References of "Deberg, Michelle"
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See detailThe urinary levels of type II collagen peptide COLL 2-1 and its nitrated form (COLL 2-1 NO2) are correlated with the clinical severity of knee osteoarthritis
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis Bang et al

in Osteoporosis International (2002, November), 13(Suppl.3), 54

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See detailHigh levels of the type II collagen peptide (COLL 2-1) in serum is predictive of the radiological progressin of knee osteoarthritis
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis Bang et al

in Osteoporosis International (2002, November), 13(Suppl.3), 53-54

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Cloos, Paul et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 54

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See detailCharacterization of the metabolism of osteoarthritic chondrocytes cultured in alginate beads
Henrotin, Yves ULg; Sanchez, Christelle ULg; Mathy-Hartert, Marianne et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 52

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 496

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See detailCharacterization of the Metabolism of Osteoarthritic Chondrocytes Cultured in Alginate Beads
Sanchez, Christelle ULg; Mathy, Marianne ULg; Deberg, Michelle ULg et al

in Osteoarthritis and Cartilage (2002), 10(SA), 34

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See detailLong-term Effects of Nonsteroidal Antiinflammatory Drugs on Human Chondrocytes in Alginate Beads
Sanchez, Christelle ULg; Deberg, Michelle ULg; Reginster, Jean-Yves ULg et al

in Annals of the Rheumatic Diseases (2001), 60(suppl1), 284

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See detailLong-term Effects of Avocado/Soybean Unsaponifiable on Human Chondrocytes Metabolism
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Osteoarthritis and Cartilage (2001), 9(supplB), 25

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See detailLong-term Effects of Nonsteroidal Antiinflammatory Drugs on Human Chondrocytes in Alginate Beads
Sanchez, Christelle ULg; Deberg, Michelle ULg; Reginster, Jean-Yves ULg et al

in Osteoarthritis and Cartilage (2001), 9(supplB), 32

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See detailLong-term Effects of Avocado/Soybean Unsaponifiable on Human Chondrocytes Metabolism
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Clinical Rheumatology (2001), 20(5), 45

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See detailHighly Specific Radioimmunoassay for Human Insulin Based on Immune Exclusion of All Insulin Precursors
Deberg, Michelle ULg; Houssa, P.; Frank, B. H. et al

in Clinical Chemistry (1998), 44(7), 1504-13

We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificity (directed ... [more ▼]

We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificity (directed, respectively, against the B10 region, the junction between A chain and C-peptide, and the junction between B chain and C-peptide), their affinity constant (approximately 10(10) L/mol), and their interactive properties in mixture. S2 and S53 were able to bind simultaneously to the same proinsulin molecule, whereas neither could bind simultaneously with S1. Preincubation of serum samples with an excess of S2 resulted in capture of proinsulin and conversion intermediates modified at the junction between B chain and C-peptide into immune complexes that no longer reacted with S1. Similarly, preincubation with S53 prevented proinsulin and conversion intermediates modified at the junction between A chain and C-peptide from reacting with S1. Preincubation with an excess of both S2 and S53 left insulin as the sole reactant with S1. Thus, separation of insulin precursors from insulin by mutually exclusive antibodies is feasible, and on the basis of this new principle, a highly specific RIA for insulin was designed. The detection limit was 11 pmol/L, and the inter- and intraassay coefficients of variation were 11% and 5%, respectively. The potential of the assay for use in clinical studies was verified by application to serum samples from control subjects and patients with diabetes or insulinoma. [less ▲]

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See detailFirst Direct Assay for Intact Human Proinsulin
Houssa, P.; Dinesen, B.; Deberg, Michelle ULg et al

in Clinical Chemistry (1998), 44(7), 1514-9

We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 microL of serum or plasma. The assay is based on the use of two monoclonal ... [more ▼]

We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 microL of serum or plasma. The assay is based on the use of two monoclonal antibodies specific for epitopes at the C-peptide/insulin A chain junction and at the insulin B chain/C-peptide junction, respectively. Cross-reactivities with insulin, C-peptide, and the four proinsulin conversion intermediates were negligible. The detection limit in buffer was 0.2 pmol/L (3 standard deviations from zero). The working range was 0.2-100 pmol/L. The mean intra- and interassay coefficients of variation were 2.4% and 8.9%, respectively. The mean recovery of added proinsulin was 103%. Dilution curves of 40 serum samples are parallel to the proinsulin calibration curve. Proinsulin concentrations in 20 fasting healthy subjects were all above the limit of detection: median (range), 2.7 pmol/L (1.1-6.9 pmol/L). Six fasting non-insulin-dependent diabetes mellitus and five insulinoma patients had proinsulin concentrations significantly higher than healthy subjects: median (range), 7.7 pmol/L (3.2-18 pmol/L) and 153 pmol/L (98-320 pmol/L), respectively. [less ▲]

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