References of "Deberg, Michelle"
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See detailRégulation du Métabolisme des Chondrocytes par l'Oncostatine M et l'Interleukine 6
Sanchez, Christelle ULg; Deberg, Michelle ULg; Devel, Philippe et al

in Revue du Rhumatisme (2004), 71(10-11), 1008

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See detailSubchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes
Sanchez, Christelle ULg; Deberg, Michelle ULg; Piccardi, Nathalie et al

in Osteoarthritis and Cartilage (2004), 12(Suppl. B), 99-100

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See detailFuranic avocado/soybean unsaponifiables prevent osteoarthritic subchondral osteoblasts-induced cartilage degradation
Sanchez, Christelle ULg; Deberg, Michelle ULg; Piccardi, Nathalie et al

in Osteoarthritis and Cartilage (2004), 12(Suppl. B), 108-109

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See detailEffects of interleukin-1 beta and dexamethasone on the expression by chondrocytes of antioxidant enzymes
Mathy, Marianne ULg; Devel, Philippe; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2004), 12(Suppl. B), 51-52

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See detailInterleukin-1, interleukin-6 and oncostatin M stimulate normal subchondral osteoblasts to induce cartilage degradation
Sanchez, Christelle ULg; Deberg, Michelle ULg; Piccardi, Nathalie et al

in Osteoarthritis and Cartilage (2004), 12(Suppl. B), 98

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See detailCartilage degradation and oxidative damage in OA and RA patients
Deberg, Michelle ULg; Labasse, Alain ULg; Christgau, S. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 44-45

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See detailOne-year increase of Coll 2-1 level in urine is predictive of OA progression
Henrotin, Yves ULg; Deberg, Michelle ULg; Labasse, Alain ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 12

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See detailCartilage degradation and oxidative damage in osteoarthritic and rheumatoid arthritic patients
Deberg, Michelle ULg; Labasse, Alain ULg; Christgau, Stephan et al

in Osteoarthritis and Cartilage (2003, October), 11(Suppl.1), 15

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See detailAvocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Journal of Rheumatology (2003), 30(8), 1825-1834

OBJECTIVE: To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days. METHODS: Enzymatically ... [more ▼]

OBJECTIVE: To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days. METHODS: Enzymatically isolated OA chondrocytes were cultured in alginate beads in a well defined culture medium for 12 days, in the presence or not of 10-10 M interleukin 1beta (IL-1beta). DNA content was measured using a fluorometric method. Production of aggrecan (AGG), stromelysin-1 (MMP-3), tissue inhibitor of metalloproteinases-1 (TIMP-1), macrophage inflammatory protein-1beta (MIP-1beta), IL-6, and IL-8 were assayed by specific enzyme amplified sensitivity immunoassays. Prostaglandin (PG) E2 was measured by a specific radioimmunoassay and nitrite by a spectrophotometric method based on the Griess reaction. A commercial avocado and soybean mixture of unsaponifiables (A1S2) and each component separately were tested in a range of 0.625 to 40.0 micro g/ml. RESULTS: After 12 days' incubation, A1S2 increased AGG synthesis and accumulation in alginate beads in a dose and time dependent manner. A1S2 promoted the recovery of aggrecan synthesis after 3 days of IL-1beta treatment. A1S2 was a potent inhibitor of basal and IL-1beta stimulated MMP-3 production. The procedure also weakly reversed the inhibitory effect of IL-1beta on TIMP-1 production. A1S2 inhibited basal production of MIP-1beta, IL-6, IL-8, NO*, and PGE2 by OA chondrocytes and partially counteracted the stimulating effect of IL-1 on PGE2. Compared to avocado or soybean added separately, the mixture had a superior effect on NO* and IL-8 production. CONCLUSION: A1S2 stimulated aggrecan production and restored aggrecan production after IL-1beta treatment. In parallel, A1S2 decreased MMP-3 production and stimulated TIMP-1 production. These results suggest A1S2 could have structure-modifying effects in OA by inhibiting cartilage degradation and promoting cartilage repair. [less ▲]

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See detailEffects of rhein on human articular chondrocytes in alginate beads
Sanchez, Christelle ULg; Mathy-Hartert, Marianne; Deberg, Michelle ULg et al

in Biochemical Pharmacology (2003), 65(3), 377-388

This study was designed to investigate the effects of them, the active metabolite of diacerhein, on the metabolic functions of human chondrocytes cultured in alginate beads. Enzymatically isolated ... [more ▼]

This study was designed to investigate the effects of them, the active metabolite of diacerhein, on the metabolic functions of human chondrocytes cultured in alginate beads. Enzymatically isolated ostcoarthritic (OA) chondrocytes were cultured in alginate beads in a well-defined culture medium for 12 days. Rhein was tested in a range of concentrations comprised between 10(-7) and 4 x 10(-5) M, in the presence or absence of 10(-10) M IL-1beta. Interleukin (IL)-6 and -8, macrophage inflammatory protein (MIP-1beta), stromelysin-1 (MMP-3), aggrecan (AGG), tissue inhibitor of metalloproteinases-1 (TIMP-1), prostaglandin E-2 (PGE(2)) and nitric oxide (NO) productions were assayed. Cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) mRNA steady-state levels were also quantified. In the basal condition, 10(-5) M them increased by 46.5% the production of AGG, decreased by 17-30% the production of IL-6, MMP-3, NO and MIP-1beta but enhanced by 50% the production of PGE2(.) IL-1beta increased IL-6, IL-8, MIP-1beta, NO, PGE(2) and MMP-3 productions, but inhibited AGG and TIMP-1 synthesis. Rhein partially reversed the effect of IL-1beta on TIMP-1 and NO production, had no effect on AGG, IL-6 and MIP-1P production, but upregulated the IL-1beta stimulated PGE(2) production. The COX-2 and iNOS mRNA levels and IL-8 production were not modified by rhein. Overall, these results contribute to explain the clinical efficiency of rhein and give new information on its mechanisms of action. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailThe urinary levels of type II collagen peptide COLL 2-1 and its nitrated form (COLL 2-1 NO2) are correlated with the clinical severity of knee osteoarthritis
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis Bang et al

in Osteoporosis International (2002, November), 13(Suppl.3), 54

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See detailHigh levels of the type II collagen peptide (COLL 2-1) in serum is predictive of the radiological progressin of knee osteoarthritis
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis Bang et al

in Osteoporosis International (2002, November), 13(Suppl.3), 53-54

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Cloos, Paul et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 54

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See detailCharacterization of the metabolism of osteoarthritic chondrocytes cultured in alginate beads
Henrotin, Yves ULg; Sanchez, Christelle ULg; Mathy-Hartert, Marianne et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 52

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 496

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See detailCharacterization of the Metabolism of Osteoarthritic Chondrocytes Cultured in Alginate Beads
Sanchez, Christelle ULg; Mathy, Marianne ULg; Deberg, Michelle ULg et al

in Osteoarthritis and Cartilage (2002), 10(SA), 34

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