References of "De Tullio, Pascal"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLes activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim
Dupont, Léon ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Annales Pharmaceutiques Françaises (1995), 53(5), 201-208

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers ... [more ▼]

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers has been reoptimized using the AM1 semiempirical Molecular Orbital method (MOPAC 5.0), and the total energy of the optimized conformers has been compared. In spite of an apparent structural dissimilarity, a good analogy has been found between the calculated isopotential map of diazoxide and that of at least one selected low energy conformer of pinacidil. It has been suggested that, unlike cromakalim, the low but observable activity of pinacidil on pancreatic B-cells could be explained by adoption for this compound of a conformation having a diazoxide-like stereoelectronical imprint which could assume a similar interaction on the same biological receptor. [less ▲]

Detailed reference viewed: 41 (3 ULg)
Peer Reviewed
See detailATP-sensitive K+ channels and insulin release: effect of BPDZ 62
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Diabetologia (1995), 38

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detail7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailPyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels
De Tullio, Pascal ULg; Pirotte, Bernard ULg; Antoine, M.-H. et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detail3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailN2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine
Dupont, L.; Masereel, B.; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailSynthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics
Masereel, B.; Dupont, L.; Laeckmann, D. et al

in European Journal of Medicinal Chemistry (1995), 30

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detail2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detail3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 3 (2 ULg)
Full Text
Peer Reviewed
See detail3-Methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailSynthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropyl-guanidines
Masereel, B.; Schynts, M.; Pirotte, Bernard ULg et al

in Journal de Pharmacie de Belgique (1995), 50

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detail3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detail3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

Detailed reference viewed: 9 (2 ULg)
Peer Reviewed
See detailPyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Conference (1994, December 10)

Detailed reference viewed: 2 (0 ULg)