References of "De Tullio, Pascal"
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See detailOriginal cromakalim analogues as KATP channel openers
Florence, Xavier ULg; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Metabolic and Functional Research on Diabetes (2009), 2

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See detail6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Kempen, I.; Hemmer, Marc ULg; Counerotte, Stéphane ULg et al

in European Journal of Medicinal Chemistry (2008), 43(12), 2735-50

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure ... [more ▼]

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. [less ▲]

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See detail1H NMR metabolomic approach of the laser-induced choroidal neovascularization in mice
Lambert, Vincent ULg; Frederich, Michel ULg; Rousseau, Rousseau et al

Poster (2008, August)

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See detailThe arylthiadiazine 1,1-dioxides in medicinal chemistry
De Tullio, Pascal ULg

Conference (2008, June 08)

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See detail6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2008, May)

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See detailKATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides
Lebrun, P.; Becker, B.; Morel, N. et al

in Biochemical Pharmacology (2008), 75

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See detailSynthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators
Khelili, S.; Florence, Xavier ULg; Bouhadja, M. et al

in Bioorganic & Medicinal Chemistry (2008), 16

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See detailSynthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
Francotte, Pierre ULg; De Tullio, Pascal ULg; Podona, Tchao et al

in Bioorganic & Medicinal Chemistry (2008), 16(23), 9948-56

Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were designed to obtain novel AMPA potentiators. The ... [more ▼]

Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were designed to obtain novel AMPA potentiators. The aim of this work was focused on the improvement of lipophilicity, which is well known as a critical parameter to obtain in vivo active central nervous system agents. For this purpose, two positions on the pyridine ring were privileged to insert selected groups. Among the synthesized compounds emerged 7-chloro-4-ethyl-3,4-dihydro-2H-pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide (12d), which was evaluated in two memory tests in Wistar rats and showed cognition enhancing effects after intraperitoneal injection at doses as low as 0.3mg/kg. [less ▲]

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See detailDesign, synthesis, and pharmacological evaluation of cromakalim analogues as pancreatic β-cell-selective KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Lebrun, Ph. et al

Conference (2007, October)

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See detailDesign, synthesis and anticancer activity of novel hydroxylated coumarin derivatives
Hemmer, Marc ULg; De Tullio, Pascal ULg; Bernard, Y. et al

Conference (2007, October)

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See detailCromakalim analogues as pancreatic β-cell-selective KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2007, July)

Detailed reference viewed: 8 (0 ULg)