References of "De Tullio, Pascal"
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See detailAbsolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1996), C52

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See detailAnticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas
Masereel, B.; Lambert, D.; Bia, F. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detail2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Pirotte, Bernard ULg; Ouedraogo, R. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailATP-sensitive K+ channels and insulin release: effect of BPDZ 62
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Poster (1995, September)

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See detailSynthesis and diuretic properties of pyrid-3-ylsulfonylcyanoguanidines
Masereel, B.; Dupont, L.; Laeckmann, D. et al

Poster (1995, June)

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See detailAnticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas
Masereel, B.; Lambert, D.; Bia, F. et al

Poster (1995, June)

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See detailLes canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62
Ouedraogo, R.; Pirotte, Bernard ULg; Antoine, M. H. et al

Poster (1995, June)

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See detailATP-sensitive K+ channels and insulin release: effect of BPDZ 62
Ouedraogo, R.; Antoine, M. H.; De Tullio, Pascal ULg et al

Poster (1995, February 18)

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See detailSynthèse et évaluation enzymatique de nouveaux dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine
Pochet; Doucet, C.; Schynts, M. et al

Poster (1995, January 12)

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See detailSynthesis and diuretic properties of novel pyrid-3-ylsulfonylcyanoguanidines
Masereel, B.; Laeckmann, D.; Dupont, L. et al

Poster (1995, January 12)

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See detailLes activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim
Dupont, Léon ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Annales Pharmaceutiques Françaises (1995), 53(5), 201-208

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers ... [more ▼]

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers has been reoptimized using the AM1 semiempirical Molecular Orbital method (MOPAC 5.0), and the total energy of the optimized conformers has been compared. In spite of an apparent structural dissimilarity, a good analogy has been found between the calculated isopotential map of diazoxide and that of at least one selected low energy conformer of pinacidil. It has been suggested that, unlike cromakalim, the low but observable activity of pinacidil on pancreatic B-cells could be explained by adoption for this compound of a conformation having a diazoxide-like stereoelectronical imprint which could assume a similar interaction on the same biological receptor. [less ▲]

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