References of "Defraigne, Jean-Olivier"
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See detailOxidative Stress in Clinical Situations--Fact or Fiction?
Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in European Journal of Anaesthesiology (1996), 13(3), 219-34

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See detailLes assistances circulatoires. Partie II. Complications et résultats
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1996), 51(5), 359-67

Le placement et le choix d'une assistance uni- ou biventriculaire reposent sur des critères hémodynamiques, cliniques et échographiques et sur certaines données qui imposent d'emblée le choix d'une ... [more ▼]

Le placement et le choix d'une assistance uni- ou biventriculaire reposent sur des critères hémodynamiques, cliniques et échographiques et sur certaines données qui imposent d'emblée le choix d'une assistance biventriculaire, telles les arythmies, l'ischémie du septum interventriculaire et des résistances vasculaires pulmonaires élevées. Le moment idéal pour transplanter un patient sous assistance n'est pas toujours aisé à déterminer. Par le passé, le patient était transplanté dès qu'un donneur était disponible, dans la crainte de la survenue de complications associées au système d'assistance et qui feraient contre-indiquer la transplantation. Actuellement, on sait qu'il est préférable de différer la transplantation jusqu'à la normalisation des fonctions hépatique et rénale, ce qui permet de transplanter le patient dans de meilleures conditions. Les complications principales sous assistance sont: les saignements qui accroissent le risque d'infection en raison des réopérations et des transfusions qu'ils imposent, l'infection, les accidents thromboemboliques et l'insuffisance rénale. Les résultats globaux actuels sont: 1) une survie initiale supérieure à 50% en cas d'assistance circulatoire en pont vers la transplantation, avec une survie actuarielle à 2 ans de l'ordre de 70% après transplantation; 2) une survie globale entre 25 et 30% en cas d'assistance post-cardiotomie. Ces résultats sont loin d'être parfaits, mais ces dispositifs s'adressent à des patients qui, sans assistance circulatoire, ont une espérance de vie nulle à très brève échéance. Néanmoins, des progrès restent à faire dans le domaine de la tolérance des matériaux utilisés ainsi que dans la sélection des patients. Dans le futur, des systèmes totalement implantables constitueront peut-être une alternative valable à la transplantation. [less ▲]

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See detailLaparoscopic-Assisted Colectomy in Heart Transplant Recipients
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Chiche, Jean-Daniel et al

in Clinical Transplantation (1996), 10(2), 191-4

Reports of laparoscopy in heart graft recipients are scarce and, to our knowledge, laparoscopic colectomy has not yet been reported in heart transplant patients. The magnitude and the tolerance of the ... [more ▼]

Reports of laparoscopy in heart graft recipients are scarce and, to our knowledge, laparoscopic colectomy has not yet been reported in heart transplant patients. The magnitude and the tolerance of the hemodynamic changes induced by pneumoperitoneum are unknown in heart graft recipients, who have a denervated heart and are "preload-dependent". The authors report the clinical courses of 2 heart graft recipients who developed acute diverticulitis without perforation or peritonitis and who underwent laparoscopic-assisted colectomy without complications. [less ▲]

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See detailLes assistances circulatoires. Partie I. Indications et description des systèmes
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1996), 51(4), 295-306

Dans l'optique d'une assistance circulatoire, les défaillances cardiaques sont classables en trois grandes catégories: 1) le choc cardiogénique inaugural consécutif à une myocardite ou à un infarctus du ... [more ▼]

Dans l'optique d'une assistance circulatoire, les défaillances cardiaques sont classables en trois grandes catégories: 1) le choc cardiogénique inaugural consécutif à une myocardite ou à un infarctus du myocarde; 2) la défaillance post-chirurgicale ou post-cardiotomie; 3) la détérioration hémodynamique rapide chez un patient préalablement inscrit dans un programme de transplantation. Dans ces circonstances, une assistance circulatoire s'impose lorsque les critères de Norman sont présents (index cardiaque inférieur à 1,8 l/min/m2; pression artérielle systolique < 90 mmHg; pressions d'oreillettes gauche et/ou droite > à 20 mmHg; débit urinaire inférieur à 20 ml/heure; résistances vasculaires systémiques > 250 dynes/cm2; acidose métabolique), et ce malgré un remplissage vasculaire correct, un support inotrope maximal et une contrepulsation infra-aortique. En assurant une perfusion tissulaire adéquate et la mise au repos du myocarde, l'assistance permet alors soit une récupération myocardique, soit d'attendre une transplantation dans de meilleures conditions (pont vers la transplantation ou bridge to transplant). Pour répondre aux objectifs d'une assistance circulatoire, plusieurs systèmes sont disponibles. Ils différent par leur mode d'insertion, le type d'assistance qu'ils fournissent (partielle ou totale, univentriculaire gauche ou droite, biventriculaire), le type de débit assuré (continu ou pulsatile), le degré d'anticoagulation requis, la durée théorique maximale d'assistance, leurs positions (interne, externe, hétérotopique ou orthotopique), leurs modes de connexion aux cavités cardiaques. Le choix est guidé par l'origine du choc, par les circonstances géographiques lors de sa survenue (salle de cathétérisme ou salle d'opération) et, bien évidemment, par la disponibilité locale des systèmes d'assistance, qui sont onéreux. [less ▲]

