characterized by perfusion defects after a period of transient hyperemia. The objectives of this study were to demonstrate the existence of this phenomenon in the kidney undergoing ischemia followed by reperfusion and to test the potential protection afforded by an iron chelator (desferrioxamine) since free radical reactions are catalyzed by iron. Adult New Zealand white rabbits were divided into the following three groups: group A, 15 minutes of ischemia plus 10 minutes of reperfusion; group B, 60 minutes of ischemia plus 10 minutes of reperfusion; and group C, 60 minutes of ischemia plus 10 minutes of reperfusion combined with infusion of desferrioxamine (50 mg/kg). Cortical microcirculation in the kidney was measured by laser Doppler flowmeter before ischemia and 1, 5, and 10 minutes after reperfusion. Vitamin E content was determined in the cortex of the left kidney after 10 minutes of reperfusion and compared with that of the right (control) kidney. After 1 minute of reperfusion the cortical microcirculatory flow was significantly increased in all three groups (reactive hyperemia). In groups A and C blood flow returned to preclamping values after 10 minutes of reperfusion; however, blood flow in group B remained significantly reduced (29.2% +/- 10.5%) after 5 minutes of reperfusion with a further reduction to 48.5% +/- 5.7% after 10 minutes. These findings were correlated with the dosage of vitamin E since the vitamin E content was greatly reduced by 46.7% +/- 7.8% in group B but did not change significantly in groups A and C. This study shows that 60 minutes of normothermic ischemia is followed by a significant reduction in cortical microcirculatory flow (no-reflow phenomenon). Infusion of an iron chelator (desferrioxamine), however, which decreases the intensity of lipid peroxidation induced by the free radicals, preserves the microcirculatory flow. [less ▲]

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