References of "De Tullio, Pascal"
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See detailOriginal cromakalim analogues as KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

Conference (2009, June)

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See detailLes canaux potassiques ATP-dépendants : nouvelles cibles potentielles pour le traitement de divers troubles métaboliques
Florence, X.; De Tullio, Pascal ULg; Lebrun, Ph. et al

Conference (2009, February 03)

Detailed reference viewed: 9 (0 ULg)
See detailApplication of Metabolomic Approaches to the Age-related Macular Degeneration (AMD)
De Tullio, Pascal ULg

Conference (2009, January 30)

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See detailNew R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: modulation of the 4-position
Florence, Xavier ULg; Sebille, Sophie; De Tullio, Pascal ULg et al

in Bioorganic & Medicinal Chemistry (2009), 17

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See detailOriginal cromakalim analogues as KATP channel openers
Florence, Xavier ULg; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Metabolic and Functional Research on Diabetes (2009), 2

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See detail6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Kempen, I.; Hemmer, Marc ULg; Counerotte, Stéphane ULg et al

in European Journal of Medicinal Chemistry (2008), 43(12), 2735-50

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure ... [more ▼]

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. [less ▲]

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See detail1H NMR metabolomic approach of the laser-induced choroidal neovascularization in mice
Lambert, Vincent ULg; Frederich, Michel ULg; Rousseau, Rousseau et al

Poster (2008, August)

Detailed reference viewed: 62 (31 ULg)
See detailThe arylthiadiazine 1,1-dioxides in medicinal chemistry
De Tullio, Pascal ULg

Conference (2008, June 08)

Detailed reference viewed: 11 (0 ULg)
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See detail6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2008, May)

Detailed reference viewed: 6 (0 ULg)