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See detailMisdiagnosed malignancy in transplanted organs
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, Milbor et al

in Touraine, J. L.; Traeger, J.; Bétuel, H. (Eds.) et al Cancer in Transplantation: Prevention and Treatment (1996)

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See detailRevisiting the evaluation of the performance of fluid-filled catheters
GERARD, P; POCHET, T; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailSelection and identification of lumped models of the arterial vasculature using multiple regression and backward elimination in the time domain
POCHET, T; GERARD, P; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailRole of pulmonary input impedance in right ventricular failure during experimental septic shock
D'Orio, Vincenzo ULg; LAMBERMONT, Bernard ULg; DETRY, Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1996), 2

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See detailEffects of PEEP on venous return
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; Defraigne, Jean-Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1996), 2

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See detailEffects of PEEP on abdominal aortic input impedance
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Intensive Care Medicine (1996), 22

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See detailEffets de la PEEP sur les propriétés hémodynamiques du réseau artériel systémique
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; fossion, A et al

in Réanimation (1996), 4

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See detailUne cause parfois meconnue de lesions vasculaires: la maladie de Behcet.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1996), 51(10), 639-46

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See detailThe Impact of Renal Revascularisation on Renal Dysfunction
Van Damme, Hendrik ULg; Jeusette, F.; Pans, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (1995), 10(3), 330-7

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990 ... [more ▼]

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990. PATIENTS AND METHODS: The study population included 23 patients with ischaemic nephropathy whose preoperative baseline creatinine level exceeded 20 mg/l (range 21-65 mg/l). This represents 20% of all patients operated on for renal artery disease during the same time interval. Preoperative risk profile, operative mortality, impact on hypertension and on renal function, and late survival were analysed. Renal function response to kidney revascularisation was defined as favourable (20% or more reduction of serum creatinine), moderate (stabilised serum creatinine values) or bad (further deterioration of renal function). All patients had atherosclerotic renal artery disease, involving a solitary kidney in five, both kidneys in 15 and one of the two kidneys in three patients. Hypertension was present in 74%. Revascularisation was unilateral in 10, bilateral in nine and associated with controlateral nephrectomy in four patients. RESULTS: Four patients died postoperatively (three myocardial infarctions, one stroke). Four patients needed postoperative short-term dialysis. After operation, renal function improved in 13, stabilised in six and deteriorated in four patients (of whom two died). Follow-up among the survivors averaged 46 months. The mean serum creatinine value at last follow-up visit was 26.2 mg/l, a decrease of 7.7 mg/l compared to preoperative values (p < 0.05). Overall, 69% of azotemic patients submitted to renal revascularisation manifested a favourable response (45% improved and 24% stabilised). Three patients required long-term dialysis. The 5-year survival rate was 48%. CONCLUSION: These data suggest that kidney revascularisation in patients with ischaemic nephropathy can restore or stabilise renal function, preventing evolution and end-stage renal disease and dialysis dependency. [less ▲]

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See detailAntioxidant Defense and Free Radical Production in a Rabbit Model of Kidney Ischemia-Reperfusion
Franssen, Colette ULg; Defraigne, Jean-Olivier ULg; Detry, Olivier ULg et al

in Transplantation Proceedings (1995), 27(5), 2880-3

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See detailDiaspirin Crosslinked Hemoglobin (Dclhb): Absence of Increased Free Radical Generation Following Administration in a Rabbit Model of Renal Ischemia and Reperfusion
Pincemail, Joël ULg; Detry, Olivier ULg; Philippart, C. et al

in Free Radical Biology & Medicine (1995), 19(1), 1-9

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free ... [more ▼]

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free glutathione (42%), protein-bound GSH (17%), and vitamin E (49%). In contrast, catalase or glutathione peroxidase activities were not affected by these experimental conditions. Free radical production in this model was also measured directly using electron spin resonance (ESR) spectroscopy associated with a PBN (alpha-phenyl N-tert-butyl-nitrone) spin trap agent in the venous blood arising from the ischemic kidney. The signal consisted of a triplet of doublets. In contrast, no signal could be detected in control blood samples taken prior to inducing ischemia. The burst of free radical production occurred in the early phase after restoration of flow in the kidneys rendered ischemic, as evidenced by a signal of weak intensity which generally appeared within the third minute after reperfusion and progressively increased to form a well-defined asymmetric signal following 10 min of reperfusion. The precise nature of free radicals trapped by the PBN agent remains, however, to be elucidated, but analysis of the coupling constants (aN = 14.5-15 G; a beta H = 2.5-3 G) and asymmetry of the central doublets suggests that the ESR signal may arise from a nitorxy-radical adduct resulting from the spin trapping by PBN of both oxygen- or carbon-centered radicals of lipid origin. As evidenced by both direct and indirect measurements, exchange of rabbit blood immediately after inducing renal ischemia with 30 ml/kg of Diaspirin Crosslinked Hemoglobin (7.5 g/dl in lactated electrolyte) or human serum albumin (7.5 g/dl in lactated electrolyte) did not exacerbate free radical production mediated by an ischemia reperfusion phenomenon, a typical situation found in a resuscitation setting. [less ▲]

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See detailAttitude of a Young Surgeon toward Experimental Surgery. Roles and Limits of Experimental Surgery
Defraigne, Jean-Olivier ULg

in Acta Chirurgica Belgica (1995), 95(2, Mar-Apr), 113-7

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is ... [more ▼]

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is through research that surgeons can keep some critical mind, essential in their daily activities. However, too often actually, the surgeons abandon research. Two essential reasons explain the phenomenon: on the one hand, the weight of the clinical tasks and on the other hand the complexity of research founded on more and more specialized basic notions. In fact, the part of a surgical investigator must be to form a link between basic research and clinical activities. As such, work in collaboration with motivated basic investigators is cardinal. Also, the success of research depends upon the will of the departments to maintain a research activity, but it meets often with the difficulty in obtaining sufficient research credits. Finally, research can play an essential part in the education of the trainees and partly fill some gaps in their clinical training. [less ▲]

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See detailValve Replacement for Acute Left Heart Endocarditis
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Cardiovascular Surgery (1995), 3(5), 529-35

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 ... [more ▼]

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 mitral valve infections. Four patients had bivalvular involvement. Fifty-three patients suffered from native valve endocarditis, with underlying valvular lesions documented for 31 patients. Staphylococci and Streptococci spp. were responsible for 68% of infection, and 20% of blood and valve cultures were negative. Refractory congestive heart failure was the leading surgical indication in 86% of patients. The mean follow-up period was 44 months. The perioperative mortality rate was 6%. Actuarial survival rates were 88.5% at 1 year and 83% at 3 years. No early recurrence of infection was noted. Six patients (9%) needed reoperation. Satisfactory results confirm that early surgical management should be considered in patients with complicated infective endocarditis. [less ▲]

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See detailEffects of PEEP on systemic vascular compliance in intact pigs
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailSuccessful abdominal aortic aneurysm resection in long-term survivors of cardiac transplantation.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; DEMOULIN, Julie ULg et al

in Cardiovascular Surgery (1995), 3(3), 321-4

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm ... [more ▼]

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm successfully operated on in cardiac allograft recipients 1 to 4 years after transplantation. Indications for transplantation were valvular, idiopathic and ischaemic cardiomyopathy. Post-transplant hypertension and hyperlipidaemia may have played a role in the rapid growth of the aneurysms. Cardiac function and the incidence of graft atherosclerosis were assessed before surgery by coronary angiography. All three patients were discharged from hospital. Abdominal aortic aneurysm resection may be a safe procedure in cardiac transplant patients. In view of the rapid increase in the size of the aneurysms in transplanted patients, careful screening should be performed during follow-up. [less ▲]

